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LSALDVAFLEAEDADRNVSLVIGVLAILEGSPPTDHVLLGSVYNRLMSIPRFTQIVERQPLDLAAPQWVE AHDFSVAHHVRRTAVPQPGDDTALFGVVADIMERRLDRSRPLWECWIIEGLPSDRWAILMKIHHCIADGI AAAQLLSYLSDEGTVDSFSSDIDGAKPTAPQKNRRFELTLNPVRLIRSAVDATASVGSEVIRVAEGALQI ASGLLDSHPLPLRGPVTDLRRYASTQVSLADVGRICHAYDVTINDVALAAITDSFRAAMIRRGERPGARS LRTLVPVSVRSNDAAAQVDNRVSLMLPCLPVDIHDPVEQLLTVHRRMENAKRTGQRQAGSVFVSAVNSLP FGITTLLVRAAVRMPQQSVVTLATNVPGPRQHLKLLGHRVVRVVPIPPIALGLRTGVAILSYADDLVFGI TADFDAIPDVEVLADDIQRAVARLARTAELPTRRAPDGTLTVVTTPR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3948 | - | - | 100% (467) | acyltransferase, ws/dgat/mgat subfamily protein |
| M. smegmatis MC2 155 | MSMEG_5242 | - | e-129 | 51.91% (472) | acyltransferase, ws/dgat/mgat subfamily protein |
| M. smegmatis MC2 155 | MSMEG_1882 | - | 3e-45 | 28.78% (469) | acyltransferase, ws/dgat/mgat subfamily protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3154c | - | 1e-127 | 50.54% (463) | hypothetical protein Mb3154c |
| M. gilvum PYR-GCK | Mflv_4977 | - | 1e-141 | 55.80% (448) | hypothetical protein Mflv_4977 |
| M. tuberculosis H37Rv | Rv3130c | tgs1 | 1e-127 | 50.54% (463) | triacylglycerol synthase |
| M. leprae Br4923 | MLBr_01244 | - | 2e-23 | 25.46% (432) | hypothetical protein MLBr_01244 |
| M. abscessus ATCC 19977 | MAB_3551c | - | 7e-51 | 31.29% (473) | hypothetical protein MAB_3551c |
| M. marinum M | MMAR_3406 | - | 1e-124 | 51.67% (449) | hypothetical protein MMAR_3406 |
| M. avium 104 | MAV_4336 | - | 2e-82 | 40.86% (443) | acyltransferase, ws/dgat/mgat subfamily protein |
| M. thermoresistible (build 8) | TH_2686 | - | 5e-50 | 30.49% (469) | PUTATIVE Diacylglycerol O-acyltransferase |
| M. ulcerans Agy99 | MUL_2420 | - | 1e-122 | 48.16% (463) | hypothetical protein MUL_2420 |
| M. vanbaalenii PYR-1 | Mvan_4104 | - | 1e-125 | 49.89% (459) | hypothetical protein Mvan_4104 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3154c|M.bovis_AF2122/97 --------MNHLTTLDAG-----FLKAEDVDRHVSLAIGALAVIEGPAP-
Rv3130c|M.tuberculosis_H37Rv --------MNHLTTLDAG-----FLKAEDVDRHVSLAIGALAVIEGPAP-
MUL_2420|M.ulcerans_Agy99 --------MNHLTTLDSG-----FLKAEDVDPRVSLAIGGLAVIEGPVP-
MSMEG_3948|M.smegmatis_MC2_155 -----------MSALDVA-----FLEAEDADRNVSLVIGVLAILEGSPP-
Mflv_4977|M.gilvum_PYR-GCK --------MERMTAFDAG-----FLDAEDADRHVSLAVGAVSVVDGPMP-
MMAR_3406|M.marinum_M --------MEHLTPLDAT-----FLEVEDSDPHVSLAIGGVSIVEGPAP-
Mvan_4104|M.vanbaalenii_PYR-1 --------MEHLSTLDAS-----FLQAEDSDPHVSLAVGAVSIIEGPAP-
MAV_4336|M.avium_104 ----------MAQTLDTA-----FLKAHDPDQHASLAIGAVAIVDGTVP-
MAB_3551c|M.abscessus_ATCC_199 MGKAARIVVSRLSALDAS-----FYSSEDS--ATPMHVGSLAIIRRPRGG
TH_2686|M.thermoresistible__bu -------MVTRLSASDAD-----FFHLEDT--STPMYVGSLAILRRPRGG
MLBr_01244|M.leprae_Br4923 ----MADSVEGIGPFDELGALDYLLHRGEANPRTRAGIMAVELLDTTPD-
. * : : . : : :: .
Mb3154c|M.bovis_AF2122/97 -DQEAFLSSLAQRLRPCTRFGQRLRLRPFDLGAPKWVDDPDFDLGRHVWR
Rv3130c|M.tuberculosis_H37Rv -DQEAFLSSLAQRLRPCTRFGQRLRLRPFDLGAPKWVDDPDFDLGRHVWR
MUL_2420|M.ulcerans_Agy99 -EQHDLVSVFSERIRACPRFAQRLRRYPFDLGAPQWVDDPDFDIARHVRR
MSMEG_3948|M.smegmatis_MC2_155 -TDHVLLGSVYNRLMSIPRFTQIVERQPLDLAAPQWVEAHDFSVAHHVRR
Mflv_4977|M.gilvum_PYR-GCK -DFDEIVAAIGEKIVTIPRLRQVVRRQPLDLSAPEWVEDPTLDLAHHIRR
MMAR_3406|M.marinum_M -AFGEFVDSFAERASAIPRFKQILRTHPLDLGSPEWVADPHFDVSRHVHH
Mvan_4104|M.vanbaalenii_PYR-1 -DYDDLVAAFAERAQGIPRCTQIVHTRPFDLAAPEWVDDPHFDIAHHLHR
MAV_4336|M.avium_104 -DPAQLEHLVAERILPIARCTQLLRAHPLNR---EWVDCPDFDLAWHLRR
MAB_3551c|M.abscessus_ATCC_199 FTYEELLALVESRLPQVPRYRQKVKEIGFGLARPVWLDDVDFDITYHIRR
TH_2686|M.thermoresistible__bu LSYETLLATVEQRLPQIPRYRQKVRKAPIGLARPVWVDDPDFDITYHVRR
MLBr_01244|M.leprae_Br4923 --WNRFRSRIEDVSQRVLRLRQKVVVPTLPTAAPRWVVDPDFELDFHVRR
: . . * * : : *: :.: *: :
Mb3154c|M.bovis_AF2122/97 IALPRPGNEDQLFELIADLMARRLDRGRPLWEVWVIEGLADSKWAILTKL
Rv3130c|M.tuberculosis_H37Rv IALPRPGNEDQLFELIADLMARRLDRGRPLWEVWVIEGLADSKWAILTKL
MUL_2420|M.ulcerans_Agy99 VALPHPGDDDALYRLVADVMGRRLDRDRPLWELWVIEGLAGERWAMLTKV
MSMEG_3948|M.smegmatis_MC2_155 TAVPQPGDDTALFGVVADIMERRLDRSRPLWECWIIEGLPSDRWAILMKI
Mflv_4977|M.gilvum_PYR-GCK AALPHPGDDDALFRFTAEAMEPRLDRERPLWQAWIIEGLADDRWAILMKV
MMAR_3406|M.marinum_M LALPQPGGDAELFEMIATVMERRLDRDRPLWECYLIEGLSDDRWAVLTKL
Mvan_4104|M.vanbaalenii_PYR-1 IALPAPGDDAEMFTTIAGIMERRLDRDRPLWECWIIEGLADGRWATLMKI
MAV_4336|M.avium_104 VAIAGTGDEAELSRVIGQALRRPLDPGRPPWECWVIEGLRGNRWAMLMKT
MAB_3551c|M.abscessus_ATCC_199 SALPSPGSDGQLQDLVARLTSRPLDRSRPLWEMYLVEGLSKNRLAIYTKT
TH_2686|M.thermoresistible__bu SALPSPGSDAQLHELIARLASRPLDKTRPLWEMYLIEGLAKNRLALYTKS
MLBr_01244|M.leprae_Br4923 VRVPDPGTLREVFDLAEVIQQSPMDVSRPLWTATLVEGLAAGRAAMLLQI
:. .* : :* ** * ::*** : * :
Mb3154c|M.bovis_AF2122/97 HHCMADGIAATHLLAGLSDES--MSDSFASNIHTTMQSQSASVRRGGFRV
Rv3130c|M.tuberculosis_H37Rv HHCMADGIAATHLLAGLSDES--MSDSFASNIHTTMQSQSASVRRGGFRV
MUL_2420|M.ulcerans_Agy99 HHCMADGIAATHILTGLCDRDGGGAADGSARCRAAQRPKTAAARP---RS
MSMEG_3948|M.smegmatis_MC2_155 HHCIADGIAAAQLLSYLSDE--GTVDSFSSDIDGAKPTAPQKNRR--FEL
Mflv_4977|M.gilvum_PYR-GCK HHCIADGIAAMHMLAGLSDD--GEGETYAGAIRAAHEAGASRPAL--PSP
MMAR_3406|M.marinum_M HHCIADGIATTQMLAKFGDES-GGGGSFATEIRAAKEPAPHGPGLP-VKV
Mvan_4104|M.vanbaalenii_PYR-1 HHCIADGIATAQMLAKLSDD--GAGETFAADIRAAQESGPSILGL--LRP
MAV_4336|M.avium_104 HHGLLDGNPAARLITRLCDDA--DADMFANNAAAQPVSSP----------
MAB_3551c|M.abscessus_ATCC_199 HQALVDGNSALSLGQVIFDRTARTPDFGEDIWVPEHEPSTSELVAGAVSE
TH_2686|M.thermoresistible__bu HQALVNGMTAPEIGHVIADRTQKPPQFGEDIWMPGREPGTAQLLIGAIGD
MLBr_01244|M.leprae_Br4923 SHAITDGVGSVEMFAEMYDLERDPPSRPRSPQPIPQDLSRNDLMLQGINH
: : :* : : : *
Mb3154c|M.bovis_AF2122/97 NPS------EALTASTAVMAGIVRAAKGASE-----IAAGVLSP-AASSL
Rv3130c|M.tuberculosis_H37Rv NPS------EALTASTAVMAGIVRAAKGASE-----IAAGVLSP-AASSL
MUL_2420|M.ulcerans_Agy99 GLS------GLWNAPAAIASGVVRLAQGSGE-----LVTGLLTP-VASAL
MSMEG_3948|M.smegmatis_MC2_155 TLNPVRLIRSAVDATASVGSEVIRVAEGALQ-----IASGLLDS-HPLPL
Mflv_4977|M.gilvum_PYR-GCK TLNPVRWARAGWNATTAVAATAAMTVEGAIG-----ILSGLVRN-AESSL
MMAR_3406|M.marinum_M SLNPLNWVTGIVRGALGAVSVVEHVALGAAE-----LTGSLLSPAPETSL
Mvan_4104|M.vanbaalenii_PYR-1 RLNPLDWMNGAWRATLAAAGAAEHAVVGAAE-----LTARVLTPGQESSL
MAV_4336|M.avium_104 ---------TGWLDALSRVSSLTGGLLGALR-----LAG----------R
MAB_3551c|M.abscessus_ATCC_199 WLARPGARLEAVRNTVADVASLTGEIGELGERMVKVVRTAARGAAPRGPL
TH_2686|M.thermoresistible__bu WLTRPGAQMIAVRDNVLGMATNAGELVDAGRRALSVARTVARGTAPSSPL
MLBr_01244|M.leprae_Br4923 LPVALAGGVVGGLSGVASVAGRAILRPASTVSGVVGYVRSGIRVLSQAAE
.
Mb3154c|M.bovis_AF2122/97 NGPISDLR----RYSAAKVPLADVEQVCRKFDVTINDVALAAITESYRNV
Rv3130c|M.tuberculosis_H37Rv NGPISDLR----RYSAAKVPLADVEQVCRKFDVTINDVALAAITESYRNV
MUL_2420|M.ulcerans_Agy99 TGPLSDLR----RFSGARVPMADLELVCETFDVTINDVALAAITESYRNV
MSMEG_3948|M.smegmatis_MC2_155 RGPVTDLR----RYASTQVSLADVGRICHAYDVTINDVALAAITDSFRAA
Mflv_4977|M.gilvum_PYR-GCK NGPVTTMR----RYSAVQVPLATVASVCQAFDVTLNDVALAAITDSFRSA
MMAR_3406|M.marinum_M SGPVTTLR----RFSVARVRLSDLHTVARAFDVTLNDVALAAITSSYRSI
Mvan_4104|M.vanbaalenii_PYR-1 NGPVTGMR----RYSAAVVDLAVMKQVSRNFDVTLNDVALAAITNGYRHM
MAV_4336|M.avium_104 AEAVAPVR----RYATVRVPIADVDRVCRKFGVSANDVALAAVTEGFRTV
MAB_3551c|M.abscessus_ATCC_199 NQRVSRSR----RFGVVSTKLADYRRVRAKYDCDVNDVVLATIAGALRNW
TH_2686|M.thermoresistible__bu NTRVSRNR----RFTVARHRLDDYRKVRARYDCDVNDVVLAVIAGALRNW
MLBr_01244|M.leprae_Br4923 PSPLLRQRSLATRTEAIEIQLSDLHKAAKAGDGSINDAYLAGLVGALRRY
: * * : . **. ** :. . *
Mb3154c|M.bovis_AF2122/97 LIQRGE-RPRFDSLRTLVPVSTRSNSALSKTD-----NRVSLMLPNLPVD
Rv3130c|M.tuberculosis_H37Rv LIQRGE-RPRFDSLRTLVPVSTRSNSALSKTD-----NRVSLMLPNLPVD
MUL_2420|M.ulcerans_Agy99 LLARGQ-QPQQGSLRTLVPVSVRADNAFDKTD-----NRVSAMLPNLPVD
MSMEG_3948|M.smegmatis_MC2_155 MIRRGE-RPGARSLRTLVPVSVRSNDAAAQVD-----NRVSLMLPCLPVD
Mflv_4977|M.gilvum_PYR-GCK LKRRGE-EPRRDSLRTLVPVSVRSDDARDRLD-----NRVSVMLPHLPVD
MMAR_3406|M.marinum_M LLERGE-KPGHTSLRTLVPVSVRGMSHFNMTD-----NQVSAMLPLLPVD
Mvan_4104|M.vanbaalenii_PYR-1 LLDRGE-SPGPHALRTLVPVSMRSAGDFDVTD-----NRVSAMLPLLPVD
MAV_4336|M.avium_104 LLDRGE-QPRADSLRTLVPLPVR-----------------SAVLSHLPVE
MAB_3551c|M.abscessus_ATCC_199 LMSRGEPVTTASTIRAMVPMSVYRDGDLDVGGEGAATTEVSPFLVDLPVG
TH_2686|M.thermoresistible__bu LLSRGEQVSSTATVRAMAPLSVQSDAELDSTAPGQAVSDVVPFLIDLPVG
MLBr_01244|M.leprae_Br4923 HEALGV---SISTLPMAVPVNVRTEADVVGSN------RFVGVTLAAPLG
* :: .*: . *:
Mb3154c|M.bovis_AF2122/97 QENPLQRLRIVHSRLTRAKAGGQRQFGNTLMAIANRLPFPMTAWAVGLLM
Rv3130c|M.tuberculosis_H37Rv QENPLQRLRIVHSRLTRAKAGGQRQFGNTLMAIANRLPFPMTAWAVGLLM
MUL_2420|M.ulcerans_Agy99 EEDPVQRLRKVHARLGQTKASGQPRAGNLFLSLADRIPFALTAWTVGVLM
MSMEG_3948|M.smegmatis_MC2_155 IHDPVEQLLTVHRRMENAKRTGQRQAGSVFVSAVNSLPFGITTLLVRAAV
Mflv_4977|M.gilvum_PYR-GCK EPDPVEQLRTVHRRLNRAKSSGQRQAGTAAVAAVKLIPFALATRAIRAVT
MMAR_3406|M.marinum_M EEDPVKQLELVHRRLVEAKASGQREGGTALVAAAKSAPFAFSAWAVRLLS
Mvan_4104|M.vanbaalenii_PYR-1 EPDPVRQLEIVHRRLSRAKGSGQREGGDAVLAAAGNIPFALSAWTIRLLT
MAV_4336|M.avium_104 HDDPVRRLQTVHARCN--PAAGTQPAG-IVESAIGLVPNMVRGNLIQLLS
MAB_3551c|M.abscessus_ATCC_199 EGNTVVRLSQIAHATESHSAAFSLVDVPNMAALSGFVPPTLHALAARVAS
TH_2686|M.thermoresistible__bu ERNPVVRLSQISHATETHPTASSLVDARTIVTLTGFAPATLHAMGVRVAT
MLBr_01244|M.leprae_Br4923 TNDPAARMQKIRSQMTQRRDEPAMNIIGSLAPLMTVLPASVLDFIVDSVA
:. :: : . * .
Mb3154c|M.bovis_AF2122/97 RLPQRGVVTVATNVPGPRRPLQIMGRRVLDLYPVSPIAMQLRTSVAMLSY
Rv3130c|M.tuberculosis_H37Rv RLPQRGVVTVATNVPGPRRPLQIMGRRVLDLYPVSPIAMQLRTSVAMLSY
MUL_2420|M.ulcerans_Agy99 RLPQRGVATVATNVPGPRQPLQIMGRPVAAVFPVPPLAMHLRTGVAMLSY
MSMEG_3948|M.smegmatis_MC2_155 RMPQQSVVTLATNVPGPRQHLKLLGHRVVRVVPIPPIALGLRTGVAILSY
Mflv_4977|M.gilvum_PYR-GCK SLPQHGVVTLATNVPGPQHRLQVMGREVVRMFPVPPMALRLRTAVAILSY
MMAR_3406|M.marinum_M RLPQRAVVALATNVPGPRAEQKLMGRRVLEMLPIPPIALNLRTGVAMVSY
Mvan_4104|M.vanbaalenii_PYR-1 RLPQRSVTALATNVPGPRGRQRVLGRKVVEILPIPPIALHLRTGIAMLSY
MAV_4336|M.avium_104 RLPQRAVVTLATNVPGPRRRLRVMGQTLERLLPVPPTATQLHTGVAVLSY
MAB_3551c|M.abscessus_ATCC_199 TLPNRLFNLLVTNVPGPQAPMYLGGARLAEIYPVPPLLRNQVLSIGLTSY
TH_2686|M.thermoresistible__bu NFSARQFNLLITNVPGAQKQMYIAGTKMLESYSVPPLLRNQVLAVAVTSY
MLBr_01244|M.leprae_Br4923 SSDVN-----ASNIPAYPGDTYFAGAKILRQYGIGPRPG-VAMMAVLMSR
. :*:*. . * : : * : *
Mb3154c|M.bovis_AF2122/97 ADDLYFGILADYDVVADAGQLARGIEDAVARLVAI--------SKRRKVT
Rv3130c|M.tuberculosis_H37Rv ADDLYFGILADYDVVADAGQLARGIEDAVARLVAI--------SKRRKVT
MUL_2420|M.ulcerans_Agy99 SDDLYFGILTDYNPVADVDQLARGTEAAVARLVAI--------SKRRKAR
MSMEG_3948|M.smegmatis_MC2_155 ADDLVFGITADFDAIPDVEVLADDIQRAVARLART--------AELPTRR
Mflv_4977|M.gilvum_PYR-GCK GDDLVFGITTDFDAFPDVDELAAGIGAAVDTLAAA--------ARPL---
MMAR_3406|M.marinum_M GDNFVFGITADYDTAPDIEVLAAGIEDGVARLVKE--------SRGKRGS
Mvan_4104|M.vanbaalenii_PYR-1 AGRFSFGITADYDSAPDVDALARGIGEGVRCLAEL--------GRAERRT
MAV_4336|M.avium_104 GDELVFGITAGPGDGFDVTRLAAAVELGMARLAALGDDSVLLFADRRRRR
MAB_3551c|M.abscessus_ATCC_199 NGTVYYGINADREAMPDADMLPLLITEALDELLEAAQ-------------
TH_2686|M.thermoresistible__bu HGMLYYGVNADRDAMSDVEVLPSLLSESLDELLEAAQ-------------
MLBr_01244|M.leprae_Br4923 GGFCTVTVRYDRASVKSEALFARCLLEGFDEVLALAGDPTPHAVPASFAA
. : . . :. .. :
Mb3154c|M.bovis_AF2122/97 RRRGALSLVV------------
Rv3130c|M.tuberculosis_H37Rv RRRGALSLVV------------
MUL_2420|M.ulcerans_Agy99 RGRGPLSLVV------------
MSMEG_3948|M.smegmatis_MC2_155 APDGTLTVVTTPR---------
Mflv_4977|M.gilvum_PYR-GCK ----------------------
MMAR_3406|M.marinum_M ---AAG----------------
Mvan_4104|M.vanbaalenii_PYR-1 PPDGAGRPIADAP---------
MAV_4336|M.avium_104 AARSPLGRVPPAHPSAPGHARH
MAB_3551c|M.abscessus_ATCC_199 ----------------------
TH_2686|M.thermoresistible__bu ----------------------
MLBr_01244|M.leprae_Br4923 RSSGSPAGWLSSS---------