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MTGDQNPAPGPAPGVPIKVTPEILLQVLTTPPASGPAPFPAVPVDLPAPADIANGALFAAGNSGVPGDVE SSGLEDLDRRAHAADAVQKFSANEADAAQQFQGVGAQAEAQGATQMMQQAVSGITGALGGAVGGVMGPLT QLPQQAMQAGQGAMQPLMSALQQTYGAEGLDVADGARLVDSIEGEPGLGGEPGAGDVGAGGGGGGTTPTG YLGPPPVPTSSPPTTPAGAPAKSVTPDPVSGTPRASGPAGMTGMPMVPPGALGAGAEGANKDKPVEKRVT APAVPNGQPVKGRLTVPPSVPVKSADDKPVVTKSTRRILVVPNDDKVKE
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3927c | - | - | 100% (329) | hypothetical protein Mb3927c |
| M. bovis AF2122 / 97 | Mb2109 | - | 2e-95 | 64.98% (297) | hypothetical protein Mb2109 |
| M. bovis AF2122 / 97 | Mb3921c | PPE69 | 6e-09 | 28.44% (211) | PPE family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2790 | - | 6e-09 | 23.94% (259) | hypothetical protein Mflv_2790 |
| M. tuberculosis H37Rv | Rv2083 | - | 3e-95 | 64.65% (297) | hypothetical protein Rv2083 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3746c | - | 4e-08 | 25.75% (268) | hypothetical protein MAB_3746c |
| M. marinum M | MMAR_3067 | - | 1e-101 | 65.75% (292) | hypothetical protein MMAR_3067 |
| M. avium 104 | MAV_5287 | - | 4e-93 | 57.94% (321) | hypothetical protein MAV_5287 |
| M. smegmatis MC2 155 | MSMEG_5153 | - | 5e-07 | 29.12% (182) | hypothetical protein MSMEG_5153 |
| M. thermoresistible (build 8) | TH_4447 | - | 2e-08 | 30.47% (233) | PUTATIVE PPE protein |
| M. ulcerans Agy99 | MUL_2312 | - | 2e-99 | 65.07% (292) | hypothetical protein MUL_2312 |
| M. vanbaalenii PYR-1 | Mvan_3258 | - | 6e-11 | 24.03% (283) | hypothetical protein Mvan_3258 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3927c|M.bovis_AF2122/97 --------------------------------------MTGDQNPAPGPA
MAV_5287|M.avium_104 --------------------------------------MGG---------
MMAR_3067|M.marinum_M --------------------------------------------------
MUL_2312|M.ulcerans_Agy99 --------------------------------------------------
Rv2083|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2790|M.gilvum_PYR-GCK MRVQLMPAVGGSAGSYGRLIVTPDMEPPDAGHWDDQEQTYRAGATSWDGI
Mvan_3258|M.vanbaalenii_PYR-1 -----MPAVGGSAGSYGRLIVTPDMEPPDAGHWDAQEQTYRVGATTWDGI
MAB_3746c|M.abscessus_ATCC_199 ------------------------------------MANKWDIEALRGEG
MSMEG_5153|M.smegmatis_MC2_155 --------------------------------------------------
TH_4447|M.thermoresistible__bu -------------------------------------------------M
Mb3927c|M.bovis_AF2122/97 PGVPIKVTPEILLQVLTTPPASGPAPFPAVPVDLPAPADIANGALFAAGN
MAV_5287|M.avium_104 PGGIIKNDLPTTTAIVGGPPASIPRPFP-VPPGGTSPADAGQGMVGGAGN
MMAR_3067|M.marinum_M --MTINSVPESYGHATGMP-APIPLAPGPVHPGGTSPVDAAMAGFGMATN
MUL_2312|M.ulcerans_Agy99 --MTINSVPESYGHATGMP-APIPLAPGPVHPGGTSPVDAAMAGFGMATN
Rv2083|M.tuberculosis_H37Rv -MTSIESHPEQYWAAAGRP-GPVPLALGPVHPGGPTLIDLLMALFGLSTN
Mflv_2790|M.gilvum_PYR-GCK HQQIVTDSARFREAADSQGFDEVHRVNAVLAEEAKTIAEWHAKVADKCGD
Mvan_3258|M.vanbaalenii_PYR-1 HQKIVTDNAEFRDAADSQGFDEAHRAGAVLAEEAKTIAEWHDKCANKCAD
MAB_3746c|M.abscessus_ATCC_199 LQAIANSQNYVTAAIRGNGKSPVTITNPDLTANERQLFDWYDMDAGMDLN
MSMEG_5153|M.smegmatis_MC2_155 ----MSPKTFLATAAAIGSSAALLLGTGIAHADPGPLPIDAAQAPGLSAV
TH_4447|M.thermoresistible__bu FWHAMPPEVNTSRLMAGAGTAPMLQAAAGWEAFAISLETQADELAGSLAA
Mb3927c|M.bovis_AF2122/97 SG------VPGDVESSGLEDLDRRAHAADAVQKFSANEADAAQQFQGVGA
MAV_5287|M.avium_104 AN------VPKDAADAAAADADRKARAADAAAKFPANEANGSQEMQ----
MMAR_3067|M.marinum_M AD------LGPVNGEIAADDADRRAHAADAAAKFPANEADAAQQFQGVG-
MUL_2312|M.ulcerans_Agy99 AD------LGPVNGEIAADDADRRAHAADAAAKFPANEADAAQQFQGVG-
Rv2083|M.tuberculosis_H37Rv AD------LGGANADIEGDDTDRRAHAADAARKFSANEANAAEQMQGVG-
Mflv_2790|M.gilvum_PYR-GCK IA------TVLRETRSGQEQVVREADAKIASAKLPGEVETLVTQYHGIAR
Mvan_3258|M.vanbaalenii_PYR-1 IA------TVLRDTRAGQEQLVREADAKIASAKLPGEAEALVTQYHGIAR
MAB_3746c|M.abscessus_ATCC_199 TLGGDLELFKNATATMKAAAERQHGQLQRLIGLWEGKGSESANDFLKTHN
MSMEG_5153|M.smegmatis_MC2_155 QG------LSPVIQQAAADPAGAAQLLMAAAQAFAANKTEPADSRNVAT-
TH_4447|M.thermoresistible__bu LAG------AWTGGASERAIAAITPMIVWLRTVSAQAHKRSAQALAQAAA
Mb3927c|M.bovis_AF2122/97 QAEAQGATQMMQQAVSGITGALGGAVGGVMG----PLTQLPQQAMQ----
MAV_5287|M.avium_104 ---------MLQQMLSSVTGALGGAMGGVMG----PLTQLPQQAMQ----
MMAR_3067|M.marinum_M ---ADGMAQMIPQMASGIGGALSGALGGVLG----PLTQIPQQALQ----
MUL_2312|M.ulcerans_Agy99 ---ADGMAQMIPQMASGIGGALSGALGGVLG----PLTQIPQQALQ----
Rv2083|M.tuberculosis_H37Rv ---AQGMA----QMASGIGGALSGALGGVMG----PLTQLPQQAMQ----
Mflv_2790|M.gilvum_PYR-GCK YRTEAGVTAAMASHTSFKRSTENTRALDLLTRWGDALAAPPVQPLDSPSP
Mvan_3258|M.vanbaalenii_PYR-1 YQTEAGVTAAMASHTAFKASTENTRALDLLTKWGDAPTAPPVQPVDHTSP
MAB_3746c|M.abscessus_ATCC_199 -STADAVTDEFGKVSTGLDGLRN-ALWNIVDLKKQASTMVDGLVTDR---
MSMEG_5153|M.smegmatis_MC2_155 -AVNQFVAEPLTATPEHIPAAGAGLDAHLPAGIDPAHAVGPAEALP----
TH_4447|M.thermoresistible__bu YSTAMATTPPLAEIEQNHITRAVLHATNFLG-----INTVP---------
.
Mb3927c|M.bovis_AF2122/97 -----------------------------------------AGQGAMQPL
MAV_5287|M.avium_104 -----------------------------------------AGQSALQPL
MMAR_3067|M.marinum_M -----------------------------------------AGQGALQPL
MUL_2312|M.ulcerans_Agy99 -----------------------------------------AGQGALQPL
Rv2083|M.tuberculosis_H37Rv -----------------------------------------AGQGAMQPL
Mflv_2790|M.gilvum_PYR-GCK GIAQGDNNPKKAPPQEEDSSKSTPLQEGSDQSPPAMSPTDSAGTSTTQP-
Mvan_3258|M.vanbaalenii_PYR-1 GIEQDENPYSDTEKREAGADAPKPVDD---------APTDPAGTSTTQPG
MAB_3746c|M.abscessus_ATCC_199 -------------------------------------THFDSAVATYKTG
MSMEG_5153|M.smegmatis_MC2_155 --------------------------------------------PAAEPL
TH_4447|M.thermoresistible__bu -----------------------------------------IGINEMDYF
.
Mb3927c|M.bovis_AF2122/97 MS-ALQQTYGAEGLDVADGAR-----LVDSIEGE-PGLGGE----PGAG-
MAV_5287|M.avium_104 MS-AVQGAHGAASL--ADNAH-----LVDSVGGAGSGLGGG----AGAG-
MMAR_3067|M.marinum_M MG-ALQQSAGVEGLEAADGAR-----LVDSLESE-PGLGGG----GAGEL
MUL_2312|M.ulcerans_Agy99 MG-ALQQSAGVEGLEAADGAR-----LVDSLESE-PGLGGG----GAGEL
Rv2083|M.tuberculosis_H37Rv MS-AMQQAQGADGLAAVDGAR-----LLDSIGGE-PGLGSG----AGG--
Mflv_2790|M.gilvum_PYR-GCK ---GIKSVTSDEGIKVATGPL-QPTPGVASPGAGASPLGGGGMSSMGGMV
Mvan_3258|M.vanbaalenii_PYR-1 VSPGSKSAAGDESIKAATGPVTQPTPGVTSS-PAASALGGAGMPSMGGIG
MAB_3746c|M.abscessus_ATCC_199 MGDKSQADETNATMIGPHVKNNIEGQLLPAFKKAWSAGGGAY---DTLIN
MSMEG_5153|M.smegmatis_MC2_155 AAPAPAPAPEAAPAPAPEAAP------APAPEAAAPAPEAPAP-APAPAA
TH_4447|M.thermoresistible__bu VRMWNQAAGAMDVYQAETAMNILFEPIMPMKPIVIPGVGEAA---VAGAL
.
Mb3927c|M.bovis_AF2122/97 DVGAGGGGGGTTPTGYLG--------------------------------
MAV_5287|M.avium_104 GGGAGLGGGGTVPTSSLG--------------------------------
MMAR_3067|M.marinum_M GTGGGGGGGGTIPTGYLG--------------------------------
MUL_2312|M.ulcerans_Agy99 GTGGGGGGGGTISTGYLG--------------------------------
Rv2083|M.tuberculosis_H37Rv GDVGGGGAGGTTPTGYLG--------------------------------
Mflv_2790|M.gilvum_PYR-GCK GGGMGSGG-APKLPGGLGSGGLPGMGSNPLGSGVDQMPSAGSGLPSAGGV
Mvan_3258|M.vanbaalenii_PYR-1 GGGMGSGGGIPKMPGGLGSGGMPGMGSNPLSGGVGQMPGAASGLPNPGAV
MAB_3746c|M.abscessus_ATCC_199 GLKQELPPDFKLPPGVFG--------------------------------
MSMEG_5153|M.smegmatis_MC2_155 AAAPGFGPDAPVTQEFMY--------------------------------
TH_4447|M.thermoresistible__bu GKAAAMAPAAAARDLVFAK-------------------------------
:
Mb3927c|M.bovis_AF2122/97 -------------------------------PPPVPTSSPPTTPAG--AP
MAV_5287|M.avium_104 -------------------------------PPPVPTSSPPTTPAG--AK
MMAR_3067|M.marinum_M -------------------------------PPPVPTSSPPTTPAG--AP
MUL_2312|M.ulcerans_Agy99 -------------------------------PPPVPTSSPPTTPAG--AP
Rv2083|M.tuberculosis_H37Rv -------------------------------PPPVPTSSPPTTPAG--AP
Mflv_2790|M.gilvum_PYR-GCK PGDGSGAGSPAVAFSQGMSTGGAIGGGMPAAPAPAPASPSPALSAG--AQ
Mvan_3258|M.vanbaalenii_PYR-1 PGAGS-ASPLSSAFNQGMATTAGMGGGIPSAPPPAPASPSPALSAGGGHA
MAB_3746c|M.abscessus_ATCC_199 --------------------------------PDYDTTDEPAKTTKGKGK
MSMEG_5153|M.smegmatis_MC2_155 -----------------------------------PSISNGCLADGGNVL
TH_4447|M.thermoresistible__bu -------------------------------VSAQATVESAALQAGRAVA
:
Mb3927c|M.bovis_AF2122/97 AKSVTPDPVSGTPRASGPAGMTG---------------------------
MAV_5287|M.avium_104 AAMMP--PTGGMPAMPGQTGMTG---------------------------
MMAR_3067|M.marinum_M TKPASMMSTGGTPSSSTPMGATG---------------------------
MUL_2312|M.ulcerans_Agy99 TKPASMMSTSGTPSSSTPMGATG---------------------------
Rv2083|M.tuberculosis_H37Rv TKSATMPPPGGASPASAHMGAAG---------------------------
Mflv_2790|M.gilvum_PYR-GCK AAPVPATAGGGVPPAAAQSGLVAPAAP----PTGAGMGTGGGAPMMLPPG
Mvan_3258|M.vanbaalenii_PYR-1 APPVSAAPGGGVSPAGAQAGMVSPATPAAAAPTGAGIG-GGGAPMMLPPG
MAB_3746c|M.abscessus_ATCC_199 QDDKDGGETSGESGESGNSGVNSGAGG-----------------------
MSMEG_5153|M.smegmatis_MC2_155 ATAISVAGPATIPLPGPGPGQTA---------------------------
TH_4447|M.thermoresistible__bu QGNMAAQRAEGTVQKTENLAHQSATRS-----------------------
. .
Mb3927c|M.bovis_AF2122/97 ------------MPMVPPGALG-AGAEGANKDKPVEKRVTAPAVPNGQPV
MAV_5287|M.avium_104 ------------MPMMPPGAMG-AGGEGGNKDKPVEKRVTAPGVPNGQPV
MMAR_3067|M.marinum_M ------------MPMMPPGAMG-AGGTGGSKEKPAEKRVTAPGVPNGQPV
MUL_2312|M.ulcerans_Agy99 ------------MPMMPPGAMG-AGGTGGSKEKPAEKRVTAPGVPNGQSV
Rv2083|M.tuberculosis_H37Rv ------------MPMVPPGAMG-ARGEGSGQEKPVEKRLTAPAVPNGQPV
Mflv_2790|M.gilvum_PYR-GCK SMGPPAGPVPPPAATVPAGALG-AGSNAPSAAPPAAAAGAGPTLIPASVV
Mvan_3258|M.vanbaalenii_PYR-1 SMGPPAG-APPPAPTVPAGTVG-STNAPAAPAPSAASAAAGPTLIPASVV
MAB_3746c|M.abscessus_ATCC_199 ----GTASGGMQGTATPASATG-NAGGQLSGAGQQQGAGQGQQGMDPSQM
MSMEG_5153|M.smegmatis_MC2_155 ------------YVFTAIGTPGPAAEQKLPLNVTWVNLTTGKSGSATLKT
TH_4447|M.thermoresistible__bu ----------EPQQLQQGVQMGMQMGSQLGSTLAQLPQQAGQMISQPMQQ
* .
Mb3927c|M.bovis_AF2122/97 KGRLTVPPSVP-VKSADDKP--VVTKSTRRILVVP--------NDDKVKE
MAV_5287|M.avium_104 KGRLTIPPSAPGSKPGEAKPTVVTNRPNRRIVIMP--------SDDEPKE
MMAR_3067|M.marinum_M KGRLTVPPSVP-VKSVDGKPP-VVTRSTRRILLPDRNEIGRNISDEKTDG
MUL_2312|M.ulcerans_Agy99 KGRLTVPPSVP-VKSVDGKPP-VVTRSTRPILLPDRNEIGRNISDEKTDG
Rv2083|M.tuberculosis_H37Rv KGRLTVPPSAPTTKPTDGKP---VVR--RRILLPEHKDFGRIAPDEKTDA
Mflv_2790|M.gilvum_PYR-GCK AAGQTAAARERRESADAAAAKELVWKLQHASYMAGNYLTGWAVGVFRSPS
Mvan_3258|M.vanbaalenii_PYR-1 AAGQTAAARERRESADAAAAKELVWKLQHAAYVALNPAAGWAVGVFRSPS
MAB_3746c|M.abscessus_ATCC_199 LSGMTGALTGALSSIGQAASG-IVSAITEGISSIPFDQMGQGLGDDQFDG
MSMEG_5153|M.smegmatis_MC2_155 RPDLNPEGPTTLTAIADTGSGSIISTIFGQVTTTEKQCQFMPTIGSTVVP
TH_4447|M.thermoresistible__bu LTAPLQQVSSVFGQMGGMGSGDSAQIGLIGASPFSNHPLAGGSGPATGAG
.
Mb3927c|M.bovis_AF2122/97 --------------------------------------------------
MAV_5287|M.avium_104 --------------------------------------------------
MMAR_3067|M.marinum_M SE------------------------------------------------
MUL_2312|M.ulcerans_Agy99 NE------------------------------------------------
Rv2083|M.tuberculosis_H37Rv GE------------------------------------------------
Mflv_2790|M.gilvum_PYR-GCK GTETVITSNDGASYIPAGVFVPRSVRVLATDLVIHDSFRQLWFGWSDPAR
Mvan_3258|M.vanbaalenii_PYR-1 GTETVITSNDGSSYIPAGVFVPRSVRVLATDPLVDDSFRQRWFGWGDPAR
MAB_3746c|M.abscessus_ATCC_199 RADEAADKKDEAAAD--GKKDPDAKMAAAKDAAIEEAR------------
MSMEG_5153|M.smegmatis_MC2_155 --------------------------------------------------
TH_4447|M.thermoresistible__bu LVRAASLPGLGGTSPTTSLISNLLG-------------------------
Mb3927c|M.bovis_AF2122/97 --------------------------------------------------
MAV_5287|M.avium_104 --------------------------------------------------
MMAR_3067|M.marinum_M --------------------------------------------------
MUL_2312|M.ulcerans_Agy99 --------------------------------------------------
Rv2083|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2790|M.gilvum_PYR-GCK VLVEYAQQRAEWGWRLVAAASTLPTPALRDAGVEHPPACTRETNPLLQPG
Mvan_3258|M.vanbaalenii_PYR-1 VLVEYAQLRAQWGWKLVAAATTAGVSVLRDAGVEHPPSCSGDTNPLLQQG
MAB_3746c|M.abscessus_ATCC_199 ----------------ADSGATFATDGKPAPGIQLAGAGGLEATPTAAPG
MSMEG_5153|M.smegmatis_MC2_155 --------------------------------------------------
TH_4447|M.thermoresistible__bu ---------------------HQNPTAAPAPTGAVAGGAGTGPAPIGGGG
Mb3927c|M.bovis_AF2122/97 --------------------------------------------------
MAV_5287|M.avium_104 --------------------------------------------------
MMAR_3067|M.marinum_M --------------------------------------------------
MUL_2312|M.ulcerans_Agy99 --------------------------------------------------
Rv2083|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2790|M.gilvum_PYR-GCK VQVPAPVLDDMHVHRLAVLWPEVYPRLLRVMDADPICQDRIVSGVSAALM
Mvan_3258|M.vanbaalenii_PYR-1 VDVPAPVLDDMHIHRLAVLWPEVYPRLLRIMDADPLCQDRIVSAVTAAMI
MAB_3746c|M.abscessus_ATCC_199 QTTPGAPLGATPTG----TIPPAAGGLSAAQPAGSSASLTPHPVQAQPPT
MSMEG_5153|M.smegmatis_MC2_155 --------------------------------------------------
TH_4447|M.thermoresistible__bu MGAPMAAMGQNQKSGGSKSGLKAPAPLVQDLSEDEGDDW-----------
Mb3927c|M.bovis_AF2122/97 --------------------------------------------------
MAV_5287|M.avium_104 --------------------------------------------------
MMAR_3067|M.marinum_M --------------------------------------------------
MUL_2312|M.ulcerans_Agy99 --------------------------------------------------
Rv2083|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2790|M.gilvum_PYR-GCK VAATTQAQAVE--IPDALRHIWVARGGDREPSTQQWAKYNEEAQTFNGTT
Mvan_3258|M.vanbaalenii_PYR-1 NAATTQAQVIDGGIDEALRLVWAVRGSDREPTVQQWADYDKAAKALNVMT
MAB_3746c|M.abscessus_ATCC_199 VPQHPEPQSAAARQPSPLPSVGPTDASAQPQEAKTEAGETPCEIAADELP
MSMEG_5153|M.smegmatis_MC2_155 --------------------------------------------------
TH_4447|M.thermoresistible__bu --------------------------------------------------
Mb3927c|M.bovis_AF2122/97 --------------------------------------------------
MAV_5287|M.avium_104 --------------------------------------------------
MMAR_3067|M.marinum_M --------------------------------------------------
MUL_2312|M.ulcerans_Agy99 --------------------------------------------------
Rv2083|M.tuberculosis_H37Rv --------------------------------------------------
Mflv_2790|M.gilvum_PYR-GCK AMSRPAFLT--GGAGHPRDSSEELANYRGHWLVARTIEHIGGWANRPLPL
Mvan_3258|M.vanbaalenii_PYR-1 AMRRPAFATNTGAVADPSDTTEFLADYRAHWLVARTAEHIGGWSRRPLPL
MAB_3746c|M.abscessus_ATCC_199 KAGR----------------------------------------------
MSMEG_5153|M.smegmatis_MC2_155 --------------------------------------------------
TH_4447|M.thermoresistible__bu --------------------------------------------------
Mb3927c|M.bovis_AF2122/97 ------------------------------------
MAV_5287|M.avium_104 ------------------------------------
MMAR_3067|M.marinum_M ------------------------------------
MUL_2312|M.ulcerans_Agy99 ------------------------------------
Rv2083|M.tuberculosis_H37Rv ------------------------------------
Mflv_2790|M.gilvum_PYR-GCK PDMCYAAAATGDPDLHDKIVKALVSVEDDLAVGS--
Mvan_3258|M.vanbaalenii_PYR-1 PDMCYAAAATGDPDLRDMIVKALVSVEEDLQYEAPR
MAB_3746c|M.abscessus_ATCC_199 ------------------------------------
MSMEG_5153|M.smegmatis_MC2_155 ------------------------------------
TH_4447|M.thermoresistible__bu ------------------------------------