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TDPARTLPLSAMISGAAGMLIPLAGARDPGDDPLVSDVALHEPGEPADYRGTIVLVNSRIDDRFVLGSLL DEVGTAGAVVLPPGATTDLSLVRGHTARLFRRSPWVGWSELFRVLVRLLGAGHTVDPAPQVDNLQALARW ISTRTGAPVTIEDLDSRVLAYAVVGHDVDPIRNQTILGGAVPAWRVERLMSTGFLPAVWRSDDVVVRNAE NGDPARMVVSVKTGGETLGTIWAALDDATDRDALRQLLLQVRQTAAAMMLREVHLEQYERRLREAALVDL ISRGVDPGVPAALLGLQPDTRHVVVALGADAPESRSLMFHMQALRAGARPARVGTDLLVVVPLQDDEVTD ADVAGNLSVHLARVSRARCGTVAVGSVVDSILDLQRSAVVARQVLDAAALDIGCRRTREATPPVITAADV ADPLTLVRAADLLDPLGDAIAEPLRALRRHDIDHGTAFVDTVAAVLDHPGNLSGAARELGIHANSLRYRL DRITAVAGLDLQSAAARLRAALALLVWERRGESVRATVHFDEKRGSR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6198 | - | - | 100% (538) | DNA-binding protein, putative |
| M. smegmatis MC2 155 | MSMEG_6290 | - | 4e-32 | 28.21% (521) | putative DNA-binding protein |
| M. smegmatis MC2 155 | MSMEG_5120 | - | 2e-17 | 23.76% (425) | hypothetical protein MSMEG_5120 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1218c | - | 1e-16 | 24.78% (448) | hypothetical protein Mb1218c |
| M. gilvum PYR-GCK | Mflv_1946 | - | 5e-27 | 27.68% (495) | putative DNA-binding protein |
| M. tuberculosis H37Rv | Rv1186c | - | 2e-16 | 24.78% (448) | hypothetical protein Rv1186c |
| M. leprae Br4923 | MLBr_01652 | - | 1e-06 | 29.55% (132) | hypothetical protein MLBr_01652 |
| M. abscessus ATCC 19977 | MAB_4202c | - | 1e-10 | 23.93% (305) | putative regulatory protein |
| M. marinum M | MMAR_4254 | - | 6e-14 | 24.39% (537) | hypothetical protein MMAR_4254 |
| M. avium 104 | MAV_1987 | - | 1e-25 | 28.27% (421) | putative DNA-binding protein |
| M. thermoresistible (build 8) | TH_2137 | - | 4e-30 | 27.83% (503) | putative DNA-binding protein |
| M. ulcerans Agy99 | MUL_0931 | - | 9e-14 | 24.44% (532) | hypothetical protein MUL_0931 |
| M. vanbaalenii PYR-1 | Mvan_4779 | - | 2e-25 | 27.02% (496) | putative DNA-binding protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1218c|M.bovis_AF2122/97 --------MRIAGVGLGQLLLALDATVVSLVDAPRGLDLPVASTALIDSD
Rv1186c|M.tuberculosis_H37Rv --------MRIAGVGLGQLLLALDATVVSLVDAPRGLDLPVASTALIDSD
MMAR_4254|M.marinum_M --------MGVAGVGLGQLLLALDATLVSLVEAPRGLDLPVASAALVDSD
MUL_0931|M.ulcerans_Agy99 --------MGVAGVGLGQLLLALDATLVSLVEAPRGLDLPVASAALVDSD
Mflv_1946|M.gilvum_PYR-GCK MHTAGPGVASTFVITLDRLINVLGGYGARWQGGSADRQTELRSVVLPEVV
Mvan_4779|M.vanbaalenii_PYR-1 ------------MITLDRLINVLGGYGARWHSGSADRQTELRSVVLPEVV
MAV_1987|M.avium_104 ------------MITLDRLVNVLGGYGVRLRWSSVPRSTELRSVVIHETP
TH_2137|M.thermoresistible__bu ------------VVTLDRLVNVLGSYGVRLQFCPVPRSTEVRSVALHENA
MSMEG_6198|M.smegmatis_MC2_155 ------MTDPARTLPLSAMISGAAGMLIPLAGARDPGDDPLVSDVALHEP
MAB_4202c|M.abscessus_ATCC_199 ----------------MRWVLDQPELKLTLKSGAAGVGREINLALTTELA
MLBr_01652|M.leprae_Br4923 --------------MNHNHFVPAPPRRLPLELLDTVPDSLLRRLKQYS--
. :
Mb1218c|M.bovis_AF2122/97 DVRLGLAAAAGSADVFFLIGVT-DDEAVRWVDDQARQRAPVAIFVKHPSD
Rv1186c|M.tuberculosis_H37Rv DVRLGLAAAAGSADVFFLIGVT-DDEAVRWVDDQARQRAPVAIFVKHPSD
MMAR_4254|M.marinum_M DVRLGLAAAAGSADIFFLLGVT-DHEALRWIDGQAG--TPVAIFVKQPSD
MUL_0931|M.ulcerans_Agy99 DVRLGLAAAAGSADIFFLLGVT-DHEALRWIDGQAG--TPVAIFVKQPSD
Mflv_1946|M.gilvum_PYR-GCK DGRT------VSGDVLLAIGATTTAEAVRWARAARA----VVVLTRGG-G
Mvan_4779|M.vanbaalenii_PYR-1 DGRT------VSGDVLLAVGAASPAEALQWARAARA----VVVLTRGEHA
MAV_1987|M.avium_104 EDRP------VVGDVLLAVGAGSLDEAVRWAASARA----AVVVLRDDET
TH_2137|M.thermoresistible__bu GGLR------VTGDVLLAVGAESVAEAVRWAETAQA----VVVLTRAG-P
MSMEG_6198|M.smegmatis_MC2_155 GEPAD-----YRGTIVLVNSRIDDRFVLGSLLDEVG--TAGAVVLPPGAT
MAB_4202c|M.abscessus_ATCC_199 DPAQWLS----GGELVLTTGIGLPKSSRDRRRYLRSLDENNVAALGFGTG
MLBr_01652|M.leprae_Br4923 ------------GRLATEAVTAMQERLPFFADLEASQRASVTLVVQTAVV
. : .
Mb1218c|M.bovis_AF2122/97 SVVAGAVRAGSAVVAVEPRARWERLYHLVNHVLEHHGDRADPTDDSGTDL
Rv1186c|M.tuberculosis_H37Rv SVVAGAVRAGSAVVAVEPRARWERLYHLVNHVLEHHGDRADPTDDSGTDL
MMAR_4254|M.marinum_M AVVAKAVRSGAAVVAVEPQARWERLYRLVNHVLEHHGDRT--TDDSGTDL
MUL_0931|M.ulcerans_Agy99 AVVAKAVRSGAAVVAVEPQARWERLYRLVNHVLEHHGDRT--TDDSGTDL
Mflv_1946|M.gilvum_PYR-GCK DPEPDTAG--VAVLVVDSAMPWSEFAAIVYGLVMEGRETE--SGRGPTDL
Mvan_4779|M.vanbaalenii_PYR-1 DPELDGAG--VAVVVIDSAMPWSDFAAIVYGLVMEGRETE--SGRGPTDL
MAV_1987|M.avium_104 PMTFDGVTDVGAVLVIDPTVSWSAVAAVVYGLVLEGRETE--SGRGPTDL
TH_2137|M.thermoresistible__bu DASRSCSDGAVAVLTVEPEVSWSELAAVVYGLVLEGRETE--SGRGPTDL
MSMEG_6198|M.smegmatis_MC2_155 TDLSLVRGHTARLFRRSPWVGWSELFRVLVRLLGAGHTVD--PAPQVDNL
MAB_4202c|M.abscessus_ATCC_199 LTFDEVPPELVSTADELGMPLLEIPLRTPFAAVVKAVSTR--IAELEYDA
MLBr_01652|M.leprae_Br4923 NFVQWMQNPHSDVSYTAQAFELVPQDLARRIALRHTVDMVRVTMEFFEEV
: :
Mb1218c|M.bovis_AF2122/97 FGLAQSLADRIHGMISIEDAQSHVLAYSASNDEADELRRLSILGRAGPPE
Rv1186c|M.tuberculosis_H37Rv FGLAQSLADRIHGMISIEDAQSHVLAYSASNDEADELRRLSILGRAGPPE
MMAR_4254|M.marinum_M FGLAQSLADRIHGMVSIEDAQSHVLAYSASSDEADELRRLSILGRAGPPE
MUL_0931|M.ulcerans_Agy99 FGLAQSLADRIHGMVSIEDAQSHVLAYSASSDEADELRRLSILGRAGPPE
Mflv_1946|M.gilvum_PYR-GCK FALADNLSNAVGGAVVIEDRASQVLAFSRGQLDADPARAKTILARQAPPS
Mvan_4779|M.vanbaalenii_PYR-1 FALADSLAGAVGGAVVIEDRSSQVLAFSRGQQDADPGRIATILARQAPPE
MAV_1987|M.avium_104 FALADSLADGIGNPVVIQDRHLGVLAYS-RLAQADPALVETVLQRQTPEP
TH_2137|M.thermoresistible__bu FALADNLADAVGGPVTIEDRMSRVLAYSQRQQHADPARAQTILARQAPEP
MSMEG_6198|M.smegmatis_MC2_155 QALARWISTRTGAPVTIEDLDSRVLAYAVVGHDVDPIRNQTILGGAVPAW
MAB_4202c|M.abscessus_ATCC_199 VLRASRAQPRITRAIVNGGVQAVTAELGRSLRASVVVLDPGGTVVASHPR
MLBr_01652|M.leprae_Br4923 VPLLARSEEQLTALTVGILKYSRDLAFTAATAYADAAEARGTWDSRMEAS
Mb1218c|M.bovis_AF2122/97 HLQWIGQWGIFDALRAGREVVRVAERPELGLRPRLAIGIHQPGVGALRPP
Rv1186c|M.tuberculosis_H37Rv HLQWIGQWGIFDALRPGREVVRVAERPELGLRPRLAIGIHQPGVGALRPP
MMAR_4254|M.marinum_M HLKWIGQWGIFDALRSGSEVVRVAERPELGLRPRLAIGIHQPPVAARRPP
MUL_0931|M.ulcerans_Agy99 HLKWIGQWGIFDALRSGSEVVRVAERPELGLRPRLAIGIHQPPVAARRPP
Mflv_1946|M.gilvum_PYR-GCK LRAVFDAHGVFAHLAVSDEPLFVPG-------DDAVGLTGRMVVAARAGR
Mvan_4779|M.vanbaalenii_PYR-1 LRAVYEAHGVFAHLAVSDDPVFVPGDAPDGMLDDAAGRTGRMVVAARAGR
MAV_1987|M.avium_104 LRALLEARGVFAHLQVADEPLFVAE-------DAERGLSGRMVVAVRAGA
TH_2137|M.thermoresistible__bu LRRLFEQLGVSEHLAAGDDPLFIAA-------RPGHDLTGRTVIAVRAGR
MSMEG_6198|M.smegmatis_MC2_155 RVERLMSTGFLPAVWRSDDVVVRNAE---------NGDPARMVVSVKTGG
MAB_4202c|M.abscessus_ATCC_199 NLDVATVNLVRGALSPGASAGVQQLDP----------GITVSQQAIGVGG
MLBr_01652|M.leprae_Br4923 VVDAVVRGDTGPELLSR-------------------------AAALNWDT
: .
Mb1218c|M.bovis_AF2122/97 VFAGTIWVQQGSQPLADDA-EEMLRGAAVLAARIMSRLATQPNTHALRVQ
Rv1186c|M.tuberculosis_H37Rv VFAGTIWVQQGSQPLADDA-EEMLRGAAVLAARIMSRLATQPNTHALRVQ
MMAR_4254|M.marinum_M VFAGSIWVQQGSQPLAEDA-DEVLRGAAVLGARIMTRLASRPSTHARRVQ
MUL_0931|M.ulcerans_Agy99 VFAGSIWVQQGSQPLAEDA-DEVLRGAAVLGARIMTRLASRPSTHARRVQ
Mflv_1946|M.gilvum_PYR-GCK ELLGSVWVAVPKPLAGQQR-QALADGARTVALHLLRSRASADLERQVESE
Mvan_4779|M.vanbaalenii_PYR-1 ELLGSVWVACASPLVGDRR-RALADGAHTVALHLLRSRASADLERQVESE
MAV_1987|M.avium_104 ELIGSVWVACEAPLQPAAL-RALADGARTVALHLLRSRASADLERQVESE
TH_2137|M.thermoresistible__bu ELLGSVWVVTPEPLDDGRR-RALADGARTVALHLLRSRASADLERQVESD
MSMEG_6198|M.smegmatis_MC2_155 ETLGTIWAALDDATDRDALRQLLLQVRQTAAAMMLREVHLEQYERRLREA
MAB_4202c|M.abscessus_ATCC_199 TSYGVLAVVSKTPLTFVDQ-VLLGHTNSLLALDFDKPSRLQEAQRRLNGQ
MLBr_01652|M.leprae_Br4923 TAPATVVVGTPTPNHDGPN-GQVSSERASQEVREIAARHGRAALTDVHGT
. : . : .
Mb1218c|M.bovis_AF2122/97 QLLGLAELNATTAPVDVSTIARELGVAAEGNATLIGFDTAENRDTAVRHV
Rv1186c|M.tuberculosis_H37Rv QLLGLAELNATTAPVDVSTIARELGVAAEGNATLIGFDTAENRDTAVRHV
MMAR_4254|M.marinum_M QLLGLADPDPTAAPADVTAIARELGLSADGNAALIGFDTIEADD---KQS
MUL_0931|M.ulcerans_Agy99 QLLGLADPDPTAAPADVTAIARELGLSADGNAALIGFDTIEADD---KQS
Mflv_1946|M.gilvum_PYR-GCK MVIRLLES-----PADAETVASRLGLPPSA-LRVIALRALDTTG---RHS
Mvan_4779|M.vanbaalenii_PYR-1 LVIRLLES-----PADAATVASRLGLPPAT-LRVIALRASDEGG---RHA
MAV_1987|M.avium_104 LVIRLLEG-----TADAATVASRLDLAHNG-LRVVAVQAFVGAD---RDA
TH_2137|M.thermoresistible__bu LVLRLLEG-----TSDAAGAAARLGLPQEA-LRIIAVRARSGVD---RQG
MSMEG_6198|M.smegmatis_MC2_155 ALVDLISR-----GVDPGVPAALLGLQPDTRHVVVALGADAPES----RS
MAB_4202c|M.abscessus_ATCC_199 ALGLLLGD-----ERNLGPVWAQLGQAADARGRIRVLVVDAESQ----TA
MLBr_01652|M.leprae_Br4923 WLVAIISG----------------QLAPTDKFFSDLLHAFSDGP------
: : . .
Mb1218c|M.bovis_AF2122/97 RLVDVMALSAS--AFRHDAQVAANGSRIYVLLPQTTTGRAVTSWVRGTIS
Rv1186c|M.tuberculosis_H37Rv RLVDVMALSAS--AFRHDAQVAANGSRIYVLLPQTTTGRAVTSWVRGTIS
MMAR_4254|M.marinum_M RLADVLALSAS--AFRRDAQVGTNGSRIYVVLPQTATARSLTSWVRGTIS
MUL_0931|M.ulcerans_Agy99 RLADVLALSAS--AFRRDAQVGTNGSRIYVVLPQTATARSLTSWVRGTIS
Mflv_1946|M.gilvum_PYR-GCK ALLQMFERATAGFGWSRPSRSALADATVYTVLAAEPAAVAR-DWVSALIS
Mvan_4779|M.vanbaalenii_PYR-1 ALLQMFERATAGFGWSRPSRSALADTTVYTVLAAEAAAVAR-DWVSALVA
MAV_1987|M.avium_104 PLLLAFERATTGFGWSRPGRSALAGNSVYAVLPADEASTAR-RWVGALRA
TH_2137|M.thermoresistible__bu PLLLAFEHATTGFGWSRAGRSALAGDTVYTVLPADHAATAR-RWVEGLQA
MSMEG_6198|M.smegmatis_MC2_155 LMFHMQALRAG-------ARPARVGTDLLVVVPLQDDEVTDADVAGNLSV
MAB_4202c|M.abscessus_ATCC_199 LVRVLPAVTRDMESAGYPVFAHTGERQLTVVLPGAETADFARRLFGDVDA
MLBr_01652|M.leprae_Br4923 -----------------------------VVIGPTAP---------MLTA
.::
Mb1218c|M.bovis_AF2122/97 ALRAELGVALRAAIAGPVAG-LAEVNPARVEVDRVLESAERHPI-LGQVT
Rv1186c|M.tuberculosis_H37Rv ALRAELGVALRAAIAGPVAG-LAEVNPARVEVDRVLESAERHPI-LGQVT
MMAR_4254|M.marinum_M ALRSELGVELRATIAAPVAG-LDGLASARVEVDRVLDSAERHPISIGRVT
MUL_0931|M.ulcerans_Agy99 ALRSELGVELRATIAAPVAG-LDGLASARVEVDRVLDSAERHPISIGRVT
Mflv_1946|M.gilvum_PYR-GCK TLPDQVTVKAGISAPAAAT----DLAVARTEADECLALQESTDAGEPP--
Mvan_4779|M.vanbaalenii_PYR-1 ALPEQLTVQAGISAPAAAT----ELAVARTEADECLALQEGTGADAPP--
MAV_1987|M.avium_104 ALPERLTMIAGISGVAEVG----DLAAARQEADECLALHEMSPAAPPP--
TH_2137|M.thermoresistible__bu ALPSEVTVSAGISGIADHT----ELPDARREADECLALHDALHDARPDTG
MSMEG_6198|M.smegmatis_MC2_155 HLARVSRARCGTVAVGSVVDSILDLQRSAVVARQVLDAAALDIGCRRTRE
MAB_4202c|M.abscessus_ATCC_199 RIKKG--LRAGLSGAHPVGR----LADAVQNARLAASVAERGGTPLEFTS
MLBr_01652|M.leprae_Br4923 AYHSASEAVSGMNAVAGWSG-----APRPVQARELLPER-----------
.
Mb1218c|M.bovis_AF2122/97 ------------SLAEARTTVLLDEIVTLVGTDQRLVDPRIRDLGAQD--
Rv1186c|M.tuberculosis_H37Rv ------------SLAEARTTVLLDEIVTLVGTDQRLVDPRIRDLGAQD--
MMAR_4254|M.marinum_M ------------SLAEARTTVLLDEIVTLVGNDARLIDPRIPDLRAKD--
MUL_0931|M.ulcerans_Agy99 ------------SLAEARTTVLLDEIVTLVGNDARLIDPRIPDLRAKD--
Mflv_1946|M.gilvum_PYR-GCK ------------AYDESWDDLLLRRLKTAARSGRTPTRGAVAELREHDSA
Mvan_4779|M.vanbaalenii_PYR-1 ------------AYDESWDDLLLRRLRAAARSGRTPPRGAVAELRAHDST
MAV_1987|M.avium_104 ------------AYDESWDDILLQRLRAAARSGRAPTRGPVADLGRHDRA
TH_2137|M.thermoresistible__bu SPDSDSDALAAVVYDESWHDVLLQRLRTAARAGRIPSRGPIAALHEHDLR
MSMEG_6198|M.smegmatis_MC2_155 ATPP------VITAADVADPLTLVRAADLLDPLGDAIAEPLRALRRHDID
MAB_4202c|M.abscessus_ATCC_199 -----------------LAGSALLSFGASREVLVAVANATLEPIVEHDAV
MLBr_01652|M.leprae_Br4923 ------------------------ALMGDASAIVALHTDVMLPLADAG--
: : .
Mb1218c|M.bovis_AF2122/97 --PVLAQTLRAYLDAFGDIGAAARSLQVHPNTVRYRIRRIEQLLSTSLGD
Rv1186c|M.tuberculosis_H37Rv --PVLAQTLRAYLDAFGDIGAAARSLQVHPNTVRYRIRRIEQLLSTSLGD
MMAR_4254|M.marinum_M --PVLADTLRVYLDSFGDIGLAAQSLQVHPNTVRYRIRRVEKLLSTSFAD
MUL_0931|M.ulcerans_Agy99 --PVLADTLRVYLDSFGDIGLAAQSLQVHPNTVRYRIRRVEKLLSTSFAD
Mflv_1946|M.gilvum_PYR-GCK HGTAYVPTLRAWLQERGDPVRTAAHLGVHENTVRYRMRRMAELTELHLDD
Mvan_4779|M.vanbaalenii_PYR-1 HGTAYVPTLRAWLQERGDPGRTGTRLGVHENTVRYRMRRMAELTDLRLDD
MAV_1987|M.avium_104 NGTDYLATLRAWLQAQGDPAEAGRQLGVHENTVRYRLRKMAEITNLSLDD
TH_2137|M.thermoresistible__bu HATQYVATLRSWLAAQGDPAAAGAVLGVHENTVRYRLRKMTAVTQLDLQD
MSMEG_6198|M.smegmatis_MC2_155 HGTAFVDTVAAVLDHPGNLSGAARELGIHANSLRYRLDRITAVAGLDLQS
MAB_4202c|M.abscessus_ATCC_199 HGSELMTSLRAYLEANGHWESAATVVGVHRHTLRKRIETVQSLLACDLDI
MLBr_01652|M.leprae_Br4923 --PTLIETLDAYLDCGGAIEACARKLFVHPNTVRYRLKRITDFTGHDPTL
. :: * * . : :* :::* *: : .
Mb1218c|M.bovis_AF2122/97 PDVRLLFSLGLRAMERTA----------------
Rv1186c|M.tuberculosis_H37Rv PDVRLLFSLGLRAMERTA----------------
MMAR_4254|M.marinum_M PDVRLVFSLGLRATDRSS----------------
MUL_0931|M.ulcerans_Agy99 PDVRLVFSLGLRATDHSS----------------
Mflv_1946|M.gilvum_PYR-GCK ARKRFAMTIELAVLD-------------------
Mvan_4779|M.vanbaalenii_PYR-1 ADKRFAMMIELAVLD-------------------
MAV_1987|M.avium_104 SKKRLAMMIELAAIHTD-----------------
TH_2137|M.thermoresistible__bu PDKRLAMMIELAAIEGPPILSG------------
MSMEG_6198|M.smegmatis_MC2_155 AAARLRAALALLVWERRGESVRATVHFDEKRGSR
MAB_4202c|M.abscessus_ATCC_199 ARVRAELLLAMLTGTPGTGN--------------
MLBr_01652|M.leprae_Br4923 PRDAYVLRVAATVGKLNYPTHH------------
. : .