For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. tuberculosis H37Rv Rv1623c (cydA)

annotation: Probable integral membrane cytochrome D ubiquinol oxidase (subunit I) cydA (Cytochrome BD-I oxidase subunit I)
coordinates: 1824430 - 1825887
length: 485

NVVDISRWQFGITTVYHFIFVPLTIGLAPLIAVMQTLWVVTDNPAWYRLTKFFGKLFLINFAIGVATGIV
QEFQFGMNWSEYSRFVGDVFGAPLAMEGLAAFFFESTFIGLWIFGWNRLPRLVHLACIWIVAIAVNVSAF
FIIAANSFMQHPVGAHYNPTTGRAELSSIVVLLTNNTAQAAFTHTVSGALLTAGTFVAAVSAWWLVRSST
THADSDTQAMYRPATILGCWVALAATAGLLFTGDHQGKLMFQQQPMKMASAESLCDTQTDPNFSVLTVGR
QNNCDSLTRVIEVPYVLPFLAEGRISGVTLQGIRDLQQEYQQRFGPNDYRPNLFVTYWSFRMMIGLMAIP
VLFALIALWLTRGGQIPNQRWFSWLALLTMPAPFLANSAGWVFTEMGRQPWVVVPNPTGDQLVRLTVKAG
VSDHSATVVATSLLMFTLVYAVLAVIWCWLLKRYIVEGPLEHDAEPAAHGAPRDDEVAPLSFAY*

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. tuberculosis H37Rv Rv1623c cydA - 100% (485) Probable integral membrane cytochrome D ubiquinol oxidase (subunit I) cydA (Cytochrome BD-I oxidase subunit I)

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb1649c cydA 0.0 100.00% (485) integral membrane cytochrome D ubiquinol oxidase (subunit I)
M. gilvum PYR-GCK Mflv_3585 - 0.0 72.78% (496) cytochrome bd ubiquinol oxidase, subunit I
M. leprae Br4923 - - - - -
M. abscessus ATCC 19977 MAB_2630 - 0.0 72.58% (485) integral membrane cytochrome D ubiquinol oxidase (subunit I)
M. marinum M MMAR_2426 cydA 0.0 83.92% (485) integral membrane cytochrome D ubiquinol oxidase (subunit I)
M. avium 104 MAV_3164 - 0.0 79.18% (490) cytochrome D ubiquinol oxidase subunit 1
M. smegmatis MC2 155 MSMEG_3233 - 0.0 78.44% (487) cytochrome D ubiquinol oxidase subunit 1
M. thermoresistible (build 8) TH_1290 appC 0.0 72.39% (489) Probable integral membrane cytochrome D ubiquinol oxidase
M. ulcerans Agy99 - - - - -
M. vanbaalenii PYR-1 Mvan_2830 - 0.0 73.46% (486) cytochrome bd ubiquinol oxidase, subunit I

CLUSTAL 2.0.9 multiple sequence alignment


Rv1623c|M.tuberculosis_H37Rv        MNVVDISRWQFGITTVYHFIFVPLTIGLAPLIAVMQTLWVVTDNPAWYRL
Mb1649c|M.bovis_AF2122/97           MNVVDISRWQFGITTVYHFIFVPLTIGLAPLIAVMQTLWVVTDNPAWYRL
MMAR_2426|M.marinum_M               MNVVDVSRWQFGITTVYHFIFVPLTIGLAPLLAIMQTAWVITDNPAWYRL
MAV_3164|M.avium_104                MNVVDISRWQFGIVTVYHFIFVPLTIGLAPLLAIMQTAWVATGNTAWYRL
Mflv_3585|M.gilvum_PYR-GCK          MDALDVSRWQFGITTVYHFIFVPLTIGLAPLIAVMQTIWHFTGNTAWYRL
Mvan_2830|M.vanbaalenii_PYR-1       MDALDVSRWQFGITTVYHFIFVPLTIGLAPLIAIMQTVWHVTGNAAWYRL
TH_1290|M.thermoresistible__bu      MDALDLSRWQFGITTVYHFIFVPLTIGLAPILAAMQTAWMVTGNTAWYRL
MSMEG_3233|M.smegmatis_MC2_155      MDALDLSRWQFGITTVYHFIFVPLTIGLAPLIAVMQTVWVATGNDTWYRL
MAB_2630|M.abscessus_ATCC_1997      MNALDVSRWQFGITTVYHFILVPLTIGLAPLIAIMQTAWVVTGNNSWYRL
                                    *:.:*:*******.******:*********::* *** *  *.* :****

Rv1623c|M.tuberculosis_H37Rv        TKFFGKLFLINFAIGVATGIVQEFQFGMNWSEYSRFVGDVFGAPLAMEGL
Mb1649c|M.bovis_AF2122/97           TKFFGKLFLINFAIGVATGIVQEFQFGMNWSEYSRFVGDVFGAPLAMEGL
MMAR_2426|M.marinum_M               TKFFGKLFLINFAIGVATGIVQEFQFGMNWSEYSRFVGDIFGAPLAMEGL
MAV_3164|M.avium_104                TKFFGKLFLINFAIGVATGIVQEFQFGMNWSEYSRFVGDIFGAPLAMEGL
Mflv_3585|M.gilvum_PYR-GCK          TKFFGKLFLINFAIGVATGIVQEFQFGMNWSEYSKFVGDIFGAPLAFEGL
Mvan_2830|M.vanbaalenii_PYR-1       TRFFGKLFLINFAIGVATGIVQEFQFGMNWSEYSRFVGDIFGAPLAFEGL
TH_1290|M.thermoresistible__bu      TRFFGKLFLINFALGVATGVVQEFQFGMNWSEYSRFVGDIFGAPLAFEGL
MSMEG_3233|M.smegmatis_MC2_155      TRFFGKLFLINFAIGVATGIVQEFQFGMNWSEYSRFVGDIFGAPLAMEGL
MAB_2630|M.abscessus_ATCC_1997      TKFFGKLFLINFALGVATGIVQEFQFGMNWSEYSRFVGDVFGAPLALEGL
                                    *:***********:*****:**************:****:******:***

Rv1623c|M.tuberculosis_H37Rv        AAFFFESTFIGLWIFGWNRLPRLVHLACIWIVAIAVNVSAFFIIAANSFM
Mb1649c|M.bovis_AF2122/97           AAFFFESTFIGLWIFGWNRLPRLVHLACIWIVAIAVNVSAFFIIAANSFM
MMAR_2426|M.marinum_M               MAFFFESTFIGLWIFGWSRLPRLVHLACIWIVAISVNVSAFFIITANSFM
MAV_3164|M.avium_104                FAFFFESTFIGLWIFGWGRLPKLIHLACIWIVAIGVNASAFFIIAANSFM
Mflv_3585|M.gilvum_PYR-GCK          IAFFFESTFIGLWIFGWSRLPRAVHLACIWIVAFGVNASAYFIIAANSFM
Mvan_2830|M.vanbaalenii_PYR-1       IAFFFESTFIGLWIFGWNRLPRVVHLACIWIVAFGVNASAYFIIAANSFM
TH_1290|M.thermoresistible__bu      VAFFFESTFIGLWVFGWGRLNRWVHLACIWIVAFAVNASAYFIIAANSFM
MSMEG_3233|M.smegmatis_MC2_155      AAFFFESTFIGLWIFGWTRLPRWLHLACIWIVAIAVNLSAFFIISANSFM
MAB_2630|M.abscessus_ATCC_1997      VAFFLESTFLGLWIFGWTRLPKLVHLACIWMVAIGVNASAFFIIAANSFM
                                     ***:****:***:*** ** : :******:**:.** **:***:*****

Rv1623c|M.tuberculosis_H37Rv        QHPVGAHYNPTTGRAELSSIVVLLTNNTAQAAFTHTVSGALLTAGTFVAA
Mb1649c|M.bovis_AF2122/97           QHPVGAHYNPTTGRAELSSIVVLLTNNTAQAAFTHTVSGALLTAGTFVAA
MMAR_2426|M.marinum_M               QHPVGAHYNPETHRAELNSIVALLTNNTGRTAFAHTVTGAFLTAGTFVAA
MAV_3164|M.avium_104                QHPVGAHYNPATRRAELDDIFALLSNNTAQAAFSHTVTGALLTAGTFVAA
Mflv_3585|M.gilvum_PYR-GCK          QHPVGARYNPESGRAELVDFGALLTNNTAIWASLHAIAGALLTAGAFVAG
Mvan_2830|M.vanbaalenii_PYR-1       QHPVGAKFNPETGRAELVDFGALLTNNTAIWAFLHAITASLLTAGAFVAG
TH_1290|M.thermoresistible__bu      QHPVGARFNPETGRAELENFVALLTNNTAIWAFLHAVAASFLTAGAFVAG
MSMEG_3233|M.smegmatis_MC2_155      QHPVGARFNPETGRAELESIFALFTNNTAIAAFTHAVSGAFLTAGVFVAC
MAB_2630|M.abscessus_ATCC_1997      QHPVGAVYNPETGRAELTSITELLTNNTALAAFPHTVAGSLLTAGTFIAG
                                    ****** :** : **** .:  *::***.  *  *:::.::****.*:* 

Rv1623c|M.tuberculosis_H37Rv        VSAWWLVRS-----STTH----------ADSDTQAMYRPATILGCWVALA
Mb1649c|M.bovis_AF2122/97           VSAWWLVRS-----STTH----------ADSDTQAMYRPATILGCWVALA
MMAR_2426|M.marinum_M               VSAWWLVRS-----KNSP----------VPPGTRAMYRPATILGCWVALI
MAV_3164|M.avium_104                VSAWWMVRSRAGGSTTPA----------AETEARTMFRPAAILGCGVVLL
Mflv_3585|M.gilvum_PYR-GCK          VSAWLMVRER----RRDRDMADPDVAPTSSLVAHSMFRPAAILGSFVALV
Mvan_2830|M.vanbaalenii_PYR-1       ICAWLMVRAH----RRGG----------EEVEARTMYRPATILGSAVALV
TH_1290|M.thermoresistible__bu      VCAWLMVRSH----RNPD----------ESAPAPTLYRPATIASCVVVLV
MSMEG_3233|M.smegmatis_MC2_155      VCAWWMVRSH----RTGGE---------SAADAATMYRPATILGCWVTLV
MAB_2630|M.abscessus_ATCC_1997      ICGWWMVRSH-----KVG----------TLDDARTMYRPAAIGACAVMIL
                                    :..* :**                        : :::***:* .. * : 

Rv1623c|M.tuberculosis_H37Rv        ATAGLLFTGDHQGKLMFQQQPMKMASAESLCDTQTDPNFSVLTVGRQNNC
Mb1649c|M.bovis_AF2122/97           ATAGLLFTGDHQGKLMFQQQPMKMASAESLCDTQTDPNFSVLTVGRQNNC
MMAR_2426|M.marinum_M               ATVGLFFSGDYQGKLMFQQQPMKMASAESLCDTQTDPNFSILTVGRQNNC
MAV_3164|M.avium_104                ATVALFFTGDRQGKLIFVQQPMKMASAESLCHTQTDPDFSVLTIGTHNNC
Mflv_3585|M.gilvum_PYR-GCK          AAGGLFFTGDIQGKLMFVQQPMKMASAESLCHTETDPDFSILTVGTHNNC
Mvan_2830|M.vanbaalenii_PYR-1       AAAGLFFTGDIQGKLMFVQQPMKMASAESLCNTETDPNFSILTVGTHNNC
TH_1290|M.thermoresistible__bu      SSVALFFTGDIQGKLMFVQQPMKMASAESLCYTATDPGFSVLTVGRHNNC
MSMEG_3233|M.smegmatis_MC2_155      AAVALFFTGDAQGKLMFEQQPMKMASAESLCHSEQDPSFSVLTVGTHNNC
MAB_2630|M.abscessus_ATCC_1997      SGVALAATGDVQGKLMFQQQPMKMASAESLCYTEKDPKFSVLTVGTHNNC
                                    :  .*  :** ****:* ************* :  ** **:**:* :***

Rv1623c|M.tuberculosis_H37Rv        DSLTRVIEVPYVLPFLAEGRISGVTLQGIRDLQQEYQQRFGPNDYRPNLF
Mb1649c|M.bovis_AF2122/97           DSLTRVIEVPYVLPFLAEGRISGVTLQGIRDLQQEYQQRFGPNDYRPNLF
MMAR_2426|M.marinum_M               DGLTRVIEVPYVLPILAQGRPTNVTLQGVRDLQRDYQQRFGPNDYRPNLF
MAV_3164|M.avium_104                GSVTEVIKVHYVLPWLAEGRFSGVTLRGVNELQQQYQQRFGPDDYRPNLF
Mflv_3585|M.gilvum_PYR-GCK          DSVTHLIEVPYVLPFLAESKFSGVTLEGVQDLQEQYQEKFGPGDYRPNLF
Mvan_2830|M.vanbaalenii_PYR-1       DGIVRVLEVPYVLPFLAESKFSGVTLEGVEDLQQAAEQKFGPGNYRPNLF
TH_1290|M.thermoresistible__bu      DSVVHLIEVPYVLPFLAEGTFSGVTLEGVEDLQQQYEQRFGPGNYRPNLF
MSMEG_3233|M.smegmatis_MC2_155      DSVVHLIEVPYVLPFLAEGKFSGVHLDGVVDLQRSYEEKFGPGDYRPNLF
MAB_2630|M.abscessus_ATCC_1997      ASVTHAISLPYVLPFLAEGKFTDVTLKGVEDLQKEYEQKFGPRNYRPNLF
                                     .:.. :.: **** **:.  :.* * *: :**.  :::*** :******

Rv1623c|M.tuberculosis_H37Rv        VTYWSFRMMIGLMAIPVLFALIALWLTRGGQIPNQRWFSWLALLTMPAPF
Mb1649c|M.bovis_AF2122/97           VTYWSFRMMIGLMAIPVLFALIALWLTRGGQIPNQRWFSWLALLTMPAPF
MMAR_2426|M.marinum_M               VTYWSFRAMIGFLAIPVLFALLALWLTRGGRIPDKRWFGWFALLTIPTPF
MAV_3164|M.avium_104                VTYWSFRLMIGFLAIPVLFALTVLWVTRRGRTPRQRWMSWFALLTIPTPF
Mflv_3585|M.gilvum_PYR-GCK          VTYWSFRAMIGLLLVPVAFALVTLWLTRRGRIPDQRWYGRFGILTIPTPF
Mvan_2830|M.vanbaalenii_PYR-1       VTYWAFRAMIGLLLVPVAFALLSLWLTRRGRIPGQRWYGTFGLLTIPTPF
TH_1290|M.thermoresistible__bu      VTYWSFRAMIGLMLVPVAFALVALWLTRRGRIPHQLWFGRFGIATIPTPF
MSMEG_3233|M.smegmatis_MC2_155      VTYWSFRAMIGFLAVPGLFALAALWLTRGGRIPDQRWFSWFALLTIPTPF
MAB_2630|M.abscessus_ATCC_1997      VTYWSFRAMIGLAAGSALLALAGLWVTRRGRIPGQRWFAWLSILAIPTPF
                                    ****:** ***:   .  :**  **:** *: * : * . :.: ::*:**

Rv1623c|M.tuberculosis_H37Rv        LANSAGWVFTEMGRQPWVVVPNPTGDQLVRLTVKAGVSDHSATVVATSLL
Mb1649c|M.bovis_AF2122/97           LANSAGWVFTEMGRQPWVVVPNPTGDQLVRLTVKAGVSDHSATVVATSLL
MMAR_2426|M.marinum_M               LANISGWVFTEMGRQPWIVAPNPTGDPNVRLTVATAVSNLTTATVVTSLV
MAV_3164|M.avium_104                LANIAGWVFTEMGRQPWVVVPNPTGDQAVRMTVREGVSNHVPGMVITSLA
Mflv_3585|M.gilvum_PYR-GCK          LANSAGWVFTEMGRQPWVVVPNPTGDPLVRMTVQEGVSNHAAGTVWVSLT
Mvan_2830|M.vanbaalenii_PYR-1       LASSAGWVFTEMGRQPWVVVPNPTGDQMVRMTVQEGVSNHAAGTVMFSLA
TH_1290|M.thermoresistible__bu      LASSAGWIFTEMGRQPWVVVPAPDGDELVRLTVQEGVSGHAPGTVLFSLT
MSMEG_3233|M.smegmatis_MC2_155      LANSAGWVFTEMGRQPWVVVPNPTGDQDIRLTVAQGVSDHSVGLVVLSLV
MAB_2630|M.abscessus_ATCC_1997      LANSAGWVFTEMGRQPWVVAPNPTGVDQIRLTVDMAVSHHSAATVWLSLI
                                    **. :**:*********:*.* * *   :*:**  .**      *  ** 

Rv1623c|M.tuberculosis_H37Rv        MFTLVYAVLAVIWCWLLKRYIVEGPLEHDAEPAAHGAPRDDEVAPLSFAY
Mb1649c|M.bovis_AF2122/97           MFTLVYAVLAVIWCWLLKRYIVEGPLEHDAEPAAHGAPRDDEVAPLSFAY
MMAR_2426|M.marinum_M               TFTLVYAVLAVIWFWLLKRYIVEGPLEHDAEPAPPRAPDDDEVAPLSFAY
MAV_3164|M.avium_104                TFTLVYAVLAVVWFFLLKRYTVEGPLEHDAEPAPPRAPSDDEVAPLSFAY
Mflv_3585|M.gilvum_PYR-GCK          VFTLLYGALAVAWFYLMRRYVVEGPLEHDSEPAPPSPPDKDDVAPLSFAY
Mvan_2830|M.vanbaalenii_PYR-1       VFTLLYGALAVVWFYLLRRYVVEGPQEHDSEPAPPTPPSKDDVAPLSFAY
TH_1290|M.thermoresistible__bu      VFTLIYGVLAVIWFWLMRRYVVEGPQEHDSEPVPPSPPGDDEMAQLSFAY
MSMEG_3233|M.smegmatis_MC2_155      AFTLVYAVLAVIWFFLLRRYIVQGPSEHDSEPAAPRPPDADDVAPLSFAY
MAB_2630|M.abscessus_ATCC_1997      TFTLLYGALGVVWFWLIRRYTIEGPLEHDAEPSPP-ASDDDSVKPLSFAY
                                     ***:*..*.* * :*::** ::** ***:** .  ..  *.:  *****

species	id	gene	e-value	identity (len)	annotation
M. tuberculosis H37Rv	Rv1623c	cydA	-	100% (485)	Probable integral membrane cytochrome D ubiquinol oxidase (subunit I) cydA (Cytochrome BD-I oxidase subunit I)