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PATPTRPVSMPKVAFASFIGTLIEFFDMFIFSTASALVFNKIFFPSLDPLAGTLAAFAAFGVAFVVRPLG GIVFGHFGDRVGRKTMLVTSLLLMGTGTAAVGVLPTYAQIGIWAPILLVATRLLQGLAIGGEWSGAVLMA VEHAPKSRRAFYGSWPLCGVPGGLVLATIAFYLIGLLPEEQMMSWGWRVPFLASAVLLLIGLYIRLRISE SPAFKAVQHNKREAKFPALEVVRSAGKGVVIAILAMAANSVFFYMATVFALSYGERQGASRGLILIAVMC AAAAQIITLPIAAVLADRYGRRPVMIAGCLIGAASAFPIFWLLDTTNFLAILAAMVLAIPVVHSLTYAPM ASFISELFETRLRYSGSAMGYQFGSMLWSAPVPFVSAALFAWAGESWPLSVYMFIGTVVSIGAIWWARET FRDEITELDQPSGPAATSSAPHLSVEHTGSSR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4122 | - | - | 100% (453) | major facilitator family protein transporter |
| M. smegmatis MC2 155 | MSMEG_0716 | - | e-125 | 51.70% (412) | major facilitator superfamily protein |
| M. smegmatis MC2 155 | MSMEG_6295 | - | e-101 | 43.19% (426) | shikimate transporter |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1232 | - | 3e-77 | 37.86% (420) | integral membrane transport protein |
| M. gilvum PYR-GCK | Mflv_2383 | - | 3e-98 | 42.31% (442) | major facilitator transporter |
| M. tuberculosis H37Rv | Rv1200 | - | 3e-77 | 37.86% (420) | integral membrane transport protein |
| M. leprae Br4923 | MLBr_01562 | - | 7e-09 | 24.82% (427) | putative transmembrane efflux protein |
| M. abscessus ATCC 19977 | MAB_2481 | - | 1e-91 | 41.35% (416) | putative integral membrane transporter |
| M. marinum M | MMAR_4238 | - | 2e-75 | 39.15% (401) | integral membrane transport protein |
| M. avium 104 | MAV_4627 | - | 3e-90 | 43.56% (404) | major facilitator superfamily protein |
| M. thermoresistible (build 8) | TH_3714 | - | 3e-98 | 43.71% (453) | PUTATIVE major facilitator superfamily MFS_1 |
| M. ulcerans Agy99 | MUL_0949 | - | 9e-76 | 39.15% (401) | integral membrane transport protein |
| M. vanbaalenii PYR-1 | Mvan_5300 | - | 1e-95 | 40.74% (432) | major facilitator superfamily transporter |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1232|M.bovis_AF2122/97 ----------------------------------------------MKRV
Rv1200|M.tuberculosis_H37Rv ----------------------------------------------MKRV
MMAR_4238|M.marinum_M ----------------------------------------------MSRV
MUL_0949|M.ulcerans_Agy99 ----------------------------------------------MSRV
MAB_2481|M.abscessus_ATCC_1997 --------------MTTTSAVPAVHA----------GGPADGDAPAARTV
Mvan_5300|M.vanbaalenii_PYR-1 -----------------MSTQHDARP----------DGPPS-ITTGLKRV
Mflv_2383|M.gilvum_PYR-GCK -----------------MGP----------------GGRT---RVSPRRV
TH_3714|M.thermoresistible__bu -----------------MSA----------------EAATPTSRVTPRRV
MAV_4627|M.avium_104 -----------------MAATLPAPAPAGLADGHPLDESAEQQRRRLRIV
MSMEG_4122|M.smegmatis_MC2_155 ------------------------------------MPATPTRPVSMPKV
MLBr_01562|M.leprae_Br4923 MVTLYDHERAVHNWTAARSDRPAPSRLTQQVEPASERTSKYPTLLPSGRF
.
Mb1232|M.bovis_AF2122/97 ALACLVGSAIEFYDFLIYGTAAALVFPTVFFPH-LDPTVAAVASMGTFAV
Rv1200|M.tuberculosis_H37Rv ALACLVGSAIEFYDFLIYGTAAALVFPTVFFPH-LDPTVAAVASMGTFAV
MMAR_4238|M.marinum_M ALACVVGSTVEYYDFCIYGTAAALVFPAVFYPG-LSPALATIASMGTFAT
MUL_0949|M.ulcerans_Agy99 ALACVVGSTVEYYDFCIYGTAAALVFPAVFYPG-LSPALATIASMGTFAT
MAB_2481|M.abscessus_ATCC_1997 ALSCMVGTTIEWYDFYLYATAAALVLKPLFFPS-VSPTAGTLASFATYAA
Mvan_5300|M.vanbaalenii_PYR-1 VVASMAGTVVEWYEFFLYATAATLVFNKVFFAEGTSEAAGLIAALLTYAV
Mflv_2383|M.gilvum_PYR-GCK AIASFVGTTVEFYDFLIYGTAAALVFPKLFFPN-ASPAAGILLSFATFGV
TH_3714|M.thermoresistible__bu AVASFIGTTVEFYDFLIYGTAAALVFPKLFFPT-ASPASGVLLSFATFGV
MAV_4627|M.avium_104 VAASLLGTTVEWYDFFLYATAAGLVFNKVFFPN-ESSLVGTLLAFATFAV
MSMEG_4122|M.smegmatis_MC2_155 AFASFIGTLIEFFDMFIFSTASALVFNKIFFPS-LDPLAGTLAAFAAFGV
MLBr_01562|M.leprae_Br4923 PSGRFIAAVIVIGGMQLLATMDSTVA-IVALPK-IQNELSLSDAGRSWGI
. . .: : : : .* * : . . . : ::.
Mb1232|M.bovis_AF2122/97 AFLSRPFGAAVFG--YFGDRLGRKKTLVATLLIMGLATVTVG--------
Rv1200|M.tuberculosis_H37Rv AFLSRPFGAAVFG--YFGDRLGRKKTLVATLLIMGLATVTVG--------
MMAR_4238|M.marinum_M AFLSRPLGAAVFG--HFGDRLGRKKTLVATLLIMALSTVTVG--------
MUL_0949|M.ulcerans_Agy99 AFLSRPLGAAVFG--HFGDRLGRKKTLVATLLIMALSTVTVG--------
MAB_2481|M.abscessus_ATCC_1997 GFGARPVGAVIAG--HLGDRVGRKAVLVGALLLMGVATAVIG--------
Mvan_5300|M.vanbaalenii_PYR-1 GFVARPLGGVVFG--HFGDKYGRKKLLQFAILLVGAVTFLMG--------
Mflv_2383|M.gilvum_PYR-GCK GFIARPLGGIVFG--HFGDRVGRRRMLVYSLVGMGVSTVLIG--------
TH_3714|M.thermoresistible__bu GFFARPLGGIVFG--HFGDRLGRKRMLVYSLVGMGVATVLIG--------
MAV_4627|M.avium_104 GFVMRPIGGLVFG--HIGDRIGRKRSLALTMLIMGGATALIG--------
MSMEG_4122|M.smegmatis_MC2_155 AFVVRPLGGIVFG--HFGDRVGRKTMLVTSLLLMGTGTAAVG--------
MLBr_01562|M.leprae_Br4923 TAYVLTFGGLMLLGGRLGDTIGRKRTFIVGVALFTISSVLCAVAWDEVTL
..*. : :** **: : : . : .
Mb1232|M.bovis_AF2122/97 -LVPTTVAIGAAAPLILTTMRLLQGFAVGGEWAGSALLSAEYAPASKRG-
Rv1200|M.tuberculosis_H37Rv -LVPTTVAIGAAAPLILTTMRLLQGFAVGGEWAGSALLSAEYAPASKRG-
MMAR_4238|M.marinum_M -VVPSTATIGVSAPLILVALRLLQGFAVGGEWAGSALLSIESAPAHKRG-
MUL_0949|M.ulcerans_Agy99 -VVPSTATIGVSAPLILVALRLLQGFAVGGEWAGSALLSIESAPAHKRG-
MAB_2481|M.abscessus_ATCC_1997 -ALPTYSEAGVLAPAALATLRVLQGLAAGAEWGGAALLAVEHAPVGRRG-
Mvan_5300|M.vanbaalenii_PYR-1 -CLPTYAQIGVWAPILLVVLRFMQGFAVGGEWGGAVLLVAEHSPNKERG-
Mflv_2383|M.gilvum_PYR-GCK -VLPTYAQIGLAAPILLTVLRLAQGFAVGGEWGGATLMAVEHATADRRG-
TH_3714|M.thermoresistible__bu -LLPTYAQIGMAAPALLTLLRLAQGFAMGGEWGGATLMAVEHASADRKG-
MAV_4627|M.avium_104 -VLPTAAQIGAWAPVLLLVLRVLQGFALGGEWGGAVLLAVEHSPGDRRG-
MSMEG_4122|M.smegmatis_MC2_155 -VLPTYAQIGIWAPILLVATRLLQGLAIGGEWSGAVLMAVEHAPKSRRA-
MLBr_01562|M.leprae_Br4923 VIARLLQGIGSAIASPTGLALVATTFSKGSARNTATAVFAAMTAIGSVMG
* . . :: *. :. : :.
Mb1232|M.bovis_AF2122/97 --WYGMFTVVGGGIALVLTSLTFLGVNYTIGESSPTFMQWGWRIPFLVSA
Rv1200|M.tuberculosis_H37Rv --WYGMFTVVGGGIALVLTSLTFLGVNYTIGESSPTFMQWGWRIPFLVSA
MMAR_4238|M.marinum_M --YYGMFTVLGGGVALVVSGLTFLGVNYTIGESSSAFLQWGWRVPFLLSA
MUL_0949|M.ulcerans_Agy99 --YYGMFTVLGGGVALVVSGLTFLGVNYTIGESSSALLQWGWRVPFLLSA
MAB_2481|M.abscessus_ATCC_1997 --LFGSFTQLGSPAGMLLATGVFGLTRALTGPE--AFLAFGWRIPFLSSI
Mvan_5300|M.vanbaalenii_PYR-1 --FWASWPQAAVPVGNMLATVVLLVLTGTLSND--AFLSWGWRVAFWLSA
Mflv_2383|M.gilvum_PYR-GCK --FYGAFPQMGAPAQTAAAT-LAFYLAARLPDD--QFLAWGWRIPFLVSA
TH_3714|M.thermoresistible__bu --FYGAFPQMGAPAGTATAT-LAFFAVSRLPDG--QFLSWGWRLPFLLSA
MAV_4627|M.avium_104 --RYGAVPQVGLALGLALGTGIFAFLQIVLGPA--RFLSYGWRIGFLLSV
MSMEG_4122|M.smegmatis_MC2_155 --FYGSWPLCGVPGGLVLAT-IAFYLIGLLPEE--QMMSWGWRVPFLASA
MLBr_01562|M.leprae_Br4923 LVVGGALTEVSWRLAFLVNVPIGLVMIYLARTALHETHKERMKLDAAGAI
. . . :: :
Mb1232|M.bovis_AF2122/97 ALIAVALYVRFNIDETP---VFAR--ERADEKTRLGPAETPIAQVLR---
Rv1200|M.tuberculosis_H37Rv ALIAVALYVRFNIDETP---VFAR--ERADEKTRLGPAETPIAQVLR---
MMAR_4238|M.marinum_M LLIAFALYVRLEINETP---VFARAMAQADDQESTAAARAPLAAVLC---
MUL_0949|M.ulcerans_Agy99 LLIAFALYVRLEINETP---VFARAMAQADDQESTAAARAPLAAVLC---
MAB_2481|M.abscessus_ATCC_1997 VLVVVGLAIRLRLRDS---VVFRKVLERGE------AARLPVVEVLR---
Mvan_5300|M.vanbaalenii_PYR-1 VVVLVGYYIRTKVTDAPIFVAAQEEVERVK------SVSYGVVEVLK---
Mflv_2383|M.gilvum_PYR-GCK ILIVIGLVVRLTVTESP---HFAELQRRSE------VTRTPIVAAFR---
TH_3714|M.thermoresistible__bu VLIGIGLAVRLTLTESP---DFAAVQARSA------VHRMPIAEAFR---
MAV_4627|M.avium_104 LLVAIGIVVRLRVEETP---AFRELQDLQA------ASTVPIRDILRE--
MSMEG_4122|M.smegmatis_MC2_155 VLLLIGLYIRLRISESP---AFKAVQHNKR------EAKFPALEVVR---
MLBr_01562|M.leprae_Br4923 LATLACTAAVFAFSMGPEKGWISLTTIGSGLVALVAAIAFAVVERTAENP
.
Mb1232|M.bovis_AF2122/97 ------RQRREIVLAAGSAVCCFGFVYLASTYLASYAQTRLGYSRGSILF
Rv1200|M.tuberculosis_H37Rv ------RQRREIVLAAGSAVCCFGFVYLASTYLASYAQTRLGYSRGSILF
MMAR_4238|M.marinum_M ------RQRREIVLAAGAMLAAFGCLYLASTFLPSYAQLHLGYSRNLVLL
MUL_0949|M.ulcerans_Agy99 ------RQRREIVLAAGAMLAAFGCLYLASTFLPSYAQLHLGYSRNLVLL
MAB_2481|M.abscessus_ATCC_1997 ------TQSRNVLLTTGLRLSQIALFVLLTTFSLTYLQGSFGGDSQIGLT
Mvan_5300|M.vanbaalenii_PYR-1 ------RYPRGVFTAMGLRFAENIMYYLVVTFSIVYLKTHVGADTSDILW
Mflv_2383|M.gilvum_PYR-GCK ------RHWRQILLVAGAYLSQGIFAYICVAYLVSYATTVAEIPRDWALL
TH_3714|M.thermoresistible__bu ------RHRRQILLVAGAYLSQGVFAYICVAYLVSYGTSVAGIDRTATLF
MAV_4627|M.avium_104 -----RRSRRNTVLGLLSRWAEGSAFNTWGVFAISYATGALGLNRVSVLI
MSMEG_4122|M.smegmatis_MC2_155 ------SAGKGVVIAILAMAANSVFFYMATVFALSYGE-RQGASRGLILI
MLBr_01562|M.leprae_Br4923 VVPFDLFRDRNRLVTFIAIFLAGGVIFSLTVSIGLYIQDILGYSALRAGI
: . . *
Mb1232|M.bovis_AF2122/97 DSVLGGLLCIVFTALSSALCDQLGRRRVLLAGWAVALPWSLLVMPLIDSG
Rv1200|M.tuberculosis_H37Rv DSVLGGLLCIVFTALSSALCDQLGRRRVLLAGWAVALPWSLLVMPLIDSG
MMAR_4238|M.marinum_M IGVLGGLVCIGFVALSAILCDRFGRRRVMLVGWAVGLFWSPLVMPLIGSG
MUL_0949|M.ulcerans_Agy99 IGVLGGLVCIGFVALSAILCDRFGRRRVMLVGWAVGLFWSPLVMPLIGSG
MAB_2481|M.abscessus_ATCC_1997 AVLISSALGILSTPVWSALSDRVGRRPLYLFGSAAGPLALGLFFLAAGSG
Mvan_5300|M.vanbaalenii_PYR-1 WLLAAHAVHFLVVPQVGRLADRFGRRPVYIAGAMLAATWGFFAFPMMNSG
Mflv_2383|M.gilvum_PYR-GCK GVFLGAVVAVATYPLFGALSDRVGRKPLYLAGVIAMALAVVPTFALINTG
TH_3714|M.thermoresistible__bu GVSVAAVLAVVMYPLFGSLSDTFGRKPLFLAGVIAMGVSIGPAFALIDTG
MAV_4627|M.avium_104 AVTIAALLMAVLLPVSGVLTDRFGARRVYLAGIACYGLAAFPAFALFGTK
MSMEG_4122|M.smegmatis_MC2_155 AVMCAAAAQIITLPIAAVLADRYGRRPVMIAGCLIGAASAFPIFWLLDTT
MLBr_01562|M.leprae_Br4923 GFIPFVIAMGIGLGVSSQLVSRFSPRVLTIGGGWLLMVAMLYGWAFMNRG
. * . . : : : * .
Mb1232|M.bovis_AF2122/97 S---PSLFAVA-VVGMYAIGGFGFGPTASFIPELFATSYRYTGSALAANL
Rv1200|M.tuberculosis_H37Rv S---PSLFAVA-VVGMYAIGGFGFGPTASFIPELFATSYRYTGSALAANL
MMAR_4238|M.marinum_M D---TVGFTVA-LLGLYAVAASGFGPAASLIPELFATRYRYTGTALALNV
MUL_0949|M.ulcerans_Agy99 D---TVGFTVA-LLGLYAVAASGFGPAASLIPELFATRYRYTGTALALNV
MAB_2481|M.abscessus_ATCC_1997 S---KVLVVLSIVFGINVVHDAMYGPQAAWFAELFDTRVRYSGASLGYQI
Mvan_5300|M.vanbaalenii_PYR-1 D---YLLILGAVILGL-MIHALMYAPQPAIMAEMFPTRMRYSGVSLGYQV
Mflv_2383|M.gilvum_PYR-GCK R---PVMFVLALVLIFGLAMAPAAGVTGALFSMAFDADVRYSGVSVGYTL
TH_3714|M.thermoresistible__bu R---PALFLVALVLVFGLAMAPAAGVTGALFAMTFDADVRYSGVSIGYTL
MAV_4627|M.avium_104 K---LLWFGLAMVIVFGVVHALFYGAQGTLYSALYPTNTRYTGLSFVYQF
MSMEG_4122|M.smegmatis_MC2_155 N---FLAILAAMVLAIPVVHSLTYAPMASFISELFETRLRYSGSAMGYQF
MLBr_01562|M.leprae_Br4923 VPYFPNLLAPIVVGGIGIGMAVVPLTLSAIAGVGFDRIGPVSAIALMLQS
. : : : : :. :.
Mb1232|M.bovis_AF2122/97 AG--VAGGALPPVIAGALVATYGSWA--IGVMLAILALISLVCTYRLPET
Rv1200|M.tuberculosis_H37Rv AG--VAGGALPPVIAGALVATYGSWA--IGVMLAILALISLVCTYRLPET
MMAR_4238|M.marinum_M AG--IVGGAAPPLIAGTLLASYGSSA--VGLMMTALVAASLLCTYLLPET
MUL_0949|M.ulcerans_Agy99 AG--IVGGAAPPLIAGTLLASYGSSA--VGLMMTALVAASLLCTYLLPET
MAB_2481|M.abscessus_ATCC_1997 GA--VLSGGFAPLIAAALLAANHGDPRLIVCYYLALSVLTFGAACVARET
Mvan_5300|M.vanbaalenii_PYR-1 TS--IVAGSLAPAIATWLLDR-FGTWVPIAVYLAGAAVITLVAAWFTRET
Mflv_2383|M.gilvum_PYR-GCK SQ--VLGSAFAPTIATALYAATGSSNSIAA-YLIAASAVSAVAVCFMPGG
TH_3714|M.thermoresistible__bu SQ--VLGSAFAPTIAAALYAATESSGSIVA-YLIGVSVISAVSVCLLPGG
MAV_4627|M.avium_104 SG--VYASGVTPMILTALIAALGGAPWLACGYLVATAVISVLATALIR--
MSMEG_4122|M.smegmatis_MC2_155 GS--MLWSAPVPFVSAALFAWAGESWPLSVYMFIG-TVVSIGAIWWARET
MLBr_01562|M.leprae_Br4923 LGGPLVLAVIQAVITSRTLYLGGTTGPVKFMNDAQLRALDHGYTYGLLWV
: . . :
Mb1232|M.bovis_AF2122/97 AG-----------SALVSR-----------------
Rv1200|M.tuberculosis_H37Rv AG-----------SALVSR-----------------
MMAR_4238|M.marinum_M AG-----------APLTAA-----------------
MUL_0949|M.ulcerans_Agy99 AG-----------APLTAA-----------------
MAB_2481|M.abscessus_ATCC_1997 Y-----------RDQIGDSL----------------
Mvan_5300|M.vanbaalenii_PYR-1 NGIDLHSLDVADREQLAKAGIV--------------
Mflv_2383|M.gilvum_PYR-GCK WR---AAPAEARPEHTPTAPTG--------------
TH_3714|M.thermoresistible__bu WGRTGDQPATEVPASVRPMVSGPD------------
MAV_4627|M.avium_104 ----------DRDLYL--------------------
MSMEG_4122|M.smegmatis_MC2_155 FRDEITELDQPSGPAATSSAPHLSVEHTGSSR----
MLBr_01562|M.leprae_Br4923 AGAVVIVGVAALFIGYTPEQVAYAQEVKEAVDAGEL