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M. thermoresistible (build 8) TH_0480 (choD)

annotation: PROBABLE CHOLESTEROL OXIDASE PRECURSOR CHOD (CHOLESTEROL-O2 OXIDOREDUCTASE)
coordinates: 1015997 - 1017733
length: 579

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_0480choD-100% (579)PROBABLE CHOLESTEROL OXIDASE PRECURSOR CHOD (CHOLESTEROL-O2 OXIDOREDUCTASE)
M. thermoresistible (build 8)TH_2629-3e-3227.21% (555) PUTATIVE putative GMC oxidoreductase
M. thermoresistible (build 8)TH_4673-9e-0925.61% (328) PUTATIVE -

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb3443cchoD0.083.04% (578) cholesterol oxidase precursor
M. gilvum PYR-GCKMflv_4906-0.082.70% (578) FAD dependent oxidoreductase
M. tuberculosis H37RvRv3409cchoD0.083.04% (578) cholesterol oxidase precursor
M. leprae Br4923MLBr_00389choD0.083.95% (567) putative cholesterol oxidase
M. abscessus ATCC 19977MAB_3719c-0.077.66% (573) putative cholesterol oxidase ChoD
M. marinum MMMAR_1140choD0.082.40% (574) cholesterol oxidase precursor ChoD
M. avium 104MAV_4354-0.084.38% (576) FAD dependent oxidoreductase
M. smegmatis MC2 155MSMEG_1604-0.088.06% (578) FAD dependent oxidoreductase
M. ulcerans Agy99MUL_0903choD0.082.40% (574) cholesterol oxidase precursor ChoD
M. vanbaalenii PYR-1Mvan_1514-0.084.08% (578) FAD dependent oxidoreductase

CLUSTAL 2.0.9 multiple sequence alignment


TH_0480|M.thermoresistible__bu      ------------MQPDYDVLVIGSGFGGSVSALRLTEKGYRVGVLEAGRR
MSMEG_1604|M.smegmatis_MC2_155      ------------MKPDYDVLVIGSGFGGSVSALRLTEKGYRVGVLEAGRR
Mflv_4906|M.gilvum_PYR-GCK          ------------MRPDYDVLIIGSGFGGSVSALRLTEKGYRVGVLEAGRR
Mvan_1514|M.vanbaalenii_PYR-1       ------------MKPDYDVLIIGSGFGGSVSALRLTEKGYRVGVLEAGRR
Mb3443c|M.bovis_AF2122/97           ------------MKPDYDVLIIGSGFGGSVTALRLTEKGYRVGVLEAGRR
Rv3409c|M.tuberculosis_H37Rv        ------------MKPDYDVLIIGSGFGGSVTALRLTEKGYRVGVLEAGRR
MMAR_1140|M.marinum_M               ------------MKPDYDVLIIGSGFGGSVSALRLTEKGYRVGVLEAGRR
MUL_0903|M.ulcerans_Agy99           ------------MKPDYDVLIIGSGFGGSVSALRLTEKGYRVGVLEAGRR
MLBr_00389|M.leprae_Br4923          ------------MKPDYDVLIIGSGFGGSVSALRLTEKGYRVGVLEAGRR
MAV_4354|M.avium_104                ------------MKPDYDVLIIGSGFGGSVSALRLTEKGYRVGVLEAGRR
MAB_3719c|M.abscessus_ATCC_199      MSSPAAVPVKPEADTDFDVLIVGSGFGGSVTAMRLTEKGYRVGVLEAGRR
                                                  .*:***::********:*:*****************

TH_0480|M.thermoresistible__bu      FADEDFAKTSWNLRKFLWAPKLGCYGIQRIHLLRNVMILAGAGVGGGSLN
MSMEG_1604|M.smegmatis_MC2_155      FSDEEFAKTSWQLRKFLWAPKLGCYGIQRIHLLRNVMILAGAGVGGGSLN
Mflv_4906|M.gilvum_PYR-GCK          YADDEFAKTSWNLRKFLWAPQFGMYGIQRIHLLRNVMILAGAGVGGGSLN
Mvan_1514|M.vanbaalenii_PYR-1       YADDEFAKTSWNLRKFLWAPQFGMYGIQRIHLLRNVMILAGAGVGGGSLN
Mb3443c|M.bovis_AF2122/97           FSDEEFAKTSWDLRKFLWAPRLGCYGIQRIHPLRNVMILAGAGVGGGSLN
Rv3409c|M.tuberculosis_H37Rv        FSDEEFAKTSWDLRKFLWAPRLGCYGIQRIHPLRNVMILAGAGVGGGSLN
MMAR_1140|M.marinum_M               FSDAEFAKTSWDLRKFLWAPKLGCYGIQRIHPLKNVMILAGAGVGGGSLN
MUL_0903|M.ulcerans_Agy99           FSDAEFAKTSWDLRKFLWAPKLGCYGIQRIHPLKNVMILAGAGVGGGSLN
MLBr_00389|M.leprae_Br4923          FADEDFAKTSWDLRKFLWAPKLGCYGIQRIHLLRNVMILAGAGVGGGSLN
MAV_4354|M.avium_104                FADEDFAETSWDLRKFLWAPKLGCYGIQRIHPLKNVLILAGAGVGGGSLN
MAB_3719c|M.abscessus_ATCC_199      FADEEFAETSWDLRKFLWAPMFKCFGIQRIHLLSNCMILAGAGVGGGSLN
                                    ::* :**:***:******** :  :****** * * :*************

TH_0480|M.thermoresistible__bu      YANTLYVPPEPFFKDRQWAHITDWRDELMPHYDQAQRMLGVVTNPTFTDA
MSMEG_1604|M.smegmatis_MC2_155      YANTLYVPPEPFFADRQWAGITDWRAELTPHYDQAQRMLGVVTNPTFTDA
Mflv_4906|M.gilvum_PYR-GCK          YANTLYVPPEPFFNDPQWRDITDWRAELMSHYDQAQRMLGVVTNPTFTDA
Mvan_1514|M.vanbaalenii_PYR-1       YANTLYVPPEPFFNDPQWKDITDWRAELMSHYDQAQRMLGVVTNPTFTDA
Mb3443c|M.bovis_AF2122/97           YANTLYVPPEPFFADQQWSHITDWRGELMPHYQQAQRMLGVVQNPTFTDA
Rv3409c|M.tuberculosis_H37Rv        YANTLYVPPEPFFADQQWSHITDWRGELMPHYQQAQRMLGVVQNPTFTDA
MMAR_1140|M.marinum_M               YANTLYVPPDPFFNDQQWKHITDWRDELMPHYQQAQRMLGVVKNPTFTDA
MUL_0903|M.ulcerans_Agy99           YANTLYVPPDPFFNDQQWKHITDWRDELMPHYQQAQRMLGVVKNPTFTDA
MLBr_00389|M.leprae_Br4923          YANTLYVPPEPFFANQQWAHITDWHSELAPHYDQAQRMLGVVCNPTFTDA
MAV_4354|M.avium_104                YANTLYVPPEPFFKDQQWAHITDWRDELMPHYDQAQRMLGVVTNPTFTDA
MAB_3719c|M.abscessus_ATCC_199      YANTLYVPPDPFFNDPQWKGITDWRAELSPHYEQAQRMLGVVKNPTFTDA
                                    *********:*** : **  ****: ** .**:********* *******

TH_0480|M.thermoresistible__bu      DRVVKEVAEEMGVGHTFVPTPVGVFFGPDGQKTPGETVPDPYFGGVGPDR
MSMEG_1604|M.smegmatis_MC2_155      DRVVKEVADDMGVGDTFVQTPVGVFFGPDGEKTPGKTVPDPYFGGVGPDR
Mflv_4906|M.gilvum_PYR-GCK          DRIMKEVADDMGVGDTFVPTPVGVFFGPDGEKTPGKTVADPYFGGAGPAR
Mvan_1514|M.vanbaalenii_PYR-1       DRIMKEVADDMGVGDTFVPTPVGVFFGPDGEKTPGKTVPDPYFGGAGPAR
Mb3443c|M.bovis_AF2122/97           DRIVKEVADEMGFGDTWVPTPVGVFFGPDGTKTPGKTVPDPYFGGAGPAR
Rv3409c|M.tuberculosis_H37Rv        DRIVKEVADEMGFGDTWVPTPVGVFFGPDGTKTPGKTVPDPYFGGAGPAR
MMAR_1140|M.marinum_M               DRIVKEVADEMGFGDTWVPTPVGVFFGPDGTKTPGKTVPDPYFGGAGPAR
MUL_0903|M.ulcerans_Agy99           DRIVKEVADEMGFGDTWVPTPVGVFFGPDGTKTPGKTVPDPYFGGAGPAR
MLBr_00389|M.leprae_Br4923          DRILKEVVDEMGFGDTFVPTPVGVFFGPDGTQTPGRTVADPYFGGVGPVR
MAV_4354|M.avium_104                DRIVKEVADEMGCGDTFVPTPVGVFFGPDGTKAPGKTVPDPYFGGAGPER
MAB_3719c|M.abscessus_ATCC_199      DRLIKEVADDMGAGDTFVATPVGVYFGPDGTKTPGVKVPDPYFGGAGPDR
                                    **::***.::** *.*:* *****:***** ::** .*.******.** *

TH_0480|M.thermoresistible__bu      TGCIECGSCMTGCRHNAKNTLVKNYLGLAEQAGTEVHAMTTVTGFEQLPD
MSMEG_1604|M.smegmatis_MC2_155      TGCIECGSCMTGCRYGAKNTLLKNYLGLAERGGAEVHPLRTVAGFEQLPD
Mflv_4906|M.gilvum_PYR-GCK          TGCIECGSCMTGCRYGAKNTLVKNYLGLAEKAGAQVHPLTMVTGFEQRPD
Mvan_1514|M.vanbaalenii_PYR-1       TGCIECGSCMTGCRYGAKNTLLKNYLGLAEKAGAHVHPLTMVTGFEQRPD
Mb3443c|M.bovis_AF2122/97           TGCLECGCCMTGCRHGAKNTLVKNYLGLAESAGAQVIPMTTVKGFERRSD
Rv3409c|M.tuberculosis_H37Rv        TGCLECGCCMTGCRHGAKNTLVKNYLGLAESAGAQVIPMTTVKGFERRSD
MMAR_1140|M.marinum_M               TGCTECGECMTGCRHGAKNTLVKNYLGLAESAGAEVIPMTTVKGFEQRPD
MUL_0903|M.ulcerans_Agy99           TGCTECGECMTGCRHGAKNTLVKNYLGLAESAGAEVIPMTTVKGFEQRPD
MLBr_00389|M.leprae_Br4923          TGCLECGCCMTGCRHGAKNTLVKNYLGLAESAGAQVIPMTTVKGFELRSE
MAV_4354|M.avium_104                TGCLECGCCMTGCRYGAKNTLLKNYLGLAESAGAQVLPMTTVKAFEQRPD
MAB_3719c|M.abscessus_ATCC_199      VGCTECGSCMTGCRVGAKNTLVKNYLGLAESNGAQVIPLTTVTAVQQGAD
                                    .** *** ****** .*****:********  *:.* .:  * ..:  .:

TH_0480|M.thermoresistible__bu      GTWRVDTVRTGRWLRKRRKSFTATHLILAAGTWGTQRLLFKMRDAGKLPN
MSMEG_1604|M.smegmatis_MC2_155      GTWRVDTVRTGRWARKDKRSFTATHVVLAAGTWGTQRLLFKMRDTGKLPK
Mflv_4906|M.gilvum_PYR-GCK          GLWEVHTARTGSKVRRRRKTFTAEHVILAAGTYGTQKLLFKMRDRGKLPK
Mvan_1514|M.vanbaalenii_PYR-1       GLWEVRTARTGSKLRRRRRTFTAQHLILAAGTYGTQKLLFKMRDQGKLPE
Mb3443c|M.bovis_AF2122/97           GLWEVRTVRTGSWLRRDRRTFTATQLVLAAGTWGTQHLLFKMRDRGRLPG
Rv3409c|M.tuberculosis_H37Rv        GLWEVRTVRTGSWLRRDRRTFTATQLVLAAGTWGTQHLLFKMRDRGRLPG
MMAR_1140|M.marinum_M               GLWEVRTVRTGSWARRDRRTFTASYLILAAGTWGTQHLLFKMRDKGKLPR
MUL_0903|M.ulcerans_Agy99           GLWEVRTVRTGSWARRDRRTFTASYLILAAGTWGTQHLLFKMRDKGKLPR
MLBr_00389|M.leprae_Br4923          GLWEVHTVRTGSWLRRGRRTFTAAHLLLAAGTWGTQRLLFRMRDQGKLPR
MAV_4354|M.avium_104                GLWQVRTVRTGSWVRRDRRTYTAKHLILAAGTWGTQHLLFKMRDEGRLPR
MAB_3719c|M.abscessus_ATCC_199      GVWRVSTKSTGRWVRKQRKTYTAKYVVLAAGTWGTQNLLFKMKDKGLLPK
                                    * *.* *  **   *: ::::**  ::*****:***.***:*:* * ** 

TH_0480|M.thermoresistible__bu      LSKRLGVLTRTNSESIVGAGRYRVSDDLDLTHGVAITSSIHPTPDTHIEP
MSMEG_1604|M.smegmatis_MC2_155      LSSRLGVLTRTNSESIVGAGRYEVTPDLDLTHGVAITSSIHPTPDTHIEP
Mflv_4906|M.gilvum_PYR-GCK          LSDKLGVLTRTNSESIVGAGRLTVGDDLNLTHGVAITSSIHPTADTHVEP
Mvan_1514|M.vanbaalenii_PYR-1       LSDRLGVLTRTNSESIVGAGRLKVGDDLDLTHGVAITSSIHPTPDTHVEP
Mb3443c|M.bovis_AF2122/97           LSKRLGVLTRTNSESIVGAATLKVNPDLDLTHGVAITSSIHPTADTHIEP
Rv3409c|M.tuberculosis_H37Rv        LSKRLGVLTRTNSESIVGAATLKVNPDLDLTHGVAITSSIHPTADTHIEP
MMAR_1140|M.marinum_M               LSKRLGVLTRTNSESIVGAATLKVNPDLDLTHGVAITSSIHPTPDTHVEP
MUL_0903|M.ulcerans_Agy99           LSKRLGVLTRTNSESIVGAATLKVNPDLDLTHGVAITSSIHPTPDTHVEP
MLBr_00389|M.leprae_Br4923          LSQRLGVLTRTNSESIVGAGTLNVMPDRDLTHGVAITSSIHPTSDTHIEP
MAV_4354|M.avium_104                LSNRLGVLTRTNSESIVGAGKLEVDPNLDLTHGVAITSSIHPTPDTHIEP
MAB_3719c|M.abscessus_ATCC_199      LSQRLGVLTRTNSESIVGAGRLEYKDDLDLTHGVAITSSFHPTSDTHIEP
                                    **.:***************.      : :**********:***.***:**

TH_0480|M.thermoresistible__bu      VRYGKGSNAMGLLQTLMTDGPGPEGTDVPRWKQLFHNAAEDPRGTLRLLN
MSMEG_1604|M.smegmatis_MC2_155      VRYGKGSNAMGLLQTLMTDGDGPDGAGIPRWKQLLRNAAEDPRGTLRLLN
Mflv_4906|M.gilvum_PYR-GCK          VRYGKGSNAMGLLQTLMTDGTGPEGTDVPRWRQLLDTARNDRKGTLRLLN
Mvan_1514|M.vanbaalenii_PYR-1       VRYGKGSNAMGLLQTLMTDGTGPQGTDVPRWRQLIETARDDPRGTLRLLN
Mb3443c|M.bovis_AF2122/97           VRYGKGSNAMGLLQTLMTDGSGPQGTDVPRWRQLLQTASQDPRGTIRMLN
Rv3409c|M.tuberculosis_H37Rv        VRYGKGSNAMGLLQTLMTDGSGPQGTDVPRWRQLLQTASQDPRGTIRMLN
MMAR_1140|M.marinum_M               VRYGKGSNAMGLLQTLMTDGSGPSGTDVARWRQLLDQAGESPRRMFRLIN
MUL_0903|M.ulcerans_Agy99           VRYGKGSNAMGLLQTLMTDGSGPSGTDVARWRQLLDQAGESPRRMFRLIN
MLBr_00389|M.leprae_Br4923          IRYGKGSNAMGLLQTLMTDGPGPEGTDVPRWRQLLHQASEDPRRMLRLIN
MAV_4354|M.avium_104                VRYGKGSNAMGLLQTLMTDGAGPQGTDVPRWKQLLDQAREDPRRLMRLLN
MAB_3719c|M.abscessus_ATCC_199      VRYGKGSNAMGLLQTLMTDGDGPK----SRWRQLIENARADWRGTFRMFN
                                    :******************* **.    .**:**:  *  . :  :*::*

TH_0480|M.thermoresistible__bu      VRRWSERTLIALVMQHLDNSITTYTKRGLFGIRRYSSKQGHGQPNPTWIP
MSMEG_1604|M.smegmatis_MC2_155      VHRWSERTLIALVMQHLDNSITTYTKRNRLGIRRYLSKQGHGAPNPTWIP
Mflv_4906|M.gilvum_PYR-GCK          PRRWSERTMIALVMQHLDNSITTYTRKTKFGFRMLDSKQGHGEPNPSWIP
Mvan_1514|M.vanbaalenii_PYR-1       PRRWSERTMIALVMQHLDNSITTFTRKTRFGFRMLDSRQGHGEPNPSWIP
Mb3443c|M.bovis_AF2122/97           PRQWSERTVIALVMQHLDNSITTFTKRGKLGIRWYSSKQGHGEPNPTWIP
Rv3409c|M.tuberculosis_H37Rv        PRQWSERTVIALVMQHLDNSITTFTKRGKLGIRWYSSKQGHGEPNPTWIP
MMAR_1140|M.marinum_M               PRQWSERTVIALVMQHLDNSITTFTKRGKLGIRWYSSKQGHGEPNPTWIP
MUL_0903|M.ulcerans_Agy99           PRQWSERTVIALVMQHLDNSITTFTKRGKLGIRWYSSKQGHGEPNPTWIP
MLBr_00389|M.leprae_Br4923          PRRWSERTVIALVMQHLDNSITTFTKRGKLGIRWYSSKQGNGEPNPSWIP
MAV_4354|M.avium_104                VHQWSERTLIALVMQHLDNSITTFTKRGRLGIRWYTSKQGHGEPNPTWIP
MAB_3719c|M.abscessus_ATCC_199      VTQWSERTVIALVMQHLDNSITTFTKKTLF-WRRLDSKQGHGEPNPTWIP
                                      :*****:**************:*::  :  *   *:**:* ***:***

TH_0480|M.thermoresistible__bu      VGNEVTRRIAEKIDGVAGGTWGELFNIPLTAHFLGGAAIGDSPEHGVIDP
MSMEG_1604|M.smegmatis_MC2_155      VGNEVTRRIAKKIDGVAGGTWGELFNIPLTAHFLGGAAIGDSPETGVIDP
Mflv_4906|M.gilvum_PYR-GCK          AGNEVTRRIAEKIDGVAGGTWGELFNIPLTAHFLGGAAIADSPERGVIDP
Mvan_1514|M.vanbaalenii_PYR-1       AGNEVTRRIAKKIDGVAGGTWGELFNIPLTAHFLGGAAIGDSAETGVIDP
Mb3443c|M.bovis_AF2122/97           IGNQVTRRIAAKIDGVAGGTWGELFNIPLTAHFLGGAVIGDDPEHGVIDP
Rv3409c|M.tuberculosis_H37Rv        IGNQVTRRIAAKIDGVAGGTWGELFNIPLTAHFLGGAVIGDDPEHGVIDP
MMAR_1140|M.marinum_M               VGNQVTRRIAEKIDGVAGGTWGELFNIPLTAHFLGGAVIGDNPDSGVIDP
MUL_0903|M.ulcerans_Agy99           VGNQVTRRIAEKIDGVAGGTWGELFNIPLTAHFLGGAVIGDNPDSGVIDP
MLBr_00389|M.leprae_Br4923          IGNEVTRRLAAKIDGVAGGTWGELFNIPLTAHFLGGAVIGDNAEHGVIDP
MAV_4354|M.avium_104                VGNEVTRRIAAKIDGVAGGTWGELFNIPLTAHFLGGAVIGQDAEHGVIDP
MAB_3719c|M.abscessus_ATCC_199      AGNEATRRLAAKIDGVAGGTWGELFNIPLTAHFLGGAVIGTSPENGVIDP
                                     **:.***:* **************************.*. ..: *****

TH_0480|M.thermoresistible__bu      YHRVYGYPTLYVTDGAAISANLGVNPSLSITAQAERAASLWPNKGEQDLR
MSMEG_1604|M.smegmatis_MC2_155      YQRVYNYPTLHVMDGAAISANLGVNPSLSITAQAERATSLWPNKGEQDQR
Mflv_4906|M.gilvum_PYR-GCK          YQRVWNYPTLSVMDGAAVSANLGVNPSLSITAQAERAAALWPNKGEEDLR
Mvan_1514|M.vanbaalenii_PYR-1       YQRVYGYPTLSVMDGAAISANLGVNPSLSITAQAERAASLWPNKGEDDLR
Mb3443c|M.bovis_AF2122/97           YHRVYGYPTLYVVDGAAISANLGVNPSLSIAAQAERAASLWPNKGETDRR
Rv3409c|M.tuberculosis_H37Rv        YHRVYGYPTLYVVDGAAISANLGVNPSLSIAAQAERAASLWPNKGETDRR
MMAR_1140|M.marinum_M               YHRVYGYPTMFVVDGAAISANLGVNPSLSITAQAERAASLWPNKGQNDER
MUL_0903|M.ulcerans_Agy99           YHRVYGYPTMFVVDGAAISANLGVNPSLSITAQAERAASLWPNKGQNDER
MLBr_00389|M.leprae_Br4923          YHRVYGYPTLYVVDGAAISANLGVNPSLSIAAQAERAASLWPNKGQHDQR
MAV_4354|M.avium_104                YHRVYGYPTLYVVDGAAISANLGVNPSLSITAQAERAAALWPNNGENDQR
MAB_3719c|M.abscessus_ATCC_199      YHRVYGYPTMYVVDGASISANLGVNPSLSITAQAERAASLWPNKGETDLR
                                    *:**:.***: * ***::************:******::****:*: * *

TH_0480|M.thermoresistible__bu      PAQGEPYRRLDPIPPKNPVVPAHAPAALRRNPTESVD---ATG
MSMEG_1604|M.smegmatis_MC2_155      PAQGEPYRRLAPIAPVRPVVPADAPGALRRLPIEPVS---SAG
Mflv_4906|M.gilvum_PYR-GCK          PEQGQPYRRLSPIEPKHPVVPADAPAALRRIPIEPVT---SAG
Mvan_1514|M.vanbaalenii_PYR-1       PAQGEPYRRLSPIAPVRPVVPAEAPAALRRIPIEPVT---STG
Mb3443c|M.bovis_AF2122/97           PPQGEPYRRLAPIQPAHPVVPADAPGALRWLPIDPVS---NAG
Rv3409c|M.tuberculosis_H37Rv        PPQGEPYRRLAPIQPAHPVVPADAPGALRWLPIDPVS---NAG
MMAR_1140|M.marinum_M               PLQGDGYSRLSPVQPEHPVVPADAPGALRWLPIDPVSRVSSAG
MUL_0903|M.ulcerans_Agy99           PLQGDGYSRLSPVQPEHPVVPADAPGALRWLPIDPVSRVSSAG
MLBr_00389|M.leprae_Br4923          PRQGESYRRLAPIAPDHPVVPAEAPGALRWL------------
MAV_4354|M.avium_104                PAQGEPYRRMDPIAPKAPVVPAEAPGALRWTPTKPVS---SAS
MAB_3719c|M.abscessus_ATCC_199      PEQGLPYQRMAPVPPVHPVVPADAPGALRRLPIEPVS---SAS
                                    * **  * *: *: *  *****.**.***