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SEVVRLSLVAHAMTDAVAAGRFPADEPLNDLGHRQVDAAGIGNDFDFAFCGPETRTRQTAERLGLQAQAL PELADLDHGCWRGNSLGDIDPGELAVWLTDPARAPHGGESIVDLVERVRRWLRTASTRHGKVIAVTHPAV IRAVILMALDAPPRSFWRIDIAPVSRTVLHHRADAWTLRSS*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_6088 | - | - | 100% (182) | phosphoglycerate mutase |
| M. smegmatis MC2 155 | MSMEG_4305 | - | 3e-12 | 29.19% (185) | bifunctional RNase H/acid phosphatase |
| M. smegmatis MC2 155 | MSMEG_4579 | - | 5e-07 | 32.80% (125) | phosphoglycerate mutase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2253c | - | 6e-10 | 28.11% (185) | bifunctional RNase H/acid phosphatase |
| M. gilvum PYR-GCK | Mflv_1433 | - | 1e-62 | 61.75% (183) | phosphoglycerate mutase |
| M. tuberculosis H37Rv | Rv2228c | - | 6e-10 | 28.11% (185) | bifunctional RNase H/acid phosphatase |
| M. leprae Br4923 | MLBr_01637 | - | 2e-09 | 27.91% (172) | bifunctional RNase H/acid phosphatase |
| M. abscessus ATCC 19977 | MAB_1905 | - | 7e-09 | 25.41% (185) | bifunctional RNase H/acid phosphatase |
| M. marinum M | MMAR_5096 | gpmB | 5e-52 | 56.35% (181) | fructose-2,6-bisphosphatase GpmB |
| M. avium 104 | MAV_0559 | - | 6e-48 | 57.58% (165) | phosphoglycerate mutase family protein, putative |
| M. thermoresistible (build 8) | TH_1467 | - | 2e-12 | 31.49% (181) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_4172 | gpmB | 1e-51 | 55.80% (181) | fructose-2,6-bisphosphatase GpmB |
| M. vanbaalenii PYR-1 | Mvan_5354 | - | 2e-63 | 64.32% (185) | phosphoglycerate mutase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1433|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5354|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6088|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_5096|M.marinum_M --------------------------------------------------
MUL_4172|M.ulcerans_Agy99 --------------------------------------------------
MAV_0559|M.avium_104 --------------------------------------------------
Mb2253c|M.bovis_AF2122/97 MKVVIEADGGSRGNPGPAGYGAVVWTADHSTVLAESKQAIGRATNNVAEY
Rv2228c|M.tuberculosis_H37Rv MKVVIEADGGSRGNPGPAGYGAVVWTADHSTVLAESKQAIGRATNNVAEY
MLBr_01637|M.leprae_Br4923 MKVIIEADGGSRGNPGPAGYGAVVWIADRSAVLTETKQAIGRATNNVAEY
MAB_1905|M.abscessus_ATCC_1997 MKVLVEADGGSRGNPGLAGYGAVVFSPDHQTVLGEACDAIGHATNNVAEY
TH_1467|M.thermoresistible__bu VKVIVEADGGSRGNPGPAGYGAVVYSADSGEVLAETKQSIGRATNNVAEY
Mflv_1433|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5354|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6088|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_5096|M.marinum_M --------------------------------------------------
MUL_4172|M.ulcerans_Agy99 --------------------------------------------------
MAV_0559|M.avium_104 --------------------------------------------------
Mb2253c|M.bovis_AF2122/97 RGLIAGLDDAVKLGATEAAVLMDSKLVVEQMSGRWKVKHPDLLKLYVQAQ
Rv2228c|M.tuberculosis_H37Rv RGLIAGLDDAVKLGATEAAVLMDSKLVVEQMSGRWKVKHPDLLKLYVQAQ
MLBr_01637|M.leprae_Br4923 RALIAGLDDAVKMGATEAEVLMDSKLVVEQMSGRWKVKHPDLIELYVHAQ
MAB_1905|M.abscessus_ATCC_1997 RGLIAGLAEAARLGATEVSVSMDSKLVVEQMSGRWKVKHPDLITLYQQAV
TH_1467|M.thermoresistible__bu RGLIAGLEQAARVGATEVEVRMDSKLVVEQMAGRWRVKHPDLQPLSQQAK
Mflv_1433|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5354|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6088|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_5096|M.marinum_M --------------------------------------------------
MUL_4172|M.ulcerans_Agy99 --------------------------------------------------
MAV_0559|M.avium_104 --------------------------------------------------
Mb2253c|M.bovis_AF2122/97 ALASQFRRINYEWVPRARNTYADRLANDAMDAA-------AQSAAADADP
Rv2228c|M.tuberculosis_H37Rv ALASQFRRINYEWVPRARNTYADRLANDAMDAA-------AQSAAADADP
MLBr_01637|M.leprae_Br4923 TLASRLASVSYTWIPRTRNSRADRLANEAMDAASCAEGRVDQAATQLAQS
MAB_1905|M.abscessus_ATCC_1997 TAAMQFESVDYTWIPRERNKHADRLANEAMDRAS------GIEPKKPKEI
TH_1467|M.thermoresistible__bu TLAARFGRVSYRWVPRAENSRADRLANEAMDAA----------AEGEPEP
Mflv_1433|M.gilvum_PYR-GCK -------------------MSEVVRLTFVSHGMTDAMAAGRFPT--DEPV
Mvan_5354|M.vanbaalenii_PYR-1 -------------------MSEVVRLTLVSHAMTDAMAAGRFPT--DESV
MSMEG_6088|M.smegmatis_MC2_155 -------------------MSEVVRLSLVAHAMTDAVAAGRFPA--DEPL
MMAR_5096|M.marinum_M -------------------MTDVTRLILVSHGMTDAMAVGRFPD--DEPL
MUL_4172|M.ulcerans_Agy99 -------------------MTDVTRLILVSHGMTDAMAVGRFPD--DEPL
MAV_0559|M.avium_104 ------------------------------------MADGRFPA--DEPL
Mb2253c|M.bovis_AF2122/97 AKIVATE-SPTSP-GWTGARGTPTRLLLLRHGQTELSEQRRYSGRGNPGL
Rv2228c|M.tuberculosis_H37Rv AKIVATE-SPTSP-GWTGARGTPTRLLLLRHGQTELSEQRRYSGRGNPGL
MLBr_01637|M.leprae_Br4923 TKAVAKE-SQTAP-GWTGARGTPTRLLLLRHGQTELSVQRRYSGRGNPAL
MAB_1905|M.abscessus_ATCC_1997 AEIKETKPADTAP-GWTGARGKPTRMLLLRHGQTELSVQRRYSGRGNPEL
TH_1467|M.thermoresistible__bu GKQAGNGGTGTNPAGWTGARGEPTRFLLLRHGQTELSRERRYSGRGNPAL
*:. : :
Mflv_1433|M.gilvum_PYR-GCK NPLGRRQIGELEP--SALGPVDRALCGPESRTQQT----AEMLGLRPVVE
Mvan_5354|M.vanbaalenii_PYR-1 NQLGRDQIHRVD-----LGPAGPAFCGPEARTQQT----AALLGLRATVE
MSMEG_6088|M.smegmatis_MC2_155 NDLGHRQVDAAG----IGNDFDFAFCGPETRTRQT----AERLGLQAQAL
MMAR_5096|M.marinum_M NHTGRRWAAPLE---SNR--DSRQYAGPERRCCQS----AELLGLRAVTE
MUL_4172|M.ulcerans_Agy99 DHTGRRWAAPLE---SNR--DSRQYAGPERRCCQS----AELLGLRAVTE
MAV_0559|M.avium_104 NELGRRQVQAIT---AQFGSAARYFVAPELRARQT----AGLLGCDGAAE
Mb2253c|M.bovis_AF2122/97 NEVGWRQVGAAAGYLARRGGIAAVVSSPLQRAYDTAVTAARALALDVVVD
Rv2228c|M.tuberculosis_H37Rv NEVGWRQVGAAAGYLARRGGIAAVVSSPLQRAYDTAVTAARALALDVVVD
MLBr_01637|M.leprae_Br4923 NNVGWRQARAAARYFAQRGGIAGVVSSPLQRAYDTAATVADLLGANLTVD
MAB_1905|M.abscessus_ATCC_1997 TELGREQAARAARYLASRGGIAAVISSPLSRAKETAAAAAGALGVPLTVD
TH_1467|M.thermoresistible__bu TDLGRRQAEAAAQYLAARGGIDAVISSPLQRAYDTAAAAAKALGLDVTVD
* .* * :: * *. .
Mflv_1433|M.gilvum_PYR-GCK SALADLDCGRWRGSSLGEVSPEE---MTIWLTDPVRAPHGGESVVDLVTR
Mvan_5354|M.vanbaalenii_PYR-1 SGLADLDFGRWRGDVLGRVPPDE---MTIWLTDPTRAPHGGESVVELIAR
MSMEG_6088|M.smegmatis_MC2_155 PELADLDHGCWRGNSLGDIDPGE---LAVWLTDPARAPHGGESIVDLVER
MMAR_5096|M.marinum_M PRLADLDCGHWRGSRLADIAPAD---LTAWLSDPGQAPHGGESILELIDR
MUL_4172|M.ulcerans_Agy99 PRLADLDCGHWRGSRLADIAPAD---LTAWLSDPGQAPHGGESILELIDR
MAV_0559|M.avium_104 PLLADLDCGRWRGRALQAVDQAD---LAAWLSDPAGAPHGGESIADLIER
Mb2253c|M.bovis_AF2122/97 DDLVETDFGAWEGLTFAEAAERDPELHRRWLQDTSITPPGGESFDDVLRR
Rv2228c|M.tuberculosis_H37Rv DDLVETDFGAWEGLTFAEAAERDPELHRRWLQDTSITPPGGESFDDVLRR
MLBr_01637|M.leprae_Br4923 DDLIEIDFGAWEGLTFAEAAARDPQLHHCWLHDTATLPPGGESFDDVLGR
MAB_1905|M.abscessus_ATCC_1997 DDLIETDFGKWEGLTFSEASERDPELHRQWLSDTSITPPEGESFDTVHHR
TH_1467|M.thermoresistible__bu DDLIETDFGAWEGLTFADAAARDPELHRRWLRDTSVQPPGGESFDAVAQR
* : * * *.* : : ** *. * ***. : *
Mflv_1433|M.gilvum_PYR-GCK VGAWMDTLAS---ERVRVVAVTHPAVVRAAVLVALNAPAKSFWRIDVAPA
Mvan_5354|M.vanbaalenii_PYR-1 VGRWMDSLTTGRTERTRVVAVTHPAVIRAAILVALDAPPKSFWRIDIAPV
MSMEG_6088|M.smegmatis_MC2_155 VRRWLRTAST---RHGKVIAVTHPAVIRAVILMALDAPPRSFWRIDIAPV
MMAR_5096|M.marinum_M VAGWLASLQGN------TVAVTHPAVIRAAILVALDGCPKSFWRIDVAPL
MUL_4172|M.ulcerans_Agy99 VAGWLASLQGN------TVAVTHPAVIRAAILVALDGCPKSFWRIDVAPL
MAV_0559|M.avium_104 ASRWLNALTANP---LHTAAVTHPAVIRAAIAAALDADPASFWRVDVAPA
Mb2253c|M.bovis_AF2122/97 VRRGRDRIIVGY-EGATVLVVSHVTPIKMLLRLALDAGSGVLYRLHLDLA
Rv2228c|M.tuberculosis_H37Rv VRRGRDRIIVGY-EGATVLVVSHVTPIKMLLRLALDAGSGVLYRLHLDLA
MLBr_01637|M.leprae_Br4923 VCSARARIIAEY-QGETVLVVSHVTPIKMLLRLALDAGAGILYRLHLDLG
MAB_1905|M.abscessus_ATCC_1997 VRRARNRIIAEY-GGATVLVVSHVTPIKTLLRLALDAGPSVLYRLHLDLA
TH_1467|M.thermoresistible__bu VRRASDRIIAEH-RASTVLVVSHVTPIKSVLRVALDAGAGLLYRLHLDLA
. . .*:* : :: : **:. . ::*:.:
Mflv_1433|M.gilvum_PYR-GCK SRTVLHCR-GHAWTLRV---------
Mvan_5354|M.vanbaalenii_PYR-1 SRTVMHFR-GHAWTLRSAP-------
MSMEG_6088|M.smegmatis_MC2_155 SRTVLHHR-ADAWTLRSS--------
MMAR_5096|M.marinum_M SRIALHYR-DRRWTLRL---------
MUL_4172|M.ulcerans_Agy99 SRIALHYR-DRRWTLRL---------
MAV_0559|M.avium_104 AYVVMHHR-GGRWTLRL---------
Mb2253c|M.bovis_AF2122/97 SLSIAEFYADGASSVRLVNQTGYL--
Rv2228c|M.tuberculosis_H37Rv SLSIAEFYADGASSVRLVNQTGYL--
MLBr_01637|M.leprae_Br4923 SLSIAEFYPDGASSVRLVNQTGYL--
MAB_1905|M.abscessus_ATCC_1997 SLSIAEFYSDGPASVRLVNETSYLT-
TH_1467|M.thermoresistible__bu SLSIAEFYPDGVASVRLVNQTDYLRG
: . ::*