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MSLVTQAREMADDLVHLRRALHQEPEVGLNLPRTQERVLAALEGLPLEITTGTNCTSVTAVLRGHGDGVV LLRADMDALPVQEHTGLDYTSRIDGAMHGCGHDLHTAMLVGAAHLLAAQREKLHGDVVFMFQPGEEGWEG ARTMIDEGVLDAAGRRPDAAYALHVFSTLGPAGTFFSRPGVALAASATLRVTVRGEGGHGSTPHLAKDPV PVLAEMVTALQTAVTRQFDVFDPVVLTIGVLRAGTRSNIIPATATFEATIRTFSVESSRRIRDIALRLVS GIADAHGVDVDADYAEGRPPTVNDPDETALAREVIIETLGENRYAPLANPFTGAEDFARVLDEVPGCFVA LGALPPGADPDKAAYNHSPQAVFDDSVLPDGAALYAELAHRRLNVNSGATSGATTQKGR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3989 | - | - | 100% (409) | peptidase M20D, amidohydrolase |
| M. smegmatis MC2 155 | MSMEG_1703 | - | 5e-39 | 33.04% (345) | amidohydrolase |
| M. smegmatis MC2 155 | MSMEG_1702 | - | 9e-15 | 25.74% (408) | amidohydrolase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3333c | amiA1 | 7e-40 | 34.21% (342) | N-acyl-L-amino acid amidohydrolase |
| M. gilvum PYR-GCK | Mflv_1971 | - | 7e-50 | 36.80% (375) | amidohydrolase |
| M. tuberculosis H37Rv | Rv3305c | amiA1 | 7e-40 | 34.21% (342) | N-acyl-L-amino acid amidohydrolase |
| M. leprae Br4923 | MLBr_01059 | dapE | 3e-05 | 25.08% (311) | succinyl-diaminopimelate desuccinylase |
| M. abscessus ATCC 19977 | MAB_4738c | - | 3e-55 | 39.48% (347) | putative amidohydrolase |
| M. marinum M | MMAR_1221 | amiA1 | 3e-37 | 33.33% (357) | N-acyl-L-amino acid amidohydrolase AmiA1 |
| M. avium 104 | MAV_3492 | - | 2e-57 | 39.72% (355) | N-alpha-acyl-glutamine aminoacylase |
| M. thermoresistible (build 8) | TH_1760 | - | 1e-45 | 35.17% (381) | POSSIBLE N-ACYL-L-AMINO ACID AMIDOHYDROLASE AMIA1 |
| M. ulcerans Agy99 | MUL_2671 | amiA1 | 4e-37 | 33.05% (357) | N-acyl-L-amino acid amidohydrolase AmiA1 |
| M. vanbaalenii PYR-1 | Mvan_4743 | - | 5e-48 | 34.34% (399) | amidohydrolase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1971|M.gilvum_PYR-GCK MAPSSTAATAVLDGLPGIRAWQEDFYRDLHRHPELSHQEHRTSAKAAEAL
Mvan_4743|M.vanbaalenii_PYR-1 MAPSS-QATTVLDGLPGIRSWQEDFYRDLHRHPELSHQEHRTAGKVVDTL
MAV_3492|M.avium_104 ----------MLAGLPGIRGWQEDLYRDLHRHPELSHQEHRTAAVVAERL
MAB_4738c|M.abscessus_ATCC_199 ------MSITLPHNWADDLGDLADFYRDLHQNPELSFQEHRTAGKIEEAI
MSMEG_3989|M.smegmatis_MC2_155 --------MSLVTQAREMADDLVHLRRALHQEPEVGLNLPRTQERVLAAL
MMAR_1221|M.marinum_M ---MSLVDTAES-WLAAHYDDLVGWRRHIHRYPELGRQEFATTQFVAERL
MUL_2671|M.ulcerans_Agy99 ---MSLVDTAES-WLAAHYDDLVGWRRHIHRYPELGRQEFATTQFVAERL
Mb3333c|M.bovis_AF2122/97 ---MSLADAAES-WLAAHHDDLVGWRRHIHRYPELGRQEYATTQFVAERL
Rv3305c|M.tuberculosis_H37Rv ---MSLADAAES-WLAAHHDDLVGWRRHIHRYPELGRQEYATTQFVAERL
TH_1760|M.thermoresistible__bu ---MSVLRHAVARWLSRHQDDLVAWRRHIHAHPELGRQEFATTQFVAERL
MLBr_01059|M.leprae_Br4923 --------------MLDLRGDPIELTAALVDIPSESRAEARIADAVETAL
: *. . :
Mflv_1971|M.gilvum_PYR-GCK --AGYRVHTGIGGTGVIGILDNGPGPTVLLRADMDALPVLEHTGLPYASS
Mvan_4743|M.vanbaalenii_PYR-1 TAAGYRVHDGIGGTGVIGILENGPGPTVLLRADMDALPVLEDTGLPYAST
MAV_3492|M.avium_104 RGFGYDVHEGVGGTGVVGVLRNGTGPAVLLRADMDALPVREDTGLPYASA
MAB_4738c|M.abscessus_ATCC_199 APLGLEVTAGIGGTGVVAVLRNGSGPVIWLRADFDALPVQEQTGLPYAST
MSMEG_3989|M.smegmatis_MC2_155 EGLPLEITTGTNCTSVTAVLRGHGDGVVLLRADMDALPVQEHTGLDYTSR
MMAR_1221|M.marinum_M ADAGLNPKILPGGTGLTCDFGPEHQPRIALRADMDALPMAERTGAPYAST
MUL_2671|M.ulcerans_Agy99 ADAGLNPKILPGGTGLTCDFGPEHQPRIALRADMDALPMAERTGAPYAST
Mb3333c|M.bovis_AF2122/97 ADAGLNPKVLPGGTGLTCDFGPQHQPRIALRADMDALPMAERTGAPYAST
Rv3305c|M.tuberculosis_H37Rv ADAGLNPKVLPGGTGLTCDFGPQHQPRIALRADMDALPMAERTGAPYAST
TH_1760|M.thermoresistible__bu ADAGLNPKVLPGGTGLICDLGPDHTPRVALRADMDALPMPERTGAPYAST
MLBr_01059|M.leprae_Br4923 RAQTAGFEIVRNGNAVLARTSLHRPARVLLAGHLDTVPVAGNLPSRCEK-
. ..: : * ..:*::*: .
Mflv_1971|M.gilvum_PYR-GCK ERATDATGHEVPVMHACGHDAHVTALLGAARLMADGRSNWGGTLVALFQP
Mvan_4743|M.vanbaalenii_PYR-1 ERATDPTGHEVPVTHACGHDLHVTALLGATRLLADGRGSWGGTLVGLFQP
MAV_3492|M.avium_104 VTATDPRGDERPVMHACGHDVHVTCLLGAASLLAGAREHWRGSLVAVFQP
MAB_4738c|M.abscessus_ATCC_199 VRATNPDGKDVPVMHACGHDMHVAALVGALRLLDQLKATWSGTVVAVFQP
MSMEG_3989|M.smegmatis_MC2_155 IDG---------AMHGCGHDLHTAMLVGAAHLLAAQREKLHGDVVFMFQP
MMAR_1221|M.marinum_M MPN---------IAHACGHDGHTAILLGTALALATVPELPVGVRLIFQAA
MUL_2671|M.ulcerans_Agy99 MPN---------IAHACGHDGHTAILLGTALALATVPELPVGVRLIFEAA
Mb3333c|M.bovis_AF2122/97 MPN---------VAHACGHDAHTAILLGAALALASVPELPVGVRLIFQAA
Rv3305c|M.tuberculosis_H37Rv MPN---------VAHACGHDAHTAILLGAALALASVPELPVGVRLIFQAA
TH_1760|M.thermoresistible__bu VPN---------VAHACGHDAHTAMLLGAALALNTVPELPIGVRLIFQAA
MLBr_01059|M.leprae_Br4923 -----------DVLHGCG-TVDMKSGDAVFLHLAATVTEPVHDLTLMFYD
*.** . .. : .
Mflv_1971|M.gilvum_PYR-GCK AEETGEGARGMVDDGLAKLLPH-VDVCLGQHVMP--FPAGTIGVHAGPFM
Mvan_4743|M.vanbaalenii_PYR-1 AEETGDGARGMVADGLANLLSH-VDVCLGQHVMP--FPAGTIGMHAGPFM
MAV_3492|M.avium_104 AEELGDGARRMVDDGLARLVGH-VDVALAQHVLP--FPAGQIVTRSGPFM
MAB_4738c|M.abscessus_ATCC_199 AEEVGGGANAMIADGILDRFPR-PDVVLGQHVGP--LPAGMIAYKTGTAL
MSMEG_3989|M.smegmatis_MC2_155 GEEGWEGARTMIDEGVLDAAGRRPDAAYALHVFSTLGPAGTFFSRPGVAL
MMAR_1221|M.marinum_M EELMPGGAIDAIAAGALTGVSR----IFALHCDPR-LEVGRVAVRQGPIT
MUL_2671|M.ulcerans_Agy99 EELMPGGAIDAIAAGALTGVSR----IFALHCDPR-LEVGRVAVRQGPIT
Mb3333c|M.bovis_AF2122/97 EELMPGGAIDAIAAGALAGVSR----IFALHCDPR-LEVGKVAVRQGPIT
Rv3305c|M.tuberculosis_H37Rv EELMPGGAIDAIAAGALAGVSR----IFALHCDPR-LEVGKVAVRQGPIT
TH_1760|M.thermoresistible__bu EELMPGGALDAIAAGVLNGVSR----IFALHCDPR-LQVGRVATRPGPIT
MLBr_01059|M.leprae_Br4923 CEEIDSAANGLVR--IERELPE----WLAADVAILGEPTGGYIEAG---C
* .* : . . . .*
Mflv_1971|M.gilvum_PYR-GCK ASADSMRITVYGRGSHGSMPQASVDPVVLAAMIVVRLQTVVSREVSPA--
Mvan_4743|M.vanbaalenii_PYR-1 ASADSMRVTVYGRGSHGSMPQASVDPVVLAAMIVVRLQTVVSREVSPV--
MAV_3492|M.avium_104 ATADSMRVTVYGRGGHGSMPQTTVDPVVLAAMIVIRLQTVVSREVAPT--
MAB_4738c|M.abscessus_ATCC_199 AASDSLKLQLFGRGGHGSQPESTIDPVVMASSVVQRLQTIVSRELSPF--
MSMEG_3989|M.smegmatis_MC2_155 AASATLRVTVRGEGGHGSTPHLAKDPVPVLAEMVTALQTAVTRQFDVF--
MMAR_1221|M.marinum_M SAADHIEITLYSPGGHTSRPHLTADLVYGLGTLITGLPGVLSRRVDPR--
MUL_2671|M.ulcerans_Agy99 SAADHIEITLYSPGGHTSRPHLTADLVYGLGTLITGLPGVLSRRVDPR--
Mb3333c|M.bovis_AF2122/97 SAADSIEITLYSPGGHTSRPHLTADLVYGLGTLVTGLPGVLSRRIDPR--
Rv3305c|M.tuberculosis_H37Rv SAADSIEITLYSPGGHTSRPHLTADLVYGLGTLVTGLPGVLSRRIDPR--
TH_1760|M.thermoresistible__bu SAADHVEVTLQSKGGHTSRPHLTGDLVYALGTLITGVPGVLSRRIDPR--
MLBr_01059|M.leprae_Br4923 QGTLRVVINAAGSRAHSARSWLGDNAIHKLGAVLDRLAAYRARTVDIDGC
: : : . .* : . : : . :: : :* .
Mflv_1971|M.gilvum_PYR-GCK -EPAVLTVGSITAGSKSNVIPDRAVLQLNIRTFNDATRTAVLDAVRRIVT
Mvan_4743|M.vanbaalenii_PYR-1 -EPVVLTVGSITSGSKSNVIPDRAVLQLNIRTFNDDTRTAVLEAVRRIVT
MAV_3492|M.avium_104 -ETAVLTIGRIESGAKSNVIGDHAVLELNLRTFSGRTRDRMLDAVRRIVT
MAB_4738c|M.abscessus_ATCC_199 -EPAVVTVGYVHAGAKDNIIPDDAELGINVRTFNEEVRKKTLASITRIAQ
MSMEG_3989|M.smegmatis_MC2_155 -DPVVLTIGVLRAGTRSNIIPATATFEATIRTFSVESSRRIRDIALRLVS
MMAR_1221|M.marinum_M -NSTVLVWGAVNAGVAANAIPQTGVLAGTVRTASRQTWIDLEEIIRESIT
MUL_2671|M.ulcerans_Agy99 -NSTVLVWGAVNAGVAANAIPQTGVLAGTVRTASRQTWIDLEEIIRESIT
Mb3333c|M.bovis_AF2122/97 -NSTVLVWGAVNAGMAANAIPQTGVLSGTVRTASRQTWVDLEELVRQAIS
Rv3305c|M.tuberculosis_H37Rv -NSTVLVWGAVNAGMAANAIPQTGVLSGTVRTASRQTWVDLEELVRQAIS
TH_1760|M.thermoresistible__bu -NGTVMVWGAVNAGVAANAIPQTGTLAGTIRTASRSTWLTLEAIVSETVS
MLBr_01059|M.leprae_Br4923 VYREGLSAVRVDGGVAGNVIPDAASVTVNYRFAPDRS----VAAALRHVH
: : .* * * . . . * .
Mflv_1971|M.gilvum_PYR-GCK AECMASRSPRDPEFELSDRFPLTDNDIPTTERVTHAFTDMFG-ERCVELP
Mvan_4743|M.vanbaalenii_PYR-1 AECAASRSPRDPEFELSDRFPVTDNDIATTERVTHAFSEMFG-ERCVELP
MAV_3492|M.avium_104 AECQASGSPRDPEFEMMNHFPATDNDPAVTARVRAVFAEHFG-DRATEIP
MAB_4738c|M.abscessus_ATCC_199 AESIASGADKEPAVTSMHTFPVTVVDDGAMQAIAAVFREHFGAERVVESP
MSMEG_3989|M.smegmatis_MC2_155 GIADAHGVDVDADYAEGR--PPTVNDPDETALAREVIIETLGENRYAPLA
MMAR_1221|M.marinum_M ALLSP--LAIEHTLQYRRGVPPVVNEEVSTHILTHAIEAVSP--DALADT
MUL_2671|M.ulcerans_Agy99 ALLSP--LAIEHTLQYRRGVPPVVNEEVSTHILTHAIEAVSP--DALADT
Mb3333c|M.bovis_AF2122/97 ALLLP--LAIEHTLQYRRGVPPVVNEEISTRILAHAIEAIGP--GVLADT
Rv3305c|M.tuberculosis_H37Rv ALLLP--LAIEHTLQYRRGVPPVVNEEISTRILAHAIEAIGP--GVLADT
TH_1760|M.thermoresistible__bu SLLAP--LGVEHSLQYRRGVPPVVNEEQSTRILTRAIEAVGP--NVLADT
MLBr_01059|M.leprae_Br4923 DVFDGLDVQIEQTDAAVGALPGLSQP-----AAKALVEAADG------QV
: * .
Mflv_1971|M.gilvum_PYR-GCK -QGAGSEDFSDIPRALGVPYTYWGVGCVDPDVYRTAAEAGSINQDIAVNH
Mvan_4743|M.vanbaalenii_PYR-1 -QGVGSEDFSEIPRALGVPYTYWGVGCVDPDAYRSAAEAGSVNQDIAVNH
MAV_3492|M.avium_104 -AQTGSEDFSNIATGLDAPYSYWGFGGADPGAYRRAEAAGRLAEDIPVNH
MAB_4738c|M.abscessus_ATCC_199 SPLAGSEDVGIFGTTAGVPTAFWFWGGYEQQRFEEAAAAG---KPVPSNH
MSMEG_3989|M.smegmatis_MC2_155 NPFTGAEDFARVLD--EVPGCFVALGALPPGADPDKAAYNHSPQAVFDDS
MMAR_1221|M.marinum_M RQSGGGEDFSWYLE--EVPGAMGRLGVWSGDGPQ---------LDLHQPT
MUL_2671|M.ulcerans_Agy99 RQSGGGEDFSWYLE--EVPGAMGRLGVWSGDGPQ---------LDLHQPT
Mb3333c|M.bovis_AF2122/97 RQSGGGEDFSWYLE--EVPGAMARLGVWSGDGLQ---------LDLHQPT
Rv3305c|M.tuberculosis_H37Rv RQSGGGEDFSWYLE--EVPGAMARLGVWSGDGLQ---------LDLHQPT
TH_1760|M.thermoresistible__bu RQSGGGEDFSWYLE--EVPGAMARLGVWSGQGPQ---------LDLHQPT
MLBr_01059|M.leprae_Br4923 RAKYGWTDVSRFAA-LGVPAVNYGPGDPN-----------------LAHR
* *.. .* *
Mflv_1971|M.gilvum_PYR-GCK SPRFAPVIQPTLDTATQALITAALAWLTPA---
Mvan_4743|M.vanbaalenii_PYR-1 SPRFAPVIQPTLDTATQALVAAAMTWLAPT---
MAV_3492|M.avium_104 SGRFAPVIQPTLDTGTEALTVAALAWLAPSAS-
MAB_4738c|M.abscessus_ATCC_199 SPEFAPVLEPTLSTGIEALTVAALSRLTARA--
MSMEG_3989|M.smegmatis_MC2_155 VLPDGAALYAELAHRRLNVNSGATSGATTQKGR
MMAR_1221|M.marinum_M FDLDERALGIGVRVMVNIIEQAAAF--------
MUL_2671|M.ulcerans_Agy99 FDLDERALGIGLRVMVNIIEQAAAF--------
Mb3333c|M.bovis_AF2122/97 FDIDERALAIGLRVMVNIIEQAAAH--------
Rv3305c|M.tuberculosis_H37Rv FDIDERALAIGLRVMVNIIEQAAAH--------
TH_1760|M.thermoresistible__bu FDLDERALPVGVRVFVNLVEQCAA---------
MLBr_01059|M.leprae_Br4923 HDERVPVVQITAAVDMLRRYLGG----------
.: .