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KSEASRKHPYRSELRAQQAEATRQLVLDTATELFVERGYAATSIDLIAQTAGVGRSTVFCAAGSKPWLLK TAYDRAVVGDDEQVPMVQRPQVRRLFEMTDPTQIVEAYVEILGDAAQRVSRIYEVVRSAAGLDPEVHQLW TEIDGQRLEGADTVAALLKKKGGLKKGLTLAAARDLVWLYNDPGMHYALVEVRGWSQRRYRAWLLDTFNH QLLGK*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3976 | - | - | 100% (216) | DNA-binding protein |
| M. smegmatis MC2 155 | MSMEG_1745 | - | 2e-19 | 28.44% (211) | transcriptional regulator |
| M. smegmatis MC2 155 | MSMEG_5424 | - | 2e-07 | 30.86% (162) | transcriptional regulator, TetR family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0310 | - | 4e-06 | 31.52% (92) | TetR/ACRR family transcriptional regulator |
| M. gilvum PYR-GCK | Mflv_1947 | - | 7e-07 | 28.50% (193) | TetR family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0302 | - | 4e-06 | 31.52% (92) | TetR/ACRR family transcriptional regulator |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_1149 | - | 4e-08 | 32.24% (152) | TetR family transcriptional regulator |
| M. marinum M | MMAR_1268 | - | 1e-13 | 27.10% (214) | putative regulatory protein |
| M. avium 104 | MAV_1159 | - | 9e-07 | 29.30% (157) | transcriptional regulator, TetR family protein |
| M. thermoresistible (build 8) | TH_0912 | - | 7e-07 | 30.07% (143) | transcriptional regulator, TetR family protein |
| M. ulcerans Agy99 | MUL_2620 | - | 3e-09 | 27.32% (205) | hypothetical protein MUL_2620 |
| M. vanbaalenii PYR-1 | Mvan_4778 | - | 6e-07 | 27.88% (208) | TetR family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1947|M.gilvum_PYR-GCK ----------------------MTGSERRQQLIEIAKSLFAERGFDGTSI
Mvan_4778|M.vanbaalenii_PYR-1 --MAVSDKRGGPDTHVRAPRARMTGTERRQQLVEIAKSLFAERGFDGTSI
TH_0912|M.thermoresistible__bu ----------------------MTGSERRQQLIEIAKSLFAERGYEGTSI
MAV_1159|M.avium_104 MAVLDSQTHKDPDKEVRAPRARMTGSERRQQLIGIARSLFAERGYEGTSI
MAB_1149|M.abscessus_ATCC_1997 -----MAVPSRPDVPGRTPRVRMAGSERRRQLIDVARSLFAERGYEATSI
Mb0310|M.bovis_AF2122/97 -------------MGVPAKKKQQQGERSRESILDATERLMATKGYAATSI
Rv0302|M.tuberculosis_H37Rv -------------MGVPAKKKQQQGERSRESILDATERLMATKGYAATSI
MMAR_1268|M.marinum_M -MLTSMERKRQRNTTRVREAGAASRAQTRHLLLTAAAEEFARVGYVASTV
MUL_2620|M.ulcerans_Agy99 -----MERKRQRNTTRVREAGAASRAQTRHLLLTAAAEEFARVGYVASTV
MSMEG_3976|M.smegmatis_MC2_155 -----MKSEASRKHPYRSELRAQQAEATRQLVLDTATELFVERGYAATSI
*. :: : :. *: .:::
Mflv_1947|M.gilvum_PYR-GCK EEIALRANVSKPVVYEHFGGKEGLYAVVVDREMSALLDGITSSLADN-RS
Mvan_4778|M.vanbaalenii_PYR-1 EEIALRANVSKPVVYEHFGGKEGLYAVVVDREMSALLDGITSSLADN-RS
TH_0912|M.thermoresistible__bu EEIALRANVSKPVVYEHFGGKEGLYAVVVDREMSALLDGITSSLTNN-RS
MAV_1159|M.avium_104 EEIALRANVSKPVVYEHFGGKEGLYAVVVDREMSALLDGITSSLTNN-RS
MAB_1149|M.abscessus_ATCC_1997 EEIAQRAGVSKPVVYEHFGGKEGLYAVVVDREMSVLLDGITSSLTSY-RS
Mb0310|M.bovis_AF2122/97 SDIRDACGLAPSSIYWHFGSKEGVLAAMMERGAQRFFAAIPTWDEAHGPV
Rv0302|M.tuberculosis_H37Rv SDIRDACGLAPSSIYWHFGSKEGVLAAMMERGAQRFFAAIPTWDEAHGPV
MMAR_1268|M.marinum_M SRIAEGAGVTVQTLYLAWGSKRALLRGYLESTLAPDAAPSGQHFAAQLQP
MUL_2620|M.ulcerans_Agy99 SRIAEGAGVTVQTLYLAWGSKRALLRGYLESTLAPDAAPSGQHFAAQLQP
MSMEG_3976|M.smegmatis_MC2_155 DLIAQTAGVGRSTVFCAAGSKPWLLKTAYDRAVVGDDEQVPMVQRPQVRR
. * ..: :: *.* : :
Mflv_1947|M.gilvum_PYR-GCK RVRV---ERVALALLTYVEERTDGFRIL----IRDSPASITQGTYSTLLN
Mvan_4778|M.vanbaalenii_PYR-1 RVRV---ERVALALLTYVEEHTDGFRIL----IRDSPASITSGTYSTLLN
TH_0912|M.thermoresistible__bu RVRV---ERVALALLTYVEERTDGFRIL----IRDSPAAITSGTYSTLLN
MAV_1159|M.avium_104 RVRV---ERVALALLTYVEERTDGFRIM----IRDSPAAISSGTYSSLLN
MAB_1149|M.abscessus_ATCC_1997 RVRL---EQVALALLSYIEERTDGFRIL----IRDSPPGVSSGTYSSLLN
Mb0310|M.bovis_AF2122/97 EQRS---ERQLTELVSLQSQHPDFLRLFYLLSMERSQDPVVAAVVRRVRN
Rv0302|M.tuberculosis_H37Rv EQRS---ERQLTELVSLQSQHPDFLRLFYLLSMERSQDPAVAAVVRRVRN
MMAR_1268|M.marinum_M DSPAGTLAQVSALVCDAARRSAIAWRAYRDGSGVDSAIAAEWHQVQMLRR
MUL_2620|M.ulcerans_Agy99 DSPAGTLAQVSALVCDAARRSAIAWRAYRDGSGVDSAIAAEWHQIQMLRR
MSMEG_3976|M.smegmatis_MC2_155 LFEMTDPTQIVEAYVEILGDAAQRVSRIY---EVVRSAAGLDPEVHQLWT
: . :
Mflv_1947|M.gilvum_PYR-GCK DAVSQVESILAGDFSRRGLDPDLAPLYAQALVG-SVSMA--AQWWLDVRE
Mvan_4778|M.vanbaalenii_PYR-1 DAVSQVASILAGDFSRRGLDPDLAPLYAQALVG-SVSMA--AQWWLDVRE
TH_0912|M.thermoresistible__bu DAVNQVSSILAGDFSRRGLDPEMAPLYAQALVG-SVSMT--AQWWLDVRE
MAV_1159|M.avium_104 DAVSQVSSILAGDFARRGLDPDLAPLYAQALVG-SVSMT--AQWWLDTRE
MAB_1149|M.abscessus_ATCC_1997 DAVSQVSSILAGDFQRRGLDAEMAPLYAQALVG-QVSMT--AQWWLDARE
Mb0310|M.bovis_AF2122/97 TAIARFRDSIT-HLLPSDIPPGKADLVVAELTAFAVALS--DGVYFAGHL
Rv0302|M.tuberculosis_H37Rv TAIARFRDSIT-HLLPSDIPPGKADLVVAELTAFAVALS--DGVYFAGHL
MMAR_1268|M.marinum_M ETMRALLVTIPDDALRLPRQDAVDTAWAITSPASH--------EIMVTHG
MUL_2620|M.ulcerans_Agy99 ETMRALLVTIPDDALRLPRQDAVDTAWAITSPASQPASQPATRSWLPTAG
MSMEG_3976|M.smegmatis_MC2_155 EIDGQRLEGADTVAALLKKKGGLKKGLTLAAARDLVWLYNDPGMHYALVE
.
Mflv_1947|M.gilvum_PYR-GCK PKKEVVAAHLVNLCWNGLTHLESDPVLHEE--------------------
Mvan_4778|M.vanbaalenii_PYR-1 PKKEVVAAHLVNLCWNGLTHLESDPVLHEE--------------------
TH_0912|M.thermoresistible__bu PKKEVVAAHLVNLCWNGLTHLEPDPVLHEE--------------------
MAV_1159|M.avium_104 PKKEVVAAHLVNLMWNGLTHLEADPRLQDE--------------------
MAB_1149|M.abscessus_ATCC_1997 PKKEVVAAHIVNLCWHGLKHLEADPQLHEE--------------------
Mb0310|M.bovis_AF2122/97 EPDTTDVERMYRRLRQALEALIP--VLLEET-------------------
Rv0302|M.tuberculosis_H37Rv EPDTTDVERMYRRLRQALEALIP--VLLEET-------------------
MMAR_1268|M.marinum_M G--FTLQRFEAWLTTTLQNAILR---DPEGSG------------------
MUL_2620|M.ulcerans_Agy99 SPCSALKPGSPPPCKTPSCAIRRAAGEPRRAAPPRRLVNRAEQRPILMSH
MSMEG_3976|M.smegmatis_MC2_155 VRGWSQRRYRAWLLDTFNHQLLGK--------------------------
:
Mflv_1947|M.gilvum_PYR-GCK ---
Mvan_4778|M.vanbaalenii_PYR-1 ---
TH_0912|M.thermoresistible__bu ---
MAV_1159|M.avium_104 ---
MAB_1149|M.abscessus_ATCC_1997 ---
Mb0310|M.bovis_AF2122/97 ---
Rv0302|M.tuberculosis_H37Rv ---
MMAR_1268|M.marinum_M ---
MUL_2620|M.ulcerans_Agy99 LTA
MSMEG_3976|M.smegmatis_MC2_155 ---