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QAIDYQDSLREVTTDAGVLRFHEAGDGPPLLLLHGSGPGVTGWRNYRGNLGFFAQHFRCLVLEFPGFGVS DDFGGHPMLDAQRAAVVFADALGLDRVDIIGNSMGGGVGINFAINHPDRVRHLVTIGGIGTNIFSPGPSE GIRLLQEFTEDPTRARLVDWLNSMVYDPALVTDELIEERWALATDPETLESARRMYGKAAFAAMMEMMRN ADFPLPWSIMHKVKAPTLLTWGRDDRVSPLDMALVPMRTIPNAELHVFPNCGHWVMIEAKSAFERTVLSF LTQDN*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2900 | - | - | 100% (286) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase |
| M. smegmatis MC2 155 | MSMEG_6037 | - | 1e-59 | 40.41% (292) | 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase |
| M. smegmatis MC2 155 | MSMEG_4867 | - | 2e-21 | 28.94% (273) | 2-hydroxy-6-ketonona-2,4-dienedoic acid hydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3600c | bphD | 2e-59 | 41.79% (280) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. gilvum PYR-GCK | Mflv_4525 | - | 1e-152 | 88.81% (286) | alpha/beta hydrolase fold |
| M. tuberculosis H37Rv | Rv3569c | bphD | 2e-59 | 41.79% (280) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. leprae Br4923 | MLBr_01899 | lipG | 7e-08 | 25.27% (182) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_3810 | - | 1e-111 | 65.60% (282) | putative hydrolase, alpha/beta fold |
| M. marinum M | MMAR_5064 | bphD | 3e-60 | 43.53% (278) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. avium 104 | MAV_3016 | - | 1e-120 | 71.93% (285) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase |
| M. thermoresistible (build 8) | TH_3363 | - | 1e-144 | 84.10% (283) | PUTATIVE alpha/beta hydrolase fold |
| M. ulcerans Agy99 | MUL_4140 | bphD | 4e-60 | 43.53% (278) | 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase BphD |
| M. vanbaalenii PYR-1 | Mvan_2898 | - | 1e-146 | 85.77% (281) | alpha/beta hydrolase fold |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3600c|M.bovis_AF2122/97 ----MTATEELTFESTSRFAEVDVDGPLKLHYHEAG---VGNDQ--TVVL
Rv3569c|M.tuberculosis_H37Rv ----MTATEELTFESTSRFAEVDVDGPLKLHYHEAG---VGNDQ--TVVL
MMAR_5064|M.marinum_M MTVTQSKTAEHTFESTSRYAEVDVDGPLKLHYHEAG---VGNDQ--TVVL
MUL_4140|M.ulcerans_Agy99 MTVTQSKTAEHTFESTSRYAEVDVDGPLKLHYHEAG---VGNDQ--TVVL
MSMEG_2900|M.smegmatis_MC2_155 -------MQAIDYQDSLREVTTDAG---VLRFHEAG---DGPP----LLL
Mflv_4525|M.gilvum_PYR-GCK -------MHSIDYQESLREVATPAG---VLRYHEAG---DGPP----LLL
Mvan_2898|M.vanbaalenii_PYR-1 ---MWNHWMTVDYHETLREVSTPSG---VLRYHEAG---DGPA----LLL
TH_3363|M.thermoresistible__bu -------MRTFDYQETLREVRTPAG---VLRYHEAG---DGPP----LLL
MAV_3016|M.avium_104 --MADTPGRTGITEQDLREISTEKG---ALRYYDTGGDTGGPDSAAVLLF
MAB_3810|M.abscessus_ATCC_1997 --------MDVTYEGTKRELATDEG---TLRYHEAGTAGEGEP----LIL
MLBr_01899|M.leprae_Br4923 --------------MEVRSGYATSG-DLKLYYEDMG--NVDDPP---VLL
* . . * : : * . :::
Mb3600c|M.bovis_AF2122/97 LHGGGPGAASWTNFSRNIAVLARHFHVLAVDQPGYGHSDKRAEHGQFNRY
Rv3569c|M.tuberculosis_H37Rv LHGGGPGAASWTNFSRNIAVLARHFHVLAVDQPGYGHSDKRAEHGQFNRY
MMAR_5064|M.marinum_M LHGGGPGASSWSNFARNIEVLAQQFHVLAVDQPGYGHSDKRAEHGQFNHY
MUL_4140|M.ulcerans_Agy99 LHGGGPGASSWSNFARNIEVLAQQFHVLAVDQPGYGHSDKRAEHGQFNHY
MSMEG_2900|M.smegmatis_MC2_155 LHGSGPGVTGWRNYRGNLGFFAQHFRCLVLEFPGFGVSDDFGGHPMLD--
Mflv_4525|M.gilvum_PYR-GCK LHGSGPGVTGWRNYRGNLAVFAQHFRCLVLEFPGFGVSDDFGGHPMLD--
Mvan_2898|M.vanbaalenii_PYR-1 LHGSGPGVTGWRNYRGNLDVFARHFRCLVLEFPGFGVSDDFGGHPMLD--
TH_3363|M.thermoresistible__bu LHGSGPGVTGWRNFRGNLGVFAEHFRCLVLEFPGFGVSDDFGGHPMID--
MAV_3016|M.avium_104 LHGSGPGVTGWRNFRGILPAFAAHYRCLVLEFPGFGVSDDFGGHPMVT--
MAB_3810|M.abscessus_ATCC_1997 LHGSGPGVTGWRNYRGNLGVFAKHFHTYVLEFPGFGVSDAVPGHPVLT--
MLBr_01899|M.leprae_Br4923 IMGLGAQLVLWR-TAFCEKLVAQGLRVVRYDNRDVGLSSRTDSTEQPCPS
: * *. * .* : : . * *.
Mb3600c|M.bovis_AF2122/97 ------------------------AAMALKGLFDQLGLGRVPLVGNSLGG
Rv3569c|M.tuberculosis_H37Rv ------------------------AAMALKGLFDQLGLGRVPLVGNSLGG
MMAR_5064|M.marinum_M ------------------------AARALKELFDQLGLGRVPLVGNSLGG
MUL_4140|M.ulcerans_Agy99 ------------------------AARALKELFDQLGLGRVLLVGNSLGG
MSMEG_2900|M.smegmatis_MC2_155 ------------------------AQRAAVVFADALGLDRVDIIGNSMGG
Mflv_4525|M.gilvum_PYR-GCK ------------------------AQSSVVAFADALGLDRVDIIGNSMGG
Mvan_2898|M.vanbaalenii_PYR-1 ------------------------AQGAVVKFVDALGLDRVDVVGNSMGG
TH_3363|M.thermoresistible__bu ------------------------AQGAALAFADALGLDRVDIIGNSMGG
MAV_3016|M.avium_104 ------------------------AFGTVAPFLDALGVEKVHIIGNSMGG
MAB_3810|M.abscessus_ATCC_1997 ------------------------AGASVIRFMDGLGISSAAVVGNSMGG
MLBr_01899|M.leprae_Br4923 QPLTARLIRFWLGQRNACAYTLEDMTDDAVALLDHLSIERAHIVGASMGG
: * *.: . ::* *:**
Mb3600c|M.bovis_AF2122/97 GTAVRFALDYPARAGRLVLMGPGGLSINLFAPDPTEGVKRLSKFSVAPTR
Rv3569c|M.tuberculosis_H37Rv GTAVRFALDYPARAGRLVLMGPGGLSINLFAPDPTEGVKRLSKFSVAPTR
MMAR_5064|M.marinum_M GTAVRFALDYPDRAGRLVLMGPGGLSINLFAPDPTEGVKRLGKFSVAPTR
MUL_4140|M.ulcerans_Agy99 GTAVRFALDYPDRAGRLVLMGPGGLSINLFAPDPTEGVKRLGKFSVAPTR
MSMEG_2900|M.smegmatis_MC2_155 GVGINFAINHPDRVRHLVTIG--GIGTNIFSPGPSEGIRLLQEFTEDPTR
Mflv_4525|M.gilvum_PYR-GCK GVGINFAVNHSHRVGKLVTIG--GIGVNIFSPGPSEGIRLLQEFTEDPTR
Mvan_2898|M.vanbaalenii_PYR-1 GVGINFAINHRDRIGRLVTIG--GIGTNLFSPGPSEGIRLLQEFTEEPTR
TH_3363|M.thermoresistible__bu GVGVSLAVRHPDRVNRLVTIG--GIGTNIFSPGPSEGIRLLQEFTDDPTR
MAV_3016|M.avium_104 GVGINFATHNPDRVGRLVTIG--GIGTNIFSPSPSEGIRLLQEFVEDPTR
MAB_3810|M.abscessus_ATCC_1997 VVGINLAIKHPDRITKLVTIG--GVGPNIFSPSPSEGLRLLQEFTDNPDR
MLBr_01899|M.leprae_Br4923 MIAQIFAARFPTRTRSLAVFFSSNNRPFLPPPAPR---ALLALLTGPPTG
. :* * *. : . : .* * * : *
Mb3600c|M.bovis_AF2122/97 ENLEAFLRVMVYDKNLITPELVDQRFALASTPESLTATRAMG--KSFAG-
Rv3569c|M.tuberculosis_H37Rv ENLEAFLRVMVYDKNLITPELVDQRFALASTPESLTATRAMG--KSFAG-
MMAR_5064|M.marinum_M ENLEAFLRVMVYDQKLITPELVDQRFELARTPESLAATRAMG--KSFAA-
MUL_4140|M.ulcerans_Agy99 ENLEAFLRVMVYDQKLITPELVDQRFELARTPESLAATRAMG--KSFAA-
MSMEG_2900|M.smegmatis_MC2_155 ARLVDWLNSMVYDPALVTDELIEERWALATDPETLESARRMYGKAAFAAM
Mflv_4525|M.gilvum_PYR-GCK QRLVDWLNSMVYDPALVTEQLIEERWELATDPETLAAARRMYGKAAFAAM
Mvan_2898|M.vanbaalenii_PYR-1 QRLVDWLRSMVYDPALVTEELIEERWQLATDPETLAAARRMYGKAAFAAM
TH_3363|M.thermoresistible__bu DRLIAWLNSMVYDPTLITEELIEERWAAATDPATLAAARRMYSKAAFAAM
MAV_3016|M.avium_104 QRLVDWLKSMVYDQALITEQLIEERWALATDPDTLAAARRMYGKAAFSAM
MAB_3810|M.abscessus_ATCC_1997 DKLIRWLNSMVWDPAVVTDELIEERWEAAINPDAHKTAQLMYGSKAFAMQ
MLBr_01899|M.leprae_Br4923 SRRDVVVDNVVRVTKITGSPLYRMPEEQVRTNAAEIYDRSFY---PLGVS
. : :* : * . : : : .:.
Mb3600c|M.bovis_AF2122/97 ----ADFEAGMMWREVYRLRQPVLLIWGREDRVNPLDGALVALKTIPRAQ
Rv3569c|M.tuberculosis_H37Rv ----ADFEAGMMWREVYRLRQPVLLIWGREDRVNPLDGALVALKTIPRAQ
MMAR_5064|M.marinum_M ----ADFELGMMWREVYKLRQPVLLIWGREDRVNPLDGALVALKTIPRAQ
MUL_4140|M.ulcerans_Agy99 ----ADFELGMMWREVYKLRQPVLLIWGREDRVNPLDGALVALKTIPRAQ
MSMEG_2900|M.smegmatis_MC2_155 MEMMRNADFPLPWSIMHKVKAPTLLTWGRDDRVSPLDMALVPMRTIPNAE
Mflv_4525|M.gilvum_PYR-GCK MEMMRDADFPLPWATMHKVKAPTLLTWGRDDRVSPLDMALVPMRTIPNAE
Mvan_2898|M.vanbaalenii_PYR-1 MEMMRKADVPMPWATMHKIAAPTLLTWGRDDRVSPLDMALVPMRTIPDAE
TH_3363|M.thermoresistible__bu MAMMRDSDTPPPWATMHKVQAPTLLTWGRDDRVSPLDMALLPMRTIPGAE
MAV_3016|M.avium_104 NAALNASDRPLPWAVMHKLTAPTLLTWGRDDRVSPPDMALIPMRTIPNAE
MAB_3810|M.abscessus_ATCC_1997 QQFLANADIPPYWAMMHKIKCPTLLTWGRDDRVSPPDMAIVPMRLIPNAE
MLBr_01899|M.leprae_Br4923 RQFSAILGSGSLLHYNQRIIAPTVVIHGRADKLVRPSSGRAVARAITGAR
:: *.:: ** *:: . . : *. *.
Mb3600c|M.bovis_AF2122/97 LHVFGQCGHWVQVEKFDEFNKLTIEFLGGGR----
Rv3569c|M.tuberculosis_H37Rv LHVFGQCGHWVQVEKFDEFNKLTIEFLGGGR----
MMAR_5064|M.marinum_M LHVFGQCGHWAQVEKFDEFNRLTIDFLGGAR----
MUL_4140|M.ulcerans_Agy99 LHVFGQCGHWAQVEKFDEFNRLTIDFLGGAR----
MSMEG_2900|M.smegmatis_MC2_155 LHVFPNCGHWVMIEAKSAFERTVLSFLTQDN----
Mflv_4525|M.gilvum_PYR-GCK FHVFPNCGHWVMIEAKAAFERTVLSFLTESSAAAR
Mvan_2898|M.vanbaalenii_PYR-1 LHVFPNCGHWVMIEAKAAFERTVLAFLTQRDA---
TH_3363|M.thermoresistible__bu LHVFPNCGHWVMIEAKSAFERTVLAFLTDPARG--
MAV_3016|M.avium_104 LHIFPNSGHWAMIEAKAAFESTVLAFLSRG-----
MAB_3810|M.abscessus_ATCC_1997 LHIFPNSGHWVMIEAKQAFEQTVVDFLRR------
MLBr_01899|M.leprae_Br4923 LVLFDGMGHDLPQQLWDQAVGVLMSNFAKAS----
: :* ** : : :