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VNVSVQGHCDARFDKVAEALGKAIENGQEVGAAIAVDIDGELVVDIWGGYADAARTRPWRADTIVNVWSS TKTVTALAGLMLIDRGLLKPTTPVAKVWPEFAANGKESVEFRHLLTHSSGLSGWDRIDSIEDLYDWESST ARLAAQAPWWEPGSASGYHAMTFGHLVGEVVRRVTGRTLKQFVADEIAAPLNADFQIGARLQDAERIAEV VPADNPMEGLPPAETWTEQMVKTFGGFFPDPAAANTDAWRAADFGAVNGHTTARALARILSSITLGGAVG GVRLLRPETVEKVFEVQIEGPDLVMARHPVKWGLGFGLPEPTTLPYIPEGKICHWGGWGGSWETMNPDKR ATVAYVMNKMGSGLLGSDRTERYLSLIYDALR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3914 | - | - | 100% (382) | beta-lactamase |
| M. smegmatis MC2 155 | MSMEG_4680 | lipP | 2e-61 | 37.31% (394) | carboxylesterase, putative |
| M. smegmatis MC2 155 | MSMEG_3162 | - | 9e-38 | 32.01% (378) | beta-lactamase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb2490 | lipP | 2e-58 | 37.40% (393) | esterase/lipase LipP |
| M. gilvum PYR-GCK | Mflv_3647 | - | 1e-38 | 33.07% (375) | beta-lactamase |
| M. tuberculosis H37Rv | Rv2463 | lipP | 2e-58 | 37.40% (393) | esterase/lipase LipP |
| M. leprae Br4923 | MLBr_00119 | lipE | 1e-21 | 27.19% (320) | putative hydrolase |
| M. abscessus ATCC 19977 | MAB_0853 | - | 3e-58 | 34.98% (406) | esterase/lipase LipP |
| M. marinum M | MMAR_3810 | lipP | 6e-59 | 37.12% (396) | esterase/lipase LipP |
| M. avium 104 | MAV_1709 | lipP | 1e-59 | 37.40% (385) | carboxylesterase, putative |
| M. thermoresistible (build 8) | TH_0350 | lipP | 2e-58 | 36.23% (403) | PROBABLE ESTERASE/LIPASE LIPP |
| M. ulcerans Agy99 | MUL_3735 | lipP | 7e-55 | 37.94% (369) | esterase/lipase LipP |
| M. vanbaalenii PYR-1 | Mvan_5383 | - | 1e-124 | 57.29% (384) | beta-lactamase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_3914|M.smegmatis_MC2_155 -------------------MNVS-VQGHCDARFDKVAEALGKAIENGQEV
Mvan_5383|M.vanbaalenii_PYR-1 -----------------MWSDMSDVAGLCDPRFESVAAALADEIACGEEL
Mb2490|M.bovis_AF2122/97 -------------------MNQPDIKGSCASEFTKVRDAFERNFVLRNEV
Rv2463|M.tuberculosis_H37Rv -------------------MNQPDIKGSCASEFTKVRDAFERNFVLRNEV
MMAR_3810|M.marinum_M -------------------MSDVDIYGSCARKFQRVRAAFERNFAQGMEV
MUL_3735|M.ulcerans_Agy99 -----------------------------------------------MEV
MAV_1709|M.avium_104 ---------------MSDLKTDAPIHGSCAPDFVGVRDAFERNFTHGGEV
TH_0350|M.thermoresistible__bu -----------MSETFQPVRSIPAVHGTCAPGFEGVRTAFVDNFTERGEI
MAB_0853|M.abscessus_ATCC_1997 ----------------MSTSLDVAVNGTNSPDFDNVRRAFALNFLENDEL
Mflv_3647|M.gilvum_PYR-GCK MTGVNSRERDEALSHGHGGHLPRGVQGAADPNFTCAVRAFAQMFPHRRFG
MLBr_00119|M.leprae_Br4923 -MTSDGKIRVPTDLDAVTAIGDEDHSDIDSAAVERIWQATRHWYQAGMHP
MSMEG_3914|M.smegmatis_MC2_155 GAAIAVDIDGELVVD--IWGGYADA------ARTRPWRADTIVNVWSSTK
Mvan_5383|M.vanbaalenii_PYR-1 GASIAVDLDGELVVD--IWAGYVDR------AKTIPWQRDTIVNFWSCTK
Mb2490|M.bovis_AF2122/97 GAAVAVWVDGDLVVN--LWGGSADA------GGTRPWQHDTLATVLSGTK
Rv2463|M.tuberculosis_H37Rv GAAVAVWVDGDLVVN--LWGGSADA------GGTRPWQHDTLATVLSGTK
MMAR_3810|M.marinum_M GAAVAVWVDGDLVVN--LWGGSADA------AGTRPWRQDTLTTVLSGSK
MUL_3735|M.ulcerans_Agy99 GAAVAVWVDGDLVVN--LWGGSADA------AGTRPWRQDTLTTVLSGSK
MAV_1709|M.avium_104 GAAVAVWVDGSLVVN--LWGGWADA------ARTRPWQQNTLTTVLSGTK
TH_0350|M.thermoresistible__bu GAAVAVWVDGELVVD--LWGGSADA------EGRLSWRRDTLASVFSGSK
MAB_0853|M.abscessus_ATCC_1997 GAAVAIWVDGELVVN--LWAGWADE------ARTRPWTEDTLAPVYSGTK
Mflv_3647|M.gilvum_PYR-GCK GGALAVYLNGEPVVD--VWTGWADR------RGKRRWTADTAPMVFSATK
MLBr_00119|M.leprae_Br4923 AIQLCIRQHGRVVLNRAIGHGWGNAPTDPHDAEKIPVTTDTPFCAYSAAK
. :.: .* *:: : * : :* * :*
MSMEG_3914|M.smegmatis_MC2_155 TVTALAGLMLIDRGLLKPTTPVAKVWPEFAANGKESVEFRHLLTHSSGLS
Mvan_5383|M.vanbaalenii_PYR-1 TLTALAALILVDRGELDPFSTVARYWPEFAANGKADIEVRHLLSHTSGVS
Mb2490|M.bovis_AF2122/97 ALTATCVHQLVDRGELDLHAPVARYWPEFGQAGKQAITLAMVMSHRSGAI
Rv2463|M.tuberculosis_H37Rv ALTATCVHQLVDRGELDLHAPVARYWPEFGQAGKQAITLAMVMSHRSGAI
MMAR_3810|M.marinum_M ALTATCVHQLADRGELDLHAPVARYWPEFGQAGKEAITVAMVLSHRSGVI
MUL_3735|M.ulcerans_Agy99 ALTATCVHQLADRGELNLHAPVARYWPEFRQAGKEAITVAMVLSHRSGVI
MAV_1709|M.avium_104 GLSATCVHQLADRGQLDLQAPVARYWPEFAQAGKQDITLAMVMSHRSGVI
TH_0350|M.thermoresistible__bu GLTATCVHLLADRGEIDLDAPIARYWPEFGQAGKDAITTAMVLGHRSGVI
MAB_0853|M.abscessus_ATCC_1997 GLMSTCVHMLVERGVLDLYAPVARYWPEFGQGGKESITLAMVLGHRSGVI
Mflv_3647|M.gilvum_PYR-GCK GVAATVIHRLADRGLIDYDAPVAEYWREFGVNGKSTITVRELMRHRAGLS
MLBr_00119|M.leprae_Br4923 AITATVVHMLVERGHFSLDDRVCEYLPTYTSYGKHRTTIRHVLTHSAGVP
: : * :** :. :.. : ** :: * :*
MSMEG_3914|M.smegmatis_MC2_155 GWDRI-DSIEDLYDWESSTARLAAQAPWWEPGSASGYHAMTFGHLVGEVV
Mvan_5383|M.vanbaalenii_PYR-1 GWQTP-FGVEDIYDWAKATSHLAGQAPWWQPGTASGYHAMNYGHLVGELV
Mb2490|M.bovis_AF2122/97 GPRGR-LGWEQVADWDFVCEQLAAAEPWWQPGAAQGYHMTTFGFILGEVF
Rv2463|M.tuberculosis_H37Rv GPRGR-LGWEQVADWDFVCEQLAAAEPWWQPGAAQGYHMTTFGFILGEVF
MMAR_3810|M.marinum_M GPNAR-MSWQQVTDWDFVCEQLALAEPRWEPGSAQGYHMTTFGFILGEVF
MUL_3735|M.ulcerans_Agy99 GPNAR-MSWQQVTDWDFVCEQLALAEPRWEPGSAQGYHMTTFGFILGEVF
MAV_1709|M.avium_104 GPRTR-MRWEQVADWDYVCEQLAAAEPWWEPGTAQGYHMTTFGFIMGEVF
TH_0350|M.thermoresistible__bu GPRTP-MRPEQTLDWDAVCAALAAAGPWWPPGAAQGYHMVTFGFILGEIV
MAB_0853|M.abscessus_ATCC_1997 GPRTR-LTPEQAANWDEVCEHIARATPWWEPGTAQGYHMATFGFILGEVV
Mflv_3647|M.gilvum_PYR-GCK QLNG--AAKTDLMDHLVMEERLAAAPASWLVG-RPAYHAFTFGWLLSGLA
MLBr_00119|M.leprae_Br4923 FPTGPRPDVTRADDHAYAQQKLSELRPFYRPGLVHIYHALTWGPLMREII
: :: . : * ** .:* :: :
MSMEG_3914|M.smegmatis_MC2_155 RRVTGRTLKQFVADEIAAPLNAD-FQIGARLQDAERIAEVVP---ADNPM
Mvan_5383|M.vanbaalenii_PYR-1 RRITGTPLKDFVAEQIAVPLGAD-VQIGARPEDDHRIAELVPPPPRDRGV
Mb2490|M.bovis_AF2122/97 RRVTGRTVGQYLRTEIAEPLGAD-VHIGLHPGEQLRCADLVDKPHIRQLL
Rv2463|M.tuberculosis_H37Rv RRVTGRTVGQYLRTEIAEPLGAD-VHIGLHPGEQLRCADLVDKPHIRQLL
MMAR_3810|M.marinum_M RRITGRTVGQYLRTEIAEPIGAD-VHIGLSPFDQSRCAERVNKPHARDLL
MUL_3735|M.ulcerans_Agy99 RRITGRTVGQYLRTEIAEPIGAD-VHIGLSPFDQSRCAERVNKPHARDLL
MAV_1709|M.avium_104 RRVTGRTIGHYLRTEIAGPFGAD-VHIGLPLAEQHRCAERVNKPHARDLL
TH_0350|M.thermoresistible__bu RRVTGRSPGRFLRTEIAEPLGAD-VHIGLPHTEHHRCAEMVNKPHIRDVL
MAB_0853|M.abscessus_ATCC_1997 RRTTGKTLGQFLRTEIAEPYGLD-VHVGLPHSEHHRCAELINKPYLRDVF
Mflv_3647|M.gilvum_PYR-GCK RSVTGTGMRELIRTEVAAPLNTDGIHLGRPPVQAPTQPARIIGPQTRLQN
MLBr_00119|M.leprae_Br4923 WTATGKEIRDILAAEILDPLGFRWTNFGVAEEDVPLVALSHATG------
** : :: * . :.* : .
MSMEG_3914|M.smegmatis_MC2_155 EGLPPAETWTEQMVKTFGGFFP--------DPAAANTDAWRAADFGAVNG
Mvan_5383|M.vanbaalenii_PYR-1 DRLPP----DHPAVKTFAAFPPGA-----YGAAHAETEAWRRADIGGANG
Mb2490|M.bovis_AF2122/97 ADVQAPGYPTSLNEHPKAALSVSMGFAPDDELGSNDLQLWRQIEFPGTNG
Rv2463|M.tuberculosis_H37Rv ADVQAPGYPTSLNEHPKAALSVSMGFAPDDELGSNDLQLWRQIEFPGTNG
MMAR_3810|M.marinum_M ADVQAPSDPTSLDDHPKAGLSIAMGFAPDDELGSNDLHLWRQLEFPGTNA
MUL_3735|M.ulcerans_Agy99 ADVQAPSDPTSLDDHPKAGLSIAMGFAPDDELGSNDLHLWRQLEFPGTNA
MAV_1709|M.avium_104 ADANAPTDPRSLAEHPKAGLSISMGFAPDDELGSHDLNLWRELEFPGTNG
TH_0350|M.thermoresistible__bu AAGGAPAHPERLDEHPMAGLAVAMGFIPDDELGSADLTGWRAAEFPATNG
MAB_0853|M.abscessus_ATCC_1997 R--GAPGEFDCMSDHPLAGPLISGDFIPDDEIARKDIALWRALEFPGTNA
Mflv_3647|M.gilvum_PYR-GCK PIFNAVAP--HIAALPFSAGFGAMYFPGVKSFVQGDTPLLDG-EIPAANG
MLBr_00119|M.leprae_Br4923 ---------RPLPPIIAAIFRKAIGGTVHEVIPYTNTPPFLTTIVPSSNT
. : . . *
MSMEG_3914|M.smegmatis_MC2_155 HTTARALARILSSITLGGAVGGVRLLRPETVEKVFEVQIEG-PDLVMARH
Mvan_5383|M.vanbaalenii_PYR-1 HGNARGLVRALSPISLGGTANGVQVVDPRTVELIFAEQSSG-MDQVLF-V
Mb2490|M.bovis_AF2122/97 QVSALGLATFYNGLAQEKLLSREHMELVRVSQGGFDT------DLVLGPR
Rv2463|M.tuberculosis_H37Rv QVSALGLATFYNGLAQEKLLSREHMELVRVSQGGFDT------DLVLGPR
MMAR_3810|M.marinum_M QVSALGLATFYNALAQEKLLSREHMDLVRVSQGGFDT------DLVLGPR
MUL_3735|M.ulcerans_Agy99 QVSALGLATFYNALAQEKLLSREHMDLVRVSQGGFDT------DLVLGPR
MAV_1709|M.avium_104 QVSALGLATFYNALAQEKLLSREHMDRVRVCQGGLDT------DLVLGPR
TH_0350|M.thermoresistible__bu HVSAVGLATVYHALAREQLISRGHLERCRMSQGGFDP------DLVLGPR
MAB_0853|M.abscessus_ATCC_1997 HVSALGMATFYNAMALGKLLSHEHMDVVRVSQGGFDP------DVVLGPR
Mflv_3647|M.gilvum_PYR-GCK VATARALARMYGAIANEGRIDGLQYLSRETTAVLAGRRS----LRLDHSM
MLBr_00119|M.leprae_Br4923 VSTANELSRFAEIWLRGGELDGIRVLRSETLLGAVAECRRLRPDFVVGLM
.* : . : . :
MSMEG_3914|M.smegmatis_MC2_155 PVKWGLGFGLPEPTTLPY-IPEGKICHWGGWGGSWETMNPDKRATVAYVM
Mvan_5383|M.vanbaalenii_PYR-1 PLRFGIGFGLPTPQSVPA-VPDGKVCWWGGWGGSLVVMDLDRRATFAYVM
Mb2490|M.bovis_AF2122/97 VADHGWGLGYMLNQRGVN-GPNPRIFGHGGLGGSFGFVDLEHRIGYAYVM
Rv2463|M.tuberculosis_H37Rv VADHGWGLGYMLNQRGVN-GPNPRIFGHGGLGGSFGFVDLEHRIGYAYVM
MMAR_3810|M.marinum_M VADHGWGLGYMLNQRAVN-GPNQKIFGHGGLGGSFGFVDLEHRIGYAYVM
MUL_3735|M.ulcerans_Agy99 VADHGWGLGYMLNQRAVN-GPNQKIFGHGGLGGSFGFVDLEHRIGYAYVM
MAV_1709|M.avium_104 VADHGWGLGYMLNQRCVN-GPNPRIFGHGGLGGSFGFVDLEHRIGYAYVM
TH_0350|M.thermoresistible__bu VADHGWGLGYMLNQRGHA-GPNRRVFGHGGSGGSFGFADLEHRIGYAYVM
MAB_0853|M.abscessus_ATCC_1997 VANHGWGLGYMLNQRCYA-GPNQKTFGHGGSGGSYAFVDLEHRIGYSYVM
Mflv_3647|M.gilvum_PYR-GCK VMPLSFHLGYHGLPIPGL-LPG---FGHVGLGGSLGWADPETGLAFGFVH
MLBr_00119|M.leprae_Br4923 PARWGTGFILGTNKFGPFGRNAPAAFGHLGLVNIAIWADPQRSMAAGLIS
. : * . : : . :
MSMEG_3914|M.smegmatis_MC2_155 NKMGSGLLGS-DRTERYLSLIYDALR------------------------
Mvan_5383|M.vanbaalenii_PYR-1 NKMGGGTTGT-PRTVRYAKLIDAALQDARG--------------------
Mb2490|M.bovis_AF2122/97 NRFDATKANADPRSVVLSNEVYAALGVNRS--------------------
Rv2463|M.tuberculosis_H37Rv NRFDATKANADPRSVVLSNEVYAALGVNRS--------------------
MMAR_3810|M.marinum_M NRFDASKANADPRSVALSNEVYAALDVAAD--------------------
MUL_3735|M.ulcerans_Agy99 NRFDASKANADPRSVALSNEVYAALDVAAD--------------------
MAV_1709|M.avium_104 NRFDATKANADPRSLALSNEVYSVLGVR----------------------
TH_0350|M.thermoresistible__bu NNFDATKAHADPRSVALSDAVYSALGVTAHRSAAPVGAAGRR--------
MAB_0853|M.abscessus_ATCC_1997 NQFDVTKADADPRSVRLINELYTTLGVSPAGESL----------------
Mflv_3647|M.gilvum_PYR-GCK NRLLTPMVVSDQAGFVATAALLRRGASQARKNGYRRVREYGSPFSDVAAT
MLBr_00119|M.leprae_Br4923 ----SGKPGQDPNAGRYGALMNTITAEIPVH-------------------
:
MSMEG_3914|M.smegmatis_MC2_155 --
Mvan_5383|M.vanbaalenii_PYR-1 --
Mb2490|M.bovis_AF2122/97 --
Rv2463|M.tuberculosis_H37Rv --
MMAR_3810|M.marinum_M --
MUL_3735|M.ulcerans_Agy99 --
MAV_1709|M.avium_104 --
TH_0350|M.thermoresistible__bu --
MAB_0853|M.abscessus_ATCC_1997 --
Mflv_3647|M.gilvum_PYR-GCK AV
MLBr_00119|M.leprae_Br4923 --