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RALVTGAAGFIGSNLVDRLLADGHQVIGVDNFWTGDPSNLEWALEQGNSSGRRFTLVKADIQAPELTDIV AGACPHVVYHLAARTEHDAVAPDPLLDARNNVLGTINVLEACREAGVRRIVYATSGDSRYGDDPVSSHAA AKLSGELYLRAYTEMYGFAPICLALSNVYGPRQRPHGVAALITILASAMVTGRPYVVNRDHADAHDFVYV GDVVDAFVRAAHAPIDTVGTYDISGSTQITATDIHHAIATVLDDAASTGATGEENRELSEKKIDVNTEYT LGWKPRVGLARGIRHTVDWLCTTLEPGYATTDVIAAGA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5985 | - | - | 100% (319) | NAD dependent epimerase/dehydratase family protein |
| M. smegmatis MC2 155 | MSMEG_6142 | - | 1e-55 | 39.62% (313) | nucleoside-diphosphate-sugar epimerase |
| M. smegmatis MC2 155 | MSMEG_1512 | rfbB | 2e-17 | 28.97% (321) | dTDP-glucose 4,6-dehydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3658c | galE1 | 1e-58 | 41.21% (313) | UDP-glucose 4-epimerase GALE1 (galactowaldenase) |
| M. gilvum PYR-GCK | Mflv_5007 | - | 1e-17 | 26.55% (339) | dTDP-glucose 4,6-dehydratase |
| M. tuberculosis H37Rv | Rv3634c | galE1 | 1e-58 | 41.21% (313) | UDP-glucose 4-epimerase GALE1 (galactowaldenase) |
| M. leprae Br4923 | MLBr_00204 | rmlB2 | 4e-54 | 40.00% (315) | putative sugar-nucleotide dehydratase |
| M. abscessus ATCC 19977 | MAB_0503 | - | 6e-59 | 41.53% (313) | UDP-glucose 4-epimerase GalE1 |
| M. marinum M | MMAR_5133 | galE1 | 3e-58 | 40.38% (317) | UDP-glucose 4-epimerase GalE1 |
| M. avium 104 | MAV_0524 | - | 2e-57 | 40.95% (315) | nucleoside-diphosphate-sugar epimerase |
| M. thermoresistible (build 8) | TH_0330 | rfbB | 5e-14 | 27.51% (269) | dTDP-glucose 4,6-dehydratase |
| M. ulcerans Agy99 | MUL_4210 | galE1 | 4e-58 | 40.06% (317) | UDP-glucose 4-epimerase GalE1 |
| M. vanbaalenii PYR-1 | Mvan_1365 | - | 2e-18 | 29.32% (324) | dTDP-glucose 4,6-dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_00204|M.leprae_Br4923 ----MYGEPVRALVTG---AAGFIGSTLVDRLLADGH-----TVVGLDNF
MAV_0524|M.avium_104 ---------MRALVTG---AAGFIGSTLVDRLLADGH-----TVVGLDNF
Mb3658c|M.bovis_AF2122/97 ---------MRALVTG---AAGFIGSTLVDRLLADGH-----SVVGLDNF
Rv3634c|M.tuberculosis_H37Rv ---------MRALVTG---AAGFIGSTLVDRLLADGH-----SVVGLDNF
MMAR_5133|M.marinum_M ---------MRALVTG---AAGFIGSTLVDRLLADGH-----TVVGLDNF
MUL_4210|M.ulcerans_Agy99 ---------MRALVTG---AAGFIGSTLVDRLLADGH-----TVVGLDNF
MAB_0503|M.abscessus_ATCC_1997 ---------MRAMVTG---AAGFIGSTLVDRLLADGH-----EVTGLDNL
MSMEG_5985|M.smegmatis_MC2_155 ---------MRALVTG---AAGFIGSNLVDRLLADGH-----QVIGVDNF
Mflv_5007|M.gilvum_PYR-GCK ---------MRLLVTG---GAGFIGANFVLATVRDRP---DVRVTVLDSL
Mvan_1365|M.vanbaalenii_PYR-1 ---------MRLLVTG---GAGFIGANFVRTTVQQRP---DVQVTVLDSL
TH_0330|M.thermoresistible__bu VAAIVAAVRCAAAVSSRSSSGGSIRPRSITPSSEKNPRSEAXXXTGLDAF
*:. ..* * . : . :* :
MLBr_00204|M.leprae_Br4923 ATGHAANLEHLAST-----PALAFVEADIVTADLQTILDEHRPEVVFHLA
MAV_0524|M.avium_104 ASGRASNLEHLVGN-----PAHVFVEADIVTADLEAILDEHRPEVVFHLA
Mb3658c|M.bovis_AF2122/97 ATGRATNLEHLADN-----SAHVFVEADIVTADLHAILEQHRPEVVFHLA
Rv3634c|M.tuberculosis_H37Rv ATGRATNLEHLADN-----SAHVFVEADIVTADLHAILEQHRPEVVFHLA
MMAR_5133|M.marinum_M ATGRATNLEHLVDN-----LAHVFVEADIVDADLQAIFEQHRPEVIFHLA
MUL_4210|M.ulcerans_Agy99 ATGRATNLEHLVDN-----LAHVFVEADIVDADLQAIFEQHRPEVIFHLA
MAB_0503|M.abscessus_ATCC_1997 ATGKVANLEAAEAN-----AKFTFVKDDIVEADLDAVVAEYSPEVIFHLA
MSMEG_5985|M.smegmatis_MC2_155 WTGDPSNLEWALEQGNSSGRRFTLVKADIQAPELTDIVAGACPHVVYHLA
Mflv_5007|M.gilvum_PYR-GCK TYAGSRESLAGVDT------QIRLVQGDITDADLVGRLVGES-DAVVHFA
Mvan_1365|M.vanbaalenii_PYR-1 TYAGSRESLRGVDS------QIRLVEGDITDAELVGKLVADS-DAVVHFA
TH_0330|M.thermoresistible__bu TYAGSRESLAPVAD------RIRVVEGDVTDSDLVDKLVAES-DAVVHFA
. : .*: *: .:* . ..: *:*
MLBr_00204|M.leprae_Br4923 AQIDVRHSVVDPQFDASVNVIGTVRLAEAARHTGVRKIV--HTSSGGSIY
MAV_0524|M.avium_104 AQIDVRHSVADPQFDASVNVIGTVRLAEAARRTGVRKIV--HTSSGGSIY
Mb3658c|M.bovis_AF2122/97 AQIDVRRSVADPQFDAAVNVIGTVRLAEAARQTGVRKIV--HTSSGGSIY
Rv3634c|M.tuberculosis_H37Rv AQIDVRRSVADPQFDAAVNVIGTVRLAEAARQTGVRKIV--HTSSGGSIY
MMAR_5133|M.marinum_M AQIDVRHSVADPQFDASVNVIGTLRLAEAARLTGVRKVV--HTSSGGSIY
MUL_4210|M.ulcerans_Agy99 AQIDVRHSVADPQFDASVNVIGTLRLAEAARLTGVRKVV--HTSSGGSIY
MAB_0503|M.abscessus_ATCC_1997 AQIDVRHSVADPQFDSSVNVVGTVRLAEAARKAGVRKIV--HTSSGGSIY
MSMEG_5985|M.smegmatis_MC2_155 ARTEHDAVAPDPLLDARNNVLGTINVLEACREAGVRRIV--YATSGDSRY
Mflv_5007|M.gilvum_PYR-GCK AETHVDNALADPEPFVRSNIVGTFTILEAVRHAAASRPVRLHHVSTDEVY
Mvan_1365|M.vanbaalenii_PYR-1 AETHVDNALADPEPFVHSNVLGTFTVLEAVRHASVTKPVRLHHISTDEVY
TH_0330|M.thermoresistible__bu AESHVDNALAEPEPFLRTNVVGTFTVLEAVR----RHRVRLHHISTDEVY
*. . :* *::**. : ** * : * : * .. *
MLBr_00204|M.leprae_Br4923 GTPSQYPT---PETVPTDPTSPYAAGKVAGEIYLNTFRHLCGLDCSHIAP
MAV_0524|M.avium_104 GTPPTYPT---PETVPTDPASPYAAGKVAGEIYLNTFRHLYGLDCSHIAP
Mb3658c|M.bovis_AF2122/97 GTPPEYPT---PETAPTDPASPYAAGKVAGEIYLNTFRHLYGLDCSHIAP
Rv3634c|M.tuberculosis_H37Rv GTPPEYPT---PETAPTDPASPYAAGKVAGEIYLNTFRHLYGLDCSHIAP
MMAR_5133|M.marinum_M GTPPQYPT---SERVPTDPASPYAAGKVAGEIYLNTFRHLYGLECSHIAP
MUL_4210|M.ulcerans_Agy99 GTPPQYPT---SERVPTDPASPYAAGKVAGEIYLNTFRHLYGLECSHIAP
MAB_0503|M.abscessus_ATCC_1997 GTPKQIPT---SETVPTDPHSPYAAGKVAGEIYLNTFRHLYGLECSHIAP
MSMEG_5985|M.smegmatis_MC2_155 GD---------------DPVSSHAAAKLSGELYLRAYTEMYGFAPICLAL
Mflv_5007|M.gilvum_PYR-GCK GDLELGDPAKFTESTPYNPSSPYSSTKAASDMLVRAWVRSYRLTATLSNC
Mvan_1365|M.vanbaalenii_PYR-1 GDLELDDPARFTDATPYNPSSPYSSTKAAADMLVRAWVRSYRVAATISNC
TH_0330|M.thermoresistible__bu GDLPLHDPRRFTESTPYNPSSPYSSTKAAADMLVRAWVRSYGVAATISNC
* :* *.::: * :.:: :.:: . .
MLBr_00204|M.leprae_Br4923 ANVYGPRQDPYGEAGVVAIFVQALLSDRPTKVFGDGTHTRDYVFVDDVVD
MAV_0524|M.avium_104 ANVYGPRQDPHGEAGVVAIFAQALLSGKPTKVFGDGTNTRDYVFVDDVVD
Mb3658c|M.bovis_AF2122/97 ANVYGPRQDPHGEAGVVAIFAQALLSGKPTRVFGDGTNTRDYVFVDDVVD
Rv3634c|M.tuberculosis_H37Rv ANVYGPRQDPHGEAGVVAIFAQALLSGKPTRVFGDGTNTRDYVFVDDVVD
MMAR_5133|M.marinum_M ANVYGPRQDPHGEAGVVAIFAQALLSGKPTKVFGDGTNTRDYVFVDDVVD
MUL_4210|M.ulcerans_Agy99 ANVYGPRQDPHGEAGVVAIFAQALLSGKPTKVFGDGTNTRDYVFVDDVVD
MAB_0503|M.abscessus_ATCC_1997 ANVYGPRQDPHGEAGVVAIFAQALLSGRSTKVFGDGGNTRDYVFVDDVVE
MSMEG_5985|M.smegmatis_MC2_155 SNVYGPRQRPHGVAALITILASAMVTGRPYVVNRDHADAHDFVYVGDVVD
Mflv_5007|M.gilvum_PYR-GCK SNNYGPFQH---VEKFIPRQITNILTGRRPKLYGTGANVRDWIHVEDHNS
Mvan_1365|M.vanbaalenii_PYR-1 SNNYGPYQH---VEKFIPRQITNVLTGRRPELYGTGANVRDWIHVDDHNS
TH_0330|M.thermoresistible__bu SNNYGPYQH---VEKFIPRQITNVLTGRRPKLYGTGANVRDWIHVEDHND
:* *** * .:. :::.: : ..:*::.* * .
MLBr_00204|M.leprae_Br4923 AFIKAS-GDAGGGQRFNIGTGIETSDRQLHTAVSAAVG-GPDDPEFHPPR
MAV_0524|M.avium_104 AFVKAS-GDAGGGQRFNIGTGVETSDRQLHSAVAAAVG-GPDDPEFHPPR
Mb3658c|M.bovis_AF2122/97 AFVRVS-ADVGGGLRFNIGTGKETSDRQLHSAVAAAVG-GPDDPEFHPPR
Rv3634c|M.tuberculosis_H37Rv AFVRVS-ADVGGGLRFNIGTGKETSDRQLHSAVAAAVG-GPDDPEFHPPR
MMAR_5133|M.marinum_M AFVRAG-SDVGGGQRFNIGTGVETSDRQLHSAVAAAVG-GPDDPEFHPPR
MUL_4210|M.ulcerans_Agy99 AFVKAG-SDVGGGQRFNIGTGVETSDRQLHSAVAAAVG-GPDDPEFHPPR
MAB_0503|M.abscessus_ATCC_1997 AFVRAS-GPDGGGQRFNVGTGVETSDRQLHSLVAAAAG-APDDPEFHPPR
MSMEG_5985|M.smegmatis_MC2_155 AFVRAAHAPIDTVGTYDISGSTQITATDIHHAIATVLD-DAASTGATGEE
Mflv_5007|M.gilvum_PYR-GCK AVWKIL-THGAVGRTYLIGADGECDNLTVMRTILRLMDRSPDDFDHVTDR
Mvan_1365|M.vanbaalenii_PYR-1 AVWRIL-HDGTVGRTYLIGADGERDNLSVMRTILRLMGRSPEDFDHVTDR
TH_0330|M.thermoresistible__bu AVWRIL-TAGQIGRTYLIGADGERDNRTVLRTILKLMDRDPDDFDHVTDR
*. : : :. . : : : . . . .
MLBr_00204|M.leprae_Br4923 LGDLKRSCLDIGLATTVLGWSP-QVQLDDGVRRTVEYFRAAQRS------
MAV_0524|M.avium_104 LGDLKRSCLDIGLAARVLGWQP-KVGLQQGVARTVEYFRNQHN-------
Mb3658c|M.bovis_AF2122/97 LGDLKRSCLDIGLAERVLGWRP-QIELADGVRRTVEYFRHKHTD------
Rv3634c|M.tuberculosis_H37Rv LGDLKRSCLDIGLAERVLGWRP-QIELADGVRRTVEYFRHKHTD------
MMAR_5133|M.marinum_M LGDLKRSCLDISRAEEVLGWRP-QVELADGVRRTVDYFRRTHGS------
MUL_4210|M.ulcerans_Agy99 LGDLKRSCLDISRAEEVLGWRP-QVELADGVRRTVDYFRRTHGS------
MAB_0503|M.abscessus_ATCC_1997 LGDLRQSCLDVGLAKRVLGWEP-RVPLADGIRRTVDFFRS----------
MSMEG_5985|M.smegmatis_MC2_155 NRELSEKKIDVN-TEYTLGWKP-RVGLARGIRHTVDWLCTTLEPGYATTD
Mflv_5007|M.gilvum_PYR-GCK AGHDLRYAIDATALRDELGWRPAHSDFEAGLRDTIDWYSANESWWGPIKD
Mvan_1365|M.vanbaalenii_PYR-1 VGHDLRYAIDPTPLRDELGWRPEHTDFESGLRDTIDWYRDNESWWGPLKD
TH_0330|M.thermoresistible__bu AGHDLRYAIDPSALIDELGWTPRHTDFEAGLRDTIQWYRDNEDWWRPLKD
. . :* *** * : : *: *:::
MLBr_00204|M.leprae_Br4923 -----------
MAV_0524|M.avium_104 -----------
Mb3658c|M.bovis_AF2122/97 -----------
Rv3634c|M.tuberculosis_H37Rv -----------
MMAR_5133|M.marinum_M -----------
MUL_4210|M.ulcerans_Agy99 -----------
MAB_0503|M.abscessus_ATCC_1997 -----------
MSMEG_5985|M.smegmatis_MC2_155 VIAAGA-----
Mflv_5007|M.gilvum_PYR-GCK AVEAGYQSRGQ
Mvan_1365|M.vanbaalenii_PYR-1 AVEATYQRRRR
TH_0330|M.thermoresistible__bu ATEDAYAERGQ