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TTERIADHIKFAYWVPNVSGGLVTSDIEQRTDWNYEYNKKLAQTAENNGFEYALSQVRYEASYGAEYQHE STSFSLALLLATERLKVIAAVHPGLWQPGVLAKLGATADHLSNGRFAVNVVSGWFKDEFIHLGEPWLEHD ERYRRSAEFLQVLRKIWTEDNVDFRGDFYRIHDFTLKPKPVDVPGRPHPELFQGGNSTAARRNGGLYADW YFSNGKDFDGFTEQVVDVREHARTVNREVKFGLNGFIIARDTEKEAKEVLREIVAKANKPAVEGFRSAVQ QAGNSTGDKKGMWADSTFEDLVQYNDGFRTQLIGTPEQIAERIAAYRKRGADLILGGFLHFQEEIEYFGA KVLPLVREIEASEQNSADEPVLVSA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_5519 | - | - | 100% (376) | monooxygenase |
| M. smegmatis MC2 155 | MSMEG_3850 | - | 1e-32 | 30.27% (337) | alkanesulfonate monooxygenase family protein |
| M. smegmatis MC2 155 | MSMEG_4103 | - | 6e-31 | 31.60% (307) | alkanesulfonate monooxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0815c | - | 6e-17 | 26.87% (268) | hypothetical protein Mb0815c |
| M. gilvum PYR-GCK | Mflv_5136 | - | 2e-27 | 29.89% (368) | alkanesulfonate monooxygenase |
| M. tuberculosis H37Rv | Rv0791c | - | 6e-17 | 26.87% (268) | hypothetical protein Rv0791c |
| M. leprae Br4923 | MLBr_00269 | - | 3e-08 | 25.60% (207) | putative F420-dependent glucose-6-phosphate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_1060 | - | 0.0 | 87.91% (364) | putative alkanesulfonate monooxygenase |
| M. marinum M | MMAR_4200 | fgd2 | 2e-30 | 29.94% (334) | F420-dependent glucose-6-phosphate dehydrogenase Fgd2 |
| M. avium 104 | MAV_3426 | - | 3e-35 | 28.22% (365) | alkanesulfonate monooxygenase |
| M. thermoresistible (build 8) | TH_0642 | - | 0.0 | 88.20% (373) | monooxygenase |
| M. ulcerans Agy99 | MUL_4507 | fgd2 | 9e-31 | 30.24% (334) | F420-dependent glucose-6-phosphate dehydrogenase Fgd2 |
| M. vanbaalenii PYR-1 | Mvan_4860 | - | 0.0 | 90.43% (376) | alkanesulfonate monooxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0815c|M.bovis_AF2122/97 MNAKDDPHFGLMLAATVNGLAVGSYREMVVVSQTAEEYGFDSVWLCDHFL
Rv0791c|M.tuberculosis_H37Rv MNAKDDPHFGLMLAATVNGLAVGSYREMVVVSQTAEEYGFDSVWLCDHFL
MSMEG_5519|M.smegmatis_MC2_155 ----------MTTERIADHIKFAYWVPNVSGGLVTSDIEQRTDWN-----
Mvan_4860|M.vanbaalenii_PYR-1 ---MAVAWLTMTTERIADHVKFAYWVPNVSGGLVTSDIEQRTDWN-----
TH_0642|M.thermoresistible__bu ----------MSTERIADHVTFAYWVPNVSGGLVTSDIEQRTDWN-----
MAB_1060|M.abscessus_ATCC_1997 ----------MTTERISDHVKFAYWVPNVSGGLVTSTIEQRTDWG-----
MMAR_4200|M.marinum_M -----------------MALSFHWFLPTYGDSRGLVAGGHGLPMS---GN
MUL_4507|M.ulcerans_Agy99 -----------------MALLFHWFLPTYGDSRGLVAGGHGLPMS---GN
Mflv_5136|M.gilvum_PYR-GCK ---------------MTHAIKLHWFLPTYGDSRHIVGGGHGTPAGSAHSD
MAV_3426|M.avium_104 --------------MPAEASRFLWYIPNTVEPG---HRGDDTVDG-----
MLBr_00269|M.leprae_Br4923 ----------------MAELRLGYKASAEQFAP-----------------
.
Mb0815c|M.bovis_AF2122/97 TISPGEYAKVAGIAADTGSATGTETGGAGQCAPSRSLPLLECWTALAALS
Rv0791c|M.tuberculosis_H37Rv TISPGEYAKVAGIAADTGSATGTETGGAGQCAPSRSLPLLECWTALAALS
MSMEG_5519|M.smegmatis_MC2_155 ----YEYNKKLAQTAENNGFEYALSQ-VRYEASYGAEYQHESTSFSLALL
Mvan_4860|M.vanbaalenii_PYR-1 ----YEYNRKLARTAENNGFEYALSQ-VRYEASYGAEYQHESTSFSLALL
TH_0642|M.thermoresistible__bu ----YDYNAELARTAENNGFEYALTQ-VRYEASYGAEYQHESTSFSLALL
MAB_1060|M.abscessus_ATCC_1997 ----YDYNVKLARTAEDNGFEYALTQ-VRYEASYGAEYQHESTSFSLALL
MMAR_4200|M.marinum_M RPATLRYLNQIAAAAESNGFEAVLTP-AGLWC-------EDAWLTTAMLV
MUL_4507|M.ulcerans_Agy99 RPATLRYLNQIAAAAESNGFEAVLTP-AGLWC-------EDAWLTTAMLV
Mflv_5136|M.gilvum_PYR-GCK RDASIDYLASIVRAAETFGFTGALIP-TGAWC-------EDAFITAALLA
MAV_3426|M.avium_104 -WGSLDYSVDLASRAEQHGWEGALIG-TGWGR-------PDTFTVATAIA
MLBr_00269|M.leprae_Br4923 -----RELVELGVAAEAHGMDSATVSDHFQPWRHQGGHASFSLSWMTAVG
*: . . :
Mb0815c|M.bovis_AF2122/97 RDTTKLRLGTSVLCN-SYRHPSVLAKMAATLDVISQGRLDLGLGAGWFRR
Rv0791c|M.tuberculosis_H37Rv RDTTKLRLGTSVLCN-SYRHPSVLAKMAATLDVISQGRLDLGLGAGWFRR
MSMEG_5519|M.smegmatis_MC2_155 LATERLKVIAAVHP--GLWQPGVLAKLGATADHLSNGRFAVNVVSGWFKD
Mvan_4860|M.vanbaalenii_PYR-1 LATERLKVIAAVHP--GLWQPAVLAKLGATADQLSGGRFAVNVVSGWFKD
TH_0642|M.thermoresistible__bu LATQRLKVIAAVHP--GLWQPGVLAKLGATADQLSGGRFAVNVVSGWFKD
MAB_1060|M.abscessus_ATCC_1997 LATERLKVIAAVHP--GLWQPGVLAKLGATADHLSGGRFAVNVVSGWFKD
MMAR_4200|M.marinum_M GTTETLKFLVALRP--GLVSPTLAAQMATTFQQQSGGRLLLNVVTGGEAH
MUL_4507|M.ulcerans_Agy99 GTTKTLKFLVALRP--GLVSPTLAAQMATTFQQQSGGRLLVNVVTGGEAH
Mflv_5136|M.gilvum_PYR-GCK RETSTLGFLVAFRP--GLVSPTLSAQMAATFARHAPGRLLLNVVVGGEAH
MAV_3426|M.avium_104 ARTTAFAPLVAVRP--GYWHPAHFASAAATLDRLNGGRLLVNIVSG--AD
MLBr_00269|M.leprae_Br4923 ERTNRILLGTSVLTPTFRYNPAVIGQAFATMGCLYPNRVFLGVGTGEALN
* : .:. * .. :* .*. :.: *
Mb0815c|M.bovis_AF2122/97 ESQA-YGIPFPPVGDRVSALAESLQVIKAVWT-EPNPTYAGRFYTLDGAT
Rv0791c|M.tuberculosis_H37Rv ESQA-YGIPFPPVGDRVSALAESLQVIKAVWT-EPNPTYAGRFYTLDGAT
MSMEG_5519|M.smegmatis_MC2_155 EFIH-LGEPWLEHDERYRRSAEFLQVLRKIWT-EDNVDFRGDFYRIHDFT
Mvan_4860|M.vanbaalenii_PYR-1 EFTH-LGEPWLEHDERYRRSAEFLQVLRKIWT-EDDVDFRGDFYRIHDFT
TH_0642|M.thermoresistible__bu EFIH-LGEPWLEHDERYRRAAEFQQVLRKIWT-EDDVDFRGDFYRIHDFT
MAB_1060|M.abscessus_ATCC_1997 EFTH-LGEPWLEHDERYRRSAEFLQVLRKIWT-EDDVDFRGDFYRIHDFT
MMAR_4200|M.marinum_M EQRA-YGD-FLDKQQRYRRTGEFLHVVRQLWASGQPVTFEGEHIHVHQAQ
MUL_4507|M.ulcerans_Agy99 EQRA-YGD-FLDKQQRYRRTGEFLHVVRQLWASGQPVTFEGEHIHVHQAQ
Mflv_5136|M.gilvum_PYR-GCK EQRS-FGD-HLDKDGRYARADEFLDVVRRLWD-GQTVSLDGEHIRVENAS
MAV_3426|M.avium_104 DVAA-YGDTEVDKSRRYDRTREFIRLLRRLWT-QDDVTFHGEFFRVEHST
MLBr_00269|M.leprae_Br4923 EVATGYQGAWPEFKERFARLRESVRLMRELWR-GDRVDFDGDYYQLKGAS
: * * ::: :* * . :.
Mb0815c|M.bovis_AF2122/97 CDPPPVQR---PHPPLWIGGEGDRVQRIAAKHAQGLNVR-WWSPQQVTQR
Rv0791c|M.tuberculosis_H37Rv CDPPPVQR---PHPPLWIGGEGDRVQRIAAKHAQGLNVR-WWSPQQVTQR
MSMEG_5519|M.smegmatis_MC2_155 LKPKPVDVPGRPHPELFQGGNSTAARRNGGLYADWYFSN-GKDFDGFTEQ
Mvan_4860|M.vanbaalenii_PYR-1 LKPKPANTAERPNPELFQGGNSTAARRNGGYYADWYFSN-GKDFDGVTEQ
TH_0642|M.thermoresistible__bu LKPKPVNTPQRPHPEIFQGGNSTAARRNGGYYADWYFSN-GKDFDGVTEQ
MAB_1060|M.abscessus_ATCC_1997 LKPKPLHT-----PELFQGGNSTAARRNGGLYSDWYFSN-GKDFAGITDQ
MMAR_4200|M.marinum_M LGRLPDPP-----PPVFFGGSSESAGAVAARYADTYLTW-GEPLSAVGKK
MUL_4507|M.ulcerans_Agy99 LGRLPDPP-----PPVFFGGSSESAGAVAARYADTYLTW-GEPLSAVGKK
Mflv_5136|M.gilvum_PYR-GCK LPTVPAPV-----PPLYFGGSSAAAGPVAARHADVYLTW-GEPPAAVAEK
MAV_3426|M.avium_104 LRPRPLGAEQGRHPKLYFGGASPAAEQVAATDADVQLFW-GESLDGIAER
MLBr_00269|M.leprae_Br4923 IYDVPEGG-----VPIYIAAGGPEVAKYAGRAGEGFVCTSGKGEELYTEK
* :: .. . . .. .: .:
Mb0815c|M.bovis_AF2122/97 RG-FLTQASEAAGRDPDTLRLSVTLLLAPTQSGEEEVRIREEFASIPEP-
Rv0791c|M.tuberculosis_H37Rv RG-FLTQASEAAGRDPDTLRLSVTLLLAPTQSGEEEVRIREEFASIPEP-
MSMEG_5519|M.smegmatis_MC2_155 VV-DVREHARTVNRE---VKFGLNGFIIARDTEKEAKEVLREIVAKANKP
Mvan_4860|M.vanbaalenii_PYR-1 VV-EVRDHARAAGRE---VRFGLNGFIIARDTEKEAKEVLREIIAKANTP
TH_0642|M.thermoresistible__bu VV-EVREHARAAGRE---VRFGLNGFIIARDSEKEAKDTLREIIAKANRP
MAB_1060|M.abscessus_ATCC_1997 IV-EVRDHARTVGRE---VNIALNGFIIARDTEAEARDVLREIVEKANRP
MMAR_4200|M.marinum_M ID-WIRGLAADHGRA---LSYGLRIHVITRDTAEEAWRVADRLLAGIDPA
MUL_4507|M.ulcerans_Agy99 ID-WIRGLAADHGRA---LSYGLRIHVITRDTAEEAWRVADRLLAGIDPA
Mflv_5136|M.gilvum_PYR-GCK VE-WIRRAAAGQGRQ---LRFGIRLHVITRDTAGAAWAEADRLVGALDDE
MAV_3426|M.avium_104 ID-RLKSLSDKLGREHPPLEFGLRVTTLVRDTSEQAWRDAEAKVAKLAGT
MLBr_00269|M.leprae_Br4923 LIPAVLEGAAVAGRDADDIDKMIEIKMSYDPDPEQALSNIRFWAPLSLAA
: : .* : :
Mb0815c|M.bovis_AF2122/97 --------------------------------------------------
Rv0791c|M.tuberculosis_H37Rv --------------------------------------------------
MSMEG_5519|M.smegmatis_MC2_155 AVEGFRSAVQQAGNSTGDKKGMWAD------------------STFEDLV
Mvan_4860|M.vanbaalenii_PYR-1 AVEGFRGAVQQAGNSTSDRKGMWAD------------------STFEDLV
TH_0642|M.thermoresistible__bu AVEGFRAAVQQAGNSTPDKKGMWAD------------------STFEDLV
MAB_1060|M.abscessus_ATCC_1997 AVEGFRAAVQQAGAATGDKKGMWAD------------------SSFEDLV
MMAR_4200|M.marinum_M DIERMQANLARSESEGQRRMAELHGGALD--------QLEIAPNLWAGVG
MUL_4507|M.ulcerans_Agy99 DIERMQANLARSESEGQRRMAELHGGVLD--------QLEIAPNLWAGVG
Mflv_5136|M.gilvum_PYR-GCK TVRNAQEGLGRSQSEGQRRMSALHQAHRANGSWHDARTLEVAPNLWTGVG
MAV_3426|M.avium_104 PTMMLLHDPAGS--EGQRRLNDLAARGEVIDS-----CLYTTPSKYGGE-
MLBr_00269|M.leprae_Br4923 EQKHSIDDPIEMEKVADALPIEQVAK------------------------
Mb0815c|M.bovis_AF2122/97 -------GLIVGTPDRCVERIREYQDRGVGHFLFTIPHVVKSDYLHIIGS
Rv0791c|M.tuberculosis_H37Rv -------GLIVGTPDRCVERIREYQDRGVGHFLFTIPHVVKSDYLHIIGS
MSMEG_5519|M.smegmatis_MC2_155 QYNDGFRTQLIGTPEQIAERIAAYRKRGADLILGGF--LHFQEEIEYFGA
Mvan_4860|M.vanbaalenii_PYR-1 QYNDGFRTQLIGTPEQIAERIAAYRERGVDLILGGF--LHFQEEIEYFGA
TH_0642|M.thermoresistible__bu QYNDGFRTGLIGTPEQIAERIAEYRKRGVDLILGGF--LHFQEEIEYFGA
MAB_1060|M.abscessus_ATCC_1997 QYNDGFRTQLIGTPEQIAERIAAYRRRGVDLILGGF--LHFQEEIEYFGA
MMAR_4200|M.marinum_M LVRGGAGTALVGSHQEVAERIIEYARLGISHFILSG--YPHLEEAYWFGE
MUL_4507|M.ulcerans_Agy99 LVRGGAGTALVGSHQEVAERIIEYARLGISHFILSG--YPHLEEAYWFGE
Mflv_5136|M.gilvum_PYR-GCK LVRGGAGTALVGSHSEVADRIAEYAEVGIDEFIFSG--YPHLEELYWLGE
MAV_3426|M.avium_104 ---GAGTTWLVGSAAEVAAALRAYADLGVSHFVLSD--TPYQSEVVRLGD
MLBr_00269|M.leprae_Br4923 ------RWIVVSDPDEAVARVGQYVTWGLNHLVFHAPGHNQRRFLELFEK
::. . . : * * . :: :
Mb0815c|M.bovis_AF2122/97 DIIPRVKTEVTIP-----------------------
Rv0791c|M.tuberculosis_H37Rv DIIPRVKTEVTIP-----------------------
MSMEG_5519|M.smegmatis_MC2_155 KVLPLVREIEASEQNSADEPVLVSA-----------
Mvan_4860|M.vanbaalenii_PYR-1 RVLPLVREIENSGRVSADSPVLVPA-----------
TH_0642|M.thermoresistible__bu KVLPLVREIESAD--SADRELVGIQ-----------
MAB_1060|M.abscessus_ATCC_1997 KVLPLVREIEAADSQETLSEYRVPVLS---------
MMAR_4200|M.marinum_M GVLPILERKRLWHRPHGSSPHSAALPVAHSSVN---
MUL_4507|M.ulcerans_Agy99 GVLPILERKRLWHRPHGSSPHSAALPVAHSSVN---
Mflv_5136|M.gilvum_PYR-GCK GVVPLLRERGLFEAGP-KQAASASIPFVGGTGRGRI
MAV_3426|M.avium_104 QLLPLLRHTALAN-----------------------
MLBr_00269|M.leprae_Br4923 DLAPRLRRLG--------------------------
: * :.