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VVTEPPQSHRDGLRSAPAIAPAPERKRAATDLRRLLPYLLPYRARWVTMVVVAIVSLGATIAIPLMTKAV IDGPVRHQDSQGLWTLGAAAVGIGISEAVLWFIRRWLVARATMGVEADIRKDLYARLQILPMSFHGRWQS GQLLSRVMNDLSTIRRFMSFGLVFLILNGLQITVVTAILLAMYWPLGVVVLVSIVPIAATVLHFEREYTR LSRLAQDQTGHVATHVEESALGLRVVKSFGREDYVFDRFDEQATRLYDTQVARVGVSAKFWTLLEVIPNL TLIVVLGFGAYAAGHGYVTMGTLVAFITMMLSLVWPIASLGFLLSMTQESFTAANRIAEIFDAPREIVDG PITEAPRGGRLQLRDVGFKFPDSDEWVLRGVNLTVEPGETVALVGSTGSGKSVLAALFSRLYDVTEGQIL IDGRDIRDLSLPALRRTVATAFEDPTLFSMSVAENLRLGRSDATDDELEQAVEVAAAHFVYDLPFGLDTR IGEQGMSLSGGQRQRLSLARAILAAPRILVLDDTLSALDVHTEARVTEALSRVLSSVTGVIVAHRASTVL LADKVALLDRDAHGAGTVTHIGTHAELLAEVPQYRYLLAADDELDDDTERTCEWEDDEDLERLRRVHDER AAIDGLDEPEYLGQEVQRR*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. smegmatis MC2 155 | MSMEG_5660 | - | - | 100% (650) | ABC transporter ATP-binding protein |
M. smegmatis MC2 155 | MSMEG_5008 | - | 9e-82 | 34.09% (569) | ABC transporter, ATP-binding protein |
M. smegmatis MC2 155 | MSMEG_5659 | - | 2e-71 | 31.34% (568) | ABC transporter, ATP-binding protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0200 | - | 1e-82 | 33.74% (578) | drugs-transport transmembrane ATP-binding protein ABC |
M. gilvum PYR-GCK | Mflv_1747 | - | 0.0 | 82.31% (616) | ABC transporter related |
M. tuberculosis H37Rv | Rv0194 | - | 3e-83 | 33.45% (577) | drugs-transport transmembrane ATP-binding protein ABC |
M. leprae Br4923 | MLBr_01113 | - | 2e-70 | 29.27% (632) | putative ABC transporter, ATP-binding component |
M. abscessus ATCC 19977 | MAB_1415c | - | 6e-72 | 31.23% (570) | ABC transporter ATP-binding protein |
M. marinum M | MMAR_5223 | - | 8e-83 | 34.80% (569) | drug-transport transmembrane ATP-binding protein ABC |
M. avium 104 | MAV_1421 | - | 7e-73 | 31.11% (569) | ABC transporter, ATP-binding protein |
M. thermoresistible (build 8) | TH_2635 | - | 0.0 | 79.54% (611) | PUTATIVE ABC transporter related |
M. ulcerans Agy99 | MUL_4010 | - | 1e-70 | 30.81% (568) | transmembrane ATP-binding protein ABC transporter |
M. vanbaalenii PYR-1 | Mvan_5006 | - | 0.0 | 80.35% (626) | ABC transporter-related protein |
CLUSTAL 2.0.9 multiple sequence alignment Mb0200|M.bovis_AF2122/97 ---------------------------MRTNCWWRLSGYVMRHRRDLLLG Rv0194|M.tuberculosis_H37Rv ---------------------------MRTNCWWRLSGYVMRHRRDLLLG MMAR_5223|M.marinum_M ---------------------------MRTNWWGRLSRYVLRYRRDLLLG Mflv_1747|M.gilvum_PYR-GCK -----MADSRTDSLHAAPAIGPPPSRVRPSSDLWRMMPYLLPYRGRWIVM Mvan_5006|M.vanbaalenii_PYR-1 -----MADTGFDSLRAAPSIGPPPKRVKPSSDLWRMMPYLLPYRGRWIVM MSMEG_5660|M.smegmatis_MC2_155 MVVTEPPQSHRDGLRSAPAIAPAPERKRAATDLRRLLPYLLPYRARWVTM TH_2635|M.thermoresistible__bu --------VVTGRLHEAAKIAPPPERSWVGADLWRLLPYLMPYRARWTAM MAV_1421|M.avium_104 ------------------------------MLLALLRQYIQPYRRLVAVL MUL_4010|M.ulcerans_Agy99 ------------------------------MLLALLRQYIRPYRRLVAAL MAB_1415c|M.abscessus_ATCC_199 --------------------------MPQGQLRALLPRYVRPYRGLIAVV MLBr_01113|M.leprae_Br4923 ---------------MTMATAPATRSCDFYCTIRRLLKQLVPQRRLSLTV : : * Mb0200|M.bovis_AF2122/97 FGAALAGTVIAVLVPLVT----KRVIDDAVAA-DHRPLAPWAVVLVAAA- Rv0194|M.tuberculosis_H37Rv FGAALAGTVIAVLVPLVT----KRVIDDAIAA-DHRPLAPWAVVLVAAA- MMAR_5223|M.marinum_M LFASVVGTAITVMVPLVT----KRVIDNAIAP-DHRPLAPWALVLVAAA- Mflv_1747|M.gilvum_PYR-GCK IVVALASLAATISIPLMT----KAVIDGPVRQQDQQGLWLVGAAALGVG- Mvan_5006|M.vanbaalenii_PYR-1 IVVALASLAATISIPLMT----KAVIDGPVRHQDQQGLWLVGAAAVAVG- MSMEG_5660|M.smegmatis_MC2_155 VVVAIVSLGATIAIPLMT----KAVIDGPVRHQDSQGLWTLGAAAVGIG- TH_2635|M.thermoresistible__bu ITVAVVSLSATVAIPLMT----KAVIDGPVRQQDQQGLWILGSAAMAVG- MAV_1421|M.avium_104 MALQVISNLASLYLPTVN----AAIIDEGVAKGDTSTIVRLGVVMLGVT- MUL_4010|M.ulcerans_Agy99 MALQLISTLASLYLPTVN----AAIIDDGVAKGDTNTIIRLGVVMLGVT- MAB_1415c|M.abscessus_ATCC_199 VTLQIISTLASLYLPTVN----AAIIDDGVAHGDTRTIARLGAVMLGVT- MLBr_01113|M.leprae_Br4923 ITLGITGTAIGIIVPWVLGHTTDLLFNGVIGRQLPKGISKTQAVAAARTR . : . : :* : ::: : : . . Mb0200|M.bovis_AF2122/97 ------------------------------------GATYLLTYVRRYYG Rv0194|M.tuberculosis_H37Rv ------------------------------------GATYLLMYVRRYYG MMAR_5223|M.marinum_M ------------------------------------VAIYFMTFVRRHYG Mflv_1747|M.gilvum_PYR-GCK ------------------------------------VTEAVLWFIRRWLV Mvan_5006|M.vanbaalenii_PYR-1 ------------------------------------VTEAVLWFIRRWLV MSMEG_5660|M.smegmatis_MC2_155 ------------------------------------ISEAVLWFIRRWLV TH_2635|M.thermoresistible__bu ------------------------------------ISEAVLMFIRRWLV MAV_1421|M.avium_104 ------------------------------------AVQALCAVGAVYFG MUL_4010|M.ulcerans_Agy99 ------------------------------------GLQVLCAVGAVYFG MAB_1415c|M.abscessus_ATCC_199 ------------------------------------LVQITCSIGAVYFG MLBr_01113|M.leprae_Br4923 GDNALADLLSGMNLVPGQGVDFVAVGRTLGLALSLYLVYTLLTWAQARLL Mb0200|M.bovis_AF2122/97 GRIAHLVQHDLRMDAFQALLRWDGRQQDRWSSGQLIVRTTNDLQLVQALL Rv0194|M.tuberculosis_H37Rv GRIAHLVQHDLRMDAFQALLRWDGRQQDRWSSGQLIVRTTNDLQLVQALL MMAR_5223|M.marinum_M GRIAHLVQHDLRVDAFATLMRWDGRQQDRWSSGQLIVRTTNDLELVQTLL Mflv_1747|M.gilvum_PYR-GCK ARATMGVEADIRKQLYARLQILPMSFHGRWQSGQLLSRIMNDLSTIRRFM Mvan_5006|M.vanbaalenii_PYR-1 ARATMGVEADIRKQLYARLQILPMSFHGQWQSGQLLSRIMNDLSTIRRFM MSMEG_5660|M.smegmatis_MC2_155 ARATMGVEADIRKDLYARLQILPMSFHGRWQSGQLLSRVMNDLSTIRRFM TH_2635|M.thermoresistible__bu ARATMGVEADIRKDLYARLQILPMSFHGRWQSGQLVSRVMNDLSTIRRLL MAV_1421|M.avium_104 SRTGMGFGRDLRAAMFEHVITFSERETARFGAPTLLTRSTNDVRQIQYLV MUL_4010|M.ulcerans_Agy99 ARTGTGFGRDLRAAMFEHVITFSERETARFGASTLLTRSTNDVRQIVFLV MAB_1415c|M.abscessus_ATCC_199 SRTGMGFGRDMRSALFHHITGFSAEESARFGAPTLLTRTTNDVQQLQLLI MLBr_01113|M.leprae_Br4923 NVTVQRIMFALRSDVEDKVHRLPLSYCDTRQRGELLSRVTNDIDNLQSSL . :* : *: * **: : : Mb0200|M.bovis_AF2122/97 -FDVPNVLRHVLTLLLGVAVMTWLSVPLALLAVLLVPVIGLIAHRSRRLL Rv0194|M.tuberculosis_H37Rv -FDVPNVLRHVLTLLLGVAVMTWLSVPLALLAVLLVPVIGLIAHRSRRLL MMAR_5223|M.marinum_M -FDLPNVIRHLLTLLLCLAVMAWLSLPLALLVVLLVPLIGLVAHRSRRLL Mflv_1747|M.gilvum_PYR-GCK SFGLIFLMLNVLQITVVTVILLVMYWPLGVVVLVSIVPITLTVLHFQQEY Mvan_5006|M.vanbaalenii_PYR-1 SFGLIFLMLNVLQITVVTAILLAMYWPLGVVVLVSIVPITLTVLHFQQEY MSMEG_5660|M.smegmatis_MC2_155 SFGLVFLILNGLQITVVTAILLAMYWPLGVVVLVSIVPIAATVLHFEREY TH_2635|M.thermoresistible__bu SFGLVFLVLNGLQIAVVTSILLAMYWPLGVVALLSIVPITMTVLHFQRLY MAV_1421|M.avium_104 QITATVLVTAPIMCLGGIVMAIHQEAALTWLLLISVPVMALTNYWVMSHM MUL_4010|M.ulcerans_Agy99 QTTATVLVAAPIMSIGGIIMAVHQEAALTWLLLVSVPILALANYWIMTHM MAB_1415c|M.abscessus_ATCC_199 QVTCTMLVTAPIMCVGGIAMAIHQNAGLSWLLMVSMPALGLANWYIVHSM MLBr_01113|M.leprae_Br4923 SITLSQLLTSLLTVVAVLVVMVSVSPLLALVALLTVPMSLLATRAIAQRS :: : : * : :: : Mb0200|M.bovis_AF2122/97 AAATHCAQEHKAAVTGVVDAAVCGIRVVKAFGQEERETVKLVMASRALYA Rv0194|M.tuberculosis_H37Rv AAATHCAQEHKAAVTGVVDAAVCGIRVVKAFGQEERETVKLVTASRALYA MMAR_5223|M.marinum_M AVATEAAQERNAVVTGVVDAAVSGIHVVKAFGQQSQETVKLTTAGRALYA Mflv_1747|M.gilvum_PYR-GCK TRLSRLAQDQAGHVATHVEEAALGLRVVKSFGREDYVYDRFDEQLTDLYD Mvan_5006|M.vanbaalenii_PYR-1 TRLSRLAQDQAGHVATHVEEAALGLRVIKSFGREDYVYERFDDQLTDLYD MSMEG_5660|M.smegmatis_MC2_155 TRLSRLAQDQTGHVATHVEESALGLRVVKSFGREDYVFDRFDEQATRLYD TH_2635|M.thermoresistible__bu TRLSRQAQDETGHVATHVEEAALGVRVVKSFGRERYSYDRFDEQATRLFR MAV_1421|M.avium_104 LPLFRRMQALIDGVNRVMRDQLSGVRVVRAFAREDFERDRFDRANATLSN MUL_4010|M.ulcerans_Agy99 LPLFRSMQALIDGINRVLRDQLSGVRVVRAFTREPFERDRFAQANTALAS MAB_1415c|M.abscessus_ATCC_199 LPIFRRMQRLIDGINRVMREQLSGIRVVRAFTREAVERKRFSAAVAEVSE MLBr_01113|M.leprae_Br4923 QQLFVAQWTSAGRLNAHIEETYSGLTVVKTFGHQTAAREQFRNVNNDVYQ : : *: *:::* :: :: : Mb0200|M.bovis_AF2122/97 AQLRVARLNAHFGPLLQTLPALGQMAVFALGGWMAAQGSITVGTFVAFWA Rv0194|M.tuberculosis_H37Rv AQLRVARLNAHFGPLLQTLPALGQMAVFALGGWMAAQGSITVGTFVAFWA MMAR_5223|M.marinum_M ARVRVARLNAYFGPLLQSLPAFGQMAVLAVGGWMAAQGTITVGTFVAFWS Mflv_1747|M.gilvum_PYR-GCK TQIDRVSVSAKFWTLLEIIPNLTLIVVLGFGAYAAGHGHVTMGTLVAFIT Mvan_5006|M.vanbaalenii_PYR-1 TQVSRVSVSAKFWTLLEIIPNLTLIVVLGFGAYAAGHGYVTMGTLVAFIT MSMEG_5660|M.smegmatis_MC2_155 TQVARVGVSAKFWTLLEVIPNLTLIVVLGFGAYAAGHGYVTMGTLVAFIT TH_2635|M.thermoresistible__bu TQVGRVEVSARFWTLLEIIPNLTLIVVLGFGAYAAGTGLVTMGTLVAFIT MAV_1421|M.avium_104 TALAAGNWQALMLPVTTLTINVSSVALIWFGGLRIDHGQMQVGSLTAFLA MUL_4010|M.ulcerans_Agy99 TALRAGNWQALMLPVTTLTINVSSVAVIWFGGLLIDQGRMQVGSLSAFLS MAB_1415c|M.abscessus_ATCC_199 AALAAGRWQALMLPATSLVINTSSVALIWFGGLRIDQGQMQVGSLVAFLS MLBr_01113|M.leprae_Br4923 ASFSAQFFSGLVSPATMFISNLGYVVVAALGGLQVATGHITLGNIQAFIQ : . .. . . :.: .*. * : :*.: ** Mb0200|M.bovis_AF2122/97 CLTLLARPACDLAGMLTIAQQARAGAVRVLELIDSRPTLVDGTKPLSLEA Rv0194|M.tuberculosis_H37Rv CLTLLARPACDLAGMLTIAQQARAGAVRVLELIDSRPTLVDGTKPLSPEA MMAR_5223|M.marinum_M CLTLVSRPACDLAGMLTIAQQARTGAMRVFELIDSRPTLVDGTKQLPSST Mflv_1747|M.gilvum_PYR-GCK MMLSLVWPIASLGFLLSMTQESFTAANRIAEIFDAPREITDGPREQAPR- Mvan_5006|M.vanbaalenii_PYR-1 MMLSLVWPIASLGFLLSMTQESFTAANRIAEIFDAPREITDGPRDQAPR- MSMEG_5660|M.smegmatis_MC2_155 MMLSLVWPIASLGFLLSMTQESFTAANRIAEIFDAPREIVDGPITEAPR- TH_2635|M.thermoresistible__bu MMLSLVWPIASLGFLLSMTQESMTAANRIAEIFDAPIEITDGPITTPPR- MAV_1421|M.avium_104 YFTQILMAVLMATMTLVVLPRASVCAERITEVLSTGAAVADPASPKSPPG MUL_4010|M.ulcerans_Agy99 YFAQILMAVLMATMTLVVLPRAAVCAERITEVLSTPAALNNPQHPRFPAA MAB_1415c|M.abscessus_ATCC_199 YFLQILMSMMMLTMLAVMVPRASACAERITEVFDTTGAITAPADPVRVAD MLBr_01113|M.leprae_Br4923 YVRQFNMPLSQVAGIYNTLQSGLASAERVFDLLDEPEELPDPMLALPPPH . . . . . * *: :::. : Mb0200|M.bovis_AF2122/97 ----R--LSLEFQRVSFGYVA----------DRPVLREISLSVRAGETLA Rv0194|M.tuberculosis_H37Rv ----R--LSLEFQRVSFGYVA----------DRPVLREISLSVRAGETLA MMAR_5223|M.marinum_M ----P--VSLAFEQASFGYAA----------EHPVLRGIDLSVRPGETLA Mflv_1747|M.gilvum_PYR-GCK ------GGRLELVDVGFRFPD---------SDEWALRHVTVTVEPGETLA Mvan_5006|M.vanbaalenii_PYR-1 ------GGRLEVVDVGFRFPDSA-------SGDWALRHVTVTVEPGETLA MSMEG_5660|M.smegmatis_MC2_155 ------GGRLQLRDVGFKFPD---------SDEWVLRGVNLTVEPGETVA TH_2635|M.thermoresistible__bu ------RGRLELRDVGFKFPDSGGVGASGGQDTWVLRHVTVTVEPGETLA MAV_1421|M.avium_104 ----AITGIVRLDRATFTYPG---------ADRPVLQDISLTARPGTTTA MUL_4010|M.ulcerans_Agy99 ----GITGAVRLENITFSYPG---------ADCPVLQDISLSAPPGATTA MAB_1415c|M.abscessus_ATCC_199 ----PYP-TVEFTRAGFRYPG---------AERAVLEEISFTAQPGMITA MLBr_01113|M.leprae_Br4923 GQVPRINGRVEFQQVSFAYRT----------GTPVIDDLSMVVEPGSTVA : . * : .: : . . .* * Mb0200|M.bovis_AF2122/97 VVGAPGSGKSTLASLATRCYDVTQGAVRIGGQDVRELTLDSLRSAIGLVP Rv0194|M.tuberculosis_H37Rv VVGAPGSGKSTLASLATRCYDVTQGAVRIGGQDVRELTLDSLRSAIGLVP MMAR_5223|M.marinum_M VVGPPGSGKSTLALLAMRCYDVTAGAVRVGGHDVRDLTLDSLRSAIGLVP Mflv_1747|M.gilvum_PYR-GCK LVGATGSGKSVLVGLLSRLYDVTEGEIRIDAQDIRELSLRALRETVATAF Mvan_5006|M.vanbaalenii_PYR-1 LVGATGSGKSVLAGLLSRLYDVTEGEIRIDAQDIRELSLDALRRTVATAF MSMEG_5660|M.smegmatis_MC2_155 LVGSTGSGKSVLAALFSRLYDVTEGQILIDGRDIRDLSLPALRRTVATAF TH_2635|M.thermoresistible__bu LVGPTGSGKSVLVSLLSRLYDVTEGQIRIDGIDIRELSLDALRRTVATAF MAV_1421|M.avium_104 IVGSTGSGKSTLISLICRLYDVTGGAVQIDGIDVRDYRTERLWSAIGLVP MUL_4010|M.ulcerans_Agy99 IVGSTGSGKSTLISLICRLYDVTGGTVLLDGIDVRDYQTERLWAAIGLVP MAB_1415c|M.abscessus_ATCC_199 IVGATGCGKSTLLNLIPRLHDVTTGSVRVGGNDVRRYDPEDLWTVMGLVP MLBr_01113|M.leprae_Br4923 IVGPTGAGKTTLVNLLMRFYDVDSGQILIDGVDITTVSRHALRSRIGMVL :**..*.**:.* * * :** * : :.. *: * :. . Mb0200|M.bovis_AF2122/97 EDAVLFSGTIGANIAYGRP---DATPEQIATAARAAHIEEFVNTLPDGYQ Rv0194|M.tuberculosis_H37Rv EDAVLFSGTIGANIAYGRP---DATPEQIATAARAAHIEEFVNTLPDGYQ MMAR_5223|M.marinum_M EQAILFSGTIGENISYGRS---NVTLEQITAAARAAHIDEFVNTLPDGYA Mflv_1747|M.gilvum_PYR-GCK EDPTLFSMSVAENLRLGRP---DATDEDLRQAVEIAAAQ-FVYDLPFGLD Mvan_5006|M.vanbaalenii_PYR-1 EDPTLFSMSVAENLRLGRP---EATDDDLRRAIDVAAAQ-FVYDLPFGLD MSMEG_5660|M.smegmatis_MC2_155 EDPTLFSMSVAENLRLGRS---DATDDELEQAVEVAAAH-FVYDLPFGLD TH_2635|M.thermoresistible__bu EDPTLFSVSVEENLRLGRPPANPASDAELAEAIEIAAAE-FVHDLPYGLH MAV_1421|M.avium_104 QRGYLFSGTVADNLRYGRA---DATEQQMWEALRVAAADDFVGAHPDGLH MUL_4010|M.ulcerans_Agy99 QRGYLFSGTVADNLRYGKS---DATDEEMWEALRVAAAEEFVRAH--GLQ MAB_1415c|M.abscessus_ATCC_199 QRGYLFSGTVESNLRYGKA---DATEDEMWAALEVAQAAGFVRQHAAGLQ MLBr_01113|M.leprae_Br4923 QDAWLFDGTIAENIAYGRP---QASEDEVMEAAKAAYVDRFVHTLSAGYQ : **. :: *: *:. .: :: * * ** * Mb0200|M.bovis_AF2122/97 TAVGARGLTLSGGQRQRIALARALLHQPRLLIMDDPTSAVDAVIECGIQE Rv0194|M.tuberculosis_H37Rv TAVGARGLTLSGGQRQRIALARALLHQPRLLIMDDPTSAVDAVIECGIQE MMAR_5223|M.marinum_M TPVGAQGLTLSGGQRQRIALARALVGNPRLLIMDEPTSAVDAVIEASIQD Mflv_1747|M.gilvum_PYR-GCK TRIGEQGMSLSGGQRQRLSLARAILTRPRILVLDDTLSALDVHTEAVVEE Mvan_5006|M.vanbaalenii_PYR-1 TRIGEQGMSLSGGQRQRISLARAILADPRILVLDDTLSALDVHTEAVVEE MSMEG_5660|M.smegmatis_MC2_155 TRIGEQGMSLSGGQRQRLSLARAILAAPRILVLDDTLSALDVHTEARVTE TH_2635|M.thermoresistible__bu TRIGEQGMSLSGGQRQRLSLARAVLAAPTILVLDDTLSALDVHTEAVVTE MAV_1421|M.avium_104 MRVAQGGINFSGGQRQRLAIARAVIRRPAIYLFDDSFAALDARTDSRVRA MUL_4010|M.ulcerans_Agy99 MRVAQGGINFSGGQRQRLAIARAIIGRPAVYLFDDAFSALDVHTDARVRA MAB_1415c|M.abscessus_ATCC_199 MPVSQGGINFSGGQRQRIAIARAVIRRPGIYLFDDAFSALDVHTDARLRA MLBr_01113|M.leprae_Br4923 TRVSGDGDNISAGEKQLITIARAFLARPQLLILDEATSSIDTRTEALIAR :. * .:*.*::* :::***.: * : ::*:. :::*. :. : Mb0200|M.bovis_AF2122/97 VLREAIADRTAVIFTRRRSMLTLADRVAVLDS-----GRLLDVGTPDEVW Rv0194|M.tuberculosis_H37Rv VLREAIADRTAVIFTRRRSMLTLADRVAVLDS-----GRLLDVGTPDEVW MMAR_5223|M.marinum_M VLREVLADRTAVIFTRRRSMLSLADRVAVLDS-----GHLLDIGTPEQLW Mflv_1747|M.gilvum_PYR-GCK ALRRVLHEVTGIVVAHRASTVLLADRVALLQN-----GTVTHVGTHAELL Mvan_5006|M.vanbaalenii_PYR-1 SLRRVLHDVTAIVVAHRASTVLLADRVALLRN-----GTITHVGTHAELL MSMEG_5660|M.smegmatis_MC2_155 ALSRVLSSVTGVIVAHRASTVLLADKVALLDRDAHGAGTVTHIGTHAELL TH_2635|M.thermoresistible__bu ALRRVLRDVTGIVVANRASTVLLADRVALLERVGPDGATITHVGTHAELL MAV_1421|M.avium_104 ALREITCDATVIVVTQRVSIAATADQVVVIDD-----GKVAGAGTHDALL MUL_4010|M.ulcerans_Agy99 SLRELATKSAIIIVTQRVSTAAQADQVIVIDD-----GRVVGAGTHDSLL MAB_1415c|M.abscessus_ATCC_199 ALREVAADATVIVVAQRISTVADADQIVVLED-----GRVAATGTHAELT MLBr_01113|M.leprae_Br4923 ATHDLLQDRTSFIIAHHLPTIRDADHILVVAA-----GKIVEQGSHAKLL . : .:.:.: . **:: :: . : *: : Mb0200|M.bovis_AF2122/97 ERCPRYRELLSPAPDLADDLVVAERSPVCRPVAGLGTKAAQHTNVHNPGP Rv0194|M.tuberculosis_H37Rv ERCPRYRELLSPAPDLADDLVVAERSPVCRPVAGLGTKAAQHTNVHNPGP MMAR_5223|M.marinum_M GRCSRYRELLSPATDPLRSLAFEDGVPEPESEP-----EAIDVAADATGP Mflv_1747|M.gilvum_PYR-GCK AGVPEYRYLLAADDELDDGSERE---------------------CDWERD Mvan_5006|M.vanbaalenii_PYR-1 ANVPEYRYLLAADDELDDGSERE---------------------CDWEEQ MSMEG_5660|M.smegmatis_MC2_155 AEVPQYRYLLAADDELDDDTERT---------------------CEWEDD TH_2635|M.thermoresistible__bu ADVPQYRYLLAADPDLDDGAEPTPXXXVRAGTVATGSRSPTPTRCHPRRG MAV_1421|M.avium_104 TDCAVYAEFADSQSVGAVPSGHTGSTP----------------------- MUL_4010|M.ulcerans_Agy99 IDCPTYAEFAVSQSVTADIRGVS--------------------------- MAB_1415c|M.abscessus_ATCC_199 RRCGTYREICDSQAVFA--------------------------------- MLBr_01113|M.leprae_Br4923 ARRGAYYRMTQA-------------------------------------- * : . Mb0200|M.bovis_AF2122/97 HDHPPGPDPLRRLLREFRGPLALSLLLVAVQTCAGLLPPLLIRHGIDVGI Rv0194|M.tuberculosis_H37Rv HDHPPGPDPLRRLLREFRGPLALSLLLVAVQTCAGLLPPLLIRHGIDVGI MMAR_5223|M.marinum_M SDHSPKPDLLRRLLHDFRGPLIVSLLLVALETGAGLLPPLLIRHGIDVGI Mflv_1747|M.gilvum_PYR-GCK EERARL---------DHEVLDGDVREREMLERRS---------------- Mvan_5006|M.vanbaalenii_PYR-1 EERARL---------DRDEECARV-DHEVLGRRA---------------- MSMEG_5660|M.smegmatis_MC2_155 EDLERLR-----RVHDERAAIDGLDEPEYLGQEVQRR------------- TH_2635|M.thermoresistible__bu SRRCRSRPPAAPRRPPRRPTSSGCRPAPGRSRRIRHRADGRPGSSRRRSA MAV_1421|M.avium_104 -------------------------------------------------- MUL_4010|M.ulcerans_Agy99 -------------------------------------------------- MAB_1415c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01113|M.leprae_Br4923 -------------------------------------------------- Mb0200|M.bovis_AF2122/97 RRHVLSALWWAALAGTATVVIRWVVQWGSAMVAGYTGEQVLFRLRSVVFA Rv0194|M.tuberculosis_H37Rv RRHVLSALWWAALAGTATVVIRWVVQWGSAMVAGYTGEQVLFRLRSVVFA MMAR_5223|M.marinum_M RQHVLTALWWAALAGAAIVAIRLVAQWGSAVVAGTAGEKALFRLRSLVFA Mflv_1747|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_5006|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_5660|M.smegmatis_MC2_155 -------------------------------------------------- TH_2635|M.thermoresistible__bu GRRPSPSPRDSRGSDRGVPVAYTGYMSCSSRLVPVVSTTFAPMLSVQM-- MAV_1421|M.avium_104 -------------------------------------------------- MUL_4010|M.ulcerans_Agy99 -------------------------------------------------- MAB_1415c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01113|M.leprae_Br4923 -------------------------------------------------- Mb0200|M.bovis_AF2122/97 HAQRLGLDAFEDDGDAQIVTAVTADVEAIVAFLRTGLVVAVISVVTLVGI Rv0194|M.tuberculosis_H37Rv HAQRLGLDAFEDDGDAQIVTAVTADVEAIVAFLRTGLVVAVISVVTLVGI MMAR_5223|M.marinum_M HAQRLDLDAFEDNGDSQIITAVTADVDAIVAFLRTGLVIAIVSLVTAVGI Mflv_1747|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_5006|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_5660|M.smegmatis_MC2_155 -------------------------------------------------- TH_2635|M.thermoresistible__bu -------------------------------------------------- MAV_1421|M.avium_104 -------------------------------------------------- MUL_4010|M.ulcerans_Agy99 -------------------------------------------------- MAB_1415c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01113|M.leprae_Br4923 -------------------------------------------------- Mb0200|M.bovis_AF2122/97 LVALLAIRARLVLLIFTTMPVLALATWQFRRASNWTYRRARHRLGTVTAT Rv0194|M.tuberculosis_H37Rv LVALLAIRARLVLLIFTTMPVLALATWQFRRASNWTYRRARHRLGTVTAT MMAR_5223|M.marinum_M LAALLAINAKLALLIFATLPMLGLATWQFRRASSWTYRQARQRLGTVTAT Mflv_1747|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_5006|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_5660|M.smegmatis_MC2_155 -------------------------------------------------- TH_2635|M.thermoresistible__bu -------------------------------------------------- MAV_1421|M.avium_104 -------------------------------------------------- MUL_4010|M.ulcerans_Agy99 -------------------------------------------------- MAB_1415c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01113|M.leprae_Br4923 -------------------------------------------------- Mb0200|M.bovis_AF2122/97 LREYAAGLRIAQAFRAEYRGLQSYFAHSDDYRRLGVRGQRLLALYYPFVA Rv0194|M.tuberculosis_H37Rv LREYAAGLRIAQAFRAEYRGLQSYFAHSDDYRRLGVRGQRLLALYYPFVA MMAR_5223|M.marinum_M LREYSAGLRIAQAYRAEYVGFQTYFAHSDDYRRLRVRGQRLLALYFPLVP Mflv_1747|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_5006|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_5660|M.smegmatis_MC2_155 -------------------------------------------------- TH_2635|M.thermoresistible__bu -------------------------------------------------- MAV_1421|M.avium_104 -------------------------------------------------- MUL_4010|M.ulcerans_Agy99 -------------------------------------------------- MAB_1415c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01113|M.leprae_Br4923 -------------------------------------------------- Mb0200|M.bovis_AF2122/97 LLCSLATTLVLLDGAREVRAGVISVGALVTYLLYIELLYTPIGELAQMFD Rv0194|M.tuberculosis_H37Rv LLCSLATTLVLLDGAREVRAGVISVGALVTYLLYIELLYTPIGELAQMFD MMAR_5223|M.marinum_M LTCSLATTLVLFEGGRDVQAGVLSVGALVTYLLYVEMLFAPVDKLSQMFD Mflv_1747|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_5006|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_5660|M.smegmatis_MC2_155 -------------------------------------------------- TH_2635|M.thermoresistible__bu -------------------------------------------------- MAV_1421|M.avium_104 -------------------------------------------------- MUL_4010|M.ulcerans_Agy99 -------------------------------------------------- MAB_1415c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01113|M.leprae_Br4923 -------------------------------------------------- Mb0200|M.bovis_AF2122/97 DYQRAAVAAGRIRSLLSTRTPSSPAARPVGTLRGEVVFDAVHYSYRTREV Rv0194|M.tuberculosis_H37Rv DYQRAAVAAGRIRSLLSTRTPSSPAARPVGTLRGEVVFDAVHYSYRTREV MMAR_5223|M.marinum_M EYQRAAVAVGRIRSLLNTPTAFSPSAAPVGTLRGEIEFDAVHFRYPTRDA Mflv_1747|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_5006|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_5660|M.smegmatis_MC2_155 -------------------------------------------------- TH_2635|M.thermoresistible__bu -------------------------------------------------- MAV_1421|M.avium_104 -------------------------------------------------- MUL_4010|M.ulcerans_Agy99 -------------------------------------------------- MAB_1415c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01113|M.leprae_Br4923 -------------------------------------------------- Mb0200|M.bovis_AF2122/97 PALAGINLRIPAGQTVVFVGSTGSGKSTLIKLVARFYDPTHGTVRVDGCD Rv0194|M.tuberculosis_H37Rv PALAGINLRIPAGQTVVFVGSTGSGKSTLIKLVARFYDPTHGTVRVDGCD MMAR_5223|M.marinum_M PALAGINLRIPAGQTVVFVGSTGSGKSTLMKLVSRFYDPTDGIIRVDGCD Mflv_1747|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_5006|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_5660|M.smegmatis_MC2_155 -------------------------------------------------- TH_2635|M.thermoresistible__bu -------------------------------------------------- MAV_1421|M.avium_104 -------------------------------------------------- MUL_4010|M.ulcerans_Agy99 -------------------------------------------------- MAB_1415c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01113|M.leprae_Br4923 -------------------------------------------------- Mb0200|M.bovis_AF2122/97 LREFDVDGYRNRLGIVTQEQYVFAGTVRDAIAYGRPDATDAQVERAAREV Rv0194|M.tuberculosis_H37Rv LREFDVDGYRNRLGIVTQEQYVFAGTVRDAIAYGRPDATDAQVERAAREV MMAR_5223|M.marinum_M LREFDIDGYRSRLSIVAQEPYLFAGTVRDAIAYGRPDATDAQVERAAREV Mflv_1747|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_5006|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_5660|M.smegmatis_MC2_155 -------------------------------------------------- TH_2635|M.thermoresistible__bu -------------------------------------------------- MAV_1421|M.avium_104 -------------------------------------------------- MUL_4010|M.ulcerans_Agy99 -------------------------------------------------- MAB_1415c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01113|M.leprae_Br4923 -------------------------------------------------- Mb0200|M.bovis_AF2122/97 GAHPMITALDNGYLHQVTAGGRNLSAGQLQLLALARARLVDPDILLLDEA Rv0194|M.tuberculosis_H37Rv GAHPMITALDNGYLHQVTAGGRNLSAGQLQLLALARARLVDPDILLLDEA MMAR_5223|M.marinum_M GAHPMIAALDGGYQHEVAAGGRNLSAGQLQLLALARARLVDSDILLLDEA Mflv_1747|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_5006|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_5660|M.smegmatis_MC2_155 -------------------------------------------------- TH_2635|M.thermoresistible__bu -------------------------------------------------- MAV_1421|M.avium_104 -------------------------------------------------- MUL_4010|M.ulcerans_Agy99 -------------------------------------------------- MAB_1415c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01113|M.leprae_Br4923 -------------------------------------------------- Mb0200|M.bovis_AF2122/97 TVALDPATEAVVQRATLTLAARRTTLIVAHGLAIAEHADRIVVLEHGTVV Rv0194|M.tuberculosis_H37Rv TVALDPATEAVVQRATLTLAARRTTLIVAHGLAIAEHADRIVVLEHGTVV MMAR_5223|M.marinum_M TVALDPATEALVHWATLGLAADRTTLIIAHELAIAEFVDRIVVLEQGTIV Mflv_1747|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_5006|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_5660|M.smegmatis_MC2_155 -------------------------------------------------- TH_2635|M.thermoresistible__bu -------------------------------------------------- MAV_1421|M.avium_104 -------------------------------------------------- MUL_4010|M.ulcerans_Agy99 -------------------------------------------------- MAB_1415c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01113|M.leprae_Br4923 -------------------------------------------------- Mb0200|M.bovis_AF2122/97 EDGAHTELLAAGGHYSRLWAAHTRLCSPEITQLQCIDA------------ Rv0194|M.tuberculosis_H37Rv EDGAHTELLAAGGHYSRLWAAHTRLCSPEITQLQCIDA------------ MMAR_5223|M.marinum_M EDGTHVELLAAGGRYAALWAAHSRVGRPSPSDDRPIPTELLVHSPDTDVL Mflv_1747|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_5006|M.vanbaalenii_PYR-1 -------------------------------------------------- MSMEG_5660|M.smegmatis_MC2_155 -------------------------------------------------- TH_2635|M.thermoresistible__bu -------------------------------------------------- MAV_1421|M.avium_104 -------------------------------------------------- MUL_4010|M.ulcerans_Agy99 -------------------------------------------------- MAB_1415c|M.abscessus_ATCC_199 -------------------------------------------------- MLBr_01113|M.leprae_Br4923 --------------------------------------------------