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CPKWVFSTGMVQSMSTDQMTDELDVIVVGAGLAGSVAALTVARAGYSVGVIECGPPRSQNRDPAPGKMRR AIARLAGRTLPRPGRWPVPLMRDRGGGRPAKAMAAVLGFGPGGSSTVYGAALSRYRRSDFTAMRPPGALP REWPIDYDDFRPFYARTEKLLRVAGAPDPLDPDDDAVLRSPPPLGPRDAALVKAMQAAGLHPYRLHVGID YLPGCSECLGDACPRACKADGNNRALQQAVASGASVFCDETVVRLEPLSGQLQVISREGGPAATSGVLRK RLARNVILAAGALNTPLLLARSSGLWRDGTAPPLLGRGLMFHITDILGLRAPSDVPNYGPQKTLAIRDLY EVGEVQSMAMRVGTAPIASYLRAEAERLGLGWLGGGLEALRIPAAVAARFLGKAATFATVQEDYAYEANR VWEDPSHPERICFRYEVPDELRERSARGRRIIRDRLRHLRPFFLSPLATPNLGHPMGTCRMGNDPAVSVT DAQGRVWGLPNVVVADAATLPTSGSTNPALTVSANALRIAESLVNRMNEAALEPSPHHAE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5967 | - | - | 100% (551) | glucose-methanol-choline oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_5944 | - | 2e-11 | 23.55% (552) | glucose-methanol-choline oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_3444 | - | 2e-09 | 25.00% (532) | choline dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0502c | - | 3e-22 | 27.82% (532) | oxidoreductase GMC-type |
| M. gilvum PYR-GCK | Mflv_4475 | - | 3e-13 | 22.94% (558) | GMC oxidoreductase |
| M. tuberculosis H37Rv | Rv0492c | - | 2e-22 | 27.82% (532) | oxidoreductase GMC-type |
| M. leprae Br4923 | MLBr_00389 | choD | 2e-06 | 26.89% (305) | putative cholesterol oxidase |
| M. abscessus ATCC 19977 | MAB_1232c | - | 6e-10 | 26.89% (305) | cholesterol oxidase ChoD |
| M. marinum M | MMAR_0817 | - | 8e-23 | 27.32% (527) | oxidoreductase GMC-type |
| M. avium 104 | MAV_3093 | - | 2e-28 | 28.25% (538) | glucose-methanol-choline oxidoreductase |
| M. thermoresistible (build 8) | TH_0480 | choD | 2e-05 | 34.21% (76) | PROBABLE CHOLESTEROL OXIDASE PRECURSOR CHOD (CHOLESTEROL-O2 |
| M. ulcerans Agy99 | MUL_4561 | - | 1e-22 | 26.94% (527) | oxidoreductase GMC-type |
| M. vanbaalenii PYR-1 | - | - | - | - | - |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0502c|M.bovis_AF2122/97 -----MSRLADRAKSYPLASFGAALLPPELGGPLPAQFVQRVDRYVTRLP
Rv0492c|M.tuberculosis_H37Rv -----MSRLADRAKSYPLASFGAALLPPELGGPLPAQFVQRVDRYVTRLP
MMAR_0817|M.marinum_M -----MSRTQA-----ALASFGAALLPEERGGPTSTEFAERVDRYLSQLP
MUL_4561|M.ulcerans_Agy99 -----MSRTQA-----ALASFGAALLPEERGGPTSTEFAERVDRYLSQLP
MLBr_00389|M.leprae_Br4923 ----------------MKPDYDVLIIGSGFGGSVSALRLTEKGYRVGVLE
TH_0480|M.thermoresistible__bu ----------------MQPDYDVLVIGSGFGGSVSALRLTEKGYRVGVLE
MAB_1232c|M.abscessus_ATCC_199 ----------------MDYDYDVVVIGSGFGGSVAALRLTEKGYRVGVLD
MSMEG_5967|M.smegmatis_MC2_155 ----------------------MCPKWVFSTGMVQSMSTDQMTDELDVIV
Mflv_4475|M.gilvum_PYR-GCK ---------MELQNGPCVDEVNYLIIGSGFGGSVMAAELATRRRGVCLFE
MAV_3093|M.avium_104 MHSRDLPGERTMRRYADDDEVDLVVVGAGAGGSVLAQRLARAGWRVVILE
* : : :
Mb0502c|M.bovis_AF2122/97 ATSRFAVRAGLASLAAASYLTTGRSLPRLHPDERARVLHRIAALSPEVAA
Rv0492c|M.tuberculosis_H37Rv ATSRFAVRAGLASLAAASYLTTGRSLPRLHPDERARVLHRIAALSPEVAA
MMAR_0817|M.marinum_M TTSRLAVRAGLVSLAAASYLTTGRSLARLEPAQREQVLRRVAAINPDTSA
MUL_4561|M.ulcerans_Agy99 TTSRLAVRAGLVSLAAASYLTTGRSLARLEPAQREQVLRRVAAINPDTSA
MLBr_00389|M.leprae_Br4923 AGRRFADED----FAKTSWDLR---KFLWAPKLGCYGIQRIHLLRNVMIL
TH_0480|M.thermoresistible__bu AGRRFADED----FAKTSWNLR---KFLWAPKLGCYGIQRIHLLRNVMIL
MAB_1232c|M.abscessus_ATCC_199 MGKRWKRED----FPPNNWHVR---KAMWAPALGCYGPQRLTVLGKTFIA
MSMEG_5967|M.smegmatis_MC2_155 VGAGLAGSVAALTVARAGYSVG---VIECGPPRSQNRDPAPGKMRRAIAR
Mflv_4475|M.gilvum_PYR-GCK RGKAYPPGS----FPRRVKEID---DSIWAPGSGKHGMFDLWSFDGIDAV
MAV_3093|M.avium_104 AGPFWHPDEDWVSDEAGSHPLY------WTQKRIIGGADPIELGKNNSGR
Mb0502c|M.bovis_AF2122/97 AVEGLKAIVLLANGADTYAHELLARAQEHDAARPDAELTVILSADSPSVT
Rv0492c|M.tuberculosis_H37Rv AVEGLKAIVLLANGADTYAHELLARAQEHDAARPDAELTVILSADSPSVT
MMAR_0817|M.marinum_M ALEGLKAVALLANGADTYAPDLLARAQAHDAARSDAALDITASPDSPSVV
MUL_4561|M.ulcerans_Agy99 ALEGLKAVALLANGADTYAPDLLARAQAHDAARSDAALDITASPDSPSVV
MLBr_00389|M.leprae_Br4923 AGAG------VGGGSLNYANTLYVPPEPFFANQQWAHITDWHSELAPHYD
TH_0480|M.thermoresistible__bu AGAG------VGGGSLNYANTLYVPPEPFFKDRQWAHITDWRDELMPHYD
MAB_1232c|M.abscessus_ATCC_199 SAVG------VGGGSLIYGNTLYEPLEQFYVDKQWAHISDWKSELAPYYD
MSMEG_5967|M.smegmatis_MC2_155 ----------LAGRTLPRPGRWPVPLMRDRGGGRPAKAMAAVLGFGP--G
Mflv_4475|M.gilvum_PYR-GCK TASG------LGGGSLIYANVMLEKPAQWFTQPVPDGNGKTETWSFTHRD
MAV_3093|M.avium_104 G---------VGGSMIHYAGYTPRFHPSDFATYTLDGVG--ADWPIRYED
:..
Mb0502c|M.bovis_AF2122/97 RADAVVVGSGAGGAMVARTLARAGLDVVVLEEGRRWTVEEFRSTHPVDRY
Rv0492c|M.tuberculosis_H37Rv RADAVVVGSGAGGAMVARTLARAGLDVVVLEEGRRWTVEEFRSTHPVDRY
MMAR_0817|M.marinum_M TADVVIVGSGAGGAMTARTLARAGLRTVVLEEGRRWTVREFRTTHPIDRY
MUL_4561|M.ulcerans_Agy99 TADVVIVGSGAGGAMTARTLARAGLRTVVLEEGRRWTVREFRTTHPIDRY
MLBr_00389|M.leprae_Br4923 QAQRMLG--------VVCNPTFTDADRILKEVVDEMGFGDTFVPTPVGVF
TH_0480|M.thermoresistible__bu QAQRMLG--------VVTNPTFTDADRVVKEVAEEMGVGHTFVPTPVGVF
MAB_1232c|M.abscessus_ATCC_199 QASRMLG--------VAQTPHTTPPDEVLLAVAKDLGVEDTYHPTNVGVF
MSMEG_5967|M.smegmatis_MC2_155 GSSTVYG---------AALSRYRRSDFTAMRPPGALPREWPIDYDDFRPF
Mflv_4475|M.gilvum_PYR-GCK LRDHYRAVR-----EVLQVQEIPRSLHEEHSKKTTKFLDAGSVLAPLAVR
MAV_3093|M.avium_104 LRRHYEQ---------VELELPVAGQNWPWGDPHRYSFAPHPISGAAAKL
Mb0502c|M.bovis_AF2122/97 AGLYRGAGATVALGRPAVVLPMGRAVGGTTVVNSGTCFRPSLAVQRRWRD
Rv0492c|M.tuberculosis_H37Rv AGLYRGAGATVALGRPAVVLPMGRAVGGTTVVNSGTCFRPSLAVQRRWRD
MMAR_0817|M.marinum_M AGLYRGGGATIALGRPAVILPMGRAVGGTTVVNSGTCFRPPLAVQQRWRD
MUL_4561|M.ulcerans_Agy99 AGLYRGGGATIALGR----LPMGRAVGGTTVVNSGTCFRPPLAVQQRWRD
MLBr_00389|M.leprae_Br4923 FGPDGTQTPGRTVADP---YFGGVGPVRTGCLECGCCMTGCRHGAKNTLV
TH_0480|M.thermoresistible__bu FGPDGQKTPGETVPDP---YFGGVGPDRTGCIECGSCMTGCRHNAKNTLV
MAB_1232c|M.abscessus_ATCC_199 FGDE----PGKTVPDP---FFGGAGPERTGCIGCAACMTGCKHNAKNTTE
MSMEG_5967|M.smegmatis_MC2_155 YARTEKLLRVAGAPDP-------LDPDDDAVLRSPPPLGPRDAALVKAMQ
Mflv_4475|M.gilvum_PYR-GCK FDGAEGPAKGAPLPPADYPNIHGDDVERTTCTMCGECDVGCNRGAKSSLD
MAV_3093|M.avium_104 WEGALKLGIEMRVGPVG--IVNGTFGNRPHCIYRGYCLQGCKVNAKASPY
Mb0502c|M.bovis_AF2122/97 EFGLGLADPDQLGRRLDDAEQTLRVAPVP---LEIMGRNGRLLLQAAKSL
Rv0492c|M.tuberculosis_H37Rv EFGLGLADPDQLGRRLDDAEQTLRVAPVP---LEIMGRNGRLLLQAAKSL
MMAR_0817|M.marinum_M EFGLDLADPDRLAGRLDDVEHTLQVAPAP---RDIMGRNGNLLLDAAASL
MUL_4561|M.ulcerans_Agy99 EFGLDLADPDRLAGRLDDVEHTLQVAPAP---RDIMGRNGNLLLDAAASL
MLBr_00389|M.leprae_Br4923 KNYLGLAESAGAQVIPMTTVKGFELRSEG-LWEVHTVRTGSWLRRGRRTF
TH_0480|M.thermoresistible__bu KNYLGLAEQAGTEVHAMTTVTGFEQLPDG-TWRVDTVRTGRWLRKRRKSF
MAB_1232c|M.abscessus_ATCC_199 TNYLYLAEHAGAQIHPLTQVLDVRPLEDGEGYAVSTKQTGRLLRKKKRTF
MSMEG_5967|M.smegmatis_MC2_155 AAGL----------HPYRLHVGIDYLPGC------SECLGDACPRACKAD
Mflv_4475|M.gilvum_PYR-GCK HTYLSVAAHHGAQICVRTEVREIAPCTDD----------SDYLFEVAYVV
MAV_3093|M.avium_104 VTHLPDALAHDVEIRANCMAARVELDGSG-------AARGVVYYDEAGGT
* . .
Mb0502c|M.bovis_AF2122/97 GWRAAPIPRNAPGCRGCCQCAIGCPSNAKFGVHLNALPQACAAGARIISW
Rv0492c|M.tuberculosis_H37Rv GWRAAPIPRNAPGCRGCCQCAIGCPSNAKFGVHLNALPQACAAGARIISW
MMAR_0817|M.marinum_M GWQAAPIPRNAPGCAGCCQCAIGCPSNAKFGVHLNALPQACAAGARIISD
MUL_4561|M.ulcerans_Agy99 GWQAAPIPRNAPGCAGCCQCAIGCPSNAKFGVHLNALPQACAAGARIISD
MLBr_00389|M.leprae_Br4923 TAAHLLLAAGTWGTQRLLFRMRDQGKLPRLSQRLGVLTRTNSE---SIVG
TH_0480|M.thermoresistible__bu TATHLILAAGTWGTQRLLFKMRDAGKLPNLSKRLGVLTRTNSE---SIVG
MAB_1232c|M.abscessus_ATCC_199 TAQHVVFSAASLGTQRLLHKFKDSGSLPNLSERLGEQTRTNSE---SVP-
MSMEG_5967|M.smegmatis_MC2_155 GNNRALQQAVASGAS--VFCDETVVRLEPLSGQLQVISREGGP-------
Mflv_4475|M.gilvum_PYR-GCK HPECRNKSEPVERVIRAKRVILAAGTLGSTYLMLRSKKLGLSD------C
MAV_3093|M.avium_104 ERLQRAKVVAIAGYSIETPRLLLNSVSDRFPNGLGNNDDQVGR-------
* .
Mb0502c|M.bovis_AF2122/97 ARVERILHRAGRAYGVRARRPDGTTLDVLADAVVVAAGATETPGLLRRSG
Rv0492c|M.tuberculosis_H37Rv ARVERILHRAGRAYGVRARRPDGTTLDVLADAVVVAAGATETPGLLRRSG
MMAR_0817|M.marinum_M ARVQRVLHQGGRARGVRARRPDGTAIDVLADIVIIAAGATETPTLLRRSG
MUL_4561|M.ulcerans_Agy99 ARVQRVLHQGGRARGVRARRPDGTAIDVRADIVIIAAGATETPTLLRRSG
MLBr_00389|M.leprae_Br4923 AGTLNVMPDRDLTHGVAITSSIHPTSDTHIEPIRYGKGSNAMG-LLQTLM
TH_0480|M.thermoresistible__bu AGRYRVSDDLDLTHGVAITSSIHPTPDTHIEPVRYGKGSNAMG-LLQTLM
MAB_1232c|M.abscessus_ATCC_199 -IVYSPTRD-DFSQGVAITSSIHPEPNTHVEVVRYGEGSTFLS-MLGTNM
MSMEG_5967|M.smegmatis_MC2_155 AATSGVLRKRLARNVILAAGALNTPLLLARSSGLWRDG--TAPPLLGRG-
Mflv_4475|M.gilvum_PYR-GCK AALGKRFCGNGDLLGFALPDGDDDELLPSGGPVITTYRSFDAGDRRILLQ
MAV_3093|M.avium_104 YVMVQGATQSAGRWSEEVRMYKAPPPEVTSEQFYETDSSRGFARGFSIQT
Mb0502c|M.bovis_AF2122/97 LGGHPRLGHNLALHPATMLAGLFDDDVFAWRGVLQSAAVHEFHES-DGVL
Rv0492c|M.tuberculosis_H37Rv LGGHPRLGHNLALHPATMLAGLFDDDVFAWRGVLQSAAVHEFHES-DGVL
MMAR_0817|M.marinum_M LGSHPRLGRNLALHPATMLAGRFDDDVYAWRGVLQSAAVHEFHES-DGVL
MUL_4561|M.ulcerans_Agy99 LGSHPRLGRNLALHPATMLAGRFDDDVYAWRGVLQSAAVHEFHES-DGVL
MLBr_00389|M.leprae_Br4923 TDGPGPEGTDVPRWRQLLHQASEDPRRMLRLINPRRWSERTVIAL-VMQH
TH_0480|M.thermoresistible__bu TDGPGPEGTDVPRWKQLFHNAAEDPRGTLRLLNVRRWSERTLIAL-VMQH
MAB_1232c|M.abscessus_ATCC_199 VDG-GP-----WRFARTWLANLRHPAMMLRSMFPYRAAQHSIIVL-VMQS
MSMEG_5967|M.smegmatis_MC2_155 -----------LMFHITDILGLRAPSDVPNYGPQKTLAIRDLYEVGEVQS
Mflv_4475|M.gilvum_PYR-GCK DGG--------LPNLATWGWGPDDLREALAKLSVPRFASAWLWRLRWPLP
MAV_3093|M.avium_104 VSP----------MPIGWAEHVLADG---HWGRALREYMRDYNHWATIGV
Mb0502c|M.bovis_AF2122/97 IEATSTPPGMGSMVFPGYGAELLRWLDRAPQIATFGAMVADRGVGTVRSV
Rv0492c|M.tuberculosis_H37Rv IEATSTPPGMGSMVFPGYGAELLRWLDRAPQIATFGAMVADRGVGTVRSV
MMAR_0817|M.marinum_M IEATATPPGMGSMVFPGYGTELLDWLDRAPQVATFGAMVADRGAGSVRSV
MUL_4561|M.ulcerans_Agy99 IEATATPPGMGSMVFPGYGTELLDWLDRAPQVATFGAMVADRGAGSVRSV
MLBr_00389|M.leprae_Br4923 LDNSITTFTKRGKLGIRWYSSKQGNGEPNPSWIPIGNEVTRRLAAKIDGV
TH_0480|M.thermoresistible__bu LDNSITTYTKRGLFGIRRYSSKQGHGQPNPTWIPVGNEVTRRIAEKIDGV
MAB_1232c|M.abscessus_ATCC_199 LDNSLTTYLKRGMFG-KKMTAKQGSGEPNPDWIPVAHDVARRMADKVDGY
MSMEG_5967|M.smegmatis_MC2_155 MAMRVGTAPIASYLRAEAERLGLGWLGGGLEALRIPAAVAARFLGKAATF
Mflv_4475|M.gilvum_PYR-GCK LLGMGADIPDGQLCLKDSDDTKMTCTWKKHTSDNHFQDVARRMEALTKDL
MAV_3093|M.avium_104 LNELLPQPDNRVTLADEKDAYGIPVARFDYTLCDNDKANMAYSTNVIGDI
:
Mb0502c|M.bovis_AF2122/97 RG-ETVVRYDIAPGEIAKLRVALQAIGRLFFAAGAVEVLTGIPGAPPMRS
Rv0492c|M.tuberculosis_H37Rv RG-ETVVRYDIAPGEIAKLRVALQAIGRLLFAAGAVEVLTGIPGAPPMRS
MMAR_0817|M.marinum_M RG-ETVVHYQVAPDDIAKLRVAVQAIGRLLFAAGAVEVLTGLPGAPTVTS
MUL_4561|M.ulcerans_Agy99 RG-ETVVHYQVAPDDIAKLRVAVQAIGRLLFAAGAVEVLTGLPGAPTVTS
MLBr_00389|M.leprae_Br4923 AG-GTWGELFNIP--LTAHFLGGAVIG-DNAEHGVIDPYHRVYGYPTLYV
TH_0480|M.thermoresistible__bu AG-GTWGELFNIP--LTAHFLGGAAIG-DSPEHGVIDPYHRVYGYPTLYV
MAB_1232c|M.abscessus_ATCC_199 AG-STHLDSMNIP--LTAHFIGGCPIG-DSPETGVIDPYQRIYGHPGLHI
MSMEG_5967|M.smegmatis_MC2_155 AT-VQEDYAYEAN----RVWEDPSHPERICFRYEVPDELRERSARGRRII
Mflv_4475|M.gilvum_PYR-GCK GAGFLPNFLWDFINEVITVHPLGGCPADTSAEEGVVDSYGRVRGVPGLWI
MAV_3093|M.avium_104 LR--AADAQDVLTIERFAHLIGGARMG-TRPDNSVVDSDHRVWGVPNLFV
. : .
Mb0502c|M.bovis_AF2122/97 LPELQDVLRRANPRSLHLAAFHPTGTAAAGADEQLCPVDATGRLRGVEGV
Rv0492c|M.tuberculosis_H37Rv LPELQDVLRRANPRSLHLAAFHPTGTAAAGADEQLCPVDATGRLRGVEGV
MMAR_0817|M.marinum_M PAALQDALQRSDPRNLHLAAFHPTGTAAAGADSQICPVDATGRLRGVDGV
MUL_4561|M.ulcerans_Agy99 PAALQDALQRSDPRNLHLAAFHPTGTAAAGADSQICPVDATGRLRGVDGV
MLBr_00389|M.leprae_Br4923 VDGAAISANLGVNPSLSIAAQAER-------AASLWPNKGQHDQRPRQGE
TH_0480|M.thermoresistible__bu TDGAAISANLGVNPSLSITAQAER-------AASLWPNKGEQDLRPAQGE
MAB_1232c|M.abscessus_ATCC_199 CDGSAISANLGVNPSFTITAQAER-------AMAFWPNKGEADPRPALGS
MSMEG_5967|M.smegmatis_MC2_155 RDRLRHLRPFFLSPLATPNLGHPMGTCRMGNDPAVSVTDAQGRVWGLPNV
Mflv_4475|M.gilvum_PYR-GCK ADGSVMPGPVGANPSLTIAAFARR---------------AAHELRKEDLA
MAV_3093|M.avium_104 ADGSVCPTQGSANPALTIMALASR---------------------LAERL
Mb0502c|M.bovis_AF2122/97 WVADASILPSCPEVNPQLSIMAMALAVADQTVAKVVGVR-----------
Rv0492c|M.tuberculosis_H37Rv WVADASILPSCPEVNPQLSIMAMALAVADQTVAKVVGVR-----------
MMAR_0817|M.marinum_M WVADASILPSCPEVNPQISIMALALAVADEVVADRSGSIYISPPACSPGP
MUL_4561|M.ulcerans_Agy99 WVADASILPSCPEVNPQISIMALALAVADEVVADRSGSIYISPPACSPGP
MLBr_00389|M.leprae_Br4923 SYRRLAPIAPDHPVVPAEAPGALRWL------------------------
TH_0480|M.thermoresistible__bu PYRRLDPIPPKNPVVPAHAPAALRRNPTESVDATG---------------
MAB_1232c|M.abscessus_ATCC_199 AYRRVAPVQPNHPTVPESAPGALRLPLTPV--------------------
MSMEG_5967|M.smegmatis_MC2_155 VVADAATLPTSGSTNPALTVSANALRIAESLVNRMNEAALEPSPHHAE--
Mflv_4475|M.gilvum_PYR-GCK TPSLPAPFIPQPYGDSDRSG------------------------------
MAV_3093|M.avium_104 AAGKVDTAAGRRSKAAARG-------------------------------
.
Mb0502c|M.bovis_AF2122/97 --
Rv0492c|M.tuberculosis_H37Rv --
MMAR_0817|M.marinum_M AP
MUL_4561|M.ulcerans_Agy99 AP
MLBr_00389|M.leprae_Br4923 --
TH_0480|M.thermoresistible__bu --
MAB_1232c|M.abscessus_ATCC_199 --
MSMEG_5967|M.smegmatis_MC2_155 --
Mflv_4475|M.gilvum_PYR-GCK --
MAV_3093|M.avium_104 --