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TADTREQSNHADLDLVVRGERMLTTAGIVAREIGIRDGRIVAIEPLGSGLPGAEIVELTDEQVMIPGLVD THVHVNEPGRTEWEGFDSATRAAAAGGVTTLIDMPLNSIPPTVNVDALNAKREAASGKLHIDVGFWGGAI PGNTGDLRGLHDDGVFGFKCFLLHSGVDEFPHLDADEMEEDMRVLVGFDSMMIVHAEDSRAIDHAPTAEG DRYSRFLASRPRGAENVAIAEVIERARWTGARAHILHLSSSDALPMIATAKRDGVRITVETCPHYLTLLA EEIPNGATAFKCCPPIREASNRELLWQGLIDGTIDCIVSDHSPSTIDLKDVENGDFGVAWGGVASLQLGL SLIWTEAKRRGVALTRVIDWMAAKPAELAGLNNKGKIALGYDADFAIFEPESAQVVDVHKLHHRNPITPY DGRAVAGVVASTWLRGTKIDFTTPRGRMLRRGGV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3169 | - | - | 100% (455) | allantoinase |
| M. gilvum PYR-GCK | Mflv_3746 | pyrC | 1e-41 | 31.78% (428) | dihydroorotase |
| M. gilvum PYR-GCK | Mflv_3352 | ureC | 1e-05 | 35.00% (100) | urease subunit alpha |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1416 | pyrC | 4e-38 | 29.86% (422) | dihydroorotase |
| M. tuberculosis H37Rv | Rv1381 | pyrC | 3e-38 | 29.86% (422) | dihydroorotase |
| M. leprae Br4923 | MLBr_00533 | pyrC | 6e-40 | 30.27% (413) | dihydroorotase |
| M. abscessus ATCC 19977 | MAB_2817c | - | 1e-40 | 29.42% (452) | phenylhydantoinase |
| M. marinum M | MMAR_2196 | pyrC | 5e-39 | 31.19% (404) | dihydroorotase PyrC |
| M. avium 104 | MAV_3392 | pyrC | 9e-41 | 29.80% (443) | dihydroorotase |
| M. smegmatis MC2 155 | MSMEG_4012 | hydA | 6e-44 | 31.64% (452) | dihydropyrimidinase |
| M. thermoresistible (build 8) | TH_0815 | pyrC | 2e-09 | 30.00% (130) | PROBABLE DIHYDROOROTASE PYRC (DHOase) |
| M. ulcerans Agy99 | MUL_1781 | pyrC | 2e-38 | 30.94% (404) | dihydroorotase |
| M. vanbaalenii PYR-1 | Mvan_2661 | pyrC | 1e-37 | 29.34% (426) | dihydroorotase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2196|M.marinum_M -MS------------VLLRGVRLYGEGER--VDVLVDDNQIADIGTG---
MUL_1781|M.ulcerans_Agy99 -MS------------VLLRGVRLYGEGER--VDVLVDDNQIADIGTG---
Mb1416|M.bovis_AF2122/97 -MS------------VLIRGVRPYGEGER--VDVLVDDGQIAQIGPD---
Rv1381|M.tuberculosis_H37Rv -MS------------VLIRGVRPYGEGER--VDVLVDDGQIAQIGPD---
MLBr_00533|M.leprae_Br4923 -MS------------VLLRGVRLYGEGEQ--VDVLVEGEQIANIGAG---
MAV_3392|M.avium_104 -MS------------VLLRGVRLYGEGDR--VDVLVDDGQIADIGAG---
Mvan_2661|M.vanbaalenii_PYR-1 -MTSSSPESLRSCPPIVLKSVRLYGEGDP--VDVLVRDGQIAEIGER---
TH_0815|M.thermoresistible__bu --------------------------------------------------
MAB_2817c|M.abscessus_ATCC_199 -MAT-----------TLIRGGTVVSATGRGAADVLVDGATIAAVLLPGST
MSMEG_4012|M.smegmatis_MC2_155 -MVT-----------TLIRGGTVVSATGRQSIDVLIDGATIAALIEPGAA
Mflv_3169|M.gilvum_PYR-GCK MTADTREQSNHADLDLVVRGERMLTTAGIVAREIGIRDGRIVAIEPLG--
MMAR_2196|M.marinum_M ----LAIPDTADVIDATDHVLLPGLVDLHTHLREP--GREYAEDIETGSA
MUL_1781|M.ulcerans_Agy99 ----LAIPDTADVIDATDHVLLPGLVDLHTHLREP--GREYAEDIETGSA
Mb1416|M.bovis_AF2122/97 ----LAIPDTADVIDATGHVLLPGFVDLHTHLREP--GREYAEDIETGSA
Rv1381|M.tuberculosis_H37Rv ----LAIPDTADVIDATGHVLLPGFVDLHTHLREP--GREYAEDIETGSA
MLBr_00533|M.leprae_Br4923 ----IDIPDTADVIDAIDQVLLPGLVDLHTHLREP--GREYAEDIETGSA
MAV_3392|M.avium_104 ----LDIPDTADVIDATGQVLLPGFVDLHTHLREP--GREYAEDIETGSA
Mvan_2661|M.vanbaalenii_PYR-1 ----LTAPTDADSIDCEGKILLPGFVDLHTHLREP--GREYAEDIETGSA
TH_0815|M.thermoresistible__bu --------------------------------------------------
MAB_2817c|M.abscessus_ATCC_199 LLGMDLAKTVDTVIEAHGKYVIPGGIDAHTHMSMPFGGTTASDDFETGTR
MSMEG_4012|M.smegmatis_MC2_155 PFGDGLAERVDNVVDATGKYVIPGGVDAHTHMQMPFGGTTASDTFETGTR
Mflv_3169|M.gilvum_PYR-GCK ----SGLPGAEIVELTDEQVMIPGLVDTHVHVNEP--GRTEWEGFDSATR
MMAR_2196|M.marinum_M AAALGGYTAVFAMANTHPVADSPVVTDHVWHRGQQVGLVDVHPVGAVTVG
MUL_1781|M.ulcerans_Agy99 AAALGGYTAVFAMANTHPVADSPVVTDHVWHRGQQVGLVDVHPVGAVTIG
Mb1416|M.bovis_AF2122/97 AAALGGYTAVFAMANTNPVADSPVVTDHVWHRGQQVGLVDVHPVGAVTVG
Rv1381|M.tuberculosis_H37Rv AAALGGYTAVFAMANTNPVADSPVVTDHVWHRGQQVGLVDVHPVGAVTVG
MLBr_00533|M.leprae_Br4923 AAALGGYTAVFAMPNTTPVADSPVVTDHVWRRGQQVGLVDVHPVGAVTVG
MAV_3392|M.avium_104 AAALGGYTAVFAMANTNPVADSPVVTDHVWHRGQQVGLVDVHPVGAVTMG
Mvan_2661|M.vanbaalenii_PYR-1 AAALGGYTAVFAMANTDPVADSAVVTDHVWHRGQQVGLVDVHPVGAVTVG
TH_0815|M.thermoresistible__bu --------------------------------------------------
MAB_2817c|M.abscessus_ATCC_199 AAAWGGTTTIIDFA-VQKFGERLQDSLDTWHEMAAGQCAIDYSFHQIVGD
MSMEG_4012|M.smegmatis_MC2_155 AAALGGTTTIVDFA-IQTPGEHVQDTLQAWHEKAAGNCAIDYGFHQIIGD
Mflv_3169|M.gilvum_PYR-GCK AAAAGGVTTLIDMPLNSIPPTVNVDALNAKREAASGKLHIDVGFWGGAIP
MMAR_2196|M.marinum_M LAGTELTEMG-MMNAGVAAVRMFSDD-GICVHDPLIMRRALEYATGLGVL
MUL_1781|M.ulcerans_Agy99 LAGTELTEMG-MMNAGVAAVRMFSDD-GICVHDPLIMRRALEYATGLGVL
Mb1416|M.bovis_AF2122/97 LAGAELTEMG-MMNAGAAQVRMFSDD-GVCVHDPLIMRRALEYATGLGVL
Rv1381|M.tuberculosis_H37Rv LAGAELTEMG-MMNAGAAQVRMFSDD-GVCVHDPLIMRRALEYATGLGVL
MLBr_00533|M.leprae_Br4923 LAGAELTEMG-MMAAGAAQVRIFSDD-GNCVHNPLVMRRALEYATGLGVL
MAV_3392|M.avium_104 LAGKELTEMG-MMAAGAAQVRMFSDD-GVCVHDPLVMRRALEYATGLGVL
Mvan_2661|M.vanbaalenii_PYR-1 LDGKQLTEMG-LMAAGAGQVRMFSDD-GVCVDDPLVMRRALEYASGLGVL
TH_0815|M.thermoresistible__bu --------------------------------------------------
MAB_2817c|M.abscessus_ATCC_199 VNDASLAALRRLTDEGITSYKMFMAYPGVFYSDDAQIVRAMQVGAATGLM
MSMEG_4012|M.smegmatis_MC2_155 VNTESLAAMGELIDEGVTSFKLFMAYPGVYYSTDGQILRAMQKCAEIGGL
Mflv_3169|M.gilvum_PYR-GCK GNTGDLRGLHDDGVFGFKCFLLHSGVDEFPHLDADEMEEDMRVLVGFDSM
MMAR_2196|M.marinum_M IAQHAEEP---RLTVGAVAHEGPNAAQLGLAGWPRAAEESIVARDALLAR
MUL_1781|M.ulcerans_Agy99 IAQHAEEP---RLTVGAVAHEGPSAAQLGLAGWPRAAEESIVARDALLTR
Mb1416|M.bovis_AF2122/97 IAQHAEEP---RLTVGAFAHEGPMAARLGLAGWPRAAEESIVARDALLAR
Rv1381|M.tuberculosis_H37Rv IAQHAEEP---RLTVGAVAHEGPMAARLGLAGWPRAAEESIVARDALLAR
MLBr_00533|M.leprae_Br4923 IAQHAEEP---RLTVGAVAHEGPTAARLGLSGWPRAAEESIVARDALLAR
MAV_3392|M.avium_104 IAQHAEEP---RLTVGAVAHEGPTAARLGLAGWPRAAEESIVARDALLAR
Mvan_2661|M.vanbaalenii_PYR-1 IAQHAEEP---RLTVGAVAHEGPNAARLGLAGWPRAAEESIVARDALLAR
TH_0815|M.thermoresistible__bu --------------------------------------------------
MAB_2817c|M.abscessus_ATCC_199 TMMHAENGPAIDVLVAQLLAEGKTDPYYHGIARAWQLEEEATHRAIMLSN
MSMEG_4012|M.smegmatis_MC2_155 MMMHAENGIAIDELVAQHLGRGETGPYFHGVSRPWQLEEEATHRAIMLAD
Mflv_3169|M.gilvum_PYR-GCK MIVHAEDS---RAIDHAPTAEGDRYSRFLAS-RPRGAENVAIAEVIERAR
MMAR_2196|M.marinum_M DAGARVHICHASTVGTVEILKWAKSQGISITAEVTPHHLLL---DDRRLS
MUL_1781|M.ulcerans_Agy99 DAGARVHICHASTVGTVEILKWAKSQGISITAEVTPHHLLL---DDRRLS
Mb1416|M.bovis_AF2122/97 DAGARVHICHASAAGTVEILKWAKDQGISITAEVTPHHLLL---DDARLA
Rv1381|M.tuberculosis_H37Rv DAGARVHICHASAAGTVEILKWAKDQGISITAEVTPHHLLL---DDARLA
MLBr_00533|M.leprae_Br4923 DAGARVHICHASTAGTVEILKWAKEQGISITAEVTPHHLLL---DDSRLA
MAV_3392|M.avium_104 DAGARVHICHASTAGTVEIVKWAKQQGISITAEVTPHHLML---DDSRLA
Mvan_2661|M.vanbaalenii_PYR-1 DAGARVHICHASTAGTVELLKWAKSQGISITAEVTPHHLLL---DDSRLD
TH_0815|M.thermoresistible__bu --------------------------------------------------
MAB_2817c|M.abscessus_ATCC_199 LTGAPLYVVHVSAKQAVAQLAAARDAGQNVYGETCPQYLYLSLEDNLGAP
MSMEG_4012|M.smegmatis_MC2_155 VTGAPLYVVHVSAHQALEQIATARGAGGNVFAETCPQYLYLSLEEQLGAG
Mflv_3169|M.gilvum_PYR-GCK WTGARAHILHLSSSDALPMIATAKRDGVRITVETCPHYLTL----LAEEI
MMAR_2196|M.marinum_M GYDGVNRVN-PPLREASD--AMALRQALADGIIDCVATDHAPHAEHEK--
MUL_1781|M.ulcerans_Agy99 GYDGVNRVN-PPLREASD--AMALRQALADGIIDCVATDHAPHAEHEK--
Mb1416|M.bovis_AF2122/97 SYDGVNRVN-PPLREASD--AVALRQALADGIIDCVATDHAPHAEHEK--
Rv1381|M.tuberculosis_H37Rv SYDGVNRVN-PPLREASD--AVALRQALADGIIDCVATDHAPHAEHEK--
MLBr_00533|M.leprae_Br4923 SYDGVNRVN-PPLRETAD--AVALRQALADGIIDCVTTDHAPHADHEK--
MAV_3392|M.avium_104 SYDGRNRVN-PPLREAAD--AAALRRALADGVIDCVATDHAPHAEHEK--
Mvan_2661|M.vanbaalenii_PYR-1 TYDGVNRVN-PPLREVSD--AVALRRALADGVIDCVATDHAPHGAHEK--
TH_0815|M.thermoresistible__bu -------------------------------VIDCVATDHAPHAEHEK--
MAB_2817c|M.abscessus_ATCC_199 GFDGAKWVCSTPLRAKHEHHQDEMWRALRTNDIQMVSTDHCPFCMKGQKD
MSMEG_4012|M.smegmatis_MC2_155 GFEGAKWVCSTPLRARSEGHQDQLWRYIRTGDVAGVATDHCPFCMVGQKE
Mflv_3169|M.gilvum_PYR-GCK PNGATAFKCCPPIREASN--RELLWQGLIDGTIDCIVSDHSPSTIDLKDV
: : :**.* :
MMAR_2196|M.marinum_M --CVEFSAARPGMLGLQTALSVVVQTMVQPGLLSWRDVARVMSENPARIV
MUL_1781|M.ulcerans_Agy99 --CVEFSAARPGMLGLQTALSVVVQTMVQPGLLSWRDVARVMSENPARIV
Mb1416|M.bovis_AF2122/97 --CVEFAAARPGMLGLQTALSVVVQTMVAPGLLSWRDIARVMSENPACIA
Rv1381|M.tuberculosis_H37Rv --CVEFAAARPGMLGLQTALSVVVQTMVAPGLLSWRDIARVMSENPACIA
MLBr_00533|M.leprae_Br4923 --CVEFSAARPGMLGLQTALSVVVHTMVVPGLLSWRDVAQVMSENPARIA
MAV_3392|M.avium_104 --CVEFSAARPGMLGLQTALSIVVHTMVRPGLLTWRDVAKVMSENPARIA
Mvan_2661|M.vanbaalenii_PYR-1 --CCEFANARPGMLGLQTALSVVVETLVNPGLLTWRDVARVMSEAPARIV
TH_0815|M.thermoresistible__bu --MCEFAAARPGMLGLQTALSVVVQTMVTPGLLDWRGVARVMSENPARIV
MAB_2817c|M.abscessus_ATCC_199 MGIGDFSKIPNGIGSIEHRMDLLYQGVVD-GRISVERWVEITSTTPARMF
MSMEG_4012|M.smegmatis_MC2_155 LGIGNFSKIPNGIGGVEHRMDLMFQGVVD-GRISLERWVEVCATTPARMF
Mflv_3169|M.gilvum_PYR-GCK E-NGDFGVAWGGVASLQLGLSLIWTEAKRRGVALTR-VIDWMAAKPAELA
:*. *: .:: :.:: * . : ** :
MMAR_2196|M.marinum_M GLPDHGRPLEVGEPANLTVIDPDATWTV-TGADLASRSANTPYESMTLPA
MUL_1781|M.ulcerans_Agy99 GLPDHGRPLEVGEPANLTVIDPDATWTV-TGADLASRSANTPYESMTLPA
Mb1416|M.bovis_AF2122/97 RLPDQGRPLEVGEPANLTVVDPDATWTV-TGADLASRSANTPFESMSLPA
Rv1381|M.tuberculosis_H37Rv RLPDQGRPLEVGEPANLTVVDPDATWTV-TGADLASRSANTPFESMSLPA
MLBr_00533|M.leprae_Br4923 GLPDHGRPLEVGEPANLTVVDPDVTWTV-TGDGLASRSANTPYEAMTLPA
MAV_3392|M.avium_104 NLPDHGRPLEVGEPANLTVVDPDASWTV-AGSDLASRSANTPYEAMTLPA
Mvan_2661|M.vanbaalenii_PYR-1 GLPDQGRPLEVGEPANLTVVDPAARWTV-KGPELASRSDNTPYEDMELPA
TH_0815|M.thermoresistible__bu GLPDQGRPLEVGEPANLTVVDPDASWVV-EGSGLASRSANTPYESMTLPA
MAB_2817c|M.abscessus_ATCC_199 GLYGRKGVIAPGADADIVVYDPNGHTSIGLGKTHHMNMDHSAWEGYEIDG
MSMEG_4012|M.smegmatis_MC2_155 GLYPRKGVISPGADADVVIYDPAGHTSIGVGKTHHMNMDHSAWEGFEIDG
Mflv_3169|M.gilvum_PYR-GCK GLNNKGK-IALGYDADFAIFEPESAQVVDVHKLHHRN-PITPYDGRAVAG
* : : * *:..: :* : . :.:: : .
MMAR_2196|M.marinum_M RVTATLLRGKITARDGKSPA-----------------
MUL_1781|M.ulcerans_Agy99 RVTATLLRGKITARDGKSPA-----------------
Mb1416|M.bovis_AF2122/97 TVTATLLRGKVTARDGKIRA-----------------
Rv1381|M.tuberculosis_H37Rv TVTATLLRGKVTARDGKIRA-----------------
MLBr_00533|M.leprae_Br4923 TVTATLLRGKVTARGQKSPV-----------------
MAV_3392|M.avium_104 TVTATLLRGKVTARDGKCPV-----------------
Mvan_2661|M.vanbaalenii_PYR-1 VVTATLLRGKVTARDGKVGA-----------------
TH_0815|M.thermoresistible__bu TVTLTMLRGKITARDGKAATS----------------
MAB_2817c|M.abscessus_ATCC_199 HVDTVLSRGKVIVDGDEYLGSKGDGVFLRRDLCQYLI
MSMEG_4012|M.smegmatis_MC2_155 AVTAVWSRGKKVVEDRRYLGAKTDGRFVRRELSQNLI
Mflv_3169|M.gilvum_PYR-GCK VVASTWLRGTKIDFTTPRGRMLRRGGV----------
* . **.