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SVVNKGFHGRRVDSARPLPPGQHLTGDFPVLQAGPTPRINLADWRFAIRNESGDEHVWTWEQMQELHHER FTVDIHCVTTWSKFDTQWEGVSLDTLFESVDTDAEFALVGSYGGYTTNIPIADLVGGKAWIVYGYQGEPL PAVHGGPARLLVPHLYFWKSAKWVRSIELCDSEKLGFWERLGYHRYGDPWREQRYAGD*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4412 | - | - | 100% (199) | oxidoreductase, molybdopterin binding |
| M. smegmatis MC2 155 | MSMEG_2278 | - | 2e-17 | 32.16% (199) | membrane-bound oxidoreductase |
| M. smegmatis MC2 155 | MSMEG_0998 | - | 3e-06 | 29.06% (117) | oxidoreductase, molybdopterin binding |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1786 | - | 2e-08 | 22.61% (230) | sulfite oxidase |
| M. gilvum PYR-GCK | Mflv_4320 | - | 4e-16 | 32.70% (159) | oxidoreductase, molybdopterin binding |
| M. tuberculosis H37Rv | Rv0218 | - | 8e-05 | 31.06% (161) | transmembrane protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4441 | - | 4e-12 | 27.18% (195) | putative oxidoreductase |
| M. marinum M | MMAR_3039 | - | 6e-14 | 31.41% (156) | membrane-bound oxidoreductase |
| M. avium 104 | MAV_2937 | - | 9e-06 | 24.39% (164) | oxidoreductase molybdopterin binding subunit |
| M. thermoresistible (build 8) | - | - | - | - | - |
| M. ulcerans Agy99 | MUL_2279 | - | 3e-14 | 31.41% (156) | membrane-bound oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_2026 | - | 3e-16 | 33.13% (166) | oxidoreductase, molybdopterin binding |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_4320|M.gilvum_PYR-GCK --------------------------------MTTPGV--RAAGG-----
Mvan_2026|M.vanbaalenii_PYR-1 --------------------------------MTTPGA--KAMTG-----
MMAR_3039|M.marinum_M --------------------------------MAGPSANERMLAG-----
MUL_2279|M.ulcerans_Agy99 --MADATVPNALVCLCGGTFALAESGASRVAGMAGPSANERMLAG-----
MAB_4441|M.abscessus_ATCC_1997 --------------------------------MEHAAR--RIIAG-----
Mb1786|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_4412|M.smegmatis_MC2_155 --------------------------------------------------
Rv0218|M.tuberculosis_H37Rv ------------------------------------------MSD-----
MAV_2937|M.avium_104 MGTPLTSIPDYRNEIHTAEDVIDVEAYGGGFDLTRRATAPKLRVGRDRWF
Mflv_4320|M.gilvum_PYR-GCK VAAAAVAVGVASLVGAAFGPEADVRTAVGSSVIDLTPGPVKEWAIATFGT
Mvan_2026|M.vanbaalenii_PYR-1 VAAAAVAVGVAQLVGAAFGPQADVRTAVGSAVIELTPGAVKEWAIDTFGT
MMAR_3039|M.marinum_M VAAASVALGVAQVVSIPFGTRADARTAVGSAVIDITPGPIKEWAIQALGP
MUL_2279|M.ulcerans_Agy99 VAAASVALGVAQVVSIPFGTRADARTAVGSAVIDITPGPIKEWAIQALGP
MAB_4441|M.abscessus_ATCC_1997 LIAAAAALAVGQLAAAAVAPDSAPFYAVGNTVVDHTPAAVREWVIGIFGT
Mb1786|M.bovis_AF2122/97 --------------------------------------------------
MSMEG_4412|M.smegmatis_MC2_155 --------------------------------------------------
Rv0218|M.tuberculosis_H37Rv PARGAEAEDAYGFPAGLWRWLQRHPPPALHRLTRFRSPLRGPWLTSVFG-
MAV_2937|M.avium_104 NLLWLIPIGFALLIAGVAVGKGLHNMPAVQSFIQRYPGTDSAGVPPGLPA
Mflv_4320|M.gilvum_PYR-GCK ADKLALAVMVLLTIAAIAAVAGLAETRRRPVCSIAIVIAG--GIGCAAVL
Mvan_2026|M.vanbaalenii_PYR-1 ADKLALTVMVLAVIAVIAAVAGILESRRRPIGSTAIVAAG--GVGCAAVL
MMAR_3039|M.marinum_M LDKPFLAIVVLVVIATLAALAGTLETQRRPLGSAVIAAAG--VLGCAAVL
MUL_2279|M.ulcerans_Agy99 LDKPFLAIVVLVVIATLAALAGTLETQRRPLGSAVIAAAG--VLGCAAVL
MAB_4441|M.abscessus_ATCC_1997 SDKAVLFACLTVIIALLAALAGLVEGERR-YGTVLIGLLG--VFGAVAAV
Mb1786|M.bovis_AF2122/97 ----------------------MTDRGENRTTIAMLETAG--LWGKRADM
MSMEG_4412|M.smegmatis_MC2_155 ---------------------------------MSVVNKG--FHGRRVDS
Rv0218|M.tuberculosis_H37Rv ------LVLLVALPFVIITGLLSYIAYAPQLGQAIPGDVG--WLRLPAFT
MAV_2937|M.avium_104 WIGWTHFFNLFMMMFIIRTGIQILCDHPRLYFSRNATPGKDEWLRVGPPV
Mflv_4320|M.gilvum_PYR-GCK SRAGSTGADIIPTLIGTACGVAVLRILQ----SDRLDGPSSETGTDPGRR
Mvan_2026|M.vanbaalenii_PYR-1 SRAGATLVDIVPTLVGTACGVAVLRLLV----SGRFTDEGEEASTDQGRR
MMAR_3039|M.marinum_M SRQGGTLLDTIPTIAGAACGVLLLRVLMRRFWPDAEDPNGSGDKSDAGRR
MUL_2279|M.ulcerans_Agy99 SRQGGTLLDTIPTIAGAACGVLLLRVLMRRFWPDAEDPNGSGDQSDAGRR
MAB_4441|M.abscessus_ATCC_1997 TRPAGTFAWIWPSVIAAVAGALVLGTLV----------HRAQSQAVPDRR
Mb1786|M.bovis_AF2122/97 IVRG----------------------------------------------
MSMEG_4412|M.smegmatis_MC2_155 --------------------------------------------------
Rv0218|M.tuberculosis_H37Rv WPTRPSWLYRLTQGLHVGLGLVIIPVVL----------------------
MAV_2937|M.avium_104 PDDELWTANADTVALPPQFGLPGFRHSIG-----LARWWHLGVDVLWLLN
Mflv_4320|M.gilvum_PYR-GCK RSLLTIGLLAAGAVSGVAGVVISRLASSVAGDRDAFALPRIDTPAAPIPE
Mvan_2026|M.vanbaalenii_PYR-1 LSLVTLGLLGAGVASGALGVVITRLASSVSGDREAFALPKVNKAAAPIPD
MMAR_3039|M.marinum_M R-LIMLGLLGFGVVTGVTGAVLARLAHSVAADRKAFTLPQPGTTAPPIPA
MUL_2279|M.ulcerans_Agy99 R-LVMLGLLGFGVVTGVTGAVLVRLAHSVAADRKAFTLPQPGTTAPPIPA
MAB_4441|M.abscessus_ATCC_1997 RFFGTAAVFALGSAGLYWLGTRWSKGTVVAAERREATVPAPVAPAPPLPE
Mb1786|M.bovis_AF2122/97 ------------------------------------CLPYNAEPPPAVLA
MSMEG_4412|M.smegmatis_MC2_155 --------------------------------------------ARPLPP
Rv0218|M.tuberculosis_H37Rv --------------------------------AKLWSVIPRLFVWPPARS
MAV_2937|M.avium_104 GAVFYVLLFATGQWRHIVPTSWDVFPNAASVAVQYLSLDWPTDNGWVAYN
Mflv_4320|M.gilvum_PYR-GCK SVQPKGVELPSWVTGNDDFYRID--TALSVPQLSRSEWRLRIHGMVDREV
Mvan_2026|M.vanbaalenii_PYR-1 GVQPKGVALPSFVTSNSDFYRID--TALSVPQLSRQDWRLRIHGMVDREV
MMAR_3039|M.marinum_M DVQPKGVALPDFITPSADFYRID--TALVVPQLSRGDWRLRIHGMVDREI
MUL_2279|M.ulcerans_Agy99 DVKPKGVALPDFITPSADFYRIN--TALVVPQLSRGDWRLRIHGMVDREI
MAB_4441|M.abscessus_ATCC_1997 GIDVKGAVP--YITSNTDFYRID--TALRVPQVSTAEWQLNIHGMVDRPR
Mb1786|M.bovis_AF2122/97 GSD---------ITPINAFYVRN--HGP-VPDIAPQHWRLTVGGLVDNPL
MSMEG_4412|M.smegmatis_MC2_155 GQHLTG-----------DFPVLQ--AGP-TPRINLADWRFAIRNESGDEH
Rv0218|M.tuberculosis_H37Rv IAQVLERLSVLMLVGGILFQIVT--GVLNIQYDYIFGFSFYTGHYFGAWV
MAV_2937|M.avium_104 GLQLLSYFTTVFIAAPAALITGLGMSPALSQRVHWLSKRLSIQHARSLHF
. : : .
Mflv_4320|M.gilvum_PYR-GCK TFTYEDLD-RFEVVEKVITLTCVSN-----------------PVGGELIS
Mvan_2026|M.vanbaalenii_PYR-1 TYRYEDLS-RFEVVEKVVTLTCVSN-----------------PVGGELIS
MMAR_3039|M.marinum_M SYTFDDLT-QFDVVETVATLTCVSN-----------------PVGGNLIS
MUL_2279|M.ulcerans_Agy99 SYTFDDLT-QFDVVETVATLTCVSN-----------------PVGGNLIS
MAB_4441|M.abscessus_ATCC_1997 TLMWADLN-AMAATQRAVTLTCVSN-----------------EIGGNLIG
Mb1786|M.bovis_AF2122/97 TVTYERLTTEFDQHCVVATLACAGNRRAELLRVRQIPGK--EPWAHGAIS
MSMEG_4412|M.smegmatis_MC2_155 VWTWEQMQ-ELHHERFTVDIHCVTT---------------------WSKF
Rv0218|M.tuberculosis_H37Rv FIAGFLLHIVVKIPHMVTGLRSIPMR----------------EVLGTNVA
MAV_2937|M.avium_104 LVLVYFLFFILVHVTMVLTTSALRNLNHMFAARDDNSWIGFGIFSAAMVL
: . . .
Mflv_4320|M.gilvum_PYR-GCK NAVWTGYRVKDLLAEAGVRSGADMVLSMSVDGWTAGT-PVEALTGD----
Mvan_2026|M.vanbaalenii_PYR-1 NAVWTGYRVGDLLAEAGVQPDADMVLSMSVDGWSAGT-PVEALTDG----
MMAR_3039|M.marinum_M TGIWTGYRVADLLSAAGVHKDADMVLSTSIDGFTAGT-PVQALTDGR---
MUL_2279|M.ulcerans_Agy99 TGIWTGYRIADLLSAAGVHKDADMVLSTSIDGFTAGT-PVQTLTDGR---
MAB_4441|M.abscessus_ATCC_1997 NAVWTGFPIKPILESVGVHPDADMLLSKSVDGWTAGT-PLQVLTDGR---
Mb1786|M.bovis_AF2122/97 TAQWCGVRLADILQAADVHIDEGLHVAFDAPDVAEEARPIQPYGSSIPLS
MSMEG_4412|M.smegmatis_MC2_155 DTQWEGVSLDTLFES--VDTDAEFALVGSYGGYTTNI-PIADLVGG----
Rv0218|M.tuberculosis_H37Rv DTRAQPCDPDGLVSVN--PGEATLSRRGALGLVGAGVLLIGVLTVGQTLG
MAV_2937|M.avium_104 TAIAWVWATPFTIRHPRVVQRVGYALVGPFQRMLEQLDPKPGAFTEKDIS
.
Mflv_4320|M.gilvum_PYR-GCK -----DALLAIGMNGEPLPIEHGYPARLVVPGLYGYVSATKWVTALELT-
Mvan_2026|M.vanbaalenii_PYR-1 -----DALLAIGMNGEPLPIEHGYPARLVVPGLYGYVSATKWVTDLELT-
MMAR_3039|M.marinum_M -----EALLALGLNGQPLPVEHGYPARLVVPGLYGYVSATKWVVELELT-
MUL_2279|M.ulcerans_Agy99 -----EALLALGLNGQPLPVEHGYPARLVVPGLYGYVSATKWVVELELT-
MAB_4441|M.abscessus_ATCC_1997 -----DAILAIAMNGTPLPVEHGYPVRQVVPGLYGYVSATKWVVDWEIT-
Mb1786|M.bovis_AF2122/97 KALSPEVLLAWQMNSEPLPRAHGGPVRVVVPGFIG-ARSVKWVTAITVQP
MSMEG_4412|M.smegmatis_MC2_155 -----KAWIVYGYQGEPLPAVHGGPARLLVP-HLYFWKSAKWVRSIELCD
Rv0218|M.tuberculosis_H37Rv -GFTRKAALLLPRGRVVSPGDFPVNKTAAAAGITAEAIGPDWRLVLCGG-
MAV_2937|M.avium_104 PHHWRNGRLPETVEYKELEANDFKDWRLKVYGLVEHPMEFSLEDLMALP-
. : . .
Mflv_4320|M.gilvum_PYR-GCK ------------RFDRAQAYWTRLG---WSARGPIKTASRVDVPRSGQDV
Mvan_2026|M.vanbaalenii_PYR-1 ------------RFDRAEAYWTRLG---WSARGPIKTESRIDVPRSGQDV
MMAR_3039|M.marinum_M ------------RFDRAKAYWTRQG---WAARAPIKTESRIDVPRRGQKV
MUL_2279|M.ulcerans_Agy99 ------------RFDRAKAYWTRQG---WAARAPIKTESRIDVPKRGQKV
MAB_4441|M.abscessus_ATCC_1997 ------------RFDKADAYWTIRG---WSARGPIKTGCRIDTPRTGDRL
Mb1786|M.bovis_AF2122/97 GASQNYFQALDYRILPADADADIVGPGEGISLSSLALNCDILDPTDGDDV
MSMEG_4412|M.smegmatis_MC2_155 --------------SEKLGFWERLG-------------------------
Rv0218|M.tuberculosis_H37Rv ------------PAEVVLDRATLAGLPQRTARLPLACVEGWSAVRTWSGV
MAV_2937|M.avium_104 ------------YHEQISQHFCIQAWSGVAKWGGVQMKTIMDIVKPLPEA
.
Mflv_4320|M.gilvum_PYR-GCK ALGPVTFGGVAWAQN-RGVRSVEVQMDDGP-WEQATLGDSYSGDTWRMWS
Mvan_2026|M.vanbaalenii_PYR-1 PVGPVTFGGVAWAQD-RGIRAVEVQIDDGD-WRQATLGDAYSGDTWRLWS
MMAR_3039|M.marinum_M PVGPVVFGGVAWAQN-RGVRAVEVRIGDGG-WQRAELGASYSNATWRLWS
MUL_2279|M.ulcerans_Agy99 PVGPVVFGGVAWAQN-RGVRAVEVRIGDGG-WQRAELGASYSNATWRLWS
MAB_4441|M.abscessus_ATCC_1997 GTGTQIVAGTAWAQH-RGIATVEVQIDDGP-WLPARLAPEYSVDTWRQWW
Mb1786|M.bovis_AF2122/97 PAGALTIRGYGMAGDGRSVERVDVSVDDGLTWQQADLHAAPSQWSWRPWS
MSMEG_4412|M.smegmatis_MC2_155 --------------------------------------YHRYGDPWREQR
Rv0218|M.tuberculosis_H37Rv PLAELALLAGVPAAR------------------SARVTSLQRGGAFGEAK
MAV_2937|M.avium_104 KWAVFYSMGLGATGG-----IYYNAHHIGQMDHHMTMLAYKMNDQQLPYM
Mflv_4320|M.gilvum_PYR-GCK YAWEARDTGFHTITVRATDDSGYTQTPDRA---DPVPDGATGWHSITFAV
Mvan_2026|M.vanbaalenii_PYR-1 FPWDARETGFHTITVRATDNDGYTQTPDRA---DPVPDGATGWHSITFAV
MMAR_3039|M.marinum_M LPWQAKSPGTHTITVRAIDNTGAVQTEDRA---DPVPDGATGWHTVTFTV
MUL_2279|M.ulcerans_Agy99 LPWQAKSPGTHTITVRAIDNTGAVQTEDRA---DPVPDGATGWHTVTFTV
MAB_4441|M.abscessus_ATCC_1997 FAWQAT-AGEHIITARATDGTGAVQTDQIA---SPVPDGATGYPKRLVTV
Mb1786|M.bovis_AF2122/97 LTVDVE-PGPLGITARAWDDTGALQPESAVSLWNPRGYGNNAWARVALRV
MSMEG_4412|M.smegmatis_MC2_155 YAGD----------------------------------------------
Rv0218|M.tuberculosis_H37Rv LAANQIADPDALLALRVDGADLSLDHGYPARIIVPALPGVHNTKWVAGIE
MAV_2937|M.avium_104 HGRPLRLRNELQHGFKLVKWIKGIEFVADYRDIGSGYGGYSEDHKYFGRH
Mflv_4320|M.gilvum_PYR-GCK K---
Mvan_2026|M.vanbaalenii_PYR-1 R---
MMAR_3039|M.marinum_M VDK-
MUL_2279|M.ulcerans_Agy99 VDK-
MAB_4441|M.abscessus_ATCC_1997 AA--
Mb1786|M.bovis_AF2122/97 S---
MSMEG_4412|M.smegmatis_MC2_155 ----
Rv0218|M.tuberculosis_H37Rv FHKR
MAV_2937|M.avium_104 QTL-