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NQPMTTPGALNWTAAPVQLPDMPPIQAGEDAMSMTIAALLPTLHASMTANVTALAAKENMFNGKLGDAQG AYENADQSGQQGVGQIGQMMGQLGQLGQMASQPAQMAGQMGGQFSSLMEPLMKAMEGAKGGGGPEGAGAP GGPGAPGAPLGPNPQQQQQEREAQLNERETKQNEREDHLNQREDEQNRREADQNAREARLNEHTGASSSA SGPASSAAAPTAPAPSAPAPAAPPASAAGPSDARPAPGPVPVAPHESPRHSGGDDIAKRM*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5988 | - | - | 100% (271) | hypothetical protein MSMEG_5988 |
| M. smegmatis MC2 155 | MSMEG_1872 | - | 4e-07 | 26.90% (145) | hypothetical protein MSMEG_1872 |
| M. smegmatis MC2 155 | MSMEG_6285 | - | 2e-06 | 46.30% (54) | DNA polymerase III subunits gamma and tau |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3927c | - | 2e-06 | 31.96% (194) | hypothetical protein Mb3927c |
| M. gilvum PYR-GCK | Mflv_0763 | - | 1e-08 | 22.17% (203) | hypothetical protein Mflv_0763 |
| M. tuberculosis H37Rv | Rv3439c | - | 7e-06 | 24.19% (248) | hypothetical protein Rv3439c |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3746c | - | 6e-06 | 27.16% (232) | hypothetical protein MAB_3746c |
| M. marinum M | MMAR_4294 | - | 8e-08 | 51.85% (54) | hypothetical protein MMAR_4294 |
| M. avium 104 | MAV_2415 | - | 1e-10 | 29.51% (244) | hypothetical protein MAV_2415 |
| M. thermoresistible (build 8) | TH_4343 | - | 2e-09 | 39.73% (73) | PUTATIVE - |
| M. ulcerans Agy99 | MUL_1004 | - | 6e-08 | 51.85% (54) | hypothetical protein MUL_1004 |
| M. vanbaalenii PYR-1 | Mvan_5049 | - | 3e-06 | 46.38% (69) | FHA domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_5988|M.smegmatis_MC2_155 --------------------------------------------------
TH_4343|M.thermoresistible__bu --------------------------------------------------
MMAR_4294|M.marinum_M --------------------------------------------------
MUL_1004|M.ulcerans_Agy99 --------------------------------------------------
Mvan_5049|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2415|M.avium_104 MAPLAVDPEAMYAAGSAVAAIGDSLAANLTILTAGVSAHTGVDRAGEVFG
Mflv_0763|M.gilvum_PYR-GCK --------------------------------------------------
Mb3927c|M.bovis_AF2122/97 --------------------------------------------------
MAB_3746c|M.abscessus_ATCC_199 --------------------------------------------------
Rv3439c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_5988|M.smegmatis_MC2_155 --------------------------------------------------
TH_4343|M.thermoresistible__bu --------------------------------------------------
MMAR_4294|M.marinum_M --------------------------------------------------
MUL_1004|M.ulcerans_Agy99 --------------------------------------------------
Mvan_5049|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2415|M.avium_104 LGYQDSAESMLKAAAGVVNACRKCGALIQQGASNYSAAEAASTLGGGSGA
Mflv_0763|M.gilvum_PYR-GCK --------------------------------------------------
Mb3927c|M.bovis_AF2122/97 --------------------------------------------------
MAB_3746c|M.abscessus_ATCC_199 --------------------------------------------------
Rv3439c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_5988|M.smegmatis_MC2_155 --------------------------------------------------
TH_4343|M.thermoresistible__bu --------------------------------------------------
MMAR_4294|M.marinum_M --------------------------------------------------
MUL_1004|M.ulcerans_Agy99 --------------------------------------------------
Mvan_5049|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2415|M.avium_104 LPAPSAPADLAAPGPPGTWGKGEPPPLLWAVIQALVSEVWPDGDEAGLHA
Mflv_0763|M.gilvum_PYR-GCK --------------------------------------------------
Mb3927c|M.bovis_AF2122/97 --------------------------------------------------
MAB_3746c|M.abscessus_ATCC_199 --------------------------------------------------
Rv3439c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_5988|M.smegmatis_MC2_155 --------------------------------------------------
TH_4343|M.thermoresistible__bu --------------------------------------------------
MMAR_4294|M.marinum_M --------------------------------------------------
MUL_1004|M.ulcerans_Agy99 --------------------------------------------------
Mvan_5049|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2415|M.avium_104 AASRWHGFAAAMNGVQGTLNASKALFDSQQIPEGEKIDHALAEIGAAAAA
Mflv_0763|M.gilvum_PYR-GCK --------------------------------------------------
Mb3927c|M.bovis_AF2122/97 --------------------------------------------------
MAB_3746c|M.abscessus_ATCC_199 --------------------------------------------------
Rv3439c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_5988|M.smegmatis_MC2_155 --------------------------------------------------
TH_4343|M.thermoresistible__bu --------------------------------------------------
MMAR_4294|M.marinum_M --------------------------------------------------
MUL_1004|M.ulcerans_Agy99 --------------------------------------------------
Mvan_5049|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2415|M.avium_104 IGQQCDALARTVDEFADRVGHAQQAIRDLLHRIEALGDIGHDIMLIIDGD
Mflv_0763|M.gilvum_PYR-GCK --------------------------------------------------
Mb3927c|M.bovis_AF2122/97 --------------------------------------------------
MAB_3746c|M.abscessus_ATCC_199 --------------------------------------------------
Rv3439c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_5988|M.smegmatis_MC2_155 --------------------------------------------------
TH_4343|M.thermoresistible__bu --------------------------------------------------
MMAR_4294|M.marinum_M --------------------------------------------------
MUL_1004|M.ulcerans_Agy99 --------------------------------------------------
Mvan_5049|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2415|M.avium_104 AWDEIQKIARDVNAVLQHLGQEARAFEQEIRLLMQAADREIVTCQKYARR
Mflv_0763|M.gilvum_PYR-GCK --------------------------------------------------
Mb3927c|M.bovis_AF2122/97 --------------------------------------------------
MAB_3746c|M.abscessus_ATCC_199 ---------------------------MANKWDIEALRGEGLQAIANSQN
Rv3439c|M.tuberculosis_H37Rv ---------------------------MADRLNVAERLAEGRPAAEHTQS
MSMEG_5988|M.smegmatis_MC2_155 --------------------------------------------------
TH_4343|M.thermoresistible__bu --------------------------------------------------
MMAR_4294|M.marinum_M --------------------------------------------------
MUL_1004|M.ulcerans_Agy99 --------------------------------------------------
Mvan_5049|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2415|M.avium_104 GLITFLGEDVGNPVATALDFGINVQEGVVKGAVGMGLGLVDLSPHWIALD
Mflv_0763|M.gilvum_PYR-GCK --------------------------------------------------
Mb3927c|M.bovis_AF2122/97 --------------------------------------------------
MAB_3746c|M.abscessus_ATCC_199 YVTAAIRGNGKSPVTITNPDLTANERQLFDWYDMDAGMDLNTLGGDLELF
Rv3439c|M.tuberculosis_H37Rv YVR------ACHLVGYQHPDLTAYPAQIHDWYGSEDGLDLHALDADCAQL
MSMEG_5988|M.smegmatis_MC2_155 ------------------------------------------------MN
TH_4343|M.thermoresistible__bu ----------------------------------------------MAIP
MMAR_4294|M.marinum_M -------------------------------------MASTWSLSKGLAA
MUL_1004|M.ulcerans_Agy99 -------------------------------------MASTWSLSKGLAA
Mvan_5049|M.vanbaalenii_PYR-1 -----------------------------MSGRHRKPAPSAVNVAKIAFT
MAV_2415|M.avium_104 PEGAGATWGGLVKNAWKESFVNAAVNPQEFAQARLQELKGLVHADDWTRD
Mflv_0763|M.gilvum_PYR-GCK --------------------------------------MVSGGLPPLSVD
Mb3927c|M.bovis_AF2122/97 -----------------------------------MTGDQNPAPGPAPGV
MAB_3746c|M.abscessus_ATCC_199 KNATATMKAAAERQHGQLQRLIGLWEGKGSESANDFLKTHNSTADAVTDE
Rv3439c|M.tuberculosis_H37Rv RAAASVLMEALRMERSQVAVLAAAWTGSGADAAVHFVQRHCETGNSVVTE
MSMEG_5988|M.smegmatis_MC2_155 QPMTTPGALNWTAAPVQLPDMPPIQAGE-----DAMSMTIAALLPTLHAS
TH_4343|M.thermoresistible__bu ELKVNESALHWDPAEVMVPSVPAIPAGE-----DPMSQVVAEALPGVAAK
MMAR_4294|M.marinum_M VVVTSAAAFGLCPGAAADPAAPQPNPNPQLP-GLPALAQLSPIIQQAAGN
MUL_1004|M.ulcerans_Agy99 VVVTSAAAFGLCPAAAADPAAPQPNPNPQLP-GLPALAQLSPIIQQAAGN
Mvan_5049|M.vanbaalenii_PYR-1 GAVIGGGGLALAGQAGAATDGEWDQVARCES-GGNWAINTGNGYHGGLQF
MAV_2415|M.avium_104 RPGLGAGEVAFDAATLIAPGLGEAGAAADGA-SAAARGAEAEADAAGAAG
Mflv_0763|M.gilvum_PYR-GCK PTQLSAAGGALKSSALDLPEAPAPFMPVG---TDPLSVAIIGQIPAIETP
Mb3927c|M.bovis_AF2122/97 PIKVTPEILLQVLTTPPASGPAPFPAVPVDL-PAPADIANGALFAAGNSG
MAB_3746c|M.abscessus_ATCC_199 FGKVSTGLDGLRNALWNIVDLKKQASTMVDG-LVTDRTHFDSAVATYKTG
Rv3439c|M.tuberculosis_H37Rv VRAAAQRCESLRDNLWQLVDSKVATAIAIDERALAQRPAWLAAAEALTTE
MSMEG_5988|M.smegmatis_MC2_155 MTANVTALAAKENMFNGKLGDAQG-AYENAD-QSGQQGVGQIGQMMGQLG
TH_4343|M.thermoresistible__bu VTEMVAATRAQEAEFAANVAAAKQ-AYQRTD-DTADQELKSAADAVYVPG
MMAR_4294|M.marinum_M PEQATQLLMAAAQAFAHNPAAPTE-SRNVAS-SVNQFVQEPVNPAPGSPP
MUL_1004|M.ulcerans_Agy99 PEQATQLLMAAAQAFAHNPAAPTE-SRNVAS-SVNQFVQEPVNPAPGSPP
Mvan_5049|M.vanbaalenii_PYR-1 SPGTWSGHGGGEYAPAAYLATKEE-QIAVAERVLASQGKGAWPSCGGPLS
MAV_2415|M.avium_104 RVGGIAGARGALTDIAKSTADLPK-NLEGVTKDLPEIKPPTGGAPVGLGP
Mflv_0763|M.gilvum_PYR-GCK IATQLPLIKAEATTTASNVEDAAQ-AYAATD----EQNSAAIDQVMQKTP
Mb3927c|M.bovis_AF2122/97 VPGDVESSGLEDLDRRAHAADAVQ-KFSANEADAAQQFQGVGAQAEAQGA
MAB_3746c|M.abscessus_ATCC_199 MGDKSQADETNATMIGPHVKNNIEGQLLPAFKKAWSAGGGAYDTLINGLK
Rv3439c|M.tuberculosis_H37Rv GADRPTAVEVVRQQIQPYVDDDVRNDWLTTMRSTTAGVAASYDAVTDQLA
MSMEG_5988|M.smegmatis_MC2_155 Q-LGQMASQPAQMAGQMGGQFSSLMEP--------LMKAMEGAKGGGGP-
TH_4343|M.thermoresistible__bu A-L-----------------------------------------------
MMAR_4294|M.marinum_M LGVPAPAAAPVEVAPPASAPVPHVPAPGAEPGTLAHLPAGIDPAHAAGP-
MUL_1004|M.ulcerans_Agy99 LGVPAPAAAPVEVAPPASAPVPHVPAPGAEPGTLAHLPAGIDPAHAAGP-
Mvan_5049|M.vanbaalenii_PYR-1 AATPRNVVAEPPAPVDPVGLNGLLPPPPVDPFAPPPAPAPVDALAAPAP-
MAV_2415|M.avium_104 GGKPIEAPVESAPRPPDGTPGAQRGSPPVATSPASPGPAGDSGAGPHGPS
Mflv_0763|M.gilvum_PYR-GCK SQMPSGS-------------------------------------------
Mb3927c|M.bovis_AF2122/97 TQMMQQAVSGITG-------------------------------------
MAB_3746c|M.abscessus_ATCC_199 QELPPDFKLPPGVFGPDYDTTDEPAKTTKGKGKQDDKDGGETSGESGESG
Rv3439c|M.tuberculosis_H37Rv SAPRAHFEIPDDLGPG----------------------------------
MSMEG_5988|M.smegmatis_MC2_155 ---EGAGAPGGPGAPGAPLGPNPQQQQQ-----------EREAQLNERET
TH_4343|M.thermoresistible__bu --------------------------------------------------
MMAR_4294|M.marinum_M ---APVAAPAGAPPASAPAPAAAAPASA-----------PGTAPAPAAAP
MUL_1004|M.ulcerans_Agy99 ---APVAAPAGAPPASAPAPAAAAPASA-----------PGTAPAPAAAP
Mvan_5049|M.vanbaalenii_PYR-1 ---LPPAPEALPPAPAPAAPFDAMSAPA-----------PLPPAPEALPP
MAV_2415|M.avium_104 SSPAPAAPPGGPVGPHDPAPAPAPAASPGGPGGSGGVHDPAPAPAPAPAA
Mflv_0763|M.gilvum_PYR-GCK ---GGSAPGGGADAAGQMSQMMGMPMQM--------------AQMPMQMM
Mb3927c|M.bovis_AF2122/97 ---ALGGAVGGVMGPLTQLPQQAMQAGQG------AMQPLMSALQQTYGA
MAB_3746c|M.abscessus_ATCC_199 NSGVNSGAGGGTASGGMQGTATPASATGN-----AGGQLSGAGQQQGAGQ
Rv3439c|M.tuberculosis_H37Rv ---RQPSPASVPAQPSATAAITPAAALP--------------PPDPVPAV
MSMEG_5988|M.smegmatis_MC2_155 KQNEREDHLNQREDEQNRREADQNAREARLNEHTGASSSASGPASSAAAP
TH_4343|M.thermoresistible__bu --------------------------------------------------
MMAR_4294|M.marinum_M GPAPAAPAPAPAAAAPAPAPAPAAPPAAPVAA----PAPVPAPAPAAAPA
MUL_1004|M.ulcerans_Agy99 GPAPAAPAPAPAAAAPAPAPAPAAPPAAPVAAPVAAPAPVPAPAPAAAPA
Mvan_5049|M.vanbaalenii_PYR-1 APAPAAPFDAMSAPAPLPPAPEALPPAPVVDAANIAPLDAPLPPPAPVDA
MAV_2415|M.avium_104 SGGPGDPASVPSGGPHEPASVPAEEPREPVSVPAGGVHDPVAEPTGGPHE
Mflv_0763|M.gilvum_PYR-GCK SGIASAPQGLMQGAQQASQQVQQMAGQFGQGATGGSASSAAQVPAPDAPA
Mb3927c|M.bovis_AF2122/97 EGLDVADGARLVDSIEGEPGLGGEPGAGDVGAGGGGGGTTPTGYLGPPPV
MAB_3746c|M.abscessus_ATCC_199 GQQGMDPSQMLSGMTGALTGALSSIGQAASGIVSAITEGISSIPFDQMGQ
Rv3439c|M.tuberculosis_H37Rv TSRPVTPSDFGSAPGDGSATPAGVGSAGGFGDAGGTGGLGGFAGLAGLAN
MSMEG_5988|M.smegmatis_MC2_155 T------------------------------APAPSAPAPAAPPASAAGP
TH_4343|M.thermoresistible__bu --------------------------------------------------
MMAR_4294|M.marinum_M P------------------------------EAAAPAPAPAPAPAAAPGF
MUL_1004|M.ulcerans_Agy99 P------------------------------EAAAPAPAPAPAPAAAPGF
Mvan_5049|M.vanbaalenii_PYR-1 PPAQSAIIAAANWDTAPVPGEHPQLWSLGVDAPLQPAPVLPPAPAPAPAP
MAV_2415|M.avium_104 PASVPAAGSRLASVQAAAGDGLPSATPQLFDHTPSQVPVPAGGSSGEAAS
Mflv_0763|M.gilvum_PYR-GCK P-------------------------------EPASEGAAAGEPDAERAP
Mb3927c|M.bovis_AF2122/97 P-----------------------------TSSPPTTPAGAPAKSVTPDP
MAB_3746c|M.abscessus_ATCC_199 G----------------------------LGDDQFDGRADEAADKKDEAA
Rv3439c|M.tuberculosis_H37Rv R----------------------------IVDAVDSLLGSVAEQLGDPLA
MSMEG_5988|M.smegmatis_MC2_155 SDARPAPGPVPVAPHESPRHSGGDDIAKRM--------------------
TH_4343|M.thermoresistible__bu --------------------------------------------------
MMAR_4294|M.marinum_M GPDAPPTQDFMYPSIGTNCLADGSNIIATALSVAGPATIPTPGPGPGQTA
MUL_1004|M.ulcerans_Agy99 GPDAPPTQDFMYPSIGTNCLADGSNIIATALSVAGPATIPTPGPGPGQTA
Mvan_5049|M.vanbaalenii_PYR-1 AAVAAPAPDPLAPLGAVEVPAPAYDIANQAISGELPVPSEVPHLASPDNL
MAV_2415|M.avium_104 VGAHSPSSASSAAPHFESPGGRPSEVPAPNGGAHGPGESGPAGGHPPGEP
Mflv_0763|M.gilvum_PYR-GCK TPDERSDREDTGAPGRHRAAEADDRIDL----------------------
Mb3927c|M.bovis_AF2122/97 VSGTPRASGPAGMTGMPMVPPGALGAGAEGANKDKPVEKRVTAPAVPNGQ
MAB_3746c|M.abscessus_ATCC_199 ADGKKDPDAKMAAAKDAAIEEARADSGATFATDGKPAPGIQLAGAGGLEA
Rv3439c|M.tuberculosis_H37Rv ADNPPGAVDPFAEDAADNADDGDDAHPEEADEAAEPKEATEPDEADEVDD
MSMEG_5988|M.smegmatis_MC2_155 --------------------------------------------------
TH_4343|M.thermoresistible__bu --------------------------------------------------
MMAR_4294|M.marinum_M YVFTAVGTPGP-----AEVQRLPLN------VTWVNLTTGKSGSVTLKPR
MUL_1004|M.ulcerans_Agy99 YVFTAVGTPGP-----AEVQRLPLN------VTWVNLTTGKSGSVTLKPR
Mvan_5049|M.vanbaalenii_PYR-1 PPGTAMAPQGPRQSPNVTYLKEIWH------AIQTQEISGADALLALTQR
MAV_2415|M.avium_104 PHGGKPSGDGGPPDEDSHRDGTPGNGDDGAAGEIDDGPAGVDGQSTPAKV
Mflv_0763|M.gilvum_PYR-GCK --------------------------------------------------
Mb3927c|M.bovis_AF2122/97 PVKG-----------------------------------------RLTVP
MAB_3746c|M.abscessus_ATCC_199 TPTAAPGQTTPGAPLGATPTGTIPPAAGGLSAAQPAGSSASLTPHPVQAQ
Rv3439c|M.tuberculosis_H37Rv ADESVPAERAQDVAEEATLPPVAEP-------------PPPAAPPVAEPP
MSMEG_5988|M.smegmatis_MC2_155 --------------------------------------------------
TH_4343|M.thermoresistible__bu --------------------------------------------------
MMAR_4294|M.marinum_M SDINPEGPTTLTGIADTGSGSIMSTIFGQVTTKERQCQFMPTIGSTVVP-
MUL_1004|M.ulcerans_Agy99 SDINPEGPTTLTGIADTGSGSIMSTIFGQVTTKERQCQFMPTIGSTVVP-
Mvan_5049|M.vanbaalenii_PYR-1 PLTTPDTPGGTPPIAPGAPGAPVAPLAGPAPAPAPVPAPAPVLPPA----
MAV_2415|M.avium_104 AGVDYPLPPSDALRVLEHPGAELQRLADGGVPSSILEGYEPLAGRSVDDF
Mflv_0763|M.gilvum_PYR-GCK --------------------------------------------------
Mb3927c|M.bovis_AF2122/97 PSVPVKSADDKPVVTKSTRRILVVPNDDKVKE------------------
MAB_3746c|M.abscessus_ATCC_199 PPTVPQHPEPQSAAARQPSPLPSVGPTDASAQPQEAKTEAGETPCEIAAD
Rv3439c|M.tuberculosis_H37Rv PPVAAPAPPGAPEPANGPSPEALSEGATPCEIAADELPQAGP--------
MSMEG_5988|M.smegmatis_MC2_155 --------------------------------------------------
TH_4343|M.thermoresistible__bu --------------------------------------------------
MMAR_4294|M.marinum_M --------------------------------------------------
MUL_1004|M.ulcerans_Agy99 --------------------------------------------------
Mvan_5049|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2415|M.avium_104 NREFTIETSNGERGWDWEAQAPENGFAGNPIESNHIPAGLHFDRIGPNGG
Mflv_0763|M.gilvum_PYR-GCK --------------------------------------------------
Mb3927c|M.bovis_AF2122/97 --------------------------------------------------
MAB_3746c|M.abscessus_ATCC_199 ELPKAGR-------------------------------------------
Rv3439c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_5988|M.smegmatis_MC2_155 --------------------------------------------------
TH_4343|M.thermoresistible__bu --------------------------------------------------
MMAR_4294|M.marinum_M --------------------------------------------------
MUL_1004|M.ulcerans_Agy99 --------------------------------------------------
Mvan_5049|M.vanbaalenii_PYR-1 --------------------------------------------------
MAV_2415|M.avium_104 GFLSPEGVPLAERATPPGLAAQYHVFEGTGREIPAGKDWVVQHGPAKEAF
Mflv_0763|M.gilvum_PYR-GCK --------------------------------------------------
Mb3927c|M.bovis_AF2122/97 --------------------------------------------------
MAB_3746c|M.abscessus_ATCC_199 --------------------------------------------------
Rv3439c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_5988|M.smegmatis_MC2_155 ------------------------------------------------
TH_4343|M.thermoresistible__bu ------------------------------------------------
MMAR_4294|M.marinum_M ------------------------------------------------
MUL_1004|M.ulcerans_Agy99 ------------------------------------------------
Mvan_5049|M.vanbaalenii_PYR-1 ------------------------------------------------
MAV_2415|M.avium_104 GQPGGGDQWIVLDRATNRPVPVDELIRRRLLREITPPNDKLAIGYRGS
Mflv_0763|M.gilvum_PYR-GCK ------------------------------------------------
Mb3927c|M.bovis_AF2122/97 ------------------------------------------------
MAB_3746c|M.abscessus_ATCC_199 ------------------------------------------------
Rv3439c|M.tuberculosis_H37Rv ------------------------------------------------