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M. thermoresistible (build 8) TH_3497 (-)

annotation: acyl-CoA thioesterase
coordinates: 2568121 - 2569815
length: 565

aa seq not available

Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. thermoresistible (build 8)TH_3497--100% (565)acyl-CoA thioesterase
M. thermoresistible (build 8)TH_2056tesB23e-4039.34% (244) PROBABLE ACYL-CoA THIOESTERASE II TESB2 (TEII)
M. thermoresistible (build 8)TH_3198-3e-3836.33% (289) PUTATIVE acyl-CoA thioesterase

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1416pyrC1e-8985.34% (191) dihydroorotase
M. gilvum PYR-GCKMflv_3746pyrC1e-8381.15% (191) dihydroorotase
M. tuberculosis H37RvRv1381pyrC4e-9085.86% (191) dihydroorotase
M. leprae Br4923MLBr_00533pyrC6e-8582.72% (191) dihydroorotase
M. abscessus ATCC 19977MAB_2830cpyrC1e-8178.01% (191) dihydroorotase
M. marinum MMMAR_2196pyrC2e-8582.72% (191) dihydroorotase PyrC
M. avium 104MAV_3392pyrC1e-8985.34% (191) dihydroorotase
M. smegmatis MC2 155MSMEG_3812-2e-9962.55% (275) acyl-CoA thioesterase
M. ulcerans Agy99MUL_1781pyrC2e-8582.20% (191) dihydroorotase
M. vanbaalenii PYR-1Mvan_2661pyrC1e-8985.34% (191) dihydroorotase

CLUSTAL 2.0.9 multiple sequence alignment


Mb1416|M.bovis_AF2122/97            MS------------VLIRGVRPYGEGERVDVLVDDGQIAQIGPDLAI---
Rv1381|M.tuberculosis_H37Rv         MS------------VLIRGVRPYGEGERVDVLVDDGQIAQIGPDLAI---
MMAR_2196|M.marinum_M               MS------------VLLRGVRLYGEGERVDVLVDDNQIADIGTGLAI---
MUL_1781|M.ulcerans_Agy99           MS------------VLLRGVRLYGEGERVDVLVDDNQIADIGTGLAI---
MAV_3392|M.avium_104                MS------------VLLRGVRLYGEGDRVDVLVDDGQIADIGAGLDI---
MLBr_00533|M.leprae_Br4923          MS------------VLLRGVRLYGEGEQVDVLVEGEQIANIGAGIDI---
MAB_2830c|M.abscessus_ATCC_199      MS------------VLIKGVLLYGEGDQVDVLIEDGQITRIEAGIGAGIE
Mflv_3746|M.gilvum_PYR-GCK          MS------------VVLKSVRLYGEGDAVDVLVRDGIIAEIGTGLSA---
Mvan_2661|M.vanbaalenii_PYR-1       MTSSSPESLRSCPPIVLKSVRLYGEGDPVDVLVRDGQIAEIGERLTAP--
TH_3497|M.thermoresistible__bu      ---------------LIRNVRPYGEGEPVDVLVADGQIAEIGEKLPIPGD
MSMEG_3812|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

Mb1416|M.bovis_AF2122/97            PDTADVIDATGHVLLPGFVDLHTHLREPGREYAEDIETGSAAAALGGYTA
Rv1381|M.tuberculosis_H37Rv         PDTADVIDATGHVLLPGFVDLHTHLREPGREYAEDIETGSAAAALGGYTA
MMAR_2196|M.marinum_M               PDTADVIDATDHVLLPGLVDLHTHLREPGREYAEDIETGSAAAALGGYTA
MUL_1781|M.ulcerans_Agy99           PDTADVIDATDHVLLPGLVDLHTHLREPGREYAEDIETGSAAAALGGYTA
MAV_3392|M.avium_104                PDTADVIDATGQVLLPGFVDLHTHLREPGREYAEDIETGSAAAALGGYTA
MLBr_00533|M.leprae_Br4923          PDTADVIDAIDQVLLPGLVDLHTHLREPGREYAEDIETGSAAAALGGYTA
MAB_2830c|M.abscessus_ATCC_199      TEVDTAIEAPGQILLPGFVDLHTHLREPGREDTETIDSGSAAAALGGYTA
Mflv_3746|M.gilvum_PYR-GCK          ---DETIDCTGRVLLPGFVDLHTHLREPGREYAEDIETGSAAAALGGYTA
Mvan_2661|M.vanbaalenii_PYR-1       -TDADSIDCEGKILLPGFVDLHTHLREPGREYAEDIETGSAAAALGGYTA
TH_3497|M.thermoresistible__bu      GELGDVIDADGQILLPGFVDLHTHLREPGREYAEDIETGSAAAALGGYTA
MSMEG_3812|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

Mb1416|M.bovis_AF2122/97            VFAMANTNPVADSPVVTDHVWHRGQQVGLVDVHPVGAVTVGLAGAELTEM
Rv1381|M.tuberculosis_H37Rv         VFAMANTNPVADSPVVTDHVWHRGQQVGLVDVHPVGAVTVGLAGAELTEM
MMAR_2196|M.marinum_M               VFAMANTHPVADSPVVTDHVWHRGQQVGLVDVHPVGAVTVGLAGTELTEM
MUL_1781|M.ulcerans_Agy99           VFAMANTHPVADSPVVTDHVWHRGQQVGLVDVHPVGAVTIGLAGTELTEM
MAV_3392|M.avium_104                VFAMANTNPVADSPVVTDHVWHRGQQVGLVDVHPVGAVTMGLAGKELTEM
MLBr_00533|M.leprae_Br4923          VFAMPNTTPVADSPVVTDHVWRRGQQVGLVDVHPVGAVTVGLAGAELTEM
MAB_2830c|M.abscessus_ATCC_199      VFAMANTNPVADSPVVTDHVWQRGQQVGIVDVHPVGAVTVGLEGKQLTEM
Mflv_3746|M.gilvum_PYR-GCK          VFAMANTDPVADSVVVTDHVWQRGQQVGLVDVHPVGAVTVGLAGKQLTEM
Mvan_2661|M.vanbaalenii_PYR-1       VFAMANTDPVADSAVVTDHVWHRGQQVGLVDVHPVGAVTVGLDGKQLTEM
TH_3497|M.thermoresistible__bu      VFAMANTDPVADSPVVTDHVWRRGQQVGLVDVHPVGAVTVGLEGRQLTEM
MSMEG_3812|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

Mb1416|M.bovis_AF2122/97            GMMNAG--------------------------------------------
Rv1381|M.tuberculosis_H37Rv         GMMNAG--------------------------------------------
MMAR_2196|M.marinum_M               GMMNAG--------------------------------------------
MUL_1781|M.ulcerans_Agy99           GMMNAG--------------------------------------------
MAV_3392|M.avium_104                GMMAAG--------------------------------------------
MLBr_00533|M.leprae_Br4923          GMMAAG--------------------------------------------
MAB_2830c|M.abscessus_ATCC_199      AMMARG--------------------------------------------
Mflv_3746|M.gilvum_PYR-GCK          GLMAAG--------------------------------------------
Mvan_2661|M.vanbaalenii_PYR-1       GLMAAG--------------------------------------------
TH_3497|M.thermoresistible__bu      GLMAAGAARVRMFSDDGLCVHDPLVMRRALEYARGLGVLIAQHAEEPRLT
MSMEG_3812|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

Mb1416|M.bovis_AF2122/97            --------------------------------------------------
Rv1381|M.tuberculosis_H37Rv         --------------------------------------------------
MMAR_2196|M.marinum_M               --------------------------------------------------
MUL_1781|M.ulcerans_Agy99           --------------------------------------------------
MAV_3392|M.avium_104                --------------------------------------------------
MLBr_00533|M.leprae_Br4923          --------------------------------------------------
MAB_2830c|M.abscessus_ATCC_199      --------------------------------------------------
Mflv_3746|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2661|M.vanbaalenii_PYR-1       --------------------------------------------------
TH_3497|M.thermoresistible__bu      VGAVAHXXXWPACPARCRPGYRSPPTWCASAPPGRPNAVRRNRSSPRRIG
MSMEG_3812|M.smegmatis_MC2_155      --------------------------------------------------
                                                                                      

Mb1416|M.bovis_AF2122/97            ----------------------------------------------AAQV
Rv1381|M.tuberculosis_H37Rv         ----------------------------------------------AAQV
MMAR_2196|M.marinum_M               ----------------------------------------------VAAV
MUL_1781|M.ulcerans_Agy99           ----------------------------------------------VAAV
MAV_3392|M.avium_104                ----------------------------------------------AAQV
MLBr_00533|M.leprae_Br4923          ----------------------------------------------AAQV
MAB_2830c|M.abscessus_ATCC_199      ----------------------------------------------AGRV
Mflv_3746|M.gilvum_PYR-GCK          ----------------------------------------------TGRV
Mvan_2661|M.vanbaalenii_PYR-1       ----------------------------------------------AGQV
TH_3497|M.thermoresistible__bu      PTPPPGTSRPATDVGRLGSADRARRPGPRCRGAWWLGHDAPVTELTLYDV
MSMEG_3812|M.smegmatis_MC2_155      -MPLP----------------------------------------QLADV
                                                                                     *

Mb1416|M.bovis_AF2122/97            RMFSDDGVCVHDPLIMRRALEYATGLGVLIAQHAEEPRLTVGAFAHEGPM
Rv1381|M.tuberculosis_H37Rv         RMFSDDGVCVHDPLIMRRALEYATGLGVLIAQHAEEPRLTVGAVAHEGPM
MMAR_2196|M.marinum_M               RMFSDDGICVHDPLIMRRALEYATGLGVLIAQHAEEPRLTVGAVAHEGPN
MUL_1781|M.ulcerans_Agy99           RMFSDDGICVHDPLIMRRALEYATGLGVLIAQHAEEPRLTVGAVAHEGPS
MAV_3392|M.avium_104                RMFSDDGVCVHDPLVMRRALEYATGLGVLIAQHAEEPRLTVGAVAHEGPT
MLBr_00533|M.leprae_Br4923          RIFSDDGNCVHNPLVMRRALEYATGLGVLIAQHAEEPRLTVGAVAHEGPT
MAB_2830c|M.abscessus_ATCC_199      RMFSDDGKCVHDPLVMRRALEYAKGLGVLIAQHAEEPRLTVGSVAHEGAN
Mflv_3746|M.gilvum_PYR-GCK          RMFSDDGVCVDDPLLMRRALEYASGLGVLIAQHAEEPRLTVGAVAHEGPN
Mvan_2661|M.vanbaalenii_PYR-1       RMFSDDGVCVDDPLVMRRALEYASGLGVLIAQHAEEPRLTVGAVAHEGPN
TH_3497|M.thermoresistible__bu      LTTLDVAQVDDD---LFEATQLDNPAHHIVGGHIAGQAVVAASRTAPQRT
MSMEG_3812|M.smegmatis_MC2_155      LATLDITDCGHD---MFVATQIDNEAHHIIGGHISAQALMAASRTAAGRV
                                        *     .:   :  * :  .    ::. *     : ..: :     

Mb1416|M.bovis_AF2122/97            AARLGLAGWPRAAEESIVARDALLARDAGARVHICHASAAGTVEILKWAK
Rv1381|M.tuberculosis_H37Rv         AARLGLAGWPRAAEESIVARDALLARDAGARVHICHASAAGTVEILKWAK
MMAR_2196|M.marinum_M               AAQLGLAGWPRAAEESIVARDALLARDAGARVHICHASTVGTVEILKWAK
MUL_1781|M.ulcerans_Agy99           AAQLGLAGWPRAAEESIVARDALLTRDAGARVHICHASTVGTVEILKWAK
MAV_3392|M.avium_104                AARLGLAGWPRAAEESIVARDALLARDAGARVHICHASTAGTVEIVKWAK
MLBr_00533|M.leprae_Br4923          AARLGLSGWPRAAEESIVARDALLARDAGARVHICHASTAGTVEILKWAK
MAB_2830c|M.abscessus_ATCC_199      AARLGLTGWPRAAEESIVARDAILSRDTGAPVHICHASTAGTVELLKWAK
Mflv_3746|M.gilvum_PYR-GCK          AARLGLAGWPRAAEESIVARDALLARDAGARVHICHASTAGTVELVRWAK
Mvan_2661|M.vanbaalenii_PYR-1       AARLGLAGWPRAAEESIVARDALLARDAGARVHICHASTAGTVELLKWAK
TH_3497|M.thermoresistible__bu      AHSAHVYFLRAGDARYPVQMRVDRLRDGGS-LSTXRVTATQDGQVLLEAL
MSMEG_3812|M.smegmatis_MC2_155      PNSLHVYLLRAGDARYPVEMQVMNMRDGGM-LSTRRVIARQGDEVLLEAL
                                    .    :     .  .  *   .   ** *  :   :. :    :::  * 

Mb1416|M.bovis_AF2122/97            DQGISITAEVTPHHLLLDDARLASYDGVNRVNPPLREASDAVALR-QALA
Rv1381|M.tuberculosis_H37Rv         DQGISITAEVTPHHLLLDDARLASYDGVNRVNPPLREASDAVALR-QALA
MMAR_2196|M.marinum_M               SQGISITAEVTPHHLLLDDRRLSGYDGVNRVNPPLREASDAMALR-QALA
MUL_1781|M.ulcerans_Agy99           SQGISITAEVTPHHLLLDDRRLSGYDGVNRVNPPLREASDAMALR-QALA
MAV_3392|M.avium_104                QQGISITAEVTPHHLMLDDSRLASYDGRNRVNPPLREAADAAALR-RALA
MLBr_00533|M.leprae_Br4923          EQGISITAEVTPHHLLLDDSRLASYDGVNRVNPPLRETADAVALR-QALA
MAB_2830c|M.abscessus_ATCC_199      GQGISITAEVTPHHLLLDDGRLSSYDGVYRVNPPLRESSDAAALR-QALA
Mflv_3746|M.gilvum_PYR-GCK          EQGIAITAEVTPHHLLLDDTRLETYDGRNRVNPPLREVSDTLALR-QALA
Mvan_2661|M.vanbaalenii_PYR-1       SQGISITAEVTPHHLLLDDSRLDTYDGVNRVNPPLREVSDAVALR-RALA
TH_3497|M.thermoresistible__bu      ASFTVRIDSVDTHHPMPDVPDPDTLPPVTEQLVAYADEFGGLWVRPQPIE
MSMEG_3812|M.smegmatis_MC2_155      VSLSDTADTVDYHQPMPDVPAPEDLPSVGELLSDYADELDGFWVKPQWIE
                                     .       *  *: : *           .      :  .   :: : : 

Mb1416|M.bovis_AF2122/97            DGIIDCVATDHAPHAEHEKCVEFAAARPGMLGLQTALSVVVQTMVA-PGL
Rv1381|M.tuberculosis_H37Rv         DGIIDCVATDHAPHAEHEKCVEFAAARPGMLGLQTALSVVVQTMVA-PGL
MMAR_2196|M.marinum_M               DGIIDCVATDHAPHAEHEKCVEFSAARPGMLGLQTALSVVVQTMVQ-PGL
MUL_1781|M.ulcerans_Agy99           DGIIDCVATDHAPHAEHEKCVEFSAARPGMLGLQTALSVVVQTMVQ-PGL
MAV_3392|M.avium_104                DGVIDCVATDHAPHAEHEKCVEFSAARPGMLGLQTALSIVVHTMVR-PGL
MLBr_00533|M.leprae_Br4923          DGIIDCVTTDHAPHADHEKCVEFSAARPGMLGLQTALSVVVHTMVV-PGL
MAB_2830c|M.abscessus_ATCC_199      DGVIDCVATDHAPHADHEKCCEFAAARPGMLGLQTALSVVVQTMVR-PGL
Mflv_3746|M.gilvum_PYR-GCK          DGVIDCVATDHAPHGEHEKMCEFANARPGMLGLQTALSVVVETMVQ-PGP
Mvan_2661|M.vanbaalenii_PYR-1       DGVIDCVATDHAPHGAHEKCCEFANARPGMLGLQTALSVVVETLVN-PGL
TH_3497|M.thermoresistible__bu      RRYIDPPPRVAYDLPEPPARTRMWWRATEPVPDDPALNSALLTYVTGTST
MSMEG_3812|M.smegmatis_MC2_155      RRYVDAPPRLALDQPEPPERTRMWWRPAESIPNDPVLNCCVLTYASGTSL
                                       :*  .             .:    .  :  :..*.  : * .  .. 

Mb1416|M.bovis_AF2122/97            LSWRDIARVMSENPACIARLPDQGRPLEVGEPANLTVVDPDATWTVTGAD
Rv1381|M.tuberculosis_H37Rv         LSWRDIARVMSENPACIARLPDQGRPLEVGEPANLTVVDPDATWTVTGAD
MMAR_2196|M.marinum_M               LSWRDVARVMSENPARIVGLPDHGRPLEVGEPANLTVIDPDATWTVTGAD
MUL_1781|M.ulcerans_Agy99           LSWRDVARVMSENPARIVGLPDHGRPLEVGEPANLTVIDPDATWTVTGAD
MAV_3392|M.avium_104                LTWRDVAKVMSENPARIANLPDHGRPLEVGEPANLTVVDPDASWTVAGSD
MLBr_00533|M.leprae_Br4923          LSWRDVAQVMSENPARIAGLPDHGRPLEVGEPANLTVVDPDVTWTVTGDG
MAB_2830c|M.abscessus_ATCC_199      LTWRDIARVMSERPAQIVGLPDQGRPIAVGEPANLTIVDPDASWTVSGDG
Mflv_3746|M.gilvum_PYR-GCK          LTWRDVARVMSEAPARIVGLPDQGRPLEVGEPANLTVVDPDARWTVSGPA
Mvan_2661|M.vanbaalenii_PYR-1       LTWRDVARVMSEAPARIVGLPDQGRPLEVGEPANLTVVDPAARWTVKGPE
TH_3497|M.thermoresistible__bu      LEAAMVAHRTTPLHSFNALIDHALWFHRPAHLTDWVLADQFSPSSLGGRG
MSMEG_3812|M.smegmatis_MC2_155      LETTVTMRRTTQATAFSALIDHTVWFQRPADLSDWVLSDQVSLSGIHGRG
                                    *      :  :   :  . : .       .. :: .: *      : *  

Mb1416|M.bovis_AF2122/97            LASRSANTPFESMSLPATVTATLLRGKVTARDGKIRA-----------
Rv1381|M.tuberculosis_H37Rv         LASRSANTPFESMSLPATVTATLLRGKVTARDGKIRA-----------
MMAR_2196|M.marinum_M               LASRSANTPYESMTLPARVTATLLRGKITARDGKSPA-----------
MUL_1781|M.ulcerans_Agy99           LASRSANTPYESMTLPARVTATLLRGKITARDGKSPA-----------
MAV_3392|M.avium_104                LASRSANTPYEAMTLPATVTATLLRGKVTARDGKCPV-----------
MLBr_00533|M.leprae_Br4923          LASRSANTPYEAMTLPATVTATLLRGKVTARGQKSPV-----------
MAB_2830c|M.abscessus_ATCC_199      LASKSANTPFESMTLPATVTATLLRGRITARDGRVASMSHLCDEDLAQ
Mflv_3746|M.gilvum_PYR-GCK          LASRSDNTPYEAMELPGVVTATLLRGTVTARDGKAGA-----------
Mvan_2661|M.vanbaalenii_PYR-1       LASRSDNTPYEDMELPAVVTATLLRGKVTARDGKVGA-----------
TH_3497|M.thermoresistible__bu      LATATMYN--RTGELVCTATQELYFGRPARSGSRR-------------
MSMEG_3812|M.smegmatis_MC2_155      LASGTMYN--RSGELVCSATQEIYFGR-GRI-----------------
                                    **: :  .  .   *   .*  :  *