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TDVTRLILVSHGMTDAMAVGRFPDDEPLNHTGRRWAAPLESNRDSRQYAGPERRCCQSAELLGLRAVTEP RLADLDCGHWRGSRLADIAPADLTAWLSDPGQAPHGGESILELIDRVAGWLASLQGNTVAVTHPAVIRAA ILVALDGCPKSFWRIDVAPLSRIALHYRDRRWTLRL*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. marinum M | MMAR_5096 | gpmB | - | 100% (177) | fructose-2,6-bisphosphatase GpmB |
| M. marinum M | MMAR_3304 | - | 8e-10 | 30.30% (198) | hypothetical protein MMAR_3304 |
| M. marinum M | MMAR_3747 | gpm_1 | 2e-07 | 29.94% (177) | phosphoglycerate mutase, Gpm_1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2253c | - | 2e-08 | 30.41% (194) | bifunctional RNase H/acid phosphatase |
| M. gilvum PYR-GCK | Mflv_1433 | - | 1e-55 | 57.92% (183) | phosphoglycerate mutase |
| M. tuberculosis H37Rv | Rv2228c | - | 2e-08 | 30.41% (194) | bifunctional RNase H/acid phosphatase |
| M. leprae Br4923 | MLBr_01637 | - | 2e-11 | 31.12% (196) | bifunctional RNase H/acid phosphatase |
| M. abscessus ATCC 19977 | MAB_1905 | - | 1e-07 | 29.38% (194) | bifunctional RNase H/acid phosphatase |
| M. avium 104 | MAV_0559 | - | 5e-47 | 56.97% (165) | phosphoglycerate mutase family protein, putative |
| M. smegmatis MC2 155 | MSMEG_6088 | - | 5e-52 | 56.35% (181) | phosphoglycerate mutase |
| M. thermoresistible (build 8) | TH_0787 | - | 7e-10 | 29.14% (175) | PROBABLE PHOSPHOGLYCERATE MUTASE (PHOSPHOGLYCEROMUTASE) |
| M. ulcerans Agy99 | MUL_4172 | gpmB | 1e-102 | 99.44% (177) | fructose-2,6-bisphosphatase GpmB |
| M. vanbaalenii PYR-1 | Mvan_5354 | - | 1e-52 | 56.04% (182) | phosphoglycerate mutase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_5096|M.marinum_M --------------------------------------------------
MUL_4172|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1433|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5354|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6088|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0559|M.avium_104 --------------------------------------------------
Mb2253c|M.bovis_AF2122/97 MKVVIEADGGSRGNPGPAGYGAVVWTADHSTVLAESKQAIGRATNNVAEY
Rv2228c|M.tuberculosis_H37Rv MKVVIEADGGSRGNPGPAGYGAVVWTADHSTVLAESKQAIGRATNNVAEY
MLBr_01637|M.leprae_Br4923 MKVIIEADGGSRGNPGPAGYGAVVWIADRSAVLTETKQAIGRATNNVAEY
MAB_1905|M.abscessus_ATCC_1997 MKVLVEADGGSRGNPGLAGYGAVVFSPDHQTVLGEACDAIGHATNNVAEY
TH_0787|M.thermoresistible__bu --------------------------------------------------
MMAR_5096|M.marinum_M --------------------------------------------------
MUL_4172|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1433|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5354|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6088|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0559|M.avium_104 --------------------------------------------------
Mb2253c|M.bovis_AF2122/97 RGLIAGLDDAVKLGATEAAVLMDSKLVVEQMSGRWKVKHPDLLKLYVQAQ
Rv2228c|M.tuberculosis_H37Rv RGLIAGLDDAVKLGATEAAVLMDSKLVVEQMSGRWKVKHPDLLKLYVQAQ
MLBr_01637|M.leprae_Br4923 RALIAGLDDAVKMGATEAEVLMDSKLVVEQMSGRWKVKHPDLIELYVHAQ
MAB_1905|M.abscessus_ATCC_1997 RGLIAGLAEAARLGATEVSVSMDSKLVVEQMSGRWKVKHPDLITLYQQAV
TH_0787|M.thermoresistible__bu --------------------------------------------------
MMAR_5096|M.marinum_M --------------------------------------------------
MUL_4172|M.ulcerans_Agy99 --------------------------------------------------
Mflv_1433|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_5354|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_6088|M.smegmatis_MC2_155 --------------------------------------------------
MAV_0559|M.avium_104 --------------------------------------------------
Mb2253c|M.bovis_AF2122/97 ALASQFRRINYEWVPRARNTYADRLANDAMDAA-------AQSAAADADP
Rv2228c|M.tuberculosis_H37Rv ALASQFRRINYEWVPRARNTYADRLANDAMDAA-------AQSAAADADP
MLBr_01637|M.leprae_Br4923 TLASRLASVSYTWIPRTRNSRADRLANEAMDAASCAEGRVDQAATQLAQS
MAB_1905|M.abscessus_ATCC_1997 TAAMQFESVDYTWIPRERNKHADRLANEAMDRAS------GIEPKKPKEI
TH_0787|M.thermoresistible__bu --------------------------------------------------
MMAR_5096|M.marinum_M ------------------MTDVTRLILVSHGMTDAMAVGRFPD--DEPLN
MUL_4172|M.ulcerans_Agy99 ------------------MTDVTRLILVSHGMTDAMAVGRFPD--DEPLD
Mflv_1433|M.gilvum_PYR-GCK ------------------MSEVVRLTFVSHGMTDAMAAGRFPT--DEPVN
Mvan_5354|M.vanbaalenii_PYR-1 ------------------MSEVVRLTLVSHAMTDAMAAGRFPT--DESVN
MSMEG_6088|M.smegmatis_MC2_155 ------------------MSEVVRLSLVAHAMTDAVAAGRFPA--DEPLN
MAV_0559|M.avium_104 -----------------------------------MADGRFPA--DEPLN
Mb2253c|M.bovis_AF2122/97 AKIVATE-SPTSPGWTGARGTPTRLLLLRHGQTELSEQRRYSGRGNPGLN
Rv2228c|M.tuberculosis_H37Rv AKIVATE-SPTSPGWTGARGTPTRLLLLRHGQTELSEQRRYSGRGNPGLN
MLBr_01637|M.leprae_Br4923 TKAVAKE-SQTAPGWTGARGTPTRLLLLRHGQTELSVQRRYSGRGNPALN
MAB_1905|M.abscessus_ATCC_1997 AEIKETKPADTAPGWTGARGKPTRMLLLRHGQTELSVQRRYSGRGNPELT
TH_0787|M.thermoresistible__bu -------------------MRVRKLVMLRHGQTEYNAGSRMQGQLDTDLS
* : :
MMAR_5096|M.marinum_M HTGRRWAAPLE-----SNRDSRQYAGPERRCCQS----AELLGLRAVTEP
MUL_4172|M.ulcerans_Agy99 HTGRRWAAPLE-----SNRDSRQYAGPERRCCQS----AELLGLRAVTEP
Mflv_1433|M.gilvum_PYR-GCK PLGRRQIGELEP--SALGPVDRALCGPESRTQQT----AEMLGLRPVVES
Mvan_5354|M.vanbaalenii_PYR-1 QLGRDQIHRVD-----LGPAGPAFCGPEARTQQT----AALLGLRATVES
MSMEG_6088|M.smegmatis_MC2_155 DLGHRQVDAAG----IGNDFDFAFCGPETRTRQT----AERLGLQAQALP
MAV_0559|M.avium_104 ELGRRQVQAIT---AQFGSAARYFVAPELRARQT----AGLLGCDGAAEP
Mb2253c|M.bovis_AF2122/97 EVGWRQVGAAAGYLARRGGIAAVVSSPLQRAYDTAVTAARALALDVVVDD
Rv2228c|M.tuberculosis_H37Rv EVGWRQVGAAAGYLARRGGIAAVVSSPLQRAYDTAVTAARALALDVVVDD
MLBr_01637|M.leprae_Br4923 NVGWRQARAAARYFAQRGGIAGVVSSPLQRAYDTAATVADLLGANLTVDD
MAB_1905|M.abscessus_ATCC_1997 ELGREQAARAARYLASRGGIAAVISSPLSRAKETAAAAAGALGVPLTVDD
TH_0787|M.thermoresistible__bu DLGRAQAVAVAEVLSKRQPLA-IVSSDLRRAFDTAVELGDRSGLPVQVDP
* . * :: . . .
MMAR_5096|M.marinum_M RLADLDCGHWRGSRLADIAPAD---LTAWLSDPGQAPHGGESILELIDRV
MUL_4172|M.ulcerans_Agy99 RLADLDCGHWRGSRLADIAPAD---LTAWLSDPGQAPHGGESILELIDRV
Mflv_1433|M.gilvum_PYR-GCK ALADLDCGRWRGSSLGEVSPEE---MTIWLTDPVRAPHGGESVVDLVTRV
Mvan_5354|M.vanbaalenii_PYR-1 GLADLDFGRWRGDVLGRVPPDE---MTIWLTDPTRAPHGGESVVELIARV
MSMEG_6088|M.smegmatis_MC2_155 ELADLDHGCWRGNSLGDIDPGE---LAVWLTDPARAPHGGESIVDLVERV
MAV_0559|M.avium_104 LLADLDCGRWRGRALQAVDQAD---LAAWLSDPAGAPHGGESIADLIERA
Mb2253c|M.bovis_AF2122/97 DLVETDFGAWEGLTFAEAAERDPELHRRWLQDTSITPPGGESFDDVLRRV
Rv2228c|M.tuberculosis_H37Rv DLVETDFGAWEGLTFAEAAERDPELHRRWLQDTSITPPGGESFDDVLRRV
MLBr_01637|M.leprae_Br4923 DLIEIDFGAWEGLTFAEAAARDPQLHHCWLHDTATLPPGGESFDDVLGRV
MAB_1905|M.abscessus_ATCC_1997 DLIETDFGKWEGLTFSEASERDPELHRQWLSDTSITPPEGESFDTVHHRV
TH_0787|M.thermoresistible__bu RLRETHLGEWQGLTHLEVDAAAPGARLAWRDDARWAPHGGESRVDVAARS
* : . * *.* * *. * *** : *
MMAR_5096|M.marinum_M AGWLASLQG------------NTVAVTHPAVIRAAILVALDGCPKSFWRI
MUL_4172|M.ulcerans_Agy99 AGWLASLQG------------NTVAVTHPAVIRAAILVALDGCPKSFWRI
Mflv_1433|M.gilvum_PYR-GCK GAWMDTLAS---------ERVRVVAVTHPAVVRAAVLVALNAPAKSFWRI
Mvan_5354|M.vanbaalenii_PYR-1 GRWMDSLTTGR------TERTRVVAVTHPAVIRAAILVALDAPPKSFWRI
MSMEG_6088|M.smegmatis_MC2_155 RRWLRTAST---------RHGKVIAVTHPAVIRAVILMALDAPPRSFWRI
MAV_0559|M.avium_104 SRWLNALTAN---------PLHTAAVTHPAVIRAAIAAALDADPASFWRV
Mb2253c|M.bovis_AF2122/97 RRGRDRIIVG-------YEGATVLVVSHVTPIKMLLRLALDAGSGVLYRL
Rv2228c|M.tuberculosis_H37Rv RRGRDRIIVG-------YEGATVLVVSHVTPIKMLLRLALDAGSGVLYRL
MLBr_01637|M.leprae_Br4923 CSARARIIAE-------YQGETVLVVSHVTPIKMLLRLALDAGAGILYRL
MAB_1905|M.abscessus_ATCC_1997 RRARNRIIAE-------YGGATVLVVSHVTPIKTLLRLALDAGPSVLYRL
TH_0787|M.thermoresistible__bu LPLVAELVAEHRDWGADGQDRPVVLVAHGGLIAALTAALLGLPVDNWPAL
. *:* : *. :
MMAR_5096|M.marinum_M D-VAPLSRIALHYR----------------DRRWTLRL------------
MUL_4172|M.ulcerans_Agy99 D-VAPLSRIALHYR----------------DRRWTLRL------------
Mflv_1433|M.gilvum_PYR-GCK D-VAPASRTVLHCR----------------GHAWTLRV------------
Mvan_5354|M.vanbaalenii_PYR-1 D-IAPVSRTVMHFR----------------GHAWTLRSAP----------
MSMEG_6088|M.smegmatis_MC2_155 D-IAPVSRTVLHHR----------------ADAWTLRSS-----------
MAV_0559|M.avium_104 D-VAPAAYVVMHHR----------------GGRWTLRL------------
Mb2253c|M.bovis_AF2122/97 H-LDLASLSIAEFYA---------------DGASSVRLVNQTGYL-----
Rv2228c|M.tuberculosis_H37Rv H-LDLASLSIAEFYA---------------DGASSVRLVNQTGYL-----
MLBr_01637|M.leprae_Br4923 H-LDLGSLSIAEFYP---------------DGASSVRLVNQTGYL-----
MAB_1905|M.abscessus_ATCC_1997 H-LDLASLSIAEFYS---------------DGPASVRLVNETSYLT----
TH_0787|M.thermoresistible__bu GGMGNASWVQLSGHGPADPDGGDPDGSVFDRIRWRLDVWNASAQVAGDVL
: : :