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MVFTETLLLLAADGEPPGLLPARQQMAFSLGWHIVLACFGVAFPTMIFVVHRRGIVRDDAVALGLAQRWA KVSAVLFAIGAVSGTVLSFEMGLLWPGLMGRFGDVLGLPFAFEGLSFFVEAIFLGIYLYGWGRMPPRRHL LTLIPMGLAGIVGTFCVVSVNAWMNNPAGFRIVNGEVVDIDPWRAMFNSGVWLQFAHMWVAAFMLVGLVV SGVYAFGMLRGRVDTHHRLGFAVPFTFASVAAVAQPLIGHVLGMRIHDTQPAKLAAFELAQTTEGPAPLR LGGVLIDGEVHWALTIPRLGSIIARNSLDAPVPGLDGVPRSDWPPVNITHLAFQSMVGIGTLLAAVAVVY WLARWRGRDLLANRWFLRLSVITGPLAVLAVESGWVATEVGRQPWTVWKVLTTTEAASQSSGLWWSYVIV LVVYLGMTIGAVVVLRSMARRWRAGETDLPSPYGPPRTEARS
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5605 | - | - | 100% (462) | cytochrome bd ubiquinol oxidase, subunit I |
| M. smegmatis MC2 155 | MSMEG_3233 | - | 1e-33 | 27.83% (406) | cytochrome D ubiquinol oxidase subunit 1 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1649c | cydA | 1e-32 | 26.05% (403) | integral membrane cytochrome D ubiquinol oxidase (subunit I) |
| M. gilvum PYR-GCK | Mflv_3585 | - | 4e-33 | 25.41% (484) | cytochrome bd ubiquinol oxidase, subunit I |
| M. tuberculosis H37Rv | Rv1623c | cydA | 1e-32 | 26.05% (403) | integral membrane cytochrome D ubiquinol oxidase (subunit I) |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_2630 | - | 3e-36 | 27.43% (401) | integral membrane cytochrome D ubiquinol oxidase (subunit I) |
| M. marinum M | MMAR_2426 | cydA | 2e-32 | 26.54% (407) | integral membrane cytochrome D ubiquinol oxidase (subunit I) |
| M. avium 104 | MAV_3164 | - | 1e-29 | 26.60% (406) | cytochrome D ubiquinol oxidase subunit 1 |
| M. thermoresistible (build 8) | TH_1290 | appC | 6e-35 | 27.16% (405) | Probable integral membrane cytochrome D ubiquinol oxidase |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_2830 | - | 7e-35 | 25.79% (473) | cytochrome bd ubiquinol oxidase, subunit I |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1649c|M.bovis_AF2122/97 ---------------MNVVDISRWQFGITTVYHFIFVPLTIGLAPLIAVM
Rv1623c|M.tuberculosis_H37Rv ---------------MNVVDISRWQFGITTVYHFIFVPLTIGLAPLIAVM
MMAR_2426|M.marinum_M ---------------MNVVDVSRWQFGITTVYHFIFVPLTIGLAPLLAIM
MAV_3164|M.avium_104 ---------------MNVVDISRWQFGIVTVYHFIFVPLTIGLAPLLAIM
Mflv_3585|M.gilvum_PYR-GCK ---------------MDALDVSRWQFGITTVYHFIFVPLTIGLAPLIAVM
Mvan_2830|M.vanbaalenii_PYR-1 ---------------MDALDVSRWQFGITTVYHFIFVPLTIGLAPLIAIM
TH_1290|M.thermoresistible__bu ---------------MDALDLSRWQFGITTVYHFIFVPLTIGLAPILAAM
MAB_2630|M.abscessus_ATCC_1997 ---------------MNALDVSRWQFGITTVYHFILVPLTIGLAPLIAIM
MSMEG_5605|M.smegmatis_MC2_155 MVFTETLLLLAADGEPPGLLPARQQMAFSLGWHIVLACFGVAFPTMIFVV
: :* *:.: :*:::. : :.:..:: :
Mb1649c|M.bovis_AF2122/97 QTLWVVTDNPAWYRLTKFFGKLFLINFAIGVATGIVQEFQFGMNWSEYSR
Rv1623c|M.tuberculosis_H37Rv QTLWVVTDNPAWYRLTKFFGKLFLINFAIGVATGIVQEFQFGMNWSEYSR
MMAR_2426|M.marinum_M QTAWVITDNPAWYRLTKFFGKLFLINFAIGVATGIVQEFQFGMNWSEYSR
MAV_3164|M.avium_104 QTAWVATGNTAWYRLTKFFGKLFLINFAIGVATGIVQEFQFGMNWSEYSR
Mflv_3585|M.gilvum_PYR-GCK QTIWHFTGNTAWYRLTKFFGKLFLINFAIGVATGIVQEFQFGMNWSEYSK
Mvan_2830|M.vanbaalenii_PYR-1 QTVWHVTGNAAWYRLTRFFGKLFLINFAIGVATGIVQEFQFGMNWSEYSR
TH_1290|M.thermoresistible__bu QTAWMVTGNTAWYRLTRFFGKLFLINFALGVATGVVQEFQFGMNWSEYSR
MAB_2630|M.abscessus_ATCC_1997 QTAWVVTGNNSWYRLTKFFGKLFLINFALGVATGIVQEFQFGMNWSEYSR
MSMEG_5605|M.smegmatis_MC2_155 HRRGIVRDDAVALGLAQRWAKVSAVLFAIGAVSGTVLSFEMGLLWPGLMG
: .: *:: :.*: : **:*..:* * .*::*: *.
Mb1649c|M.bovis_AF2122/97 FVGDVFGAPLAMEGLAAFFFESTFIGLWIFGWNRLPRLVHLACIWIVAIA
Rv1623c|M.tuberculosis_H37Rv FVGDVFGAPLAMEGLAAFFFESTFIGLWIFGWNRLPRLVHLACIWIVAIA
MMAR_2426|M.marinum_M FVGDIFGAPLAMEGLMAFFFESTFIGLWIFGWSRLPRLVHLACIWIVAIS
MAV_3164|M.avium_104 FVGDIFGAPLAMEGLFAFFFESTFIGLWIFGWGRLPKLIHLACIWIVAIG
Mflv_3585|M.gilvum_PYR-GCK FVGDIFGAPLAFEGLIAFFFESTFIGLWIFGWSRLPRAVHLACIWIVAFG
Mvan_2830|M.vanbaalenii_PYR-1 FVGDIFGAPLAFEGLIAFFFESTFIGLWIFGWNRLPRVVHLACIWIVAFG
TH_1290|M.thermoresistible__bu FVGDIFGAPLAFEGLVAFFFESTFIGLWVFGWGRLNRWVHLACIWIVAFA
MAB_2630|M.abscessus_ATCC_1997 FVGDVFGAPLALEGLVAFFLESTFLGLWIFGWTRLPKLVHLACIWMVAIG
MSMEG_5605|M.smegmatis_MC2_155 RFGDVLGLPFAFEG-LSFFVEAIFLGIYLYGWGRMPPRRHLLTLIPMGLA
.**::* *:*:** :**.*: *:*::::** *: ** : :.:.
Mb1649c|M.bovis_AF2122/97 VNVSAFFIIAANSFMQHPVGAHYNPTTGRAELSSIVVLLTNNTAQAAFTH
Rv1623c|M.tuberculosis_H37Rv VNVSAFFIIAANSFMQHPVGAHYNPTTGRAELSSIVVLLTNNTAQAAFTH
MMAR_2426|M.marinum_M VNVSAFFIITANSFMQHPVGAHYNPETHRAELNSIVALLTNNTGRTAFAH
MAV_3164|M.avium_104 VNASAFFIIAANSFMQHPVGAHYNPATRRAELDDIFALLSNNTAQAAFSH
Mflv_3585|M.gilvum_PYR-GCK VNASAYFIIAANSFMQHPVGARYNPESGRAELVDFGALLTNNTAIWASLH
Mvan_2830|M.vanbaalenii_PYR-1 VNASAYFIIAANSFMQHPVGAKFNPETGRAELVDFGALLTNNTAIWAFLH
TH_1290|M.thermoresistible__bu VNASAYFIIAANSFMQHPVGARFNPETGRAELENFVALLTNNTAIWAFLH
MAB_2630|M.abscessus_ATCC_1997 VNASAFFIIAANSFMQHPVGAVYNPETGRAELTSITELLTNNTALAAFPH
MSMEG_5605|M.smegmatis_MC2_155 GIVGTFCVVSVNAWMNNPAG--FRIVNGEVVDIDPWRAMFNSGVWLQFAH
..:: :::.*::*::*.* :. . .. . : *. *
Mb1649c|M.bovis_AF2122/97 TVSGALLTAGTFVAAVSAWWLVRS-----------STTHADSDTQAMYRP
Rv1623c|M.tuberculosis_H37Rv TVSGALLTAGTFVAAVSAWWLVRS-----------STTHADSDTQAMYRP
MMAR_2426|M.marinum_M TVTGAFLTAGTFVAAVSAWWLVRS-----------KNSPVPPGTRAMYRP
MAV_3164|M.avium_104 TVTGALLTAGTFVAAVSAWWMVRSRAGGS------TTPAAETEARTMFRP
Mflv_3585|M.gilvum_PYR-GCK AIAGALLTAGAFVAGVSAWLMVRERRRDRDMADPDVAPTSSLVAHSMFRP
Mvan_2830|M.vanbaalenii_PYR-1 AITASLLTAGAFVAGICAWLMVRAHRRGG----------EEVEARTMYRP
TH_1290|M.thermoresistible__bu AVAASFLTAGAFVAGVCAWLMVRSHRNPD----------ESAPAPTLYRP
MAB_2630|M.abscessus_ATCC_1997 TVAGSLLTAGTFIAGICGWWMVRSHKVG-----------TLDDARTMYRP
MSMEG_5605|M.smegmatis_MC2_155 MWVAAFMLVGLVVSGVYAFGMLRG------------------RVDTHHRL
.::: .* .::.: .: ::* . : .*
Mb1649c|M.bovis_AF2122/97 ATILGCWVALAATAGLLFTGDHQGKLMFQQQPMKMASAESLCDTQTDPNF
Rv1623c|M.tuberculosis_H37Rv ATILGCWVALAATAGLLFTGDHQGKLMFQQQPMKMASAESLCDTQTDPNF
MMAR_2426|M.marinum_M ATILGCWVALIATVGLFFSGDYQGKLMFQQQPMKMASAESLCDTQTDPNF
MAV_3164|M.avium_104 AAILGCGVVLLATVALFFTGDRQGKLIFVQQPMKMASAESLCHTQTDPDF
Mflv_3585|M.gilvum_PYR-GCK AAILGSFVALVAAGGLFFTGDIQGKLMFVQQPMKMASAESLCHTETDPDF
Mvan_2830|M.vanbaalenii_PYR-1 ATILGSAVALVAAAGLFFTGDIQGKLMFVQQPMKMASAESLCNTETDPNF
TH_1290|M.thermoresistible__bu ATIASCVVVLVSSVALFFTGDIQGKLMFVQQPMKMASAESLCYTATDPGF
MAB_2630|M.abscessus_ATCC_1997 AAIGACAVMILSGVALAATGDVQGKLMFQQQPMKMASAESLCYTEKDPKF
MSMEG_5605|M.smegmatis_MC2_155 GFAVPFTFASVAAVAQPLIGHVLGMRIHDTQPAKLAAFELAQTTEGP---
. . : . *. * :. ** *:*: * *
Mb1649c|M.bovis_AF2122/97 SVLTVGRQNNCDSLTRVIEVPYVLPFLAEGRISGVTLQGIRDLQQEYQQR
Rv1623c|M.tuberculosis_H37Rv SVLTVGRQNNCDSLTRVIEVPYVLPFLAEGRISGVTLQGIRDLQQEYQQR
MMAR_2426|M.marinum_M SILTVGRQNNCDGLTRVIEVPYVLPILAQGRPTNVTLQGVRDLQRDYQQR
MAV_3164|M.avium_104 SVLTIGTHNNCGSVTEVIKVHYVLPWLAEGRFSGVTLRGVNELQQQYQQR
Mflv_3585|M.gilvum_PYR-GCK SILTVGTHNNCDSVTHLIEVPYVLPFLAESKFSGVTLEGVQDLQEQYQEK
Mvan_2830|M.vanbaalenii_PYR-1 SILTVGTHNNCDGIVRVLEVPYVLPFLAESKFSGVTLEGVEDLQQAAEQK
TH_1290|M.thermoresistible__bu SVLTVGRHNNCDSVVHLIEVPYVLPFLAEGTFSGVTLEGVEDLQQQYEQR
MAB_2630|M.abscessus_ATCC_1997 SVLTVGTHNNCASVTHAISLPYVLPFLAEGKFTDVTLKGVEDLQKEYEQK
MSMEG_5605|M.smegmatis_MC2_155 APLRLGGVLIDGEVHWALTIPRLGSIIARNSLD-APVPGLDGVPRS----
: * :* : : : : . :*.. ..: *: : .
Mb1649c|M.bovis_AF2122/97 FGPNDYRPNLFVTYWSFRMMIGLMAIPVLFALIALWLTRGGQ-IPNQRWF
Rv1623c|M.tuberculosis_H37Rv FGPNDYRPNLFVTYWSFRMMIGLMAIPVLFALIALWLTRGGQ-IPNQRWF
MMAR_2426|M.marinum_M FGPNDYRPNLFVTYWSFRAMIGFLAIPVLFALLALWLTRGGR-IPDKRWF
MAV_3164|M.avium_104 FGPDDYRPNLFVTYWSFRLMIGFLAIPVLFALTVLWVTRRGR-TPRQRWM
Mflv_3585|M.gilvum_PYR-GCK FGPGDYRPNLFVTYWSFRAMIGLLLVPVAFALVTLWLTRRGR-IPDQRWY
Mvan_2830|M.vanbaalenii_PYR-1 FGPGNYRPNLFVTYWAFRAMIGLLLVPVAFALLSLWLTRRGR-IPGQRWY
TH_1290|M.thermoresistible__bu FGPGNYRPNLFVTYWSFRAMIGLMLVPVAFALVALWLTRRGR-IPHQLWF
MAB_2630|M.abscessus_ATCC_1997 FGPRNYRPNLFVTYWSFRAMIGLAAGSALLALAGLWVTRRGR-IPGQRWF
MSMEG_5605|M.smegmatis_MC2_155 -----DWPPVNITHLAFQSMVGIGTLLAAVAVVYWLARWRGRDLLANRWF
* : :*: :*: *:*: . .*: *: : *
Mb1649c|M.bovis_AF2122/97 SWLALLTMPAPFLANSAGWVFTEMGRQPWVVVPNPTGDQLVRLTVKAGVS
Rv1623c|M.tuberculosis_H37Rv SWLALLTMPAPFLANSAGWVFTEMGRQPWVVVPNPTGDQLVRLTVKAGVS
MMAR_2426|M.marinum_M GWFALLTIPTPFLANISGWVFTEMGRQPWIVAPNPTGDPNVRLTVATAVS
MAV_3164|M.avium_104 SWFALLTIPTPFLANIAGWVFTEMGRQPWVVVPNPTGDQAVRMTVREGVS
Mflv_3585|M.gilvum_PYR-GCK GRFGILTIPTPFLANSAGWVFTEMGRQPWVVVPNPTGDPLVRMTVQEGVS
Mvan_2830|M.vanbaalenii_PYR-1 GTFGLLTIPTPFLASSAGWVFTEMGRQPWVVVPNPTGDQMVRMTVQEGVS
TH_1290|M.thermoresistible__bu GRFGIATIPTPFLASSAGWIFTEMGRQPWVVVPAPDGDELVRLTVQEGVS
MAB_2630|M.abscessus_ATCC_1997 AWLSILAIPTPFLANSAGWVFTEMGRQPWVVAPNPTGVDQIRLTVDMAVS
MSMEG_5605|M.smegmatis_MC2_155 LRLSVITGPLAVLAVESGWVATEVGRQPWTVWK--------VLTTTEAAS
:.: : * ..** :**: **:***** * :*. ..*
Mb1649c|M.bovis_AF2122/97 DHSATVVATSLLMFTLVYAVLAVIWCWLLKRYIVEGPLEHDAEPAAHGAP
Rv1623c|M.tuberculosis_H37Rv DHSATVVATSLLMFTLVYAVLAVIWCWLLKRYIVEGPLEHDAEPAAHGAP
MMAR_2426|M.marinum_M NLTTATVVTSLVTFTLVYAVLAVIWFWLLKRYIVEGPLEHDAEPAPPRAP
MAV_3164|M.avium_104 NHVPGMVITSLATFTLVYAVLAVVWFFLLKRYTVEGPLEHDAEPAPPRAP
Mflv_3585|M.gilvum_PYR-GCK NHAAGTVWVSLTVFTLLYGALAVAWFYLMRRYVVEGPLEHDSEPAPPSPP
Mvan_2830|M.vanbaalenii_PYR-1 NHAAGTVMFSLAVFTLLYGALAVVWFYLLRRYVVEGPQEHDSEPAPPTPP
TH_1290|M.thermoresistible__bu GHAPGTVLFSLTVFTLIYGVLAVIWFWLMRRYVVEGPQEHDSEPVPPSPP
MAB_2630|M.abscessus_ATCC_1997 HHSAATVWLSLITFTLLYGALGVVWFWLIRRYTIEGPLEHDAEPSPP-AS
MSMEG_5605|M.smegmatis_MC2_155 QSSG--LWWSYVIVLVVYLGMTIGAVVVLRSMARRWRAGETDLPSPYGPP
: * . ::* : : ::: . . * . ..
Mb1649c|M.bovis_AF2122/97 RDDEVAPLSFAY
Rv1623c|M.tuberculosis_H37Rv RDDEVAPLSFAY
MMAR_2426|M.marinum_M DDDEVAPLSFAY
MAV_3164|M.avium_104 SDDEVAPLSFAY
Mflv_3585|M.gilvum_PYR-GCK DKDDVAPLSFAY
Mvan_2830|M.vanbaalenii_PYR-1 SKDDVAPLSFAY
TH_1290|M.thermoresistible__bu GDDEMAQLSFAY
MAB_2630|M.abscessus_ATCC_1997 DDDSVKPLSFAY
MSMEG_5605|M.smegmatis_MC2_155 RTEARS------
: