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RAAMCREYGPPEVVRVEDVAEPVAGPGQIGVRVDAAAVNFPDVLLVAGTYQISVPPPFVPGSEFAGVVDE IGPGTEGFTIGDRVSGTAMFGAFAERTVVDAAALAPIPDGVDARTAAAFGVAYRTAYHTLRSVARVSEGD ELVVLGAGGGVGLAAVQLGVALGANVTAVASSAEKLAAAAEYGAAHLVDHREQDLRAALRTAVPDGADVV IDPVGGRLSEPALRSLGRGGRFVTVGFASGEIPRIPLNLVLLKGVQVLGFQFQDVPGDEFVRNDHELRAL LSARRVTPHVGAVYPLEEVAAALRHVGEGRAIGKVLIDVPA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_2449 | - | - | 100% (322) | alcohol dehydrogenase |
| M. gilvum PYR-GCK | Mflv_0740 | - | 6e-44 | 33.74% (326) | alcohol dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4503 | - | 8e-41 | 35.35% (331) | alcohol dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0154 | - | 1e-42 | 34.05% (326) | putative quinone oxidoreductase (NADPH:quinone oxidoreductase) |
| M. tuberculosis H37Rv | Rv0149 | - | 1e-42 | 34.05% (326) | quinone oxidoreductase |
| M. leprae Br4923 | MLBr_00118 | - | 1e-31 | 29.35% (310) | putative oxidireductase |
| M. abscessus ATCC 19977 | MAB_4603c | - | 2e-45 | 35.08% (325) | oxidoreductase |
| M. marinum M | MMAR_5313 | - | 2e-93 | 54.49% (323) | quinone oxidoreductase |
| M. avium 104 | MAV_0308 | - | 6e-91 | 55.42% (323) | alcohol dehydrogenase, zinc-binding |
| M. smegmatis MC2 155 | MSMEG_4828 | - | 1e-125 | 71.56% (320) | alcohol dehydrogenase, zinc-binding |
| M. thermoresistible (build 8) | TH_3212 | - | 1e-119 | 67.50% (320) | PUTATIVE Alcohol dehydrogenase, zinc-binding domain protein |
| M. ulcerans Agy99 | MUL_4387 | - | 6e-92 | 54.49% (323) | quinone oxidoreductase |
| M. vanbaalenii PYR-1 | Mvan_4202 | - | 1e-140 | 77.50% (320) | alcohol dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0154|M.bovis_AF2122/97 MKACVVKELSGPSGMVYTDIDEVSGDGGKVVIDVRAAGVCFPDLLLTKGE
Rv0149|M.tuberculosis_H37Rv MKACVVKELSGPSGMVYTDIDEVSGDGGKVVIDVRAAGVCFPDLLLTKGE
MAB_4603c|M.abscessus_ATCC_199 MKAIQAQSLSGPEGLVYTDVETPGAGPNVVVVDVKAAGVCFPDYLMTKGE
Mflv_2449|M.gilvum_PYR-GCK MRAAMCREYGPPEVVRVEDVAEPVAGPGQIGVRVDAAAVNFPDVLLVAGT
Mvan_4202|M.vanbaalenii_PYR-1 MRAAVCPQYGPPEVVRVEERPEPSAGPGQVVVRVEAAAVNFPDVLLVADS
TH_3212|M.thermoresistible__bu MRAAVCTAHGPPEVVCIEERPAPGLLPGQVRVRVAAAGVNFPDVLLIAGR
MSMEG_4828|M.smegmatis_MC2_155 MRAAVCPRYGPPEVVRVEELPVPELGPDQVRVRVGAAAVNFPDVLLVADR
MMAR_5313|M.marinum_M MRAIVCNAYGPPEDLVLDEVPDPVPAPGQVLVRVRAAAVNFPDVLFIAGK
MUL_4387|M.ulcerans_Agy99 MRAIVCDAYGPPEDLVLDEVPDPVPAPGQVLVRVRAVAVNFPDVLFIAGK
MAV_0308|M.avium_104 MRAVVCRSYGTPEDLVLDEVPDPVPGPGQLLVRVRAAAVNFPDVLFIAGK
MLBr_00118|M.leprae_Br4923 MHAIVAESAN---QMVWREVPDVTAGPGEVLIEVAASGVNRADVLQVAGK
*:* . : : . : : * * .* .* * .
Mb0154|M.bovis_AF2122/97 YQLKLTPPFVPGMETAGVVRSAPSDAG-FHVGERVSAFGVLGGYAEQIAV
Rv0149|M.tuberculosis_H37Rv YQLKLTPPFVPGMETAGVVRSAPSDAG-FHVGERVSAFGVLGGYAEQIAV
MAB_4603c|M.abscessus_ATCC_199 YQLKMEPPFVPGIETAGVVRSAPEGSG-IKPGDRVMAFNFIGGYAERVAV
Mflv_2449|M.gilvum_PYR-GCK YQISVPPPFVPGSEFAGVVDEIGPGTEGFTIGDRVSGTAMFGAFAERTVV
Mvan_4202|M.vanbaalenii_PYR-1 YQVSVAPPFVPGSEFTGVVDEIGPHTTGFTVGERVAGTGMFGAFAERVVA
TH_3212|M.thermoresistible__bu YQLPVPPPFVPGSEFAGVIVETCGDTGGFAVGDPVTGTVLHGAFATEVAV
MSMEG_4828|M.smegmatis_MC2_155 YQATVPVPFVPGSEFAGVVTETADGVTDFAVGDRVVGTGMHGAFAEEVCV
MMAR_5313|M.marinum_M YQIKIPPPFIPGNEIAGEVVSVGAGVT-LVPGQRVFGT-TFGAFAELALL
MUL_4387|M.ulcerans_Agy99 YQIKIPPPFVPGNEIAGEVVGAGAGVI-LVPGQRVFGT-TFGAFAELALL
MAV_0308|M.avium_104 YQVKIPPPFIPGNEIAGEVIAAGEGAR-FLPGQRVAGT-TFGAFAEQALL
MLBr_00118|M.leprae_Br4923 YPHPPGASAIIGMEVAGVVAAVSSGVTEWSVGQEVCALLAGGGYAEYVAV
* . : * * :* : *: * . *.:*
Mb0154|M.bovis_AF2122/97 PVANVVRSPVELDDAGAVSLLVNYNTMYFALARRAALRPGDTVLVLGAAG
Rv0149|M.tuberculosis_H37Rv PVANVVRSPVELDDAGAVSLLVNYNTMYFALARRAALRPGDTVLVLGAAG
MAB_4603c|M.abscessus_ATCC_199 APSNILPTPPQLDDAEAVALIANYHTMYFAYARRGQLRAGETVLVLGAAG
Mflv_2449|M.gilvum_PYR-GCK DAAALAPIPDGVDARTAAAFGVAYRTAYHTLRSVARVSEGDELVVLGAGG
Mvan_4202|M.vanbaalenii_PYR-1 DAAGLTPVPDGVDARTAAAFGVAHRTAYHALRSTARLSAGDELVVLGAGG
TH_3212|M.thermoresistible__bu PAAGLTRVPDGVPLRTAAAFGVAHRTAYHALRSMARLTAGQELIVLGAGS
MSMEG_4828|M.smegmatis_MC2_155 DASCLQRAVERLDDRGAAASGVAHRTAFHALRSVARVSTGDDVVVLGAGG
MMAR_5313|M.marinum_M DGAAAEPIPDDADFASAAAFGVTYRTAYHALRSVAQVSQGDWVVVLGAAG
MUL_4387|M.ulcerans_Agy99 DGAAAQPIPDDADFASAAAFGVTYRTAYHALRSVAQVSQGDWVVVLGAAG
MAV_0308|M.avium_104 DADQAEPIPDDADFASAAAFGVTYRTAYHALRSTAGVTAGDWVVVLGAAG
MLBr_00118|M.leprae_Br4923 PASQVMPIPKGVNVVDSAGIPEVACTVWSNLVMAAHLSAGQLLLLHGGTS
:.. * : . : *: ::: *. .
Mb0154|M.bovis_AF2122/97 GVGTAAVQIAKAMQAGKVIAMVHREGAIDYVASLGADVVLPLTEGWAQQV
Rv0149|M.tuberculosis_H37Rv GVGTAAVQIAKAMQAGKVIAMVHREGAIDYVASLGADVVLPLTEGWAQQV
MAB_4603c|M.abscessus_ATCC_199 GIGTAAIQIAKGMGA-KVIAVVNRTAATEFVKSVGADIVLPLEEGWAKAV
Mflv_2449|M.gilvum_PYR-GCK GVGLAAVQLGVALGA-NVTAVASSAEKLAAAAEYGAAHLVDHREQDLRAA
Mvan_4202|M.vanbaalenii_PYR-1 GVGLATVQLGVALGA-RVTAVASSNEKLAVAGGYGAATLINHRDGELRQA
TH_3212|M.thermoresistible__bu GVGLAAVQLGVALGA-QVTAVASTAEKLAVAGAHGAGRRICHRDTDLRAA
MSMEG_4828|M.smegmatis_MC2_155 GVGLAAVQIAAALGA-RVTAVASSSEKLDAAARYGAHHLVDHTAGPLRAA
MMAR_5313|M.marinum_M GVGLAAVDLAVAMGA-RVLAAASSPEKLGLCRQRGAEAVVDYDQEDLKLR
MUL_4387|M.ulcerans_Agy99 GVGLAAVDLAVAMGA-RVLAAASSPEKLGLCRQRGAEAVVDYDQEDLKLR
MAV_0308|M.avium_104 GVGLAAVDLAVAMQA-RVLAAASSPEKLELCRRRGAEATVDYDREDLKTR
MLBr_00118|M.leprae_Br4923 GIGSHGIQVARALGA-KVAVTAGSEEKLEFCRALGAQITINYRDEDFVAR
*:* :::. .: * .* . . ** :
Mb0154|M.bovis_AF2122/97 RDHTYGQGVDIVVDPIGGPTFDDALGVLAIDGKLLLIGFAAGAVPTLKVN
Rv0149|M.tuberculosis_H37Rv RDHTYGQGVDIVVDPIGGPTFDDALGVLAIDGKLLLIGFAAGAVPTLKVN
MAB_4603c|M.abscessus_ATCC_199 REATGGAGVDMVVDPIGGPAFDDAVRTLASEGRLLVVGFAAGGIPTIKVN
Mflv_2449|M.gilvum_PYR-GCK LRTAVPDGADVVIDPVGGRLSEPALRSLGRGGRFVTVGFASGEIPRIPLN
Mvan_4202|M.vanbaalenii_PYR-1 LRQAIPDGADVVVDPVGGDVSEPALRSLGRGGRFVSVGFASGVIPRIPLN
TH_3212|M.thermoresistible__bu LREVLPGGADAVIDPVGGDLSEPALRSLRRGGRFVTVGYASGVIPRIPLN
MSMEG_4828|M.smegmatis_MC2_155 LRDAVPDGADAVLDPVGGDLSEPALRALRRGGRFVTIGFASGAIPRIPLN
MMAR_5313|M.marinum_M IRELTGESARVVLDPVGGSYAEPALRGLARGGMFVTLGYAAGSIPAIPLN
MUL_4387|M.ulcerans_Agy99 IRELTGESARVVLDPVGGSYAEPALRGLARGGIFVTLGYAAGSIPAIPLN
MAV_0308|M.avium_104 IRDLTGDRARVVLDPVGGPYSEPALRGLARGGTFVTLGYASGTIPAIPLN
MLBr_00118|M.leprae_Br4923 LQQQN-GGADVILDIMGAAYLDRNIDALAIDGQLIVIGLQGGVKGELNLG
. ::* :*. : : * * :: :* .* : :.
Mb0154|M.bovis_AF2122/97 RLLVRNISVVGVGWGEYLNAVPGSAALFAWGLNQ----LVFLG-LRPPPP
Rv0149|M.tuberculosis_H37Rv RLLVRNISVVGVGWGEYLNAVPGSAALFAWGLNQ----LVFLG-LRPPPP
MAB_4603c|M.abscessus_ATCC_199 RLLLRNASLIGVAWGEFLRTHADYLYETQAGLEK----LVAEG-MRPPVS
Mflv_2449|M.gilvum_PYR-GCK LVLLKGVQVLGFQFQDVP---GDEFVRNDHELRA----LLSARRVTPHVG
Mvan_4202|M.vanbaalenii_PYR-1 LVLIKGVHVLGFQFQDVP---ADEFTRNEVELRE----LLVSGRVKPHVG
TH_3212|M.thermoresistible__bu LVLVKGVHILGFQFQDVA---PEEFTRNEDELGG----FLVSGRARPHIG
MSMEG_4828|M.smegmatis_MC2_155 LVLVKGVQILGFAFQDVP---PEEFARNESELGE----LLASGAVTPHIG
MMAR_5313|M.marinum_M LVMLKNLTIRGMEIRTFMGDYPNECARDVAELSQ----MFAAGKIRPHIG
MUL_4387|M.ulcerans_Agy99 LVMLKNLTIRGMEIRTFMGDYPDECARDVAELSQ----MFAAGKIRPHIG
MAV_0308|M.avium_104 LVLLKDICVRGMEIRTFMTDRPDDAVRDLTELSQ----MFAAGTVRPYIG
MLBr_00118|M.leprae_Br4923 KVLSKRARIIGSTLRARPVNGPNSKSEIVAAVTASIWPMIADGSVRPIIG
:: : : * : :. *
Mb0154|M.bovis_AF2122/97 QRYPLSEAQAALQSLDDGGVLGKVVLEP-------------
Rv0149|M.tuberculosis_H37Rv QRYPLSEAQAALQSLDDGGVLGKVVLEP-------------
MAB_4603c|M.abscessus_ATCC_199 ARIPLSEGRQALQDFADGKVYGKMVLVP-------------
Mflv_2449|M.gilvum_PYR-GCK AVYPLEEVAAALRHVGEGRAIGKVLIDVPA-----------
Mvan_4202|M.vanbaalenii_PYR-1 AVYSLDDTVAALRHVSDGRAIGKVVIDLS------------
TH_3212|M.thermoresistible__bu AVFPLSEAAAALRHVADGRAVGKVVIDLTD-----------
MSMEG_4828|M.smegmatis_MC2_155 AVYPLVEVAAALRHVAEGRAVGKVVLDVSRVR---------
MMAR_5313|M.marinum_M ARFPLADTPAALRYVAERKVLGKVVIDVV------------
MUL_4387|M.ulcerans_Agy99 ARFPLADTPAALRYVAERKVLGKVVIDVA------------
MAV_0308|M.avium_104 ARFPLARTAAALRHVADRKVLGKVVIDVA------------
MLBr_00118|M.leprae_Br4923 ARMAVQQAADAHQLLLSGKVSGKIVLTVAGSGTETLLSRHH
.: * : . . . **:::