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IRLEIAGAVARIVLDRPQKRNALSSQLLTELRTRLEDVAASDVRVVQLIGEGPVFCAGADTVEFADTPPE LVRRRWTRLGQQVFRAVAELPQTTVAVLAGSAFGGGLELAMHCDFRVAADNVVLGLPEATLGTTPGWSGL GKISEIAGLAAARKLALTGRPIGAAEALRLGIVDVVAADVHSAADSLVRDVLDTAPGAQSILKRALASSA PADAASLIDSLAGGYLAASGETHSRRH*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4164 | - | - | 100% (238) | 3-hydroxybutyryl-CoA dehydratase |
| M. smegmatis MC2 155 | MSMEG_4119 | - | 6e-26 | 32.35% (238) | 3-hydroxybutyryl-CoA dehydratase |
| M. smegmatis MC2 155 | MSMEG_4077 | - | 2e-25 | 34.88% (215) | enoyl-CoA hydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1099c | echA8 | 3e-24 | 35.37% (229) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_4495 | - | 2e-23 | 33.96% (212) | enoyl-CoA hydratase |
| M. tuberculosis H37Rv | Rv1070c | echA8 | 3e-24 | 35.37% (229) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_02402 | - | 2e-24 | 35.89% (209) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_3382c | - | 4e-29 | 36.28% (215) | enoyl-CoA hydratase/isomerase |
| M. marinum M | MMAR_4536 | echA7 | 1e-25 | 35.29% (221) | enoyl-CoA hydratase EchA7 |
| M. avium 104 | MAV_1195 | - | 4e-24 | 34.58% (240) | enoyl-CoA hydratase |
| M. thermoresistible (build 8) | TH_3655 | - | 3e-24 | 34.64% (179) | PUTATIVE short chain enoyl-CoA hydratase |
| M. ulcerans Agy99 | MUL_4708 | echA7 | 4e-25 | 34.39% (221) | enoyl-CoA hydratase |
| M. vanbaalenii PYR-1 | Mvan_4851 | - | 8e-25 | 34.84% (221) | enoyl-CoA hydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1099c|M.bovis_AF2122/97 ----------------MTYETILVERDQR-VGIITLNRPQALNALNSQVM
Rv1070c|M.tuberculosis_H37Rv ----------------MTYETILVERDQR-VGIITLNRPQALNALNSQVM
MAV_1195|M.avium_104 ----------MTDSTDRTFETILVEREER-VGIITLNRPKALNALNTQVM
MLBr_02402|M.leprae_Br4923 ----------------MKYDTILVDGYQR-VGIITLNRPQALNALNSQMM
MAB_3382c|M.abscessus_ATCC_199 -------------MIEPEFVSVRTAPEHPGIGTIALSRP-PTNTFTRQMY
Mflv_4495|M.gilvum_PYR-GCK -----------------MTEDLVLTADHDGVRVITLNRPAARNALSRDLI
MMAR_4536|M.marinum_M -----------------MADRLVEYARDGVVARLTLNSPHNRNALSTTLV
MUL_4708|M.ulcerans_Agy99 -----------------MADRLVEYARDGVVARLTLNSPHNRNALSTTLV
Mvan_4851|M.vanbaalenii_PYR-1 MGVPPACGGRSREEATVLMSTLVTYERDGAVARLTLDSPHNRNALSTALV
MSMEG_4164|M.smegmatis_MC2_155 ---------------------MIRLEIAGAVARIVLDRPQKRNALSSQLL
TH_3655|M.thermoresistible__bu ---------------------MVDLELTDGLAVITIDRPQARNAIAPATM
: : :.:. * *::
Mb1099c|M.bovis_AF2122/97 NEVTSAATELDDDPDIGAIIITGS-AKAFAAGADIKEMADLTFADAFT--
Rv1070c|M.tuberculosis_H37Rv NEVTSAATELDDDPDIGAIIITGS-AKAFAAGADIKEMADLTFADAFT--
MAV_1195|M.avium_104 NEVTTAATDFDADPGIGAIIITGS-AKAFAAGADIKEMAELTFADAYG--
MLBr_02402|M.leprae_Br4923 NEITNAAKELDIDPDVGAILITGS-PKVFAAGADIKEMASLTFTDAFD--
MAB_3382c|M.abscessus_ATCC_199 RELAQAAAEVNARADIRVVIVYGG-HEIFCAGDDLAELSELSADEMARS-
Mflv_4495|M.gilvum_PYR-GCK RATYTALTSADDDDAVRAVVLTGA-DPAFCAGVDLKEAARDGLSYFAE--
MMAR_4536|M.marinum_M TQLHEGLRDAAADPGVRVVVLGHT-GGTFCAGADLTEAGSGDPYDLAVAR
MUL_4708|M.ulcerans_Agy99 TQLHEGLRDAAADPGVRVVVLGHT-GGTFCTGADLSEAGSGDPYDLAVAR
Mvan_4851|M.vanbaalenii_PYR-1 EQLHDGLTRASSEPRVRTVVLGHT-GRTFCAGADLSEAAGRDPSDLAVDR
MSMEG_4164|M.smegmatis_MC2_155 TELRTRLEDVAAS-DVRVVQLIGE-GPVFCAGADTVEFADTPPELVRRRW
TH_3655|M.thermoresistible__bu EQLEKALDSLAGNPDAQALVIRGAGDRAFVSGGDLKELAALRTELEASAM
.: : * :* * * .
Mb1099c|M.bovis_AF2122/97 -ADFFATWGKLAAVRTPTIAAVAGYALGGGCELAMMCDVLIAADTAKFGQ
Rv1070c|M.tuberculosis_H37Rv -ADFFATWGKLAAVRTPTIAAVAGYALGGGCELAMMCDVLIAADTAKFGQ
MAV_1195|M.avium_104 -ADFFAPWGKLAALRTPTIAAVAGHALGGGCELAMMCDVLIAADTAKFGQ
MLBr_02402|M.leprae_Br4923 -ADFFSAWGKLAAVRTPMIAAVAGYALGGGCELAMMCDLLIAADTAKFGQ
MAB_3382c|M.abscessus_ATCC_199 AGDRQAALTAVAELAKPTIAAITGYALGSGLELALTADWRIAGDNVKVGS
Mflv_4495|M.gilvum_PYR-GCK -FRTQSCIAAVAAMRTPVVGAINGATFTGGLEMALGCDFMIASERAVFAD
MMAR_4536|M.marinum_M AREMTTVLRAIVESPRPVIGAINGHVRAGGFGLVGACDIVVAGPACTFAL
MUL_4708|M.ulcerans_Agy99 AREMTTVLRAIVESPRPVIGAINGHVRAGGFGLVSACDIVVAGPACTFAL
Mvan_4851|M.vanbaalenii_PYR-1 AREMTRLLRRILELPLPVIAAVDGHVRAGGLGLVGACDIAVAGDSSTFAL
MSMEG_4164|M.smegmatis_MC2_155 TRLGQQVFRAVAELPQTTVAVLAGSAFGGGLELAMHCDFRVAADNVVLGL
TH_3655|M.thermoresistible__bu AWRMRSICDRLARFPGPVIAALNGHALGGGAEVAVAADIRIAADDIRIGF
: . :..: * . .* :. .* :*. ..
Mb1099c|M.bovis_AF2122/97 PEIKLGVLPGMGGSQRLTRAIGKAKAMDLILTGRTMDAAEAERSGLVSRV
Rv1070c|M.tuberculosis_H37Rv PEIKLGVLPGMGGSQRLTRAIGKAKAMDLILTGRTMDAAEAERSGLVSRV
MAV_1195|M.avium_104 PEIKLGVLPGMGGSQRLTRAIGKAKAMDLILTGRTIDAAEAERSGLVSRV
MLBr_02402|M.leprae_Br4923 PEIKLGVLPGMGGSQRLTRAIGKAKAMDLILTGRTIDAAEAERSGLVSRV
MAB_3382c|M.abscessus_ATCC_199 PEILVGMIPGGGGTVRLARVVGLSRAKEMVFSGRFVGADEARGAGLIDQV
Mflv_4495|M.gilvum_PYR-GCK THARVGILPGGGMTARLPQLVGAAMARRLSMTGEVVDAARAERIGLVTEV
MMAR_4536|M.marinum_M TEARIGVAPAIISLTLLPKLSARAAAR-YYLTGAKFGADEAAEMGLVT--
MUL_4708|M.ulcerans_Agy99 TEARIGVAPAIISLTLLPKLSARAAAR-YYLTGAKFGADEAAEMGLVT--
Mvan_4851|M.vanbaalenii_PYR-1 TEARIGVAPSIISLTLLPKMTARAAGR-YFVTGEKFGAAEAAAMGLVT--
MSMEG_4164|M.smegmatis_MC2_155 PEATLGTTPGWSGLGKISEIAGLAAARKLALTGRPIGAAEALRLGIVD--
TH_3655|M.thermoresistible__bu NQVALAIMPAWGGAERLAELVGRSKALLLAGTGTVLTAAEAERVGLVDKV
. :. *. :.. . : . :* . * .* *::
Mb1099c|M.bovis_AF2122/97 VPADDLLTEARATATTISQ--------MSASAARMAKEAVNRAFESSLSE
Rv1070c|M.tuberculosis_H37Rv VPADDLLTEARATATTISQ--------MSASAARMAKEAVNRAFESSLSE
MAV_1195|M.avium_104 VPADDLLTEAKKVATTISQ--------MSRSAARMAKEAVNRAFETTLAE
MLBr_02402|M.leprae_Br4923 VLADDLLPEAKAVATTISQ--------MSRSATRMAKEAVNRSFESTLAE
MAB_3382c|M.abscessus_ATCC_199 VAPDDVYTEAASWARRFVD--------GPPLALAAAKEAIDHGFDGPLAA
Mflv_4495|M.gilvum_PYR-GCK VAHQHLLQRAIDLAHQIAE--------VPRPTMRGLKEIYTAGASAVVDP
MMAR_4536|M.marinum_M IAADDVEAAVAALIADVGR--------GSPQGLAASKALTTAAVLAGFDR
MUL_4708|M.ulcerans_Agy99 IAADDMEAAVAALIADVGR--------GSPQGLAASKALTTAAVLAGFDR
Mvan_4851|M.vanbaalenii_PYR-1 VATDDVPGTVADLTSAIAQ--------GSPQGLAASKALTTAALIDDFER
MSMEG_4164|M.smegmatis_MC2_155 VVAADVHSAADSLVRDVLD--------TAPG----AQSILKRALASSAPA
TH_3655|M.thermoresistible__bu VPRASFDTEWRAIARSLATRPAAEIKRGARGGRRQPDEPDEVAVGFSPGS
: . . . . .
Mb1099c|M.bovis_AF2122/97 GLLYERRLFHSAFATED-QSEGMAAFIEKRAPQFTHR-------------
Rv1070c|M.tuberculosis_H37Rv GLLYERRLFHSAFATED-QSEGMAAFIEKRAPQFTHR-------------
MAV_1195|M.avium_104 GLLYERRLFHSTFATAD-QSEGMAAFVEKRAPNFTHR-------------
MLBr_02402|M.leprae_Br4923 GLLHERRLFHSTFVTDD-QSEGMAAFIEKRAPQFTHR-------------
MAB_3382c|M.abscessus_ATCC_199 GLDKERELFCQVFATQD-RADGVTAQLEIGPGTARFRGA-----------
Mflv_4495|M.gilvum_PYR-GCK ALAAEERIAFAQHRDLEGLGDRFSAVSQRNRDQIGGA-------------
MMAR_4536|M.marinum_M DAERLTEESARLFVSEE-AREGMLAFLQKRQPSWASD-------------
MUL_4708|M.ulcerans_Agy99 DAERLTEESARLFVSEE-AREGMLAFLQKRQPSWASD-------------
Mvan_4851|M.vanbaalenii_PYR-1 RAEKLTQESARLFVSEE-AREGMLAFLEKRPPRWVG--------------
MSMEG_4164|M.smegmatis_MC2_155 DAASLIDSLAGGYLAAS-GETHSRRH------------------------
TH_3655|M.thermoresistible__bu RIARSDRRPHNRSAGSAREVPSLRAQLRGQVPTGEQPRGRGHPAPDPPPV
Mb1099c|M.bovis_AF2122/97 --------------------------------------------------
Rv1070c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1195|M.avium_104 --------------------------------------------------
MLBr_02402|M.leprae_Br4923 --------------------------------------------------
MAB_3382c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_4495|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_4536|M.marinum_M --------------------------------------------------
MUL_4708|M.ulcerans_Agy99 --------------------------------------------------
Mvan_4851|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4164|M.smegmatis_MC2_155 --------------------------------------------------
TH_3655|M.thermoresistible__bu AGAYQLIVVVTDRVDPVLPVVRAQHQHRVHIRARGGPVAVDVDDDVAHAV
Mb1099c|M.bovis_AF2122/97 --------------------------------------------------
Rv1070c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1195|M.avium_104 --------------------------------------------------
MLBr_02402|M.leprae_Br4923 --------------------------------------------------
MAB_3382c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_4495|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_4536|M.marinum_M --------------------------------------------------
MUL_4708|M.ulcerans_Agy99 --------------------------------------------------
Mvan_4851|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4164|M.smegmatis_MC2_155 --------------------------------------------------
TH_3655|M.thermoresistible__bu VGRSHRSVHLRHHLGEGVRIGEGAELVVVDVDPVGPAAAEQRPVLLVDTR
Mb1099c|M.bovis_AF2122/97 --------------------------------------------------
Rv1070c|M.tuberculosis_H37Rv --------------------------------------------------
MAV_1195|M.avium_104 --------------------------------------------------
MLBr_02402|M.leprae_Br4923 --------------------------------------------------
MAB_3382c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_4495|M.gilvum_PYR-GCK --------------------------------------------------
MMAR_4536|M.marinum_M --------------------------------------------------
MUL_4708|M.ulcerans_Agy99 --------------------------------------------------
Mvan_4851|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_4164|M.smegmatis_MC2_155 --------------------------------------------------
TH_3655|M.thermoresistible__bu CVADQYVGDLRPVGVHLSHGNRRGGSRRDHHRPCNRFSLDENVVSGYCHR
Mb1099c|M.bovis_AF2122/97 ---------------------------
Rv1070c|M.tuberculosis_H37Rv ---------------------------
MAV_1195|M.avium_104 ---------------------------
MLBr_02402|M.leprae_Br4923 ---------------------------
MAB_3382c|M.abscessus_ATCC_199 ---------------------------
Mflv_4495|M.gilvum_PYR-GCK ---------------------------
MMAR_4536|M.marinum_M ---------------------------
MUL_4708|M.ulcerans_Agy99 ---------------------------
Mvan_4851|M.vanbaalenii_PYR-1 ---------------------------
MSMEG_4164|M.smegmatis_MC2_155 ---------------------------
TH_3655|M.thermoresistible__bu RRHRARPPGPGRRGPAGGVNAVVQTPG