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MVTNIALPRFAKIGAGAADTLGEVIADLGISRPVLVTDRYLVETGQAERLAKTLHAAGSTAAVFSDTVPD PTVESLSAGLELVRAHRADGIIGFGGGSPMDTAKALAVLSANGGDIASYKAPSSYTGPALPIVAVPTTAG SGSEATQFTVITDGETDEKMLCPGLSFLPIAIVVDYELTVSMPARLTADTGVDALTHAIEAYVSRRAGGF SDALALAAMQSISKHLRRAYVDGDDREAREAMMLASTQAGMAFSNSSVALVHGMSRPIGGHFHVAHGLSN AMLLPAVTRFSVESAIGRYADCARAMGIVGAAVADRDAASELVTELERLCADVEVPTPRSYGIDEKDWEA RLPTMAEQALASGSPQNNPRVPTHDEIVALYREIY
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1392 | - | - | 100% (385) | alcohol dehydrogenase, class IV |
| M. smegmatis MC2 155 | MSMEG_6239 | - | 2e-56 | 35.96% (356) | 1,3-propanediol dehydrogenase |
| M. smegmatis MC2 155 | MSMEG_3006 | - | 3e-40 | 27.85% (395) | Fe-dependent alcohol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_1025 | - | 2e-35 | 29.25% (359) | iron-containing alcohol dehydrogenase |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | - | - | - | - | - |
| M. marinum M | MMAR_4110 | - | 9e-49 | 34.64% (407) | aldehyde dehydrogenase |
| M. avium 104 | - | - | - | - | - |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_3976 | - | 3e-47 | 34.15% (407) | bifunctional acetaldehyde-CoA/alcohol dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_5476 | - | 8e-60 | 36.52% (356) | iron-containing alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4110|M.marinum_M MTTTPTESASPVEAPAIDNLRTAEIDAIVDTAAEAARAFRKLDQQQVDAI
MUL_3976|M.ulcerans_Agy99 MTTTPTESASPVEAPAIDNLRTAEIDAIVDTAAEAARAFRKLDQQQVDAI
MSMEG_1392|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5476|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_4110|M.marinum_M VEAMVRAGVRAAGELAGVAIEETGFGVFEDKVVKNYVATEFLHDYLRGKK
MUL_3976|M.ulcerans_Agy99 VEAMVRAGVRAAGELAGVAIEETGFGVFEDKVVKNYVATEFLHDYLRGKK
MSMEG_1392|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5476|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_4110|M.marinum_M SVGVIDEDVEHNIVYVAEPIGVVLGITPVTNPTSTVLFKAIVAAKTRNAI
MUL_3976|M.ulcerans_Agy99 SVGVIDEDVEHNIVYVAEPIGVVLGITPVTNPTSTVLFKAIVAAKTRNAI
MSMEG_1392|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5476|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_4110|M.marinum_M LFRPSPYAVRCCEQSIEILRTAAEAAGMPPGALQVIPDAAHEVTHYLFKH
MUL_3976|M.ulcerans_Agy99 LFRPSPYAVRCCEQSIEILRTAAEAAGMPPGALQVIPDAAHEVTHYLFKH
MSMEG_1392|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5476|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_4110|M.marinum_M PKVDFIWVTGGPKIVALANSAGKPGLSVGPGNAPIYIHKTADLKGAVVDI
MUL_3976|M.ulcerans_Agy99 PKVDFIWVTGGPKIVALANSAGKPGLSVGPGNAPIYIHKTADLKGAVVDI
MSMEG_1392|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5476|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_4110|M.marinum_M LISKTFDSSVICPAEQTCIIDDEIYDEMIAEFERMGAQLLTADQAKAVAE
MUL_3976|M.ulcerans_Agy99 LISKTFDSSVICPAKQTCIIDDEIYDEMIAEFERMGAQLLTADQAKAVAE
MSMEG_1392|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5476|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_4110|M.marinum_M FAFGCGDKVSLDAVGQKAPELAARAGFSVPPTVKVLLAQLPSDLGELAAH
MUL_3976|M.ulcerans_Agy99 FAFGCGDKVSLDAVGQKAPELAARAGFSVPPTVKVPLAQLPSDLDELAAH
MSMEG_1392|M.smegmatis_MC2_155 --------------------------------------------------
Mvan_5476|M.vanbaalenii_PYR-1 -------------------------MGARYPTLTPELDRGRAATTPRLLK
Mflv_1025|M.gilvum_PYR-GCK --------------------------------MASVMSCCHTGDGDGAFT
MMAR_4110|M.marinum_M PLVQEKLMPVLGVVRARSVQHGIDAAVLVTEHGGLGHTSAIYANDDDVIE
MUL_3976|M.ulcerans_Agy99 PLVQEKLMPVLGVVRARSVQHGIDAAVLVTEHGGLGHTSAIYANDDDVIE
MSMEG_1392|M.smegmatis_MC2_155 -MVTNIALPRFAKIGAG---------------------------------
Mvan_5476|M.vanbaalenii_PYR-1 FHAPEIVFGIDSMVEAA---------------------------------
Mflv_1025|M.gilvum_PYR-GCK VDASRVTFGRGCIAEVG---------------------------------
. . : .
MMAR_4110|M.marinum_M AYGLAVRTGRILVNAPTAVGALGGVYNNLTPTFSLGCGTWGGSSTTENVN
MUL_3976|M.ulcerans_Agy99 AYGLAVRTGRILVNAPTAVGALGGVYNNLTPTFSLGCGTWGGSSTTENVN
MSMEG_1392|M.smegmatis_MC2_155 -----------------AADTLG---------------------------
Mvan_5476|M.vanbaalenii_PYR-1 --------------------------------------------------
Mflv_1025|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_4110|M.marinum_M YRQLLNIKTVSRRRTPPQWFRVPSNTYFNEGALDNLRELDCETVVVVTDA
MUL_3976|M.ulcerans_Agy99 YRQLLNIKTVSRRRTPPQWFRVPSNTYFNEGALDNLRELDCETVVVVTDA
MSMEG_1392|M.smegmatis_MC2_155 ---------------------------------EVIADLGISRPVLVTDR
Mvan_5476|M.vanbaalenii_PYR-1 ---------------------------------HAAVRLGAQRPMLVTDP
Mflv_1025|M.gilvum_PYR-GCK ---------------------------------DRARALGITRAALFSDS
. *. :.:*
MMAR_4110|M.marinum_M LTEERGVVEALRGKLRAQ--HVQVFSEVTPEPDETTIRRGVALMQRVQPD
MUL_3976|M.ulcerans_Agy99 LTEERGVVEALRGKLRAQ--HVQVFSEVTPEPDETTIRRGVALMQRVQPD
MSMEG_1392|M.smegmatis_MC2_155 YLVETGQAERLAKTLHAAGSTAAVFSDTVPDPTVESLSAGLELVRAHRAD
Mvan_5476|M.vanbaalenii_PYR-1 GLIEAGWSDEMVTHLAGMGVRAAIWSDLTPNPKDHEVAAGYQKYAEHGCD
Mflv_1025|M.gilvum_PYR-GCK AVAQLEVFDAAQRSLRAAGIDVVDYIDVRVEPTDESFRSAAAFATEASPD
: : * . . : : :* . . *
MMAR_4110|M.marinum_M LLIAIGGGSVLDAGKAMRLFYEHPEKSLDALTMPFLDPRKRVADYPTDRH
MUL_3976|M.ulcerans_Agy99 LLIAIGGGSVLDAGKAMRLFYEHPEKSLDALTMPFLDPRKRVADYPTDRH
MSMEG_1392|M.smegmatis_MC2_155 GIIGFGGGSPMDTAKALAVLSANGG-----------DIASYKAPSSYTGP
Mvan_5476|M.vanbaalenii_PYR-1 VIVAVGGGSVIDAAKGVAILAANGG-----------DILDYEGVDKAQVP
Mflv_1025|M.gilvum_PYR-GCK GYISVGGGSVIDTAKAANLYATHPADFLEYVN------APVGAGAPVPGP
:..**** :*:.*. : : .
MMAR_4110|M.marinum_M RIQLVAVPTTSGTGSEVSPAAVLTVGGKKETLVD--YSLVPDLAIVDPVL
MUL_3976|M.ulcerans_Agy99 RIQLVAVPTTSGTGSEVSPAAVLTVGGKKETLVD--YSLVPDLAIVDPVL
MSMEG_1392|M.smegmatis_MC2_155 ALPIVAVPTTAGSGSEATQFTVITDGETDEKMLCPGLSFLPIAIVVDYEL
Mvan_5476|M.vanbaalenii_PYR-1 IPPMVVVPSTSGTGADVSQFCIVTDTTRNTKITILGRALVPDITVIDPRL
Mflv_1025|M.gilvum_PYR-GCK LAPHIACPTTSGTGSEVTGIAIFDLLSMAAKTGIASPALRPTEALVDPDC
:. *:*:*:*::.: :. . :: * ::*
MMAR_4110|M.marinum_M TSSMPQKLTADTGIDALTHALEAIVS------------------IFASPY
MUL_3976|M.ulcerans_Agy99 TSSMPQKLTADIGIDALTHALEAIVS------------------IFASPY
MSMEG_1392|M.smegmatis_MC2_155 TVSMPARLTADTGVDALTHAIEAYVS------------------RRAGGF
Mvan_5476|M.vanbaalenii_PYR-1 LTTMPEWLNAATGLDALTHGIEAFVS------------------LGHNQL
Mflv_1025|M.gilvum_PYR-GCK TGTLPATVVACSGLDVLSHALESYTARPYTHRAAPARPTQRPMSQGANPW
::* : * *:*.*:*.:*: .: .
MMAR_4110|M.marinum_M TDALCAQAVRLIFDALPRAYDDPDDLSARTSMSNAATLAGLAFSNAFVGT
MUL_3976|M.ulcerans_Agy99 TDALCAQAVRLIFDALPRAYDDPDDLSARTSMSNAATLAGLAFSNAFVGT
MSMEG_1392|M.smegmatis_MC2_155 SDALALAAMQSISKHLRRAYVDGDDREAREAMMLASTQAGMAFSNSSVAL
Mvan_5476|M.vanbaalenii_PYR-1 TDHHALRAVQMVTDNLVHTIDRPNEMPARVLMAQAALEAGLAFTNAILGA
Mflv_1025|M.gilvum_PYR-GCK SDLGCGEALRLLGTYLARAVADASDSEAREQVMWAATLAGIAFGNAGVHL
:* . *:: : * :: .: ** : *: **:** *: :
MMAR_4110|M.marinum_M NHALAHAVGAKFS-------------VPHGRANGIFLPHVLRYNASLPTK
MUL_3976|M.ulcerans_Agy99 NHTLAHAVGAKFS-------------VPHGRANGIFLPHVLRYNASLPTK
MSMEG_1392|M.smegmatis_MC2_155 VHGMSRPIGGHFH-------------VAHGLSNAMLLPAVTRFSVESAIG
Mvan_5476|M.vanbaalenii_PYR-1 AHAMSHQVGGLLD-------------LPHGVINGVLLPHVIRFNAEADPE
Mflv_1025|M.gilvum_PYR-GCK PHAMAYAVAGQVRDFRPVGYPDSEPLVPHGMSVILNAPAAFRLTAHTDPA
* :: :.. . :.** : * . * ..
MMAR_4110|M.marinum_M FMPAPGYSAYIAP--DKYAQLGQLVFGGHLPDDSRQRLFAGVDDLLDRLD
MUL_3976|M.ulcerans_Agy99 FMPAPGYSAYIAP--DKYAQLGQLVFGGHLPDDSRQRLFAGVDDLLDRLD
MSMEG_1392|M.smegmatis_MC2_155 RYADCARAMGIVG--AAVADR-----------DAASELVTELERLCADVE
Mvan_5476|M.vanbaalenii_PYR-1 PYQVIATSLGVTDPGAPAA-------------EAALALADRIDRLARDVG
Mflv_1025|M.gilvum_PYR-GCK RHLFAAARLGADT--ADAAP-----------EDAGTVLAEHLMTIMRQVG
. * :: * : : :
MMAR_4110|M.marinum_M MPRSLREFGVDEQEFLAALPTLAMTAFEDLSNRTNPRMPLVSEITDLLRL
MUL_3976|M.ulcerans_Agy99 MPRSLREFGVDEQGFLVALPTLAMTAFEDLSNRTNPRMPLVSEITDLLRL
MSMEG_1392|M.smegmatis_MC2_155 VP-TPRSYGIDEKDWEARLPTMAEQALASGSPQNNPRVPTHDEIVALYRE
Mvan_5476|M.vanbaalenii_PYR-1 VPRGLAELGVAED----DLPRLARTALQDACMSTNPRPADEAQMHALFRA
Mflv_1025|M.gilvum_PYR-GCK MPNGLAGVGYTDADAAALADGAWPQQRLLANAPIDVDKPLLANAFEQSMR
:* * : : . :
MMAR_4110|M.marinum_M GYYGDTGVGEPALAPIKPGDVDGRSV
MUL_3976|M.ulcerans_Agy99 GYYGDTGVGEPALAPIKPGDVDGRSV
MSMEG_1392|M.smegmatis_MC2_155 IY------------------------
Mvan_5476|M.vanbaalenii_PYR-1 AL------------------------
Mflv_1025|M.gilvum_PYR-GCK YW------------------------