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VSEVVRLTFVSHGMTDAMAAGRFPTDEPVNPLGRRQIGELEPSALGPVDRALCGPESRTQQTAEMLGLRP VVESALADLDCGRWRGSSLGEVSPEEMTIWLTDPVRAPHGGESVVDLVTRVGAWMDTLASERVRVVAVTH PAVVRAAVLVALNAPAKSFWRIDVAPASRTVLHCRGHAWTLRV
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_1433 | - | - | 100% (183) | phosphoglycerate mutase |
| M. gilvum PYR-GCK | Mflv_2892 | - | 3e-10 | 28.49% (179) | bifunctional RNase H/acid phosphatase |
| M. gilvum PYR-GCK | Mflv_3044 | - | 2e-08 | 31.17% (154) | phosphoglycerate mutase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2253c | - | 1e-10 | 27.93% (179) | bifunctional RNase H/acid phosphatase |
| M. tuberculosis H37Rv | Rv2228c | - | 1e-10 | 27.93% (179) | bifunctional RNase H/acid phosphatase |
| M. leprae Br4923 | MLBr_01452 | - | 4e-09 | 26.53% (196) | putative phosphoglycerate mutase |
| M. abscessus ATCC 19977 | MAB_1905 | - | 1e-08 | 25.70% (179) | bifunctional RNase H/acid phosphatase |
| M. marinum M | MMAR_5096 | gpmB | 1e-55 | 57.92% (183) | fructose-2,6-bisphosphatase GpmB |
| M. avium 104 | MAV_0559 | - | 3e-46 | 51.20% (166) | phosphoglycerate mutase family protein, putative |
| M. smegmatis MC2 155 | MSMEG_6088 | - | 1e-62 | 61.75% (183) | phosphoglycerate mutase |
| M. thermoresistible (build 8) | TH_1467 | - | 2e-11 | 28.57% (182) | CONSERVED HYPOTHETICAL PROTEIN |
| M. ulcerans Agy99 | MUL_4172 | gpmB | 3e-55 | 57.38% (183) | fructose-2,6-bisphosphatase GpmB |
| M. vanbaalenii PYR-1 | Mvan_5354 | - | 6e-75 | 74.05% (185) | phosphoglycerate mutase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1433|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5354|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6088|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_5096|M.marinum_M --------------------------------------------------
MUL_4172|M.ulcerans_Agy99 --------------------------------------------------
MAV_0559|M.avium_104 --------------------------------------------------
Mb2253c|M.bovis_AF2122/97 MKVVIEADGGSRGNPGPAGYGAVVWTADHSTVLAESKQAIGRATNNVAEY
Rv2228c|M.tuberculosis_H37Rv MKVVIEADGGSRGNPGPAGYGAVVWTADHSTVLAESKQAIGRATNNVAEY
MAB_1905|M.abscessus_ATCC_1997 MKVLVEADGGSRGNPGLAGYGAVVFSPDHQTVLGEACDAIGHATNNVAEY
TH_1467|M.thermoresistible__bu VKVIVEADGGSRGNPGPAGYGAVVYSADSGEVLAETKQSIGRATNNVAEY
MLBr_01452|M.leprae_Br4923 --------------------------------------------------
Mflv_1433|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5354|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6088|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_5096|M.marinum_M --------------------------------------------------
MUL_4172|M.ulcerans_Agy99 --------------------------------------------------
MAV_0559|M.avium_104 --------------------------------------------------
Mb2253c|M.bovis_AF2122/97 RGLIAGLDDAVKLGATEAAVLMDSKLVVEQMSGRWKVKHPDLLKLYVQAQ
Rv2228c|M.tuberculosis_H37Rv RGLIAGLDDAVKLGATEAAVLMDSKLVVEQMSGRWKVKHPDLLKLYVQAQ
MAB_1905|M.abscessus_ATCC_1997 RGLIAGLAEAARLGATEVSVSMDSKLVVEQMSGRWKVKHPDLITLYQQAV
TH_1467|M.thermoresistible__bu RGLIAGLEQAARVGATEVEVRMDSKLVVEQMAGRWRVKHPDLQPLSQQAK
MLBr_01452|M.leprae_Br4923 --------------------------------------------------
Mflv_1433|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5354|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6088|M.smegmatis_MC2_155 --------------------------------------------------
MMAR_5096|M.marinum_M --------------------------------------------------
MUL_4172|M.ulcerans_Agy99 --------------------------------------------------
MAV_0559|M.avium_104 --------------------------------------------------
Mb2253c|M.bovis_AF2122/97 ALASQFRRINYEWVPRARNTYADRLANDAMD-AAAQSAAADADPAKIVAT
Rv2228c|M.tuberculosis_H37Rv ALASQFRRINYEWVPRARNTYADRLANDAMD-AAAQSAAADADPAKIVAT
MAB_1905|M.abscessus_ATCC_1997 TAAMQFESVDYTWIPRERNKHADRLANEAMDRASGIEPKKPKEIAEIKET
TH_1467|M.thermoresistible__bu TLAARFGRVSYRWVPRAENSRADRLANEAMD-AAAEGEPEPGKQAGNGGT
MLBr_01452|M.leprae_Br4923 --------------------------------------------------
Mflv_1433|M.gilvum_PYR-GCK ------------MSEVVRLTFVSHGMTDAMAAGRFPT--DEPVNPLGRRQ
Mvan_5354|M.vanbaalenii_PYR-1 ------------MSEVVRLTLVSHAMTDAMAAGRFPT--DESVNQLGRDQ
MSMEG_6088|M.smegmatis_MC2_155 ------------MSEVVRLSLVAHAMTDAVAAGRFPA--DEPLNDLGHRQ
MMAR_5096|M.marinum_M ------------MTDVTRLILVSHGMTDAMAVGRFPD--DEPLNHTGRRW
MUL_4172|M.ulcerans_Agy99 ------------MTDVTRLILVSHGMTDAMAVGRFPD--DEPLDHTGRRW
MAV_0559|M.avium_104 -----------------------------MADGRFPA--DEPLNELGRRQ
Mb2253c|M.bovis_AF2122/97 ESP-TSPGWTGARGTPTRLLLLRHGQTELSEQRRYSGRGNPGLNEVGWRQ
Rv2228c|M.tuberculosis_H37Rv ESP-TSPGWTGARGTPTRLLLLRHGQTELSEQRRYSGRGNPGLNEVGWRQ
MAB_1905|M.abscessus_ATCC_1997 KPADTAPGWTGARGKPTRMLLLRHGQTELSVQRRYSGRGNPELTELGREQ
TH_1467|M.thermoresistible__bu GTN--PAGWTGARGEPTRFLLLRHGQTELSRERRYSGRGNPALTDLGRRQ
MLBr_01452|M.leprae_Br4923 -------------MRTRRLVMLRHGQTDFNLGGRMQGQLDTELSELGRAQ
* : : *
Mflv_1433|M.gilvum_PYR-GCK IGELEP--SALGPVDRALCGPESRTQQT----AEMLGLRPVVESALADLD
Mvan_5354|M.vanbaalenii_PYR-1 IHRVD-----LGPAGPAFCGPEARTQQT----AALLGLRATVESGLADLD
MSMEG_6088|M.smegmatis_MC2_155 VDAAG----IGNDFDFAFCGPETRTRQT----AERLGLQAQALPELADLD
MMAR_5096|M.marinum_M AAPLE---SNR--DSRQYAGPERRCCQS----AELLGLRAVTEPRLADLD
MUL_4172|M.ulcerans_Agy99 AAPLE---SNR--DSRQYAGPERRCCQS----AELLGLRAVTEPRLADLD
MAV_0559|M.avium_104 VQAIT---AQFGSAARYFVAPELRARQT----AGLLGCDGAAEPLLADLD
Mb2253c|M.bovis_AF2122/97 VGAAAGYLARRGGIAAVVSSPLQRAYDTAVTAARALALDVVVDDDLVETD
Rv2228c|M.tuberculosis_H37Rv VGAAAGYLARRGGIAAVVSSPLQRAYDTAVTAARALALDVVVDDDLVETD
MAB_1905|M.abscessus_ATCC_1997 AARAARYLASRGGIAAVISSPLSRAKETAAAAAGALGVPLTVDDDLIETD
TH_1467|M.thermoresistible__bu AEAAAQYLAARGGIDAVISSPLQRAYDTAAAAAKALGLDVTVDDDLIETD
MLBr_01452|M.leprae_Br4923 AVAVAEVLGKLQPLRIVSS-DLRRAYDTAIKLGERTGLKIWVDDRLREAH
* :: . . . * : .
Mflv_1433|M.gilvum_PYR-GCK CGRWRGSSLGEVS---PEEMTIWLTDPVRAPHGGESVVDLVTRVGAWMDT
Mvan_5354|M.vanbaalenii_PYR-1 FGRWRGDVLGRVP---PDEMTIWLTDPTRAPHGGESVVELIARVGRWMDS
MSMEG_6088|M.smegmatis_MC2_155 HGCWRGNSLGDID---PGELAVWLTDPARAPHGGESIVDLVERVRRWLRT
MMAR_5096|M.marinum_M CGHWRGSRLADIA---PADLTAWLSDPGQAPHGGESILELIDRVAGWLAS
MUL_4172|M.ulcerans_Agy99 CGHWRGSRLADIA---PADLTAWLSDPGQAPHGGESILELIDRVAGWLAS
MAV_0559|M.avium_104 CGRWRGRALQAVD---QADLAAWLSDPAGAPHGGESIADLIERASRWLNA
Mb2253c|M.bovis_AF2122/97 FGAWEGLTFAEAAERDPELHRRWLQDTSITPPGGESFDDVLRRVRRGRDR
Rv2228c|M.tuberculosis_H37Rv FGAWEGLTFAEAAERDPELHRRWLQDTSITPPGGESFDDVLRRVRRGRDR
MAB_1905|M.abscessus_ATCC_1997 FGKWEGLTFSEASERDPELHRQWLSDTSITPPEGESFDTVHHRVRRARNR
TH_1467|M.thermoresistible__bu FGAWEGLTFADAAARDPELHRRWLRDTSVQPPGGESFDAVAQRVRRASDR
MLBr_01452|M.leprae_Br4923 LGDWQGLTHSQIDADAPGARLAWREDATWAPHSGESRVDVAARSLPVVTE
* *.* * *. * *** : *
Mflv_1433|M.gilvum_PYR-GCK LAS---ER-------VRVVAVTHPAVVRAAVLVALNAPAKSFWRI-----
Mvan_5354|M.vanbaalenii_PYR-1 LTTGRTER-------TRVVAVTHPAVIRAAILVALDAPPKSFWRI-----
MSMEG_6088|M.smegmatis_MC2_155 AST---RH-------GKVIAVTHPAVIRAVILMALDAPPRSFWRI-----
MMAR_5096|M.marinum_M LQGN-------------TVAVTHPAVIRAAILVALDGCPKSFWRI-----
MUL_4172|M.ulcerans_Agy99 LQGN-------------TVAVTHPAVIRAAILVALDGCPKSFWRI-----
MAV_0559|M.avium_104 LTANP----------LHTAAVTHPAVIRAAIAAALDADPASFWRV-----
Mb2253c|M.bovis_AF2122/97 IIVGY-EG-------ATVLVVSHVTPIKMLLRLALDAGSGVLYRL-----
Rv2228c|M.tuberculosis_H37Rv IIVGY-EG-------ATVLVVSHVTPIKMLLRLALDAGSGVLYRL-----
MAB_1905|M.abscessus_ATCC_1997 IIAEY-GG-------ATVLVVSHVTPIKTLLRLALDAGPSVLYRL-----
TH_1467|M.thermoresistible__bu IIAEH-RA-------STVLVVSHVTPIKSVLRVALDAGAGLLYRL-----
MLBr_01452|M.leprae_Br4923 VVSGAPEWGDCHEPDRPVVLVAHGGLITALSAALLRLPVANWSILGSMGN
. *:* : * :
Mflv_1433|M.gilvum_PYR-GCK ----------DVAPASRTVLHCR-GHAWTLRV---------
Mvan_5354|M.vanbaalenii_PYR-1 ----------DIAPVSRTVMHFR-GHAWTLRSAP-------
MSMEG_6088|M.smegmatis_MC2_155 ----------DIAPVSRTVLHHR-ADAWTLRSS--------
MMAR_5096|M.marinum_M ----------DVAPLSRIALHYR-DRRWTLRL---------
MUL_4172|M.ulcerans_Agy99 ----------DVAPLSRIALHYR-DRRWTLRL---------
MAV_0559|M.avium_104 ----------DVAPAAYVVMHHR-GGRWTLRL---------
Mb2253c|M.bovis_AF2122/97 ----------HLDLASLSIAEFYADGASSVRLVNQTGYL--
Rv2228c|M.tuberculosis_H37Rv ----------HLDLASLSIAEFYADGASSVRLVNQTGYL--
MAB_1905|M.abscessus_ATCC_1997 ----------HLDLASLSIAEFYSDGPASVRLVNETSYLT-
TH_1467|M.thermoresistible__bu ----------HLDLASLSIAEFYPDGVASVRLVNQTDYLRG
MLBr_01452|M.leprae_Br4923 ASWVQLSGHSDESDSELDLIQWR-LDVWNASVQVSNDVL--
. . .