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VGVPPACGGRSREEATVLMSTLVTYERDGAVARLTLDSPHNRNALSTALVEQLHDGLTRASSEPRVRTVV LGHTGRTFCAGADLSEAAGRDPSDLAVDRAREMTRLLRRILELPLPVIAAVDGHVRAGGLGLVGACDIAV AGDSSTFALTEARIGVAPSIISLTLLPKMTARAAGRYFVTGEKFGAAEAAAMGLVTVATDDVPGTVADLT SAIAQGSPQGLAASKALTTAALIDDFERRAEKLTQESARLFVSEEAREGMLAFLEKRPPRWVG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_4851 | - | - | 100% (273) | enoyl-CoA hydratase |
| M. vanbaalenii PYR-1 | Mvan_0344 | - | 3e-27 | 33.85% (260) | enoyl-CoA hydratase/isomerase |
| M. vanbaalenii PYR-1 | Mvan_5216 | - | 2e-26 | 33.60% (253) | enoyl-CoA hydratase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0996c | echA7 | 8e-97 | 71.95% (246) | enoyl-CoA hydratase |
| M. gilvum PYR-GCK | Mflv_1880 | - | 1e-113 | 81.32% (257) | enoyl-CoA hydratase |
| M. tuberculosis H37Rv | Rv0971c | echA7 | 8e-97 | 71.95% (246) | enoyl-CoA hydratase |
| M. leprae Br4923 | MLBr_02402 | - | 2e-20 | 29.92% (254) | enoyl-CoA hydratase |
| M. abscessus ATCC 19977 | MAB_1069c | - | 4e-92 | 68.87% (257) | enoyl-CoA hydratase |
| M. marinum M | MMAR_4536 | echA7 | 2e-99 | 73.20% (250) | enoyl-CoA hydratase EchA7 |
| M. avium 104 | MAV_1087 | - | 9e-93 | 68.20% (261) | enoyl-CoA hydratase |
| M. smegmatis MC2 155 | MSMEG_5495 | - | 1e-110 | 79.45% (253) | enoyl-CoA hydratase |
| M. thermoresistible (build 8) | TH_3726 | - | 6e-29 | 30.68% (264) | PUTATIVE probable enoyl-CoA hydratase |
| M. ulcerans Agy99 | MUL_4708 | echA7 | 2e-98 | 72.40% (250) | enoyl-CoA hydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0996c|M.bovis_AF2122/97 ------------------MDSPVDYAGPAACGGPFARLTLNSPHNRNALS
Rv0971c|M.tuberculosis_H37Rv ------------------MDSPVDYAGPAACGGPFARLTLNSPHNRNALS
MAV_1087|M.avium_104 ------------------MDALVDYAGPAATGGPVARLTLNSPHNRNALS
MMAR_4536|M.marinum_M -----------------MADRLVEYAR----DGVVARLTLNSPHNRNALS
MUL_4708|M.ulcerans_Agy99 -----------------MADRLVEYAR----DGVVARLTLNSPHNRNALS
Mvan_4851|M.vanbaalenii_PYR-1 MGVPPACGGRSREEATVLMSTLVTYER----DGAVARLTLDSPHNRNALS
Mflv_1880|M.gilvum_PYR-GCK ------------------MSSLVRYDR----DGAVARLTLDSPHNRNALS
MSMEG_5495|M.smegmatis_MC2_155 ------------------MDTLVRYEV----DGAVARLTLDSPHNRNALS
MAB_1069c|M.abscessus_ATCC_199 -----------------MSDTLVQYEV----EGRAARLTLDSPHNRNALS
MLBr_02402|M.leprae_Br4923 -----------------MKYDTILVDG----YQRVGIITLNRPQALNALN
TH_3726|M.thermoresistible__bu -------------MTTSIESPVILSTG----EDGIARLRLNRPEASNGLT
: . : *: *. *.*.
Mb0996c|M.bovis_AF2122/97 STLVSQLHQGLSAAEADPAVRLVVLGHTGGTFCAGADLSE--AGGGGG--
Rv0971c|M.tuberculosis_H37Rv STLVSQLHQGLSAAEADPAVRLVVLGHTGGTFCAGADLSE--AGGGGG--
MAV_1087|M.avium_104 TALVSQLHQGLRDASSDPAVRVVVLAHTGGTFCAGADLSE--AGSGGSPS
MMAR_4536|M.marinum_M TTLVTQLHEGLRDAAADPGVRVVVLGHTGGTFCAGADLTE--AGSGDP--
MUL_4708|M.ulcerans_Agy99 TTLVTQLHEGLRDAAADPGVRVVVLGHTGGTFCTGADLSE--AGSGDP--
Mvan_4851|M.vanbaalenii_PYR-1 TALVEQLHDGLTRASSEPRVRTVVLGHTGRTFCAGADLSE--AAGRDP--
Mflv_1880|M.gilvum_PYR-GCK TALVAQLHDGLTRASTETGVRAVVLTHTGGTFCAGADLSESPASGGDP--
MSMEG_5495|M.smegmatis_MC2_155 TALVEQLHEGFARAAGQSGVRVVVLGHTGGTFCAGADLSE--AAGRDP--
MAB_1069c|M.abscessus_ATCC_199 SGLVRQLREGLQRAAADQTVRAVVLTHTGNTFCAGADLSE--ASEGSP--
MLBr_02402|M.leprae_Br4923 SQMMNEITNAAKELDIDPDVGAILITGSPKVFAAGADIKEMAS-------
TH_3726|M.thermoresistible__bu VELLKALHEAVLACHADPAVKIVLLSGEGRNFCAGGDVKTFESKGESL--
:: : :. : * ::: *.:*.*:. :
Mb0996c|M.bovis_AF2122/97 DPYRMAVARAREMTALLRAIVESPLPVVGAINGHVRAGG-FGLVGACDMV
Rv0971c|M.tuberculosis_H37Rv DPYRMAVARAREMTALLRAIVESPLPVVGAINGHVRAGG-FGLVGACDMV
MAV_1087|M.avium_104 SAYDMAVERAREMAALMRAIVESRLPVIAAIDGHVRAGG-FGLVGACDIA
MMAR_4536|M.marinum_M --YDLAVARAREMTTVLRAIVESPRPVIGAINGHVRAGG-FGLVGACDIV
MUL_4708|M.ulcerans_Agy99 --YDLAVARAREMTTVLRAIVESPRPVIGAINGHVRAGG-FGLVSACDIV
Mvan_4851|M.vanbaalenii_PYR-1 --SDLAVDRAREMTRLLRRILELPLPVIAAVDGHVRAGG-LGLVGACDIA
Mflv_1880|M.gilvum_PYR-GCK --AEAALGRAREMTTLLRRILEVPLPVIAAIDGHVRAGG-LGLVGACDIV
MSMEG_5495|M.smegmatis_MC2_155 --ADIAVDRAREMTTLLRAILELRLPVIGAIDGHVRAGG-LGLVGACDVV
MAB_1069c|M.abscessus_ATCC_199 --QDIAKDRAGQLTALLRDILELPLPVIIAVNGHVRAGG-FGLVGAADIA
MLBr_02402|M.leprae_Br4923 --LTFTDAFDADFFSAWGKLAAVRTPMIAAVAGYALGGG-CELAMMCDLL
TH_3726|M.thermoresistible__bu --PEYLREATAWLQLATAALIQLRVPVVTAVQGYVAGGGGLGLVCASDFV
: : *:: *: *:. .** *. .*.
Mb0996c|M.bovis_AF2122/97 VAGPESTFALTEARIGVAP-AIISLTLLPKLSPRAAARYYLTGEKFGARE
Rv0971c|M.tuberculosis_H37Rv VAGPESTFALTEARIGVAP-AIISLTLLPKLSPRAAARYYLTGEKFGARE
MAV_1087|M.avium_104 VAGPRSSFALTEARIGVAP-AIISLTLLPKLSARAAARYYLTGEKFDARR
MMAR_4536|M.marinum_M VAGPACTFALTEARIGVAP-AIISLTLLPKLSARAAARYYLTGAKFGADE
MUL_4708|M.ulcerans_Agy99 VAGPACTFALTEARIGVAP-AIISLTLLPKLSARAAARYYLTGAKFGADE
Mvan_4851|M.vanbaalenii_PYR-1 VAGDSSTFALTEARIGVAP-SIISLTLLPKMTARAAGRYFVTGEKFGAAE
Mflv_1880|M.gilvum_PYR-GCK VAGRASTFALTEARIGVAP-SIISLTVLPKMSLRSAGRYFVTGEKFGAEE
MSMEG_5495|M.smegmatis_MC2_155 VAGPGSTFALTEARIGVAP-SIISLTLLPKMTPRSAGRYFLTGERFGAEE
MAB_1069c|M.abscessus_ATCC_199 VAGPDSTFALTEARIGVAP-SIISLTLLPRLTSRAAGRYFVTGEKFDARV
MLBr_02402|M.leprae_Br4923 IAADTAKFGQPEIKLGVLPGMGGSQRLTRAIGKAKAMDLILTGRTIDAAE
TH_3726|M.thermoresistible__bu IAARSAKFFSGAVRVGMAPDGGASVTLTQLVGLRQALRILLANPTLSAEE
:*. ..* ::*: * * : : * ::. :.*
Mb0996c|M.bovis_AF2122/97 AADIGLITMAAD---DVDAAVAALVADVGRGSPQGLAASKALTTAAVLEG
Rv0971c|M.tuberculosis_H37Rv AADIGLITMAAD---DVDAAVAALVADVGRGSPQGLAASKALTTAAVLEG
MAV_1087|M.avium_104 AEEIGLITMAAE---DLDAAIDQLVTDVGRGSPQGLAASKALTTAAVLER
MMAR_4536|M.marinum_M AAEMGLVTIAAD---DVEAAVAALIADVGRGSPQGLAASKALTTAAVLAG
MUL_4708|M.ulcerans_Agy99 AAEMGLVTIAAD---DMEAAVAALIADVGRGSPQGLAASKALTTAAVLAG
Mvan_4851|M.vanbaalenii_PYR-1 AAAMGLVTVATD---DVPGTVADLTSAIAQGSPQGLAASKALTTAALIDD
Mflv_1880|M.gilvum_PYR-GCK AAAAGLVTLAAD---DVAAAVSELTSAIAKGSPQGLAASKALTTAAVIDD
MSMEG_5495|M.smegmatis_MC2_155 AAAVGLVTVAAD---DVDTAVAALAGEIAKGSPQGLATSKALTTAAILRD
MAB_1069c|M.abscessus_ATCC_199 AAEIGLVTQSVDSAEAVEAAVTSLVDDIALGSPQGLAESKRLTTAPILAD
MLBr_02402|M.leprae_Br4923 AERSGLVSRVVLA-DDLLPEAKAVATTISQMSRSATRMAKEAVNRSFEST
TH_3726|M.thermoresistible__bu AAGIGLITEVVDD-VELTARAEALAAELTALPPLALSATKRLVWSGVGQS
* **:: . : : : . . :* . .
Mb0996c|M.bovis_AF2122/97 FDRDAERLTEESARLFVSDEAREGMLAFLQKRPPRWVQPATMRAAD
Rv0971c|M.tuberculosis_H37Rv FDRDAERLTEESARLFVSDEAREGMLAFLQKRPPRWVQPATMRAAD
MAV_1087|M.avium_104 FDRDAERLAEESARLFVSDEAREGMLAFLEKRSPNWTS--------
MMAR_4536|M.marinum_M FDRDAERLTEESARLFVSEEAREGMLAFLQKRQPSWASD-------
MUL_4708|M.ulcerans_Agy99 FDRDAERLTEESARLFVSEEAREGMLAFLQKRQPSWASD-------
Mvan_4851|M.vanbaalenii_PYR-1 FERRAEKLTQESARLFVSEEAREGMLAFLEKRPPRWVG--------
Mflv_1880|M.gilvum_PYR-GCK FDRRAEKLTRESAELFVSDEAREGMLAFLQKRAPSWAG--------
MSMEG_5495|M.smegmatis_MC2_155 FDEHAEELTQQSARLFVSDEAREGMLAFLQKRSPNWAD--------
MAB_1069c|M.abscessus_ATCC_199 FDARAVELTETSARLFVSPEAQEGMLAFLQKRPPAWQV--------
MLBr_02402|M.leprae_Br4923 LAEGLLHERRLFHSTFVTDDQSEGMAAFIEKRAPQFTHR-------
TH_3726|M.thermoresistible__bu VAERLAEEARTVSELSGTADSLEGLRAVIERRPPRFTGR-------
. . . : : **: *.:::* * :