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SVTDWRGRLQEEQDPNNDNLPIDESIPLRREARSLLISLLRPYRWIVAVLALVVIVENAARLSVPVLVQR GIDHGIPPILAGGPARELMVIVATLCAVVLVQATSRMFFLRRSGRVGQKVLLELRRRVFRHFQRLDLAFH DRYTSGRVVSRSTNDVEAIQDMLETGFDSLITAVLTLFGTAVLLVVLDWRLGLMCLAAFPILVALVWWFR NESARTYRKVRESAALVIVQFVETMTGIKAVQAYRREPRNQEIFSDIADDYREINEKTFKLLAIFMPGVK LVGNITTGVVLIYGGYRVLNDQMTIGTLAAFLLYLRMFFEPMQEISQFFNTFQSASSALEKLAGVLAQRP GIADPERPVALHAVAGTITFDHVHFAYAPGRPVLPDLTLTVPAGQTVALVGTTGAGKTTIAKLIARFYDP TSGTVTLDGVDLRDLSQSELRRHVVMVTQENFMFEGTVADNIRFGRPDATDAQVRAAAEAVGADRFIATL PEGYGTDVAKRGGRLSAGQRQLIAFARAFLADPAVLILDEATSSLDIPSERMVQRALETVLADRTALVIA HRLSTVQIADRVLVLEHGRIIEDGSPADLIGRTDGAYAALHRAWVDSLA*
Operon Prediction Model: Genebank
Paralogs
species | id | gene | e-value | identity (len) | annotation |
M. smegmatis MC2 155 | MSMEG_5659 | - | - | 100% (610) | ABC transporter, ATP-binding protein |
M. smegmatis MC2 155 | MSMEG_5009 | - | 7e-92 | 37.05% (475) | ABC transporter |
M. smegmatis MC2 155 | MSMEG_5008 | - | 6e-82 | 32.62% (561) | ABC transporter, ATP-binding protein |
Closest Orthologs (e-value cutoff: 1e-4)
species | id | gene | e-value | identity (len) | annotation |
M. bovis AF2122 / 97 | Mb0200 | - | 1e-107 | 39.97% (578) | drugs-transport transmembrane ATP-binding protein ABC transporter |
M. gilvum PYR-GCK | Mflv_1748 | - | 0.0 | 80.33% (610) | ABC transporter related |
M. tuberculosis H37Rv | Rv0194 | - | 1e-107 | 39.97% (578) | drugs-transport transmembrane ATP-binding protein ABC transporter |
M. leprae Br4923 | MLBr_01113 | - | 6e-88 | 35.85% (491) | putative ABC transporter, ATP-binding component |
M. abscessus ATCC 19977 | MAB_1414c | - | 7e-92 | 36.98% (484) | ABC transporter ATP-binding protein |
M. marinum M | MMAR_5223 | - | 1e-104 | 38.80% (598) | drug-transport transmembrane ATP-binding protein ABC transporter |
M. avium 104 | MAV_1420 | - | 6e-91 | 35.77% (548) | ABC transporter |
M. thermoresistible (build 8) | TH_3634 | - | 0.0 | 84.89% (503) | PUTATIVE ABC transporter, ATP-binding protein |
M. ulcerans Agy99 | MUL_4011 | - | 8e-92 | 36.64% (494) | transmembrane ATP-binding protein ABC transporter |
M. vanbaalenii PYR-1 | Mvan_5005 | - | 0.0 | 81.19% (606) | ABC transporter-related protein |
CLUSTAL 2.0.9 multiple sequence alignment MLBr_01113|M.leprae_Br4923 -------------------------------------------------- MUL_4011|M.ulcerans_Agy99 -------------------------------------------------- MAV_1420|M.avium_104 -------------------------------------------------- MAB_1414c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5659|M.smegmatis_MC2_155 -------------------------------------------------- TH_3634|M.thermoresistible__bu -------------------------------------------------- Mflv_1748|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_5005|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb0200|M.bovis_AF2122/97 MRTNCWWRLSGYVMRHRRDLLLGFGAALAGTVIAVLVPLVTKRVIDDAVA Rv0194|M.tuberculosis_H37Rv MRTNCWWRLSGYVMRHRRDLLLGFGAALAGTVIAVLVPLVTKRVIDDAIA MMAR_5223|M.marinum_M MRTNWWGRLSRYVLRYRRDLLLGLFASVVGTAITVMVPLVTKRVIDNAIA MLBr_01113|M.leprae_Br4923 -------------------------------------------------- MUL_4011|M.ulcerans_Agy99 -------------------------------------------------- MAV_1420|M.avium_104 -------------------------------------------------- MAB_1414c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5659|M.smegmatis_MC2_155 -------------------------------------------------- TH_3634|M.thermoresistible__bu -------------------------------------------------- Mflv_1748|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_5005|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb0200|M.bovis_AF2122/97 ADHRPLAPWAVVLVAAAGATYLLTYVRRYYGGRIAHLVQHDLRMDAFQAL Rv0194|M.tuberculosis_H37Rv ADHRPLAPWAVVLVAAAGATYLLMYVRRYYGGRIAHLVQHDLRMDAFQAL MMAR_5223|M.marinum_M PDHRPLAPWALVLVAAAVAIYFMTFVRRHYGGRIAHLVQHDLRVDAFATL MLBr_01113|M.leprae_Br4923 -------------------------------------------------- MUL_4011|M.ulcerans_Agy99 -------------------------------------------------- MAV_1420|M.avium_104 -------------------------------------------------- MAB_1414c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5659|M.smegmatis_MC2_155 -------------------------------------------------- TH_3634|M.thermoresistible__bu -------------------------------------------------- Mflv_1748|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_5005|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb0200|M.bovis_AF2122/97 LRWDGRQQDRWSSGQLIVRTTNDLQLVQALLFDVPNVLRHVLTLLLGVAV Rv0194|M.tuberculosis_H37Rv LRWDGRQQDRWSSGQLIVRTTNDLQLVQALLFDVPNVLRHVLTLLLGVAV MMAR_5223|M.marinum_M MRWDGRQQDRWSSGQLIVRTTNDLELVQTLLFDLPNVIRHLLTLLLCLAV MLBr_01113|M.leprae_Br4923 -------------------------------------------------- MUL_4011|M.ulcerans_Agy99 -------------------------------------------------- MAV_1420|M.avium_104 -------------------------------------------------- MAB_1414c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5659|M.smegmatis_MC2_155 -------------------------------------------------- TH_3634|M.thermoresistible__bu -------------------------------------------------- Mflv_1748|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_5005|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb0200|M.bovis_AF2122/97 MTWLSVPLALLAVLLVPVIGLIAHRSRRLLAAATHCAQEHKAAVTGVVDA Rv0194|M.tuberculosis_H37Rv MTWLSVPLALLAVLLVPVIGLIAHRSRRLLAAATHCAQEHKAAVTGVVDA MMAR_5223|M.marinum_M MAWLSLPLALLVVLLVPLIGLVAHRSRRLLAVATEAAQERNAVVTGVVDA MLBr_01113|M.leprae_Br4923 -------------------------------------------------- MUL_4011|M.ulcerans_Agy99 -------------------------------------------------- MAV_1420|M.avium_104 -------------------------------------------------- MAB_1414c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5659|M.smegmatis_MC2_155 -------------------------------------------------- TH_3634|M.thermoresistible__bu -------------------------------------------------- Mflv_1748|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_5005|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb0200|M.bovis_AF2122/97 AVCGIRVVKAFGQEERETVKLVMASRALYAAQLRVARLNAHFGPLLQTLP Rv0194|M.tuberculosis_H37Rv AVCGIRVVKAFGQEERETVKLVTASRALYAAQLRVARLNAHFGPLLQTLP MMAR_5223|M.marinum_M AVSGIHVVKAFGQQSQETVKLTTAGRALYAARVRVARLNAYFGPLLQSLP MLBr_01113|M.leprae_Br4923 -------------------------------------------------- MUL_4011|M.ulcerans_Agy99 -------------------------------------------------- MAV_1420|M.avium_104 -------------------------------------------------- MAB_1414c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5659|M.smegmatis_MC2_155 -------------------------------------------------- TH_3634|M.thermoresistible__bu -------------------------------------------------- Mflv_1748|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_5005|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb0200|M.bovis_AF2122/97 ALGQMAVFALGGWMAAQGSITVGTFVAFWACLTLLARPACDLAGMLTIAQ Rv0194|M.tuberculosis_H37Rv ALGQMAVFALGGWMAAQGSITVGTFVAFWACLTLLARPACDLAGMLTIAQ MMAR_5223|M.marinum_M AFGQMAVLAVGGWMAAQGTITVGTFVAFWSCLTLVSRPACDLAGMLTIAQ MLBr_01113|M.leprae_Br4923 -------------------------------------------------- MUL_4011|M.ulcerans_Agy99 -------------------------------------------------- MAV_1420|M.avium_104 -------------------------------------------------- MAB_1414c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5659|M.smegmatis_MC2_155 -------------------------------------------------- TH_3634|M.thermoresistible__bu -------------------------------------------------- Mflv_1748|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_5005|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb0200|M.bovis_AF2122/97 QARAGAVRVLELIDSRPTLVDGTKPLSLEARLSLEFQRVSFGYVADRPVL Rv0194|M.tuberculosis_H37Rv QARAGAVRVLELIDSRPTLVDGTKPLSPEARLSLEFQRVSFGYVADRPVL MMAR_5223|M.marinum_M QARTGAMRVFELIDSRPTLVDGTKQLPSSTPVSLAFEQASFGYAAEHPVL MLBr_01113|M.leprae_Br4923 -------------------------------------------------- MUL_4011|M.ulcerans_Agy99 -------------------------------------------------- MAV_1420|M.avium_104 -------------------------------------------------- MAB_1414c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5659|M.smegmatis_MC2_155 -------------------------------------------------- TH_3634|M.thermoresistible__bu -------------------------------------------------- Mflv_1748|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_5005|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb0200|M.bovis_AF2122/97 REISLSVRAGETLAVVGAPGSGKSTLASLATRCYDVTQGAVRIGGQDVRE Rv0194|M.tuberculosis_H37Rv REISLSVRAGETLAVVGAPGSGKSTLASLATRCYDVTQGAVRIGGQDVRE MMAR_5223|M.marinum_M RGIDLSVRPGETLAVVGPPGSGKSTLALLAMRCYDVTAGAVRVGGHDVRD MLBr_01113|M.leprae_Br4923 -------------------------------------------------- MUL_4011|M.ulcerans_Agy99 -------------------------------------------------- MAV_1420|M.avium_104 -------------------------------------------------- MAB_1414c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5659|M.smegmatis_MC2_155 -------------------------------------------------- TH_3634|M.thermoresistible__bu -------------------------------------------------- Mflv_1748|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_5005|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb0200|M.bovis_AF2122/97 LTLDSLRSAIGLVPEDAVLFSGTIGANIAYGRPDATPEQIATAARAAHIE Rv0194|M.tuberculosis_H37Rv LTLDSLRSAIGLVPEDAVLFSGTIGANIAYGRPDATPEQIATAARAAHIE MMAR_5223|M.marinum_M LTLDSLRSAIGLVPEQAILFSGTIGENISYGRSNVTLEQITAAARAAHID MLBr_01113|M.leprae_Br4923 -------------------------------------------------- MUL_4011|M.ulcerans_Agy99 -------------------------------------------------- MAV_1420|M.avium_104 -------------------------------------------------- MAB_1414c|M.abscessus_ATCC_199 -------------------------------------------------- MSMEG_5659|M.smegmatis_MC2_155 -------------------------------------------------- TH_3634|M.thermoresistible__bu -------------------------------------------------- Mflv_1748|M.gilvum_PYR-GCK -------------------------------------------------- Mvan_5005|M.vanbaalenii_PYR-1 -------------------------------------------------- Mb0200|M.bovis_AF2122/97 EFVNTLPDGYQTAVGARGLTLSGGQRQRIALARALLHQPRLLIMDDPTSA Rv0194|M.tuberculosis_H37Rv EFVNTLPDGYQTAVGARGLTLSGGQRQRIALARALLHQPRLLIMDDPTSA MMAR_5223|M.marinum_M EFVNTLPDGYATPVGAQGLTLSGGQRQRIALARALVGNPRLLIMDEPTSA MLBr_01113|M.leprae_Br4923 --------MTMAT-------APA-TRSCDFYCTIRRLLKQLVPQRRLS-- MUL_4011|M.ulcerans_Agy99 --------MTAALNQRPRGGAPAPTRSRDFWGSATRLVKRLAPQRRRS-- MAV_1420|M.avium_104 --------MTTTTRPAPP--APA-GRSRDFWGSAARLVKQLAPQRRTA-- MAB_1414c|M.abscessus_ATCC_199 --------MTRAIGFRGVQQGPA-ERSRDFRGTAIRMVKRLAPQRFLT-- MSMEG_5659|M.smegmatis_MC2_155 -------------------------------MSVTDWRGRLQE------- TH_3634|M.thermoresistible__bu -------------------------------------------------- Mflv_1748|M.gilvum_PYR-GCK -------------------------------MTETNWRGKFDE------- Mvan_5005|M.vanbaalenii_PYR-1 ------------------------------MSADGEWRGKYDE------- Mb0200|M.bovis_AF2122/97 VDAVIECGIQEVLREAIADRTAVIFTRRRSMLTLADRVAVLDSGRLLDVG Rv0194|M.tuberculosis_H37Rv VDAVIECGIQEVLREAIADRTAVIFTRRRSMLTLADRVAVLDSGRLLDVG MMAR_5223|M.marinum_M VDAVIEASIQDVLREVLADRTAVIFTRRRSMLSLADRVAVLDSGHLLDIG MLBr_01113|M.leprae_Br4923 ---------------LTVITLGITGTAIGIIVPWVLGHTT---------- MUL_4011|M.ulcerans_Agy99 ---------------LAVIALGIVGTAIGVAVPRILGHAA---------- MAV_1420|M.avium_104 ---------------IAVITLGIAGTVIGVMVPRILGHAT---------- MAB_1414c|M.abscessus_ATCC_199 ---------------ATVITLSMIGIAIGVIGPRILGHAT---------- MSMEG_5659|M.smegmatis_MC2_155 -----------------EQDPNNDNLPIDESIPLRREAR----------- TH_3634|M.thermoresistible__bu -------------------------------------------------- Mflv_1748|M.gilvum_PYR-GCK -----------------SAD-----LPIDETVPRQREAR----------- Mvan_5005|M.vanbaalenii_PYR-1 -----------------HTD-----LPIDETVPRRREAR----------- Mb0200|M.bovis_AF2122/97 TPDEVWERCPRYRELLSPAPDLADDLVVAERSPVCRPVAGLGTKAAQHTN Rv0194|M.tuberculosis_H37Rv TPDEVWERCPRYRELLSPAPDLADDLVVAERSPVCRPVAGLGTKAAQHTN MMAR_5223|M.marinum_M TPEQLWGRCSRYRELLSPATDPLRSLAFEDGVPEPESEP-----EAIDVA MLBr_01113|M.leprae_Br4923 ------------DLLFNGVIGRQLPKGISKTQAVAAARTRGDNALADLLS MUL_4011|M.ulcerans_Agy99 ------------DLLFNGVIGRQLPAGITKAQAIAGARARGDNTFAELLS MAV_1420|M.avium_104 ------------DLLFNGVVGRQLPAGISKAQAVAAARSRGQNTFADLLS MAB_1414c|M.abscessus_ATCC_199 ------------DLLFNGVIGRQLPAGQSREQAVETARARGDGQFAQMLS MSMEG_5659|M.smegmatis_MC2_155 -------------SLLISLLRPYRWIVAVLALVVIVENAARLSVPVLVQR TH_3634|M.thermoresistible__bu -------------------------------------------------- Mflv_1748|M.gilvum_PYR-GCK -------------ALLGSLLRPYRWAVVLLAVVVVVENAARLSVPILVQK Mvan_5005|M.vanbaalenii_PYR-1 -------------SLLYLLLRPYRWVVLALAVVVVVENAARLSVPLLVQK Mb0200|M.bovis_AF2122/97 VHNPGPHDHPPGPDPLRRLLREFRGPLALSLLLVAVQTCAGLLPPLLIRH Rv0194|M.tuberculosis_H37Rv VHNPGPHDHPPGPDPLRRLLREFRGPLALSLLLVAVQTCAGLLPPLLIRH MMAR_5223|M.marinum_M ADATGPSDHSPKPDLLRRLLHDFRGPLIVSLLLVALETGAGLLPPLLIRH MLBr_01113|M.leprae_Br4923 GMNLVPG---QGVDFVAVGRTLGLALSLYLVYTLLTWAQARLLNVTVQRI MUL_4011|M.ulcerans_Agy99 GMKVTPG---QGVDFGAVVRTLALALALYLIASLLIWGQARLLNVTVQRT MAV_1420|M.avium_104 GMNVVPG---RGVDFGAVARTLALALLLYLVSALLIWVQARLLNRTVQRT MAB_1414c|M.abscessus_ATCC_199 GMNVIPG---QGVDFHAIGMTLALALSLYLIAGMLAWVQARLLNVTVQRT MSMEG_5659|M.smegmatis_MC2_155 GIDHGIPPILAGGPARELMVIVATLCAVVLVQATSRMFFLRRSGRVGQKV TH_3634|M.thermoresistible__bu ------------------------------------MYFLRRSGRIGQEV Mflv_1748|M.gilvum_PYR-GCK GIDDGIPPLLEGGPAITLMTIVATLCGVVVVQAVGRMYFLRRSGRIGQKV Mvan_5005|M.vanbaalenii_PYR-1 GIDDGIPPLLAGERATTLLTIVAALCGVVVVQACSRMYFLRRSGRIGQKV Mb0200|M.bovis_AF2122/97 GIDVGIR----RHVLSALWWAALAGTATVVIRWVVQWGSAMVAGYTGEQV Rv0194|M.tuberculosis_H37Rv GIDVGIR----RHVLSALWWAALAGTATVVIRWVVQWGSAMVAGYTGEQV MMAR_5223|M.marinum_M GIDVGIR----QHVLTALWWAALAGAAIVAIRLVAQWGSAVVAGTAGEKA . :. MLBr_01113|M.leprae_Br4923 MFALRSDVEDKVHRLPLSYCDTRQRGELLSRVTNDIDNLQSSLSITLSQL MUL_4011|M.ulcerans_Agy99 VAALRADVEHKLHRLPLSYFDGRQRGELLSRVTNDIDNIQSSLSMTISQL MAV_1420|M.avium_104 MVALRSAVEDKVHRLPLAYFDGRQRGELLSRVTNDIDNIQSSLSMTISQL MAB_1414c|M.abscessus_ATCC_199 VVALRTEVENKIHRLPLSYFDSRQRGEILSRVTNDVDNIQTSLQMSINQL MSMEG_5659|M.smegmatis_MC2_155 LLELRRRVFRHFQRLDLAFHDRYTSGRVVSRSTNDVEAIQDMLETGFDSL TH_3634|M.thermoresistible__bu LLELRRRLFRHFQRLDVAFHERYTSGRVVSRSTNDVEAIQDMLETGFDSL Mflv_1748|M.gilvum_PYR-GCK LLELRRRVFRHFGRLDIAFHDRYTSGRVVSRSTNDVEAIQDMLETGFDSL Mvan_5005|M.vanbaalenii_PYR-1 LLELRRRVFRHFGRLDIAFHDRYTSGRVVSRSTNDVEAIQDMLETGFDSL Mb0200|M.bovis_AF2122/97 LFRLRSVVFAHAQRLGLDAFEDDGDAQIVTAVTADVEAIVAFLRTGLVVA Rv0194|M.tuberculosis_H37Rv LFRLRSVVFAHAQRLGLDAFEDDGDAQIVTAVTADVEAIVAFLRTGLVVA MMAR_5223|M.marinum_M LFRLRSLVFAHAQRLDLDAFEDNGDSQIITAVTADVDAIVAFLRTGLVIA : ** : : ** : : ..::: * *:: : * : MLBr_01113|M.leprae_Br4923 LTSLLTVVAVLVVMVSVSPLLALVALLTVPMSLLATRAIAQRSQQLFVAQ MUL_4011|M.ulcerans_Agy99 VTAILTVVAVLSMMVWISPLLALITLLTVPLSLLVTRAITRRSQRLFVAH MAV_1420|M.avium_104 LTSVLTVLTVLAMMLSISPLLAGITLLTVPLSLLATRVIVRRSQRLFVAQ MAB_1414c|M.abscessus_ATCC_199 LSSMLTLVAVLAMMLSISPLLAVITLATVPLSLWVTRTIARRSQRLFVAQ MSMEG_5659|M.smegmatis_MC2_155 ITAVLTLFGTAVLLVVLDWRLGLMCLAAFPILVALVWWFRNESARTYRKV TH_3634|M.thermoresistible__bu ITAVLTLGGTAILLVTLDVRLGLMCLGAFPVLIALVWWFREESAKTYRKV Mflv_1748|M.gilvum_PYR-GCK ITAVLTMVGTAVLLVVLDVKLGLMCLVAFPVLVLLVWWFQRESSKTYREV Mvan_5005|M.vanbaalenii_PYR-1 ITAVLTLVGTAVLLVVLDVKLGLMCLAAFPILVLLVMWFRRESSKTYREV Mb0200|M.bovis_AF2122/97 VISVVTLVGILVALLAIRARLVLLIFTTMPVLALATWQFRRASNWTYRRA Rv0194|M.tuberculosis_H37Rv VISVVTLVGILVALLAIRARLVLLIFTTMPVLALATWQFRRASNWTYRRA MMAR_5223|M.marinum_M IVSLVTAVGILAALLAINAKLALLIFATLPMLGLATWQFRRASSWTYRQA : :::* :: : * : : :.*: . : . * : MLBr_01113|M.leprae_Br4923 WTSAGRLNAHIEETYSGLTVVKTFGHQTAAREQFRNVNNDVYQASFSAQF MUL_4011|M.ulcerans_Agy99 WTSTGRLNAHIEETYSGFTVVKTFGHQAAAREQFHNLNDDVYQASFGAQL MAV_1420|M.avium_104 WTSVGRLNAHIEETYSGFTVVQTFGHRAAARDRFRALNDEVYRASFGAQF MAB_1414c|M.abscessus_ATCC_199 WANTGKLNAHIEETYSGFTIVKTYGHRAEAEAIFADRNAEVYRSAFGAQF MSMEG_5659|M.smegmatis_MC2_155 RESAALVIVQFVETMTGIKAVQAYRREPRNQEIFSDIADDYREINEKTFK TH_3634|M.thermoresistible__bu RESAALVIVQFVETMTGIKAVQAYRREPRNQEIFEQVADDYREINEKTLR Mflv_1748|M.gilvum_PYR-GCK REISALVIVQFVETMTGIKAVQAYRREPRNQQIFEDVADRYREINERTFK Mvan_5005|M.vanbaalenii_PYR-1 REISALVIVQFVETMTGIKAVQAYRREPRNQQIFEDIADRYRVINEKTFK Mb0200|M.bovis_AF2122/97 RHRLGTVTATLREYAAGLRIAQAFRAEYRGLQSYFAHSDDYRRLGVRGQR Rv0194|M.tuberculosis_H37Rv RHRLGTVTATLREYAAGLRIAQAFRAEYRGLQSYFAHSDDYRRLGVRGQR MMAR_5223|M.marinum_M RQRLGTVTATLREYSAGLRIAQAYRAEYVGFQTYFAHSDDYRRLRVRGQR . : . : * :*: .::: . : MLBr_01113|M.leprae_Br4923 FSGLVSPATMFISNLGYVVVAALGGLQVATGHITLGNIQAFIQYVRQFNM MUL_4011|M.ulcerans_Agy99 LSALVQPATTFIGNLGYVAVAVMGGLQVATGQITLGSVQAFIQYVRQFNT MAV_1420|M.avium_104 FSGLVAPATAVIGNLGYAAVAVLGGLQVATGQITLGNIQAFIQYVRQFNS MAB_1414c|M.abscessus_ATCC_199 FSGLVSPATAFVGNLSYVAVAVVGGLKVASGGLTLGSIQAFSQYVRQFNQ MSMEG_5659|M.smegmatis_MC2_155 LLAIFMPGVKLVGNITTGVVLIYGGYRVLNDQMTIGTLAAFLLYLRMFFE TH_3634|M.thermoresistible__bu LLAIFMPGVRLVGNITTGVVLLYGGYLVLNDQMTIGTLTAFLLYLRMFFE Mflv_1748|M.gilvum_PYR-GCK LLAVFMPGVKLVGNLTTGVVLLYGGYRALHGEMTIGTLTAFLLYLRMFFE Mvan_5005|M.vanbaalenii_PYR-1 LLAVFMPGVKLVGNLTTGVVLLYGGYRVLHGEMTIGTLAAFLLYLRMFFE Mb0200|M.bovis_AF2122/97 LLALYYPFVALLCSLATTLVLLDGAREVRAGVISVGALVTYLLYIELLYT Rv0194|M.tuberculosis_H37Rv LLALYYPFVALLCSLATTLVLLDGAREVRAGVISVGALVTYLLYIELLYT MMAR_5223|M.marinum_M LLALYFPLVPLTCSLATTLVLFEGGRDVQAGVLSVGALVTYLLYVEMLFA : .: * . . .: * *. . . :::* : :: *:. : MLBr_01113|M.leprae_Br4923 PLSQVAGIYNTLQSGLASAERVFDLLDEPEELPDPMLALPPPH----GQV MUL_4011|M.ulcerans_Agy99 PVSQVAAMYNSLQSGVASAERVFELLDEPEEAADPASALQPPVS-RTGRA MAV_1420|M.avium_104 PLSQLAGMYNTLQSGVASAERVFALLDEPEEPPDAPPEEKPTAPGPAGRD MAB_1414c|M.abscessus_ATCC_199 PLTQVAAMYNTLQSGLASAERVFELLDADEETPDPLAAATAPTG------ MSMEG_5659|M.smegmatis_MC2_155 PMQEISQFFNTFQSASSALEKLAGVLAQRPGIADPE---RPVA------L TH_3634|M.thermoresistible__bu PMQEISQFFNTFQSAASALEKLAGVLAEEPAIKDPQ---HPVSP-----A Mflv_1748|M.gilvum_PYR-GCK PMQEISQFFNTFQSASSALEKLAGVLAEKPGISDPA---KPVR------V Mvan_5005|M.vanbaalenii_PYR-1 PMQEISQFFNTFQSAASALEKLAGVLAEKPGISDPP---HPVA------L Mb0200|M.bovis_AF2122/97 PIGELAQMFDDYQRAAVAAGRIRSLLSTRTPSSPAA---RPVG------- Rv0194|M.tuberculosis_H37Rv PIGELAQMFDDYQRAAVAAGRIRSLLSTRTPSSPAA---RPVG------- MMAR_5223|M.marinum_M PVDKLSQMFDEYQRAAVAVGRIRSLLNTPTAFSPSA---APVG------- *: ::: ::: * . : :: :* . . MLBr_01113|M.leprae_Br4923 PRINGRVEFQQVSFAYRT-GTPVIDDLSMVVEPGSTVAIVGPTGAGKTTL MUL_4011|M.ulcerans_Agy99 PALTGRVEFERVNFAYHP-GHPVIHDLSLVAEPGSTVAIVGPTGAGKTTL MAV_1420|M.avium_104 AGGGGRVEFAHVSFAYRP-GIRVIDDLSLVAEPGSTVAIVGPTGAGKTTL MAB_1414c|M.abscessus_ATCC_199 ---SVRVEFEDISFGYSP-GQPVIEGLSLRVEPGQTVAIVGPTGAGKTTL MSMEG_5659|M.smegmatis_MC2_155 HAVAGTITFDHVHFAYAP-GRPVLPDLTLTVPAGQTVALVGTTGAGKTTI TH_3634|M.thermoresistible__bu RPVRGEIAFHGVQFAYVP-GRPVIPELTLTVPAGQTVALVGTTGAGKTTI Mflv_1748|M.gilvum_PYR-GCK DEVRGEVALLDVHFAYVP-GRPVLPGLDLVIPAGQTVALVGTTGAGKTTI Mvan_5005|M.vanbaalenii_PYR-1 GEVRGEIALRDLTFEYVP-GRPVLPGLDLVIPAGQTVALVGTTGAGKTTI Mb0200|M.bovis_AF2122/97 -TLRGEVVFDAVHYSYRTREVPALAGINLRIPAGQTVVFVGSTGSGKSTL Rv0194|M.tuberculosis_H37Rv -TLRGEVVFDAVHYSYRTREVPALAGINLRIPAGQTVVFVGSTGSGKSTL MMAR_5223|M.marinum_M -TLRGEIEFDAVHFRYPTRDAPALAGINLRIPAGQTVVFVGSTGSGKSTL : : : : * . .: : : .*.**.:**.**:**:*: MLBr_01113|M.leprae_Br4923 VNLLMRFYDVDSGQILIDGVDITTVSRHALRSRIGMVLQDAWLFDGTIAE MUL_4011|M.ulcerans_Agy99 VNLLMRFYEVDSGRILVDGIDITTVSRQSLRSHIGMVLQDTWLFDGTISE MAV_1420|M.avium_104 VNLLMRFYDVDAGRISIDGVDIATMDRRALRSRIGMVLQDTWLFDGTIAE MAB_1414c|M.abscessus_ATCC_199 VNLLMRFYEVDSGRILLDGIDVSTMTRHDLRSRMGMVLQDTWLFGGTIVE MSMEG_5659|M.smegmatis_MC2_155 AKLIARFYDPTSGTVTLDGVDLRDLSQSELRRHVVMVTQENFMFEGTVAD TH_3634|M.thermoresistible__bu ATLIARFYDPTAGSVTLDGIDLRDIAQSELRRHVVMVTQENFMFDGTVAD Mflv_1748|M.gilvum_PYR-GCK AKLITRFYDPGSGTVSLDGVDLRDMSQADLRRHVVMVTQENFMFGGTIAD Mvan_5005|M.vanbaalenii_PYR-1 AKLITRFYDPVAGTVMLDEIDLRDVAQAELRRHVVMVTQENFMFGGTVAD Mb0200|M.bovis_AF2122/97 IKLVARFYDPTHGTVRVDGCDLREFDVDGYRNRLGIVTQEQYVFAGTVRD Rv0194|M.tuberculosis_H37Rv IKLVARFYDPTHGTVRVDGCDLREFDVDGYRNRLGIVTQEQYVFAGTVRD MMAR_5223|M.marinum_M MKLVSRFYDPTDGIIRVDGCDLREFDIDGYRSRLSIVAQEPYLFAGTVRD .*: ***: * : :* *: . * :: :* *: ::* **: : MLBr_01113|M.leprae_Br4923 NIAYGRPQASEDEVMEAAKAAYVDRFVHTLSAGYQTRVSGDGDNISAGEK MUL_4011|M.ulcerans_Agy99 NIAYGRPEASPDDIIQAAKAAYVDRFVHMLPASYQTRISGDGSNISAGEK MAV_1420|M.avium_104 NIGYGRPGAGDDEIVAAARAAYVDRFVQNLPDGYHTRVSGDGGNLSAGER MAB_1414c|M.abscessus_ATCC_199 NIAYGRPGASQEEILEAARAAYVDRFVRTLPDGYDTKIADDGGNISAGEK MSMEG_5659|M.smegmatis_MC2_155 NIRFGRPDATDAQVRAAAEAVGADRFIATLPEGYGTDVAKRGGRLSAGQR TH_3634|M.thermoresistible__bu NIRFGRPEATDAEIAAAAEAVGADRFIAALPDGYHTDVAKRGSRLSAGQR Mflv_1748|M.gilvum_PYR-GCK NIRFGRPGATDDEVRAAARAVGAHTFIDVLPDGYDTDVAKRGGRLSAGQR Mvan_5005|M.vanbaalenii_PYR-1 NIRFGRPDATDDEVRAAARAVGAHTFIGALPDGYDTDVAKRGGRLSAGQR Mb0200|M.bovis_AF2122/97 AIAYGRPDATDAQVERAAREVGAHPMITALDNGYLHQVTAGGRNLSAGQL Rv0194|M.tuberculosis_H37Rv AIAYGRPDATDAQVERAAREVGAHPMITALDNGYLHQVTAGGRNLSAGQL MMAR_5223|M.marinum_M AIAYGRPDATDAQVERAAREVGAHPMIAALDGGYQHEVAAGGRNLSAGQL * :*** * :: **. . .. :: * .* :: * .:***: MLBr_01113|M.leprae_Br4923 QLITIARAFLARPQLLILDEATSSIDTRTEALIARATHDLLQDRTSFIIA MUL_4011|M.ulcerans_Agy99 QLITIARAFLARPQLLILDEATSSVDTRTELLIARATAELRRDRTSFIIA MAV_1420|M.avium_104 QLITIARAFLARPQLLILDEATSSVDTRTEALIAHATRELRRDRTSFIIA MAB_1414c|M.abscessus_ATCC_199 QLITIARAFLARPQLLILDEATSSVDTRTELRIQRAMAELRRDRTSFIIA MSMEG_5659|M.smegmatis_MC2_155 QLIAFARAFLADPAVLILDEATSSLDIPSERMVQRALETVLADRTALVIA TH_3634|M.thermoresistible__bu QLIAFARAFLADPAVLILDEATSALDIPSERMVQRALRTVLADRTALVIA Mflv_1748|M.gilvum_PYR-GCK QLVAFARAFLADPAVLILDEATSSLDIPSERLVQRALETVLADRTAVVIA Mvan_5005|M.vanbaalenii_PYR-1 QLVAFARAFLADPAVLILDEATSSLDIPSERMVQRALETVLADRTAVVIA Mb0200|M.bovis_AF2122/97 QLLALARARLVDPDILLLDEATVALDPATEAVVQRATLTLAARRTTLIVA Rv0194|M.tuberculosis_H37Rv QLLALARARLVDPDILLLDEATVALDPATEAVVQRATLTLAARRTTLIVA MMAR_5223|M.marinum_M QLLALARARLVDSDILLLDEATVALDPATEALVHWATLGLAADRTTLIIA **:::*** *. . :*:***** ::* :* : * : **:.::* MLBr_01113|M.leprae_Br4923 HHLPTIRDADHILVVAAGKIVEQGSHAKLLARRGAYYRMTQA-------- MUL_4011|M.ulcerans_Agy99 HRLSTIRDADQILVVQAGQIVEHGTHAELLANRGAYYAMTRA-------- MAV_1420|M.avium_104 HRLSTIRDADRIAVIEAGRIFEQGTHAELLARRGVYYAMTQA-------- MAB_1414c|M.abscessus_ATCC_199 HRLSTIRDADRIVVLDGGRVTESGTHTELLARHGAYFAMTQS-------- MSMEG_5659|M.smegmatis_MC2_155 HRLSTVQIADRVLVLEHGRIIEDGSPADLIGRTDGAYAALHRAWVDSLA- TH_3634|M.thermoresistible__bu HRLSTVEIADRVLVLERGRVVEDGPPGELIRRGEGRYAALHHAWLESLG- Mflv_1748|M.gilvum_PYR-GCK HRLSTVQIADRVLVLEHGRIVEDGPPEELTAREGGHYAALHRSWVQSLA- Mvan_5005|M.vanbaalenii_PYR-1 HRLSTVQIADRVLVLEHGRIVEDGAPDELTARDHGHYAALHRSWVQSLA- Mb0200|M.bovis_AF2122/97 HGLAIAEHADRIVVLEHGTVVEDGAHTELLAAG-GHYSRLWAAHTRLCSP Rv0194|M.tuberculosis_H37Rv HGLAIAEHADRIVVLEHGTVVEDGAHTELLAAG-GHYSRLWAAHTRLCSP MMAR_5223|M.marinum_M HELAIAEFVDRIVVLEQGTIVEDGTHVELLAAG-GRYAALWAAHSRVGRP * *. . .*:: *: * : * *. .* : MLBr_01113|M.leprae_Br4923 ---------------------- MUL_4011|M.ulcerans_Agy99 ---------------------- MAV_1420|M.avium_104 ---------------------- MAB_1414c|M.abscessus_ATCC_199 ---------------------- MSMEG_5659|M.smegmatis_MC2_155 ---------------------- TH_3634|M.thermoresistible__bu ---------------------- Mflv_1748|M.gilvum_PYR-GCK ---------------------- Mvan_5005|M.vanbaalenii_PYR-1 ---------------------- Mb0200|M.bovis_AF2122/97 EITQLQCIDA------------ Rv0194|M.tuberculosis_H37Rv EITQLQCIDA------------ MMAR_5223|M.marinum_M SPSDDRPIPTELLVHSPDTDVL