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MVTTLIRGGTVVSATGRQSIDVLIDGATIAALIEPGAAPFGDGLAERVDNVVDATGKYVIPGGVDAHTHM QMPFGGTTASDTFETGTRAAALGGTTTIVDFAIQTPGEHVQDTLQAWHEKAAGNCAIDYGFHQIIGDVNT ESLAAMGELIDEGVTSFKLFMAYPGVYYSTDGQILRAMQKCAEIGGLMMMHAENGIAIDELVAQHLGRGE TGPYFHGVSRPWQLEEEATHRAIMLADVTGAPLYVVHVSAHQALEQIATARGAGGNVFAETCPQYLYLSL EEQLGAGGFEGAKWVCSTPLRARSEGHQDQLWRYIRTGDVAGVATDHCPFCMVGQKELGIGNFSKIPNGI GGVEHRMDLMFQGVVDGRISLERWVEVCATTPARMFGLYPRKGVISPGADADVVIYDPAGHTSIGVGKTH HMNMDHSAWEGFEIDGAVTAVWSRGKKVVEDRRYLGAKTDGRFVRRELSQNLI
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_4012 | hydA | - | 100% (473) | dihydropyrimidinase |
| M. smegmatis MC2 155 | MSMEG_3996 | hydA | 0.0 | 75.90% (473) | dihydropyrimidinase |
| M. smegmatis MC2 155 | MSMEG_3553 | hydA | 0.0 | 67.86% (473) | dihydropyrimidinase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1416 | pyrC | 5e-23 | 26.05% (453) | dihydroorotase |
| M. gilvum PYR-GCK | Mflv_3169 | - | 6e-44 | 31.64% (452) | allantoinase |
| M. tuberculosis H37Rv | Rv1381 | pyrC | 2e-23 | 26.27% (453) | dihydroorotase |
| M. leprae Br4923 | MLBr_00533 | pyrC | 2e-20 | 25.57% (438) | dihydroorotase |
| M. abscessus ATCC 19977 | MAB_2817c | - | 0.0 | 72.09% (473) | phenylhydantoinase |
| M. marinum M | MMAR_2196 | pyrC | 1e-25 | 27.53% (454) | dihydroorotase PyrC |
| M. avium 104 | MAV_3392 | pyrC | 3e-24 | 26.11% (452) | dihydroorotase |
| M. thermoresistible (build 8) | TH_3497 | - | 7e-10 | 28.81% (177) | PUTATIVE acyl-CoA thioesterase |
| M. ulcerans Agy99 | MUL_1781 | pyrC | 2e-25 | 27.53% (454) | dihydroorotase |
| M. vanbaalenii PYR-1 | Mvan_2661 | pyrC | 1e-25 | 26.48% (438) | dihydroorotase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_00533|M.leprae_Br4923 -MS------------VLLRG--VRLYGEGEQVDVLVEGEQIANIGAGIDI
MAV_3392|M.avium_104 -MS------------VLLRG--VRLYGEGDRVDVLVDDGQIADIGAGLDI
Mb1416|M.bovis_AF2122/97 -MS------------VLIRG--VRPYGEGERVDVLVDDGQIAQIGPDLAI
Rv1381|M.tuberculosis_H37Rv -MS------------VLIRG--VRPYGEGERVDVLVDDGQIAQIGPDLAI
MMAR_2196|M.marinum_M -MS------------VLLRG--VRLYGEGERVDVLVDDNQIADIGTGLAI
MUL_1781|M.ulcerans_Agy99 -MS------------VLLRG--VRLYGEGERVDVLVDDNQIADIGTGLAI
Mvan_2661|M.vanbaalenii_PYR-1 -MTSSSPESLRSCPPIVLKS--VRLYGEGDPVDVLVRDGQIAEIGERLTA
TH_3497|M.thermoresistible__bu ----------------LIRN--VRPYGEGEPVDVLVADGQIAEIGEKLPI
MSMEG_4012|M.smegmatis_MC2_155 ------------MVTTLIRGGTVVSATGRQSIDVLIDGATIAALIEPGAA
MAB_2817c|M.abscessus_ATCC_199 ------------MATTLIRGGTVVSATGRGAADVLVDGATIAAVLLPGST
Mflv_3169|M.gilvum_PYR-GCK MTADTREQSNHADLDLVVRGERMLTTAGIVAREIGIRDGRIVAIEPLGSG
:::. : :: : . *. :
MLBr_00533|M.leprae_Br4923 P-------DTADVIDAIDQVLLPGLVDLHTHLREP--GREYAEDIETGSA
MAV_3392|M.avium_104 P-------DTADVIDATGQVLLPGFVDLHTHLREP--GREYAEDIETGSA
Mb1416|M.bovis_AF2122/97 P-------DTADVIDATGHVLLPGFVDLHTHLREP--GREYAEDIETGSA
Rv1381|M.tuberculosis_H37Rv P-------DTADVIDATGHVLLPGFVDLHTHLREP--GREYAEDIETGSA
MMAR_2196|M.marinum_M P-------DTADVIDATDHVLLPGLVDLHTHLREP--GREYAEDIETGSA
MUL_1781|M.ulcerans_Agy99 P-------DTADVIDATDHVLLPGLVDLHTHLREP--GREYAEDIETGSA
Mvan_2661|M.vanbaalenii_PYR-1 P-------TDADSIDCEGKILLPGFVDLHTHLREP--GREYAEDIETGSA
TH_3497|M.thermoresistible__bu PG----DGELGDVIDADGQILLPGFVDLHTHLREP--GREYAEDIETGSA
MSMEG_4012|M.smegmatis_MC2_155 PFGDGLAERVDNVVDATGKYVIPGGVDAHTHMQMPFGGTTASDTFETGTR
MAB_2817c|M.abscessus_ATCC_199 LLGMDLAKTVDTVIEAHGKYVIPGGIDAHTHMSMPFGGTTASDDFETGTR
Mflv_3169|M.gilvum_PYR-GCK LP------GAEIVELTDEQVMIPGLVDTHVHVNEP--GRTEWEGFDSATR
: ::** :* *.*: * * : :::.:
MLBr_00533|M.leprae_Br4923 AAALGGYTAVFAMPNTTPVADSPVVTDHVWRRGQQVGLVDVHPVGAVTVG
MAV_3392|M.avium_104 AAALGGYTAVFAMANTNPVADSPVVTDHVWHRGQQVGLVDVHPVGAVTMG
Mb1416|M.bovis_AF2122/97 AAALGGYTAVFAMANTNPVADSPVVTDHVWHRGQQVGLVDVHPVGAVTVG
Rv1381|M.tuberculosis_H37Rv AAALGGYTAVFAMANTNPVADSPVVTDHVWHRGQQVGLVDVHPVGAVTVG
MMAR_2196|M.marinum_M AAALGGYTAVFAMANTHPVADSPVVTDHVWHRGQQVGLVDVHPVGAVTVG
MUL_1781|M.ulcerans_Agy99 AAALGGYTAVFAMANTHPVADSPVVTDHVWHRGQQVGLVDVHPVGAVTIG
Mvan_2661|M.vanbaalenii_PYR-1 AAALGGYTAVFAMANTDPVADSAVVTDHVWHRGQQVGLVDVHPVGAVTVG
TH_3497|M.thermoresistible__bu AAALGGYTAVFAMANTDPVADSPVVTDHVWRRGQQVGLVDVHPVGAVTVG
MSMEG_4012|M.smegmatis_MC2_155 AAALGGTTTIVDFA-IQTPGEHVQDTLQAWHEKAAGNCAIDYGFHQIIGD
MAB_2817c|M.abscessus_ATCC_199 AAAWGGTTTIIDFA-VQKFGERLQDSLDTWHEMAAGQCAIDYSFHQIVGD
Mflv_3169|M.gilvum_PYR-GCK AAAAGGVTTLIDMPLNSIPPTVNVDALNAKREAASGKLHIDVGFWGGAIP
*** ** *::. :. : .. :. .
MLBr_00533|M.leprae_Br4923 LAGAELTEMG-MMAAGAAQVRIFSDD-GNCVHNPLVMRRALEYATGLGVL
MAV_3392|M.avium_104 LAGKELTEMG-MMAAGAAQVRMFSDD-GVCVHDPLVMRRALEYATGLGVL
Mb1416|M.bovis_AF2122/97 LAGAELTEMG-MMNAGAAQVRMFSDD-GVCVHDPLIMRRALEYATGLGVL
Rv1381|M.tuberculosis_H37Rv LAGAELTEMG-MMNAGAAQVRMFSDD-GVCVHDPLIMRRALEYATGLGVL
MMAR_2196|M.marinum_M LAGTELTEMG-MMNAGVAAVRMFSDD-GICVHDPLIMRRALEYATGLGVL
MUL_1781|M.ulcerans_Agy99 LAGTELTEMG-MMNAGVAAVRMFSDD-GICVHDPLIMRRALEYATGLGVL
Mvan_2661|M.vanbaalenii_PYR-1 LDGKQLTEMG-LMAAGAGQVRMFSDD-GVCVDDPLVMRRALEYASGLGVL
TH_3497|M.thermoresistible__bu LEGRQLTEMG-LMAAGAARVRMFSDD-GLCVHDPLVMRRALEYARGLGVL
MSMEG_4012|M.smegmatis_MC2_155 VNTESLAAMGELIDEGVTSFKLFMAYPGVYYSTDGQILRAMQKCAEIGGL
MAB_2817c|M.abscessus_ATCC_199 VNDASLAALRRLTDEGITSYKMFMAYPGVFYSDDAQIVRAMQVGAATGLM
Mflv_3169|M.gilvum_PYR-GCK GNTGDLRGLHDDGVFGFKCFLLHSGVDEFPHLDADEMEEDMRVLVGFDSM
.* : * :. : . :. . :
MLBr_00533|M.leprae_Br4923 IAQHAEEPRLTVGAVAHE--------------------------------
MAV_3392|M.avium_104 IAQHAEEPRLTVGAVAHE--------------------------------
Mb1416|M.bovis_AF2122/97 IAQHAEEPRLTVGAFAHE--------------------------------
Rv1381|M.tuberculosis_H37Rv IAQHAEEPRLTVGAVAHE--------------------------------
MMAR_2196|M.marinum_M IAQHAEEPRLTVGAVAHE--------------------------------
MUL_1781|M.ulcerans_Agy99 IAQHAEEPRLTVGAVAHE--------------------------------
Mvan_2661|M.vanbaalenii_PYR-1 IAQHAEEPRLTVGAVAHE--------------------------------
TH_3497|M.thermoresistible__bu IAQHAEEPRLTVGAVAHXXXWPACPARCRPGYRSPPTWCASAPPGRPNAV
MSMEG_4012|M.smegmatis_MC2_155 MMMHAENGIAIDELVAQHLG------------------------------
MAB_2817c|M.abscessus_ATCC_199 TMMHAENGPAIDVLVAQLLA------------------------------
Mflv_3169|M.gilvum_PYR-GCK MIVHAEDSRAIDHAPTAE--------------------------------
***: :
MLBr_00533|M.leprae_Br4923 ----------GPT-----------AARLGLSGWPR---------------
MAV_3392|M.avium_104 ----------GPT-----------AARLGLAGWPR---------------
Mb1416|M.bovis_AF2122/97 ----------GPM-----------AARLGLAGWPR---------------
Rv1381|M.tuberculosis_H37Rv ----------GPM-----------AARLGLAGWPR---------------
MMAR_2196|M.marinum_M ----------GPN-----------AAQLGLAGWPR---------------
MUL_1781|M.ulcerans_Agy99 ----------GPS-----------AAQLGLAGWPR---------------
Mvan_2661|M.vanbaalenii_PYR-1 ----------GPN-----------AARLGLAGWPR---------------
TH_3497|M.thermoresistible__bu RRNRSSPRRIGPTPPPGTSRPATDVGRLGSADRARRPGPRCRGAWWLGHD
MSMEG_4012|M.smegmatis_MC2_155 ---------RGET-------------GPYFHGVSR-------------PW
MAB_2817c|M.abscessus_ATCC_199 ---------EGKT-------------DPYYHGIAR-------------AW
Mflv_3169|M.gilvum_PYR-GCK ----------GDR------------YSRFLASRPR---------------
* . .*
MLBr_00533|M.leprae_Br4923 AAEESIVARDALLARDAG--------------ARVHICHASTAGTVEILK
MAV_3392|M.avium_104 AAEESIVARDALLARDAG--------------ARVHICHASTAGTVEIVK
Mb1416|M.bovis_AF2122/97 AAEESIVARDALLARDAG--------------ARVHICHASAAGTVEILK
Rv1381|M.tuberculosis_H37Rv AAEESIVARDALLARDAG--------------ARVHICHASAAGTVEILK
MMAR_2196|M.marinum_M AAEESIVARDALLARDAG--------------ARVHICHASTVGTVEILK
MUL_1781|M.ulcerans_Agy99 AAEESIVARDALLTRDAG--------------ARVHICHASTVGTVEILK
Mvan_2661|M.vanbaalenii_PYR-1 AAEESIVARDALLARDAG--------------ARVHICHASTAGTVELLK
TH_3497|M.thermoresistible__bu APVTELTLYDVLTTLDVAQVDDDLFEATQLDNPAHHIVGGHIAG-QAVVA
MSMEG_4012|M.smegmatis_MC2_155 QLEEEATHRAIMLADVTG--------------APLYVVHVSAHQALEQIA
MAB_2817c|M.abscessus_ATCC_199 QLEEEATHRAIMLSNLTG--------------APLYVVHVSAKQAVAQLA
Mflv_3169|M.gilvum_PYR-GCK GAENVAIAEVIERARWTG--------------ARAHILHLSSSDALPMIA
: .. . :: :
MLBr_00533|M.leprae_Br4923 WAKEQGISITAEVTPHHLLLDDSRLASYDGVNRVN-------PPLRETAD
MAV_3392|M.avium_104 WAKQQGISITAEVTPHHLMLDDSRLASYDGRNRVN-------PPLREAAD
Mb1416|M.bovis_AF2122/97 WAKDQGISITAEVTPHHLLLDDARLASYDGVNRVN-------PPLREASD
Rv1381|M.tuberculosis_H37Rv WAKDQGISITAEVTPHHLLLDDARLASYDGVNRVN-------PPLREASD
MMAR_2196|M.marinum_M WAKSQGISITAEVTPHHLLLDDRRLSGYDGVNRVN-------PPLREASD
MUL_1781|M.ulcerans_Agy99 WAKSQGISITAEVTPHHLLLDDRRLSGYDGVNRVN-------PPLREASD
Mvan_2661|M.vanbaalenii_PYR-1 WAKSQGISITAEVTPHHLLLDDSRLDTYDGVNRVN-------PPLREVSD
TH_3497|M.thermoresistible__bu ASRTAPQRTAHSAHVYFLRAGDARYPVQMRVDRLRDGGSLSTXRVTATQD
MSMEG_4012|M.smegmatis_MC2_155 TARGAGGNVFAETCPQYLYLSLEEQLGAGGFEGAKWVCS---TPLRARSE
MAB_2817c|M.abscessus_ATCC_199 AARDAGQNVYGETCPQYLYLSLEDNLGAPGFDGAKWVCS---TPLRAKHE
Mflv_3169|M.gilvum_PYR-GCK TAKRDGVRITVETCPHYLTLLAEEIPNGATAFKCC-------PPIREASN
:: .. .* : :
MLBr_00533|M.leprae_Br4923 --AVALRQALADG--IIDCVTTDHAP---------HADHEKCVEFSAARP
MAV_3392|M.avium_104 --AAALRRALADG--VIDCVATDHAP---------HAEHEKCVEFSAARP
Mb1416|M.bovis_AF2122/97 --AVALRQALADG--IIDCVATDHAP---------HAEHEKCVEFAAARP
Rv1381|M.tuberculosis_H37Rv --AVALRQALADG--IIDCVATDHAP---------HAEHEKCVEFAAARP
MMAR_2196|M.marinum_M --AMALRQALADG--IIDCVATDHAP---------HAEHEKCVEFSAARP
MUL_1781|M.ulcerans_Agy99 --AMALRQALADG--IIDCVATDHAP---------HAEHEKCVEFSAARP
Mvan_2661|M.vanbaalenii_PYR-1 --AVALRRALADG--VIDCVATDHAP---------HGAHEKCCEFANARP
TH_3497|M.thermoresistible__bu --GQVLLEALASFTVRIDSVDTHHPMPDVPDPDTLPPVTEQLVAYADEFG
MSMEG_4012|M.smegmatis_MC2_155 GHQDQLWRYIRTG--DVAGVATDHCPFCMV-----GQKELGIGNFSKIPN
MAB_2817c|M.abscessus_ATCC_199 HHQDEMWRALRTN--DIQMVSTDHCPFCMK-----GQKDMGIGDFSKIPN
Mflv_3169|M.gilvum_PYR-GCK --RELLWQGLIDG--TIDCIVSDHSPS------TIDLKDVENGDFGVAWG
: . : : : :.* :.
MLBr_00533|M.leprae_Br4923 GMLGLQTALS--------VVVHTMVVPGLLS--WRDVAQVMSENPARIAG
MAV_3392|M.avium_104 GMLGLQTALS--------IVVHTMVRPGLLT--WRDVAKVMSENPARIAN
Mb1416|M.bovis_AF2122/97 GMLGLQTALS--------VVVQTMVAPGLLS--WRDIARVMSENPACIAR
Rv1381|M.tuberculosis_H37Rv GMLGLQTALS--------VVVQTMVAPGLLS--WRDIARVMSENPACIAR
MMAR_2196|M.marinum_M GMLGLQTALS--------VVVQTMVQPGLLS--WRDVARVMSENPARIVG
MUL_1781|M.ulcerans_Agy99 GMLGLQTALS--------VVVQTMVQPGLLS--WRDVARVMSENPARIVG
Mvan_2661|M.vanbaalenii_PYR-1 GMLGLQTALS--------VVVETLVNPGLLT--WRDVARVMSEAPARIVG
TH_3497|M.thermoresistible__bu GLWVRPQPIERRYIDPPPRVAYDLPEPPARTRMWWRATEPVPDDPALNSA
MSMEG_4012|M.smegmatis_MC2_155 GIGGVEHRMD---------LMFQGVVDGRIS--LERWVEVCATTPARMFG
MAB_2817c|M.abscessus_ATCC_199 GIGSIEHRMD---------LLYQGVVDGRIS--VERWVEITSTTPARMFG
Mflv_3169|M.gilvum_PYR-GCK GVASLQLGLS---------LIWTEAKRRGVA--LTRVIDWMAAKPAELAG
*: :. : : . **
MLBr_00533|M.leprae_Br4923 LPDHGR---PLEVGEPAN-------LTVVDPDVTWTVTGDGLASRSANTP
MAV_3392|M.avium_104 LPDHGR---PLEVGEPAN-------LTVVDPDASWTVAGSDLASRSANTP
Mb1416|M.bovis_AF2122/97 LPDQGR---PLEVGEPAN-------LTVVDPDATWTVTGADLASRSANTP
Rv1381|M.tuberculosis_H37Rv LPDQGR---PLEVGEPAN-------LTVVDPDATWTVTGADLASRSANTP
MMAR_2196|M.marinum_M LPDHGR---PLEVGEPAN-------LTVIDPDATWTVTGADLASRSANTP
MUL_1781|M.ulcerans_Agy99 LPDHGR---PLEVGEPAN-------LTVIDPDATWTVTGADLASRSANTP
Mvan_2661|M.vanbaalenii_PYR-1 LPDQGR---PLEVGEPAN-------LTVVDPAARWTVKGPELASRSDNTP
TH_3497|M.thermoresistible__bu LLTYVTGTSTLEAAMVAHRTTPLHSFNALIDHALWFHRPAHLTDWVLADQ
MSMEG_4012|M.smegmatis_MC2_155 LYPRKGVISPGADADVVIYDPAGHTSIGVGKTHHMNMDHSAWEGFEIDGA
MAB_2817c|M.abscessus_ATCC_199 LYGRKGVIAPGADADIVVYDPNGHTSIGLGKTHHMNMDHSAWEGYEIDGH
Mflv_3169|M.gilvum_PYR-GCK LNNKGK-IALGYDADFAIFEPESAQVVDVHKLHHRNPITP-YDGRAVAGV
* . . : .
MLBr_00533|M.leprae_Br4923 YEAMTLPAT--VTATLLRGK--------------VTARGQKSPV--
MAV_3392|M.avium_104 YEAMTLPAT--VTATLLRGK--------------VTARDGKCPV--
Mb1416|M.bovis_AF2122/97 FESMSLPAT--VTATLLRGK--------------VTARDGKIRA--
Rv1381|M.tuberculosis_H37Rv FESMSLPAT--VTATLLRGK--------------VTARDGKIRA--
MMAR_2196|M.marinum_M YESMTLPAR--VTATLLRGK--------------ITARDGKSPA--
MUL_1781|M.ulcerans_Agy99 YESMTLPAR--VTATLLRGK--------------ITARDGKSPA--
Mvan_2661|M.vanbaalenii_PYR-1 YEDMELPAV--VTATLLRGK--------------VTARDGKVGA--
TH_3497|M.thermoresistible__bu FSPSSLGGRGLATATMYNRTGELVCTATQELYFGRPARSGSRR---
MSMEG_4012|M.smegmatis_MC2_155 VTAVWSRGKKVVEDRRYLGAKTD----------GRFVRRELSQNLI
MAB_2817c|M.abscessus_ATCC_199 VDTVLSRGKVIVDGDEYLGSKGD----------GVFLRRDLCQYLI
Mflv_3169|M.gilvum_PYR-GCK VASTWLRGT-KIDFTTPRGR---------------MLRRGGV----
. *