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ITFTDVTKQYPDGTVAVDNLNLEVPQGTLAAFVGPSGCGKTTSMRMVNRMIDPTSGTLTVNGEDVTQVDP VKLRLGIGYVIQSAGLMPHLRVVDNVATVPVLRGESRRSARKAAIGVMERVGLDPKLADRYPAQLSGGQQ QRVGVARALAADPPILLMDEPFSAVDPVVREDLQAEIIRLQGELRKTVIFVTHDIDEAIKLGDKVAVFGR GGVLQQYDAPARLLSNPANEFVAGFVGADRGYRGLQFFHATGLPLHEIRHVAEPLIDSLDLAPGDWVLVT KPDGSPYAWINAEGVEVHRSGKSLYDSTIAGGSLFRPDGTLRHALDAALSSPSGLGVAVDADDHVIGGVR ADDVLAALAEQRQIPEL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6333 | - | - | 100% (368) | amino acid ABC transporter, ATP-binding protein |
| M. smegmatis MC2 155 | MSMEG_2926 | - | 4e-80 | 43.58% (374) | glycine betaine/carnitine/choline transport ATP-binding protein |
| M. smegmatis MC2 155 | MSMEG_6521 | - | 2e-49 | 46.64% (238) | sulfate/thiosulfate import ATP-binding protein CysA 2 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3784c | proV | 1e-133 | 67.13% (359) | osmoprotectant (glycine betaine/carnitine/choline/L-proline) |
| M. gilvum PYR-GCK | Mflv_1208 | - | 0.0 | 86.81% (364) | ABC transporter related |
| M. tuberculosis H37Rv | Rv3758c | proV | 1e-133 | 67.13% (359) | osmoprotectant (glycine betaine/carnitine/choline/L-proline) |
| M. leprae Br4923 | MLBr_01424 | - | 1e-43 | 41.42% (239) | putative binding-protein-dependent transport protein |
| M. abscessus ATCC 19977 | MAB_0262 | - | 1e-159 | 76.37% (364) | amino acid ABC transporter ATP-binding protein |
| M. marinum M | MMAR_5301 | proV | 1e-133 | 65.56% (363) | osmoprotectant transport ATP-binding protein ABC transporter |
| M. avium 104 | MAV_0318 | - | 1e-133 | 66.21% (364) | amino acid ABC transporter, ATP-binding protein |
| M. thermoresistible (build 8) | TH_4520 | - | 1e-80 | 44.44% (369) | PUTATIVE osmoprotectant (glycine |
| M. ulcerans Agy99 | MUL_0033 | proV_1 | 7e-74 | 42.90% (373) | osmoprotectant (glycine |
| M. vanbaalenii PYR-1 | Mvan_5600 | - | 1e-180 | 86.23% (363) | ABC transporter-related protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3784c|M.bovis_AF2122/97 ---------------------MICFDDVSKVY-AHGATAVDRLTLEVPNG
Rv3758c|M.tuberculosis_H37Rv ---------------------MICFDDVSKVY-AHGATAVDRLTLEVPNG
MMAR_5301|M.marinum_M ---------------------MIRFDNVDKVY-ADGTTAVDQLSLEVADG
MAV_0318|M.avium_104 ---------------------MIVFDNVSKVF-ADGTAAVDRLSLTVPTG
Mflv_1208|M.gilvum_PYR-GCK ---------------------MITFENVTKRY-PDGTVAVDDLTLEVPEG
Mvan_5600|M.vanbaalenii_PYR-1 ---------------------MISFEHVTKRY-PDGTVAVDDLTLEVPEG
MSMEG_6333|M.smegmatis_MC2_155 ---------------------MITFTDVTKQY-PDGTVAVDNLNLEVPQG
MAB_0262|M.abscessus_ATCC_1997 ---------------------MITFENVTKQY-PDGTTAVDDLNMHVDKG
TH_4520|M.thermoresistible__bu ------VSEP-TSDLQSGGGARILLDGVTKRYDPKSPPAVDNITMEIPAG
MUL_0033|M.ulcerans_Agy99 MPEAASADQPTTSDAPQSSGLRILLDGVTKRYGVRSTPAVDNVTLEIGAG
MLBr_01424|M.leprae_Br4923 -------------------MASVTFEQATRQFPDTDRPALDRLDLDVDDG
: : . : : . *:* : : : *
Mb3784c|M.bovis_AF2122/97 MLTVFVGPSGCGKTTALRMINRMVDPTSGTITVDGTDVSTVNAVKLRLGI
Rv3758c|M.tuberculosis_H37Rv MLTVFVGPSGCGKTTALRMINRMVDPTSGTITVDGTDVSTVNAVKLRLGI
MMAR_5301|M.marinum_M MLTVFVGPSGCGKTTALRMINRMVEPSSGTVTVNGTDVSTVNPVKLRLGI
MAV_0318|M.avium_104 KLTVFVGSSGSGKTTALRMINRMIEPTSGTISIDGVDVSTLDPVKLRLGI
Mflv_1208|M.gilvum_PYR-GCK TLTVFVGPSGCGKTTSMRMINRMIEPTSGTLTVDGKDVTKVDPVKLRLGI
Mvan_5600|M.vanbaalenii_PYR-1 TLAVFVGPSGCGKTTSMRMINRMIEPTSGTLTVDGRDVTKVDAVKLRLGI
MSMEG_6333|M.smegmatis_MC2_155 TLAAFVGPSGCGKTTSMRMVNRMIDPTSGTLTVNGEDVTQVDPVKLRLGI
MAB_0262|M.abscessus_ATCC_1997 SFTVFVGPSGCGKTTSMRMINRMTDLTSGLLTVDGADVRTVDPVKLRLGI
TH_4520|M.thermoresistible__bu EIVMLVGPSGCGKTTTMKMINRLIEPTSGRIFIGDDDVTERDADELRRHI
MUL_0033|M.ulcerans_Agy99 EIVMLVGPSGCGKTTTMKVINRLIEPTSGRIFIGDDDVTRRNPDELRRHI
MLBr_01424|M.leprae_Br4923 EFVVVVGPSGCGKTTSLRMVAGLETLDSGCIRIGDRDVTHVDPK--DRDV
:. .**.**.****::::: : ** : :.. ** :. :
Mb3784c|M.bovis_AF2122/97 GYVIQNAGLMPHQRVIDNVATVPVLKGQPRRAARKAGYEVLERVGLDP-K
Rv3758c|M.tuberculosis_H37Rv GYVIQNAGLMPHQRVIDNVATVPVLKGQPRRAARKAGYEVLERVGLDP-K
MMAR_5301|M.marinum_M GYVIQNAGLMPHQRVIDNVATVPVLKGQSRRAARKAAYEVLERVGLNP-K
MAV_0318|M.avium_104 GYVIQHAGLMPHQRVIDNVATVPVLRGQRRRAARTAAYQVLERVGLDV-K
Mflv_1208|M.gilvum_PYR-GCK GYVIQSAGLMPHLRVIDNVATVPVLQGESRRSARKSALGVMERVGLDP-K
Mvan_5600|M.vanbaalenii_PYR-1 GYVIQSAGLMPHLRVVDNVATVPVLRGESRRSARRSALGVLERVGLDP-K
MSMEG_6333|M.smegmatis_MC2_155 GYVIQSAGLMPHLRVVDNVATVPVLRGESRRSARKAAIGVMERVGLDP-K
MAB_0262|M.abscessus_ATCC_1997 GYVIQNAGLMPHQRVIDNVATVPVLRGESRRAARKTALEVLERVGLDP-K
TH_4520|M.thermoresistible__bu GYVIQGAGLFPHYTVAENIAIVPRLLKWDRKRIAARVDELLDLVSLDPDE
MUL_0033|M.ulcerans_Agy99 GYVVQGAGVFLHLTVGDNIGIVPRLLKWDKNRVAARIDELLDLVNLDPAQ
MLBr_01424|M.leprae_Br4923 AMVFQNYALYPHMTVAQNLGFALKISKISKAEIHDRILVVAKLLDLQP--
. *.* .: * * :*:. . : : : . :.*:
Mb3784c|M.bovis_AF2122/97 VATRYPAQLSGGEQQRVGVARALAADPPILLMDEPFSAVDPVVRHELQNE
Rv3758c|M.tuberculosis_H37Rv VATRYPAQLSGGEQQRVGVARALAADPPILLMDEPFSAVDPVVRHELQNE
MMAR_5301|M.marinum_M VASRYPAQLSGGEQQRVGVARALAADPPILLMDEAFSAVDPVVRHDLQNE
MAV_0318|M.avium_104 LARRYPAQLSGGEQQRVGVARALAADPPILLMDEPFSAVDPVVRHDLQNE
Mflv_1208|M.gilvum_PYR-GCK LADRYPAQLSGGQQQRVGVARALAADPPILLMDEPFSAVDPVVRDDLQAE
Mvan_5600|M.vanbaalenii_PYR-1 LADRYPAQLSGGQQQRVGVARALAADPPILLMDEPFSAVDPVVREDLQTE
MSMEG_6333|M.smegmatis_MC2_155 LADRYPAQLSGGQQQRVGVARALAADPPILLMDEPFSAVDPVVREDLQAE
MAB_0262|M.abscessus_ATCC_1997 LATRYPAQLSGGQQQRVGVARALAADPPILLMDEPFSAVDPNVRDDLQAE
TH_4520|M.thermoresistible__bu YRDRYPRELSGGQQQRVGVARALAADPPVLLMDEPFGAVDPITRQRLQDE
MUL_0033|M.ulcerans_Agy99 YRDRFPRELSGGQQQRVGVARALAADPPVLLMDEPFGAVDPITRQRLQDE
MLBr_01424|M.leprae_Br4923 YLDRKPKDLSGGQRQRVAMGRAIVRRPQVFLMDEPLSNLDAKLRAQTRNQ
* * :****::***.:.**:. * ::****.:. :*. * : :
Mb3784c|M.bovis_AF2122/97 ILRLQAELHKTIVFVTHDIDEALKLADLVAVFAPGGALAQYDETARLLSS
Rv3758c|M.tuberculosis_H37Rv ILRLQAELHKTIVFVTHDIDEALKLADLVAVFAPGGALAQYDETARLLSS
MMAR_5301|M.marinum_M ILRLQSDLHKTIVFVTHDIDEAFKLGEVVAVFAPGGRLQQCDQPARLLAR
MAV_0318|M.avium_104 ILRLQSELHKTIVFVTHDIDEALRLGERVAVFK-GGMLQQCDEPARLLSR
Mflv_1208|M.gilvum_PYR-GCK IVRLQSELRKTIVFVTHDIDEAIKLGDRVAVFGRGGVLEQYDAPARLLSN
Mvan_5600|M.vanbaalenii_PYR-1 ILRLQSELRKTIVFVTHDIDEAIKLGDKVAVFGRGGVLQQYDAPARLLSN
MSMEG_6333|M.smegmatis_MC2_155 IIRLQGELRKTVIFVTHDIDEAIKLGDKVAVFGRGGVLQQYDAPARLLSN
MAB_0262|M.abscessus_ATCC_1997 MQRLQAELNKTIVFVTHDIDEAVKLGDKVAVFGPGGVLQQYDEPERVLSN
TH_4520|M.thermoresistible__bu LLRLQDELRKTIVFVTHDFDEAVKLGDRIAILQQGSKVVQYDTPEEILTN
MUL_0033|M.ulcerans_Agy99 LLRLQEELHKTIVFVTHDFGEAVKLGDRIAILTTGSKVVQYDTPERVLAE
MLBr_01424|M.leprae_Br4923 IAELQCQLGTTTVYVTHDQVEAMTMGDRVAVLCYG-VLQQFATPRELYHK
: .** :* .* ::**** **. :.: :*:: * : * . .:
Mb3784c|M.bovis_AF2122/97 PANDFVSKFIGL-GRGYRWLQLFDAAGLPVRDIEQVSV---NGLSDARDR
Rv3758c|M.tuberculosis_H37Rv PANDFVSKFIGL-GRGYRWLQLFDAAGLPVRDIEQVSV---NGLSDARDR
MMAR_5301|M.marinum_M PANEFVSKFIGL-GRGYRLLQLFDGAGLELHDLERICV---SSLGRS---
MAV_0318|M.avium_104 PANDFVSRFIGL-GRGYRWLQLIDAAGLPVHDVRRLFA---ENLSGA---
Mflv_1208|M.gilvum_PYR-GCK PANDSVAGFVGA-DRGYRGLQFFHATGLPLHDIRHVGE---PEIDALT--
Mvan_5600|M.vanbaalenii_PYR-1 PANDEVAEFVGA-DRGYRGLQFFHATGLPLHDIRRVAE---PEINALT--
MSMEG_6333|M.smegmatis_MC2_155 PANEFVAGFVGA-DRGYRGLQFFHATGLPLHEIRHVAE---PLIDSLD--
MAB_0262|M.abscessus_ATCC_1997 PASDFVAGFIGR-DRGYRGLQFREAGEVPLYEIRQVRE---PQITDLI--
TH_4520|M.thermoresistible__bu PADDFVKGFVGH-GAALKQLTLTRVRDVDLHDAVTARAGGDPDEAIHAAR
MUL_0033|M.ulcerans_Agy99 PANDFVRGFVGA-GATLMQLSLTRVRDIDLHEAVVAQAGGDPAEAVELAG
MLBr_01424|M.leprae_Br4923 PENVFVAGFIGSPGMNLVTLSIVDSSVLLGDWPIRIPREIASAASEVIIG
* . * *:* . * : :
Mb3784c|M.bovis_AF2122/97 QVRDGWVLVVDGAGAPLGWIDADGRRRHRGGAALSDAMTVGGSVFRPNGN
Rv3758c|M.tuberculosis_H37Rv QVRDGWVLVVDGAGAPLGWIDADGRRRHRGGAALSDAMTVGGSVFRPNGN
MMAR_5301|M.marinum_M QLPDGWALVVSDDDVPVGWIDADGLRRHRDGATLPDAMTVVGAVFRPNGN
MAV_0318|M.avium_104 DVFDGWAVVVDEAGAPLGWIDAEGLRRHRDGLALSDSMTGVGSLFRPRGN
Mflv_1208|M.gilvum_PYR-GCK LGSGDWVLVTRPDGTPYAWIDAEGVDLHRKGASLYDSTIAGGSLFRPDGT
Mvan_5600|M.vanbaalenii_PYR-1 LNPGDWVLVTRTDGTPYAWINAAGVELHRNGSSLYDSTIAGGSLFQPDGT
MSMEG_6333|M.smegmatis_MC2_155 LAPGDWVLVTKPDGSPYAWINAEGVEVHRSGKSLYDSTIAGGSLFRPDGT
MAB_0262|M.abscessus_ATCC_1997 IAPGDWVLVCNADGTPFGWMDDAGADVYRSGKSLYDSVIAGGSLFGPDGT
TH_4520|M.thermoresistible__bu AADREHVIVLDAQNRPMRWMSLAELARPGALIRVSRDENLECVTLAS--T
MUL_0033|M.ulcerans_Agy99 SLDRAHAIVLDRQNRPLRWLPLEELAKPQALAQVTRDDDLECVNLAS--T
MLBr_01424|M.leprae_Br4923 VRPEHFELGSLGVEVEIDMVEELGADAYLYG-------RIAGASKVTDQL
: : .
Mb3784c|M.bovis_AF2122/97 LSQALDAALSSPSGVGVAVDGGGKVIGGILAADVLAEFQKGKKAGGGAKP
Rv3758c|M.tuberculosis_H37Rv LSQALDAALSSPSGVGVAVDGGGKVIGGILAADVLAEFQKGKKAGGGAKP
MMAR_5301|M.marinum_M LSQALDAALSSPSSMGVAVDDGGKVIGGVLADDVLSALKSRR--------
MAV_0318|M.avium_104 LSQALDAALSSPSGIGVAVDDDGRVIGGVLAADVLAAVESQRKSR-----
Mflv_1208|M.gilvum_PYR-GCK LRLALDAALSSPSGLGVAVDADGQVVGGVKADDVLAALDTQRRARHEG--
Mvan_5600|M.vanbaalenii_PYR-1 LRLALDAALSSPAGLGVAVDGAGQVIGGVRADDVLAALDKQRAARQAEG-
MSMEG_6333|M.smegmatis_MC2_155 LRHALDAALSSPSGLGVAVDADDHVIGGVRADDVLAALAEQRQIPEL---
MAB_0262|M.abscessus_ATCC_1997 LRQALDAALSSPCGLGVAIDADGRVRGGVRGDDVLTALDRQRRNGQR---
TH_4520|M.thermoresistible__bu LTDALDDMLTSSHGVVVVTGRRNTYQGVIRLETIMDAIADARGTAGSQGA
MUL_0033|M.ulcerans_Agy99 LNDALDEMLTSAHGVVVVTGRRNTYQGVIRVETIMEAIADIRGAANSEEP
MLBr_01424|M.leprae_Br4923 VVARVDGRNPPAKGSRVRLYTEPGNVHFFGVDGHRIS-------------
: :* ... . * .
Mb3784c|M.bovis_AF2122/97 CTT
Rv3758c|M.tuberculosis_H37Rv CTT
MMAR_5301|M.marinum_M ---
MAV_0318|M.avium_104 ---
Mflv_1208|M.gilvum_PYR-GCK ---
Mvan_5600|M.vanbaalenii_PYR-1 ---
MSMEG_6333|M.smegmatis_MC2_155 ---
MAB_0262|M.abscessus_ATCC_1997 ---
TH_4520|M.thermoresistible__bu GAP
MUL_0033|M.ulcerans_Agy99 DT-
MLBr_01424|M.leprae_Br4923 ---