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AIELNQIWDFPIKEFHPFPRALLGVGAHDIIGVEAKNLGFKRTLLMTTGLRGSGIIEELTGKIEYQGVEV VLYDKVESNPKDYNVMEAAALYQQEKCDSIISVGGGSSHDAAKGARVVIAHDGRNINEFEGFAKSTNKQN PPHIAVSTTAGTGSETSWAYVITDTSDMDHPHKWVGFDEATIVTLAIDDPLLYYSCPQHFTAYCGFDVLA HGSEPFVSRLDFAPSLGNALYSVELVAKHLREAVFEPRNLKAREGMMNAQYIAGQAFNSGGLGIVHSISH AVSAFFDSHHGLNNAIALPRVWEYNLPARYERYAQLATAMGVDTRNMTTVQAADAAVEAAIRLAQDVGIP DNFSQVRVDSYAKNQMNTGKYAGKGEVIKGDDKTIRAISEHIQDDWCTPGNPREVTVESMIPVVNHAINE SY*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6242 | - | - | 100% (423) | alcohol dehydrogenase, iron-containing |
| M. smegmatis MC2 155 | MSMEG_6239 | - | 5e-41 | 32.10% (352) | 1,3-propanediol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_1392 | - | 6e-36 | 32.43% (333) | alcohol dehydrogenase, class IV |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_1025 | - | 2e-21 | 26.93% (375) | iron-containing alcohol dehydrogenase |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_4110 | - | 9e-31 | 34.38% (288) | aldehyde dehydrogenase |
| M. avium 104 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_3976 | - | 6e-31 | 34.38% (288) | bifunctional acetaldehyde-CoA/alcohol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5479 | - | 1e-161 | 63.92% (413) | iron-containing alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_6242|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5479|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4110|M.marinum_M MTTTPTESASPVEAPAIDNLRTAEIDAIVDTAAEAARAFRKLDQQQVDAI
MUL_3976|M.ulcerans_Agy99 MTTTPTESASPVEAPAIDNLRTAEIDAIVDTAAEAARAFRKLDQQQVDAI
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6242|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5479|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4110|M.marinum_M VEAMVRAGVRAAGELAGVAIEETGFGVFEDKVVKNYVATEFLHDYLRGKK
MUL_3976|M.ulcerans_Agy99 VEAMVRAGVRAAGELAGVAIEETGFGVFEDKVVKNYVATEFLHDYLRGKK
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6242|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5479|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4110|M.marinum_M SVGVIDEDVEHNIVYVAEPIGVVLGITPVTNPTSTVLFKAIVAAKTRNAI
MUL_3976|M.ulcerans_Agy99 SVGVIDEDVEHNIVYVAEPIGVVLGITPVTNPTSTVLFKAIVAAKTRNAI
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6242|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5479|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4110|M.marinum_M LFRPSPYAVRCCEQSIEILRTAAEAAGMPPGALQVIPDAAHEVTHYLFKH
MUL_3976|M.ulcerans_Agy99 LFRPSPYAVRCCEQSIEILRTAAEAAGMPPGALQVIPDAAHEVTHYLFKH
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6242|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5479|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4110|M.marinum_M PKVDFIWVTGGPKIVALANSAGKPGLSVGPGNAPIYIHKTADLKGAVVDI
MUL_3976|M.ulcerans_Agy99 PKVDFIWVTGGPKIVALANSAGKPGLSVGPGNAPIYIHKTADLKGAVVDI
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6242|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5479|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4110|M.marinum_M LISKTFDSSVICPAEQTCIIDDEIYDEMIAEFERMGAQLLTADQAKAVAE
MUL_3976|M.ulcerans_Agy99 LISKTFDSSVICPAKQTCIIDDEIYDEMIAEFERMGAQLLTADQAKAVAE
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6242|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5479|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4110|M.marinum_M FAFGCGDKVSLDAVGQKAPELAARAGFSVPPTVKVLLAQLPSDLGELAAH
MUL_3976|M.ulcerans_Agy99 FAFGCGDKVSLDAVGQKAPELAARAGFSVPPTVKVPLAQLPSDLDELAAH
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6242|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5479|M.vanbaalenii_PYR-1 --------------------------------------------------
MMAR_4110|M.marinum_M PLVQEKLMPVLGVVRARSVQHGIDAAVLVTEHGGLGHTSAIYANDDDVIE
MUL_3976|M.ulcerans_Agy99 PLVQEKLMPVLGVVRARSVQHGIDAAVLVTEHGGLGHTSAIYANDDDVIE
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MSMEG_6242|M.smegmatis_MC2_155 ----------------------------------------------MAIE
Mvan_5479|M.vanbaalenii_PYR-1 ----------------------------------------------MKVE
MMAR_4110|M.marinum_M AYGLAVRTGRILVNAPTAVGALGGVYNNLTPTFSLGCGTWGGSSTTENVN
MUL_3976|M.ulcerans_Agy99 AYGLAVRTGRILVNAPTAVGALGGVYNNLTPTFSLGCGTWGGSSTTENVN
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------MASVMS
:.
MSMEG_6242|M.smegmatis_MC2_155 LNQIWDFPIKEFHPFPRALLGVGAHDIIGVEAKN----LGFKRTLLMTTG
Mvan_5479|M.vanbaalenii_PYR-1 D-LLKPFPIKEFHPFPRAMMGPGAHEMVGPEALK----MGFKRVLLMSSG
MMAR_4110|M.marinum_M YRQLLNIKTVSRRRTPPQWFRVPSNTYFNEGALDNLRELDCETVVVVTDA
MUL_3976|M.ulcerans_Agy99 YRQLLNIKTVSRRRTPPQWFRVPSNTYFNEGALDNLRELDCETVVVVTDA
Mflv_1025|M.gilvum_PYR-GCK CCHTGDGDGAFTVDASRVTFGRGCIAEVGDRARA----LGITRAALFSDS
. : . .. * :. . :.: .
MSMEG_6242|M.smegmatis_MC2_155 LRGS-GIIEELTGKIEYQGVEVVLYDKVESNPKDYNVMEAAALYQQEKCD
Mvan_5479|M.vanbaalenii_PYR-1 LRGT-DIVHNMAESLKWHGLEVVVYDQVESNPKDYNVMDAVKLYQQNECD
MMAR_4110|M.marinum_M LTEERGVVEALRGKLRAQ--HVQVFSEVTPEPDETTIRRGVALMQRVQPD
MUL_3976|M.ulcerans_Agy99 LTEERGVVEALRGKLRAQ--HVQVFSEVTPEPDETTIRRGVALMQRVQPD
Mflv_1025|M.gilvum_PYR-GCK AVAQLEVFDAAQRSLRAAGIDVVDYIDVRVEPTDESFRSAAAFATEASPD
:.. .:. .* : .* :* : .. .. : . . *
MSMEG_6242|M.smegmatis_MC2_155 SIISVGGGSSHDAAKGARVVIAHDGRNINEFEG---------FAKSTNKQ
Mvan_5479|M.vanbaalenii_PYR-1 SFVSIGGGSTHDACKGARISIAHDGRNVNDFEG---------FNKSENPK
MMAR_4110|M.marinum_M LLIAIGGGSVLDAGKAMRLFYEHPEKSLDALTMPFLDPRKRVADYPTDRH
MUL_3976|M.ulcerans_Agy99 LLIAIGGGSVLDAGKAMRLFYEHPEKSLDALTMPFLDPRKRVADYPTDRH
Mflv_1025|M.gilvum_PYR-GCK GYISVGGGSVIDTAKAANLYATHPADFLEYVNAPVG------AGAPVPGP
:::**** *: *. .: * :: . .
MSMEG_6242|M.smegmatis_MC2_155 NPPHIAVSTTAGTGSETSWAYVITDTS-DMDHPHKWVGFDEATIVTLAID
Mvan_5479|M.vanbaalenii_PYR-1 NPPHIAISTTAGTGSETSWAYVITDTTTDPDNPHKYVAFDDASVATLAVD
MMAR_4110|M.marinum_M RIQLVAVPTTSGTGSEVSPAAVLTVGG------KKETLVDYSLVPDLAIV
MUL_3976|M.ulcerans_Agy99 RIQLVAVPTTSGTGSEVSPAAVLTVGG------KKETLVDYSLVPDLAIV
Mflv_1025|M.gilvum_PYR-GCK LAPHIACPTTSGTGSEVTGIAIFDLLS----MAAKTGIASPALRPTEALV
:* .**:*****.: :: * . : *:
MSMEG_6242|M.smegmatis_MC2_155 DPLLYYSCPQHFTAYCGFDVLAHGSEPFVSRLDFAPSLGNALYSVELVAK
Mvan_5479|M.vanbaalenii_PYR-1 DPVLYYQCPVDYTAQCGFDVLAHASEPYVSRLNFEPSLGNAIRAIKLTAE
MMAR_4110|M.marinum_M DPVLTSSMPQKLTADTGIDALTHALEAIVSIFASPYTDALCAQAVRLIFD
MUL_3976|M.ulcerans_Agy99 DPVLTSSMPQKLTADIGIDALTHALEAIVSIFASPYTDALCAQAVRLIFD
Mflv_1025|M.gilvum_PYR-GCK DPDCTGTLPATVVACSGLDVLSHALESYTARPYTHR-----AAPARPTQR
** * .* *:*.*:*. *. .: . .
MSMEG_6242|M.smegmatis_MC2_155 HLREAVFEPRNLKAREGMMNAQYIAGQAFNSGGLGIVHSISHAVSAFFDS
Mvan_5479|M.vanbaalenii_PYR-1 NLREATWNGTDLKGREGMMYAQYIAAQAFNSGGLGIIHSISHAVSAFYDT
MMAR_4110|M.marinum_M ALPRAYDDPDDLSARTSMSNAATLAGLAFSNAFVGTNHALAHAVGAKFSV
MUL_3976|M.ulcerans_Agy99 ALPRAYDDPDDLSARTSMSNAATLAGLAFSNAFVGTNHTLAHAVGAKFSV
Mflv_1025|M.gilvum_PYR-GCK PMSQGANPWSDLGCGEALRLLGTYLARAVADASDSEAREQVMWAATLAGI
: .. :* .: . *. .. . : ..: .
MSMEG_6242|M.smegmatis_MC2_155 HHGLNNAIALPRVWEYN--LPARYERYAQLATAMGVDTRNMTTVQAADAA
Mvan_5479|M.vanbaalenii_PYR-1 HHGLNNAIALPRVWAFN--MPVAYKRFADIAQAMGVDTYGMTDVQAADAA
MMAR_4110|M.marinum_M PHGRANGIFLPHVLRYNASLPTKFMPAPGYSAYIAPDKYAQLGQLVFGGH
MUL_3976|M.ulcerans_Agy99 PHGRANGIFLPHVLRYNASLPTKFMPAPGYSAYIAPDKYAQLGQLVFGGH
Mflv_1025|M.gilvum_PYR-GCK AFG-NAGVHLPHAMAYAVAGQVRDFRPVGYPDSEPLVPHGMSVILNAPAA
.* .: **:. : . . .
MSMEG_6242|M.smegmatis_MC2_155 VEAAIR---------LAQDVGIPDNFSQVRVD--SYAKNQMNTG--KYAG
Mvan_5479|M.vanbaalenii_PYR-1 LAAAIR---------LLRDVNIIEKFTDVKQD--SYSKNRLGQGPTKYYE
MMAR_4110|M.marinum_M LPDDSRQRLFAGVDDLLDRLDMPRSLREFGVDEQEFLAALPTLAMTAFED
MUL_3976|M.ulcerans_Agy99 LPDDSRQRLFAGVDDLLDRLDMPRSLREFGVDEQGFLVALPTLAMTAFED
Mflv_1025|M.gilvum_PYR-GCK FRLTAHTDP---ARHLFAAARLGADTADAAPEDAGTVLAEHLMTIMRQVG
. : * : . : :
MSMEG_6242|M.smegmatis_MC2_155 KGEVIKGDDKTIRAISEHIQDDWCTPGNPREVTVESMIPVVNHAINESY-
Mvan_5479|M.vanbaalenii_PYR-1 NAPVIKGDKADVDRITNHVLGDACTPGNAKECTFDTVRPVVEHCMNGDLD
MMAR_4110|M.marinum_M LSNRTNPRMPLVSEITDLLRLGYYGDTGVGEPALAPIKPGDVDGRSV---
MUL_3976|M.ulcerans_Agy99 LSNRTNPRMPLVSEITDLLRLGYYGDTGVGEPALAPIKPGDVDGRSV---
Mflv_1025|M.gilvum_PYR-GCK MPNGLAGVGYTDADAAALADGAWPQQRLLANAPIDVDKPLLANAFEQSMR
: : .. * . .
MSMEG_6242|M.smegmatis_MC2_155 ----
Mvan_5479|M.vanbaalenii_PYR-1 ELLP
MMAR_4110|M.marinum_M ----
MUL_3976|M.ulcerans_Agy99 ----
Mflv_1025|M.gilvum_PYR-GCK YW--