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VTSTVPGTSIGSLVRQWRQRRRISQLDLAIEADVSPRHVSFIETGRAQPSRAMVLRLAEALDVPRREQNQ LLLAAGLAPVYAERSLDDPEMTAVRDGLTRVLDAYDPYPCVAVDREWNLLRANAGAGVMLDGVAPHLLER PNALRITLHPEGMAPRIRNLAEWRHHLISRLRREVAVSGSGGLAALLAEIESYPGGFATKHDLGGVAVPL ELDTGRGEVLTFLSTVTTFGTALDLTAAELSVEAFLPADEQTAAALRG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3525 | - | - | 100% (258) | transcriptional regulator, XRE family protein |
| M. smegmatis MC2 155 | MSMEG_0906 | - | 7e-06 | 36.08% (97) | DNA-binding protein |
| M. smegmatis MC2 155 | MSMEG_0260 | - | 2e-05 | 29.50% (139) | DNA-binding protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0474c | - | 1e-05 | 34.26% (108) | transcriptional regulatory protein |
| M. gilvum PYR-GCK | Mflv_3292 | - | 3e-98 | 73.36% (244) | XRE family transcriptional regulator |
| M. tuberculosis H37Rv | Rv0465c | - | 5e-05 | 34.62% (104) | transcriptional regulatory protein |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_4363c | - | 1e-05 | 37.04% (81) | putative DNA-binding protein |
| M. marinum M | MMAR_3947 | - | 9e-06 | 32.52% (123) | transcriptional regulatory protein |
| M. avium 104 | MAV_4684 | - | 1e-05 | 34.26% (108) | DNA-binding protein |
| M. thermoresistible (build 8) | TH_1958 | - | 1e-105 | 75.20% (250) | transcriptional regulator, XRE family protein |
| M. ulcerans Agy99 | MUL_4534 | - | 5e-05 | 33.33% (108) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_3014 | - | 1e-100 | 71.43% (252) | XRE family transcriptional regulator |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_3292|M.gilvum_PYR-GCK --------------------------MRGWRRRRRLSQLELALHAGVSAR
Mvan_3014|M.vanbaalenii_PYR-1 MAPHGRASQTGTVTSVQRPPMTFGAMMRDWRRRRRLSQLDLALAAGVSAR
TH_1958|M.thermoresistible__bu VESRPASGHDAEVTRTAAP--AFGAMLRDWRRRRRLSQLDLALEAGVSAR
MSMEG_3525|M.smegmatis_MC2_155 -------------MTSTVPGTSIGSLVRQWRQRRRISQLDLAIEADVSPR
Mb0474c|M.bovis_AF2122/97 -----------------MSKTYVGSRVRQLRNERGFSQAALAQMLEISPS
Rv0465c|M.tuberculosis_H37Rv -----------------MSKTYVGSRVRQLRNERGFSQAALAQMLEISPS
MAV_4684|M.avium_104 -----------------MSKTFVGSRVRQLRHERGFSQAALAQMLEISPS
MUL_4534|M.ulcerans_Agy99 -----------------MSKTFVGSRVRQLRNERGFSQAALAQLLEISPS
MMAR_3947|M.marinum_M -------------------MPNRGGFVHAARERAGLTCRELAEKAGCSLR
MAB_4363c|M.abscessus_ATCC_199 ---------------MTDHNTLVARNVRRYRQERALSLGDLARRSGLSKQ
:: *.. :: ** *
Mflv_3292|M.gilvum_PYR-GCK HISFIETGRAKPSRAMVLRLSSVLGVPQ---RDQNAMLIAAGLAPAYTER
Mvan_3014|M.vanbaalenii_PYR-1 HVSFIETGRSAPSRAMVLRLATVLDVPQ---REQNRLFVAAGLAPVYGER
TH_1958|M.thermoresistible__bu HVSFMETGRAAPSRTMVLRLAEVLEVPP---REQNGLLVAAGYAPVYAER
MSMEG_3525|M.smegmatis_MC2_155 HVSFIETGRAQPSRAMVLRLAEALDVPR---REQNQLLLAAGLAPVYAER
Mb0474c|M.bovis_AF2122/97 YLDQIEHDVRPLTVAVLLRITEVFGVDATFFASQDDTRLVAELREVTLDR
Rv0465c|M.tuberculosis_H37Rv YLNQIEHDVRPLTVAVLLRITEVFGVDATFFASQDDTRLVAELREVTLDR
MAV_4684|M.avium_104 YLNQIEHDVRPLTVAVLLRITEVFGVDATFFSSQDDTRLVAELREVTMDR
MUL_4534|M.ulcerans_Agy99 YLNQIEHDVRPLTVAVLLRITEVFGVDATFFSSQDDTRLVAELREVTMDR
MMAR_3947|M.marinum_M YVHDIEQGCS-PSIRVLNGLVRALQLSA-----WEQRFLFAACGRILPDP
MAB_4363c|M.abscessus_ATCC_199 TVSKIEQGVGNPTVETLALLGEALQVPP-------QRLLTEWGTPVFVQR
: :* . : : : .: : : :
Mflv_3292|M.gilvum_PYR-GCK SLDA--------------PDMAAVRAGVARVLDAYEPFPCVVVTRGWWIL
Mvan_3014|M.vanbaalenii_PYR-1 SLQA--------------PDMAAVRAGVQMVLAAYDPYPCVMVDRGWWIL
TH_1958|M.thermoresistible__bu DLDD--------------PEMAAVRHGVQRVLDAHDPYPCVAVDRGWRVV
MSMEG_3525|M.smegmatis_MC2_155 SLDD--------------PEMTAVRDGLTRVLDAYDPYPCVAVDREWNLL
Mb0474c|M.bovis_AF2122/97 DLDIAIDPHEVAEMVSAHPGLARAVVNLHRRYRITTAQLAAATEERFSDG
Rv0465c|M.tuberculosis_H37Rv DLDIAIDPHEVAEMVSAHPGLACAVVNLHRRYRITTAQLAAATEERFSDG
MAV_4684|M.avium_104 DLDIDVDPTEVAEMVSAHPGLARAVVNLHRRYRITTAQLAAATEERFFDG
MUL_4534|M.ulcerans_Agy99 DLDISVDPTEVAEMVSAHPSLARAMVNLHRRYRITTAQLAAATEERYSDG
MMAR_3947|M.marinum_M ALTD--------------------TDISQRYLDALQPHPAAALHPSWRFK
MAB_4363c|M.abscessus_ATCC_199 -----------------------------------------ASEDGWVDK
:
Mflv_3292|M.gilvum_PYR-GCK QTNAGAGVLLDGVAAHLLERPN------------ALRIALHPDGLAPRIG
Mvan_3014|M.vanbaalenii_PYR-1 QANPGASILLDGVAPHLLDRPN------------ALRIALHPDGLAPRIR
TH_1958|M.thermoresistible__bu QTNAGAAVLLDGVADHLLEQPN------------ALRIALHPDGLAPRIR
MSMEG_3525|M.smegmatis_MC2_155 RANAGAGVMLDGVAPHLLERPN------------ALRITLHPEGMAPRIR
Mb0474c|M.bovis_AF2122/97 SGRGSITMPHEEVRDYFYQRQNYLHALDTAAEDLTAQMRMHHGDLARELT
Rv0465c|M.tuberculosis_H37Rv SGRGSITMPHEEVRDYFYQRQNYLHALDTAAEDLTAQMRMHHGDLARELT
MAV_4684|M.avium_104 SGTGSITMPHEEVRDYFYQRQNYLHELDTAAEDLTIKMRLHHGDLARELT
MUL_4534|M.ulcerans_Agy99 SGTGSITMPHEEVRDYFYQRQNYLHELDAAAEDLTIQMRLHHGDLRSELT
MMAR_3947|M.marinum_M AWNQQWQRLFQGVLLAPS-----------------MHQWLYLSTTSRRIL
MAB_4363c|M.abscessus_ATCC_199 GARS--ERLLDEIYGSGYVRN--------------LVVRLERTAQAGEEI
: : : .
Mflv_3292|M.gilvum_PYR-GCK ---------------NLAQWRTHLIERLRREVAVDGCAELDRLLAEIESY
Mvan_3014|M.vanbaalenii_PYR-1 ---------------NLAQWRTHLVERLRREVDTAGSAELADLLAEIDSY
TH_1958|M.thermoresistible__bu ---------------NLAQWRHHLISRLRREVALSRAPGAVALLAEIESY
MSMEG_3525|M.smegmatis_MC2_155 ---------------NLAEWRHHLISRLRREVAVSGSGGLAALLAEIESY
Mb0474c|M.bovis_AF2122/97 RRLTEVHGVRINKRIDLGDTVLHRYDPATNTLEISSHLSPGQQVFKMAAE
Rv0465c|M.tuberculosis_H37Rv RRLTEVHGVRINKRIDLGDTVLHRYDPATNTLEISSHLSPGQQVFKMAAE
MAV_4684|M.avium_104 RRLTEVHGVHINRRIDLGDTVLHRYDPETKTLEISNHLSWGQQVFKMAAE
MUL_4534|M.ulcerans_Agy99 RRLTEVHGVRITRRIDLGDTVLHRLDPATMTLEISNHLASGQQVFKMAAE
MMAR_3947|M.marinum_M R--------------NWDEVSQWCVGWLRYGLAVD----VDAVKPMVSAL
MAB_4363c|M.abscessus_ATCC_199 G--------------------AHAPGTLHHVYVIEGILRTGPLNDPVELR
:
Mflv_3292|M.gilvum_PYR-GCK PGGFEHSPDLGGVAVPLVLRTTGGRTLRFLSTVTTFGTALDLTAAELS--
Mvan_3014|M.vanbaalenii_PYR-1 PGGFDDSPDLGSVAVPLELVTEDGRLLRFLSMVTTFGTALDLTAAELS--
TH_1958|M.thermoresistible__bu PGGFDDPGDLGGVVVPLELYTTSRRLLSFLSTVTTFGTALDLTAAELS--
MSMEG_3525|M.smegmatis_MC2_155 PGGFATKHDLGGVAVPLELDTGRGEVLTFLSTVTTFGTALDLTAAELS--
Mb0474c|M.bovis_AF2122/97 LAYLEFGDLIDAMVTDGKFTSAESRTLARLGLANYFAAATVLPYRQFHDV
Rv0465c|M.tuberculosis_H37Rv LAYLEFGDLIDAMVTDGKFTSAESRTLARLGLANYFAAATVLPYRQFHDV
MAV_4684|M.avium_104 LAYLEFGDLIDSLVAQGKFTSEESHKLARLGLANYFAAAAVLPYRQFHDV
MUL_4534|M.ulcerans_Agy99 LAYLEFGDLIDAMVTDGKFTSDESRTLARLGLANYFAAAAVLPYRQFHDV
MMAR_3947|M.marinum_M MPVTEFRREWEAQVIPVDPATR-------LWVVRDGGTELRIDMRFWH--
MAB_4363c|M.abscessus_ATCC_199 TGDFARFPGDVPHRHESISPRVVAHLVTTLPQIRQFDPIR----------
* .
Mflv_3292|M.gilvum_PYR-GCK ----------VEAFLPADDATAAALR------------------------
Mvan_3014|M.vanbaalenii_PYR-1 ----------IEAFLPADDETAASLR------------------------
TH_1958|M.thermoresistible__bu ----------IEAFLPADERTASALAGPTSPAAAS------FPDPDTGTA
MSMEG_3525|M.smegmatis_MC2_155 ----------VEAFLPADEQTAAALRG-----------------------
Mb0474c|M.bovis_AF2122/97 AENFRYDVERLSAFYSVSYETIAHRLSTLQRPSMRGVPFTFVQVDRAGNM
Rv0465c|M.tuberculosis_H37Rv AENFRYDVERLSAFYSVSYETIAHRLSTLQRPSMRGVPFTFVRVDRAGNM
MAV_4684|M.avium_104 AENFRYDVERLSSFYSVSYETIAHRLSTLQRPSMRGVPFSFIRVDRAGNM
MUL_4534|M.ulcerans_Agy99 AENFRYDVERLSAFYSVSYETIAHRLSTLQRPSMRGVPFSFIRVDRAGNM
MMAR_3947|M.marinum_M -----------ASPMPGGLLLGVILDAG----------------------
MAB_4363c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_3292|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3014|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1958|M.thermoresistible__bu AARQP---------------------------------------------
MSMEG_3525|M.smegmatis_MC2_155 --------------------------------------------------
Mb0474c|M.bovis_AF2122/97 SKRQSATGFHFSSSGGTCPLWNVYETFANPGKILVQIAQMPDGRNYLWVA
Rv0465c|M.tuberculosis_H37Rv SKRQSATGFHFSSSGGTCPLWNVYETFANPGKILVQIAQMPDGRNYLWVA
MAV_4684|M.avium_104 SKRQSATGFHFSSSGGTCPLWNVYETFANPGKILVQIAQMPDGRNYMWVA
MUL_4534|M.ulcerans_Agy99 SKRQSATGFHFSSSGGTCPLWNVYETFANPGKILVQIAQMPDGRNYMWVA
MMAR_3947|M.marinum_M --------------------------------------------------
MAB_4363c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_3292|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_3014|M.vanbaalenii_PYR-1 --------------------------------------------------
TH_1958|M.thermoresistible__bu --------------------------------------------------
MSMEG_3525|M.smegmatis_MC2_155 --------------------------------------------------
Mb0474c|M.bovis_AF2122/97 RTVELRAARYGQPGKTFAIGLGCELRHAHRLVYSEGLDLSGDPNTAATPI
Rv0465c|M.tuberculosis_H37Rv RTVELRAARYGQPGKTFAIGLGCELRHAHRLVYSEGLDLSGDPNTAATPI
MAV_4684|M.avium_104 RTVERRAARYGQPGKTFAIGLGCELRHAHRLVYSEGLDVSGGPGTVATPI
MUL_4534|M.ulcerans_Agy99 RTVERRAARYGQPGKTFAIGLGCELRHAHRLVYSEGLDLSGDPNIAATPI
MMAR_3947|M.marinum_M --------------------------------------------------
MAB_4363c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_3292|M.gilvum_PYR-GCK -----------------------------------------
Mvan_3014|M.vanbaalenii_PYR-1 -----------------------------------------
TH_1958|M.thermoresistible__bu -----------------------------------------
MSMEG_3525|M.smegmatis_MC2_155 -----------------------------------------
Mb0474c|M.bovis_AF2122/97 GAGCRVCERDNCPQRAFPALGRALDLDEHRSTVSPYLVKQL
Rv0465c|M.tuberculosis_H37Rv GAGCRVCERDNCPQRAFPALGRALDLDEHRSTVSPYLVKQL
MAV_4684|M.avium_104 GAGCRVCERDNCPQRAFPALGRALDLDEHRSTVSPYLVKQP
MUL_4534|M.ulcerans_Agy99 GAGCRVCERDNCPQRAFPALGRALDLDEHRSTVSPYLVKQP
MMAR_3947|M.marinum_M -----------------------------------------
MAB_4363c|M.abscessus_ATCC_199 -----------------------------------------