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MVAEPNPVPPAATARSAPRHIRLTSHHGAEGALAIRWGAPTAAERGPLIGTTTTRAHRNVIGTHSGSYSV YRALAVASGALSPEHRADLTNTAPTDVIGPYAQWSDPSAIVSLDPWGAMVAEAFTTELAAGFDIRPTIAI TKAHVILPEIADAIAKGRLQPDGRILLPNGAALVTKAAIEPVWYLPGVAARFGCSETTLRRVLFEETGGM YPELVTRSDLEVFLPPIGGQTLYIFGNARDLADSSVELTARVHDECNGSDVFGSDICTCRPYLTHAIEEC IRGAQRGGVGLVAYSRKEGRALGEVTKFLVYNARKRQAGGDTADQYFARTECVAGVQDMRFQELMPDVLH WLGIRKIHRLVSMSNMKYDAIVGSGIEVGERINIPEELIPADARVEIDAKMAAGYFTPGPVPDAEELKIA KGRELA
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3471 | - | - | 100% (426) | hypothetical protein MSMEG_3471 |
| M. smegmatis MC2 155 | MSMEG_3072 | - | 5e-09 | 33.57% (140) | bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1450 | ribA2 | 2e-09 | 32.86% (140) | bifunctional 3,4-dihydroxy-2-butanone 4-phosphate |
| M. gilvum PYR-GCK | Mflv_3257 | - | 0.0 | 84.48% (406) | hypothetical protein Mflv_3257 |
| M. tuberculosis H37Rv | Rv1415 | ribA2 | 2e-09 | 32.86% (140) | bifunctional 3,4-dihydroxy-2-butanone 4-phosphate |
| M. leprae Br4923 | MLBr_00559 | ribA | 2e-09 | 32.14% (140) | bifunctional 3,4-dihydroxy-2-butanone 4-phosphate |
| M. abscessus ATCC 19977 | MAB_2796c | - | 2e-09 | 32.86% (140) | bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP |
| M. marinum M | MMAR_2222 | ribA2 | 5e-09 | 32.86% (140) | riboflavin biosynthesis protein RibA2 |
| M. avium 104 | MAV_3365 | - | 3e-09 | 32.86% (140) | bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP |
| M. thermoresistible (build 8) | TH_0344 | ribA2 | 1e-09 | 27.04% (233) | PROBABLE RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBA2 : GTP |
| M. ulcerans Agy99 | MUL_1809 | ribA2 | 3e-08 | 32.14% (140) | bifunctional 3,4-dihydroxy-2-butanone 4-phosphate |
| M. vanbaalenii PYR-1 | Mvan_2974 | - | 0.0 | 82.54% (418) | hypothetical protein Mvan_2974 |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_2222|M.marinum_M --------------------------------------------------
MUL_1809|M.ulcerans_Agy99 --------------------------------------------------
MAV_3365|M.avium_104 --------------------------------------------------
Mb1450|M.bovis_AF2122/97 --------------------------------------------------
Rv1415|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_00559|M.leprae_Br4923 -----------------------------------------------MGP
MAB_2796c|M.abscessus_ATCC_199 --------------------------------------------------
Mflv_3257|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_2974|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_3471|M.smegmatis_MC2_155 --------------------------------------------------
TH_0344|M.thermoresistible__bu VATAHGSGVVAGGLARPGDDDYWRRCAAGGAAMVIAGGTVVSPDSANRTG
MMAR_2222|M.marinum_M -------MTRLDSVERAVADIGAGKAVIVID--DEDRENEGDLIFAAEKA
MUL_1809|M.ulcerans_Agy99 -------MTRLDSVERAVADIGAGKAVIVID--DEDRENEGDLIFAAEKA
MAV_3365|M.avium_104 -------MTRLDSVERAVADIAAGKAVIVID--DEDRENEGDLIFAAEKA
Mb1450|M.bovis_AF2122/97 -------MTRLDSVERAVADIAAGKAVIVID--DEDRENEGDLIFAAEKA
Rv1415|M.tuberculosis_H37Rv -------MTRLDSVERAVADIAAGKAVIVID--DEDRENEGDLIFAAEKA
MLBr_00559|M.leprae_Br4923 FDSKVAKMTRLDSVERAVADIAAGKAVVVID--DEDRENEGDLIFAAEKA
MAB_2796c|M.abscessus_ATCC_199 -------MTRLDSIERAVADIAAGKAVVVVD--DEDRENEGDLIFAAEKA
Mflv_3257|M.gilvum_PYR-GCK -------------------MPGG--HIRLTS--HSGGADAPALQWGAATA
Mvan_2974|M.vanbaalenii_PYR-1 --------MSTDAVPPPAKPPGG--HIRLTS--HSAGSDAPALRWGAPTA
MSMEG_3471|M.smegmatis_MC2_155 ------MVAEPNPVPPAATARSAPRHIRLTS--HHGAEGALAIRWGAPTA
TH_0344|M.thermoresistible__bu NITEAWRPEAVDGLRRRASAIAREGAVPVCQLVHLGRETLGAEIWEHPVA
. : : . . : *
MMAR_2222|M.marinum_M TP------------------------ELVAFMVRYTSGYLCVP-LDGAVC
MUL_1809|M.ulcerans_Agy99 TP------------------------ELVAFMVRYTSGYLCVP-LDGAVC
MAV_3365|M.avium_104 TP------------------------EMVAFMVRYTSGYLCVP-LDGAIC
Mb1450|M.bovis_AF2122/97 TP------------------------EMVAFMVRYTSGYLCVP-LDGAIC
Rv1415|M.tuberculosis_H37Rv TP------------------------EMVAFMVRYTSGYLCVP-LDGAIC
MLBr_00559|M.leprae_Br4923 TL------------------------EMVAFMVRYTSGYLCAP-LDGAIC
MAB_2796c|M.abscessus_ATCC_199 TP------------------------ELVAFMVRYTSGYLCVP-LAGEDC
Mflv_3257|M.gilvum_PYR-GCK AE------------------------RGPVVGTTTTRGHRNVIGTHSGAY
Mvan_2974|M.vanbaalenii_PYR-1 AE------------------------RGPLVGTTTKRAHRNVIGTHSGAY
MSMEG_3471|M.smegmatis_MC2_155 AE------------------------RGPLIGTTTTRAHRNVIGTHSGSY
TH_0344|M.thermoresistible__bu PSPVRSPREPVRARTMSESDIDRVIDDFVVSSRHAAEAGFRAVELHAAHG
. . . .
MMAR_2222|M.marinum_M DRLGLLPMYAVNQDKHGT-------------AYTVTVDAKNGVGTGISAS
MUL_1809|M.ulcerans_Agy99 DRLGLLPMYAVNQDKHGT-------------AYTVTVDAKNGVGTGISAS
MAV_3365|M.avium_104 DRLGLLPMYAVNQDKHGT-------------AYTVTVDARNGVGTGISAS
Mb1450|M.bovis_AF2122/97 DRLGLLPMYAVNQDKHGT-------------AYTVTVDARNGIGTGISAS
Rv1415|M.tuberculosis_H37Rv DRLGLLPMYAVNQDKHGT-------------AYTVTVDARNGIGTGISAS
MLBr_00559|M.leprae_Br4923 DRLGLLPMFAVNQDKHGT-------------AYTVTVDARNGVGTGISAS
MAB_2796c|M.abscessus_ATCC_199 DRLGLLPQYAVNQDKHGT-------------AYTVTVDAKNGIGTGISAS
Mflv_3257|M.gilvum_PYR-GCK GVYRALAVAAGALSREHR-------------ADLTNTSPTDVIGPYPQWA
Mvan_2974|M.vanbaalenii_PYR-1 GVYRALAVAAGKLSREHR-------------ADLTNTAPTDIIGPHPQWA
MSMEG_3471|M.smegmatis_MC2_155 SVYRALAVASGALSPEHR-------------ADLTNTAPTDVIGPYAQWS
TH_0344|M.thermoresistible__bu YLLGQFLSPAINRRPDAQNTAGRVRILHRLRSAIVEACPDLVVGVRVSVE
: : . : . . . :* .
MMAR_2222|M.marinum_M DRA---------------------TTMRLLADPASVAEDFTRPGHVVPLR
MUL_1809|M.ulcerans_Agy99 DRA---------------------TTMRLLADPASVAEDFTRPGHVVPLR
MAV_3365|M.avium_104 DRA---------------------TTMRLLADPTSIAEDFTRPGHVVPLR
Mb1450|M.bovis_AF2122/97 DRA---------------------TTMRLLADPTSVADDFTRPGHVVPLR
Rv1415|M.tuberculosis_H37Rv DRA---------------------TTMRLLADPTSVADDFTRPGHVVPLR
MLBr_00559|M.leprae_Br4923 DRA---------------------TTMRLLADPASVADDFTRPGHVVPLR
MAB_2796c|M.abscessus_ATCC_199 DRA---------------------ATMRLLADAASTADDFTKPGHVVPLR
Mflv_3257|M.gilvum_PYR-GCK DPE---------------------TIVSLDPWGAMVADAFRG--------
Mvan_2974|M.vanbaalenii_PYR-1 DPE---------------------TIVSLDPWGAMVADVFAR--------
MSMEG_3471|M.smegmatis_MC2_155 DPS---------------------AIVSLDPWGAMVAEAFTT--------
TH_0344|M.thermoresistible__bu DADEGDLGLDRVCEILPLLEPFDYLNVTVGVRTTYVRDMATAAPPLLPHI
* : : : :
MMAR_2222|M.marinum_M AKDGGVLRRPGHTEAAVDLARMAG--------------------------
MUL_1809|M.ulcerans_Agy99 AKDGGVLRRPGHTEAAVDLARMAG--------------------------
MAV_3365|M.avium_104 AKDGGVLRRPGHTEAAVDLARMAG--------------------------
Mb1450|M.bovis_AF2122/97 AKDGGVLRRPGHTEAAVDLARMAG--------------------------
Rv1415|M.tuberculosis_H37Rv AKDGGVLRRPGHTEAAVDLARMAG--------------------------
MLBr_00559|M.leprae_Br4923 AKDGGVLRRPGHTEAAVDLARLAG--------------------------
MAB_2796c|M.abscessus_ATCC_199 AKDGGVLRRPGHTEASVDLAKLAG--------------------------
Mflv_3257|M.gilvum_PYR-GCK QIADGVDIRP---TIAVTKAQVIL--------------------------
Mvan_2974|M.vanbaalenii_PYR-1 EIADGVDIRP---TIAVTKAQVIL--------------------------
MSMEG_3471|M.smegmatis_MC2_155 ELAAGFDIRP---TIAITKAHVIL--------------------------
TH_0344|M.thermoresistible__bu ERLRGATSKPLLVSQAFRSRDDIESALHRGADLIGLARPLIADPELPRKL
* :* :.
MMAR_2222|M.marinum_M --------------------------------LQPAGAICEIVSQKDEGS
MUL_1809|M.ulcerans_Agy99 --------------------------------LQPAGAICEIVSRKDEGS
MAV_3365|M.avium_104 --------------------------------LQPAGAICEIVSQKDEGS
Mb1450|M.bovis_AF2122/97 --------------------------------LQPAGAICEIVSQKDEGS
Rv1415|M.tuberculosis_H37Rv --------------------------------LQPAGAICEIVSQKDEGS
MLBr_00559|M.leprae_Br4923 --------------------------------LQPAGAICEIVSQKDEGS
MAB_2796c|M.abscessus_ATCC_199 --------------------------------LRPAAVICEIVSQKDEGA
Mflv_3257|M.gilvum_PYR-GCK --------------------------------PEVHDALARGRLTPD-GR
Mvan_2974|M.vanbaalenii_PYR-1 --------------------------------PEVHDAIGKARLIPD-GR
MSMEG_3471|M.smegmatis_MC2_155 --------------------------------PEIADAIAKGRLQPD-GR
TH_0344|M.thermoresistible__bu ISGADSRIRPCVSCNEDCRSFTPVLLCTVNPTLAPPGQSARPATPLRFGT
. *
MMAR_2222|M.marinum_M MAQTDELRVFADEHGLALITIADLIEWRRKHEKH-IERVAEARIPTRHGE
MUL_1809|M.ulcerans_Agy99 MAQTDELRVFADEHGLALITIADLIEWRRKHEKH-IERVAEARIPTRRGE
MAV_3365|M.avium_104 MAQTDELRVFADEHDLAMITIADLIEWRRKHEKH-IERIAEARIPTRHGE
Mb1450|M.bovis_AF2122/97 MAHTDELRVFADEHGLALITIADLIEWRRKHEKH-IERVAEARIPTRHGE
Rv1415|M.tuberculosis_H37Rv MAHTDELRVFADEHGLALITIADLIEWRRKHEKH-IERVAEARIPTRHGE
MLBr_00559|M.leprae_Br4923 MAQTDELRVFADEHDLALITIADLIAWRRKHEKH-IERVAEARIPTRHGE
MAB_2796c|M.abscessus_ATCC_199 MAQTEELRVFADEHNLALVSIADLIEWRRKHEKH-VQRIAEARIPTQHGE
Mflv_3257|M.gilvum_PYR-GCK VLLSTGAAQVTKAAIEPVWHLPGVARRFGCSESD-LRRVLFEETGGMYPE
Mvan_2974|M.vanbaalenii_PYR-1 VLLGNGAAQVTKAAIEPVWYLPGVARRFGCSETD-LRRALFEETGGMYPE
MSMEG_3471|M.smegmatis_MC2_155 ILLPNGAALVTKAAIEPVWYLPGVAARFGCSETT-LRRVLFEETGGMYPE
TH_0344|M.thermoresistible__bu APGTPARVAVVGAGPAGLEXXXGAPGLVGAAQPGGVRRTGIAEIPTRHGS
.. : . : :.* . .
MMAR_2222|M.marinum_M FRAIGYTSIYED--VEHVALVRGEIAGPNSDGDDVLVRVHSECLTGDVFG
MUL_1809|M.ulcerans_Agy99 FRAIGYTSIYEN--VEHVALVRGEIAGPNSDGDDVLVRVHSECLTGDVFG
MAV_3365|M.avium_104 FRAIGYTSIYEE--VEHVALVRGEIAGPNSDGDDVLVRVHSECLTGDVFG
Mb1450|M.bovis_AF2122/97 FRAIGYTSIYED--VEHVALVRGEIAGPNADGDDVLVRVHSECLTGDVFG
Rv1415|M.tuberculosis_H37Rv FRAIGYTSIYED--VEHVALVRGEIAGPNADGDDVLVRVHSECLTGDVFG
MLBr_00559|M.leprae_Br4923 FRAIGYTSIYDD--VKHVALVRGEIAGSSGDGDDILVRVHSECLTGDVFG
MAB_2796c|M.abscessus_ATCC_199 FRAVGYTSIYDD--VEHVALVLGDISGPDGDGNDVLVRVHSECLTGDVFG
Mflv_3257|M.gilvum_PYR-GCK LVTRSDLEVFLPPIGGQTIYIFGDPRDLADPSVELTARVHDECNGSDVFG
Mvan_2974|M.vanbaalenii_PYR-1 LVTRSDLDVFLPPIGGQTIYVFGDPRALADPGVELTARVHDECNGSDVFG
MSMEG_3471|M.smegmatis_MC2_155 LVTRSDLEVFLPPIGGQTLYIFGNARDLADSSVELTARVHDECNGSDVFG
TH_0344|M.thermoresistible__bu FQAIAYQSETGEH--EHLALVRGDLEQLHDLPEGVLTRIHSECLTGDVVG
: : . . : : *: : .*:*.** .**.*
MMAR_2222|M.marinum_M SRRCDCGPQLDAAMAMVAR----EGRGVVLYMRGHEGRGIGLLHKLQAY-
MUL_1809|M.ulcerans_Agy99 SRRCDCGSQLDAAMAMVAR----EGRGVVLYMRGHEGRGIGLLHKLQTY-
MAV_3365|M.avium_104 SRRCDCGPQLDAAMAMVAR----EGRGIVLYMRGHEGRGIGLMHKLQAY-
Mb1450|M.bovis_AF2122/97 SRRCDCGPQLDAALAMVAR----EGRGVVLYMRGHEGRGIGLMHKLQAY-
Rv1415|M.tuberculosis_H37Rv SRRCDCGPQLDAALAMVAR----EGRGVVLYMRGHEGRGIGLMHKLQAY-
MLBr_00559|M.leprae_Br4923 SRRCDCGTQLDAAMAMVAR----EGRGVVLYMRGHEGRGIGLMHKLQAY-
MAB_2796c|M.abscessus_ATCC_199 SRRCDCGPQLDAAMEMVAK----EGRGIVLYMRGHEGRGIGLMHKLQAY-
Mflv_3257|M.gilvum_PYR-GCK SDICTCRPYLTHAIEECIQGAQRGGVGLIAYSR-KEGRALGEVTKFLVYN
Mvan_2974|M.vanbaalenii_PYR-1 SDICTCRPYLTHAIEECIQGAQRGGVGLVAYFR-KEGRALGEVTKFLVYN
MSMEG_3471|M.smegmatis_MC2_155 SDICTCRPYLTHAIEECIRGAQRGGVGLVAYSR-KEGRALGEVTKFLVYN
TH_0344|M.thermoresistible__bu SLRCDCGAQLDAAIAALAA----EPAGVLIYLRGQEGRGIGLGPKLCAY-
* * * . * *: *:: * * :***.:* *: .*
MMAR_2222|M.marinum_M -QLQDAGDDTVDANLK----LGLPADARDYGIGAQILVDLGVRSMR-LLT
MUL_1809|M.ulcerans_Agy99 -QLQDAGDDTVDANLK----LGLPADARDYGIGAQILVDLGVRSMR-LLT
MAV_3365|M.avium_104 -QLQDAGEDTVDANLK----LGFPADARDYGIGAQILVDLGVRSMR-LLT
Mb1450|M.bovis_AF2122/97 -QLQDAGADTVDANLK----LGLPADARDYGIGAQILVDLGVRSMR-LLT
Rv1415|M.tuberculosis_H37Rv -QLQDAGADTVDANLK----LGLPADARDYGIGAQILVDLGVRSMR-LLT
MLBr_00559|M.leprae_Br4923 -QLQDAGADTVDANIK----LGFPSDARDYGIGAQILVDLGVRSMR-LLT
MAB_2796c|M.abscessus_ATCC_199 -QLQDAGEDTVDANLK----LGLPADARDYGLGAQILVDLGVKSMR-LLT
Mflv_3257|M.gilvum_PYR-GCK ARKRQVGGDTADQYFARTECVAGVQDMRFQELMPDVLHWLGIRTIHRLVS
Mvan_2974|M.vanbaalenii_PYR-1 ARKRQAGGDTADQYFARTECVAGVQDMRFQELMPDVLHWLGIRKIHRFVS
MSMEG_3471|M.smegmatis_MC2_155 ARKRQAGGDTADQYFARTECVAGVQDMRFQELMPDVLHWLGIRKIHRLVS
TH_0344|M.thermoresistible__bu -ALQEAGLDTVDANRA----LGLPVDCRDYGVAAAILHHLGIRRVR-LIT
::.* **.* :. * * : . :* **:: :: :::
MMAR_2222|M.marinum_M NNPAKRVGLDGYGLHIIERVPLPVRANAENIRYLMTKRDRMGHDLTGLDD
MUL_1809|M.ulcerans_Agy99 NNPAKRVGLDGYGLHIIERVPLPVRANAENIRYLMTKRDRMGHDLTGLDD
MAV_3365|M.avium_104 NNPAKRVGLDGYGLHIIERVPLPVRANAENIRYLMTKRDKMGHDLAGLDD
Mb1450|M.bovis_AF2122/97 NNPAKRVGLDGYGLHIIERVPLPVRANAENIRYLMTKRDKLGHDLAGLDD
Rv1415|M.tuberculosis_H37Rv NNPAKRVGLDGYGLHIIERVPLPVRANAENIRYLMTKRDKLGHDLAGLDD
MLBr_00559|M.leprae_Br4923 NNPAKRVGLDGYGLQIIERVPLPVRANADNIRYLMTKRDKMGHDLGGLDD
MAB_2796c|M.abscessus_ATCC_199 NNPAKRVGLDGYGLHIIERVPLPVRANSENIRYLRTKRDRMGHDLADLDD
Mflv_3257|M.gilvum_PYR-GCK MSNMKYDAITGSGIEVGERVSIPDELIPADAQVEIDAKTAAGYYTAGVVP
Mvan_2974|M.vanbaalenii_PYR-1 MSNMKYDAITGSGIEIGERVSIPDDLIPADAQVEIDAKMAAGYYTPGQVP
MSMEG_3471|M.smegmatis_MC2_155 MSNMKYDAIVGSGIEVGERINIPEELIPADARVEIDAKMAAGYFTPGPVP
TH_0344|M.thermoresistible__bu NNGAKSAALSRHGVEVSSTVHHPPHVTADNVSYLQTKRDRMGHLLPATLP
. * .: *:.: . : * . : : *:
MMAR_2222|M.marinum_M FHESVHLPGEFGGAL-----------------
MUL_1809|M.ulcerans_Agy99 FHESVHLPGEFGGAL-----------------
MAV_3365|M.avium_104 FHESVHLPGEFGGAL-----------------
Mb1450|M.bovis_AF2122/97 FHESVHLPGEFGGAL-----------------
Rv1415|M.tuberculosis_H37Rv FHESVHLPGEFGGAL-----------------
MLBr_00559|M.leprae_Br4923 FHESNYFPGEFGGAL-----------------
MAB_2796c|M.abscessus_ATCC_199 HPEAD-------GA------------------
Mflv_3257|M.gilvum_PYR-GCK DTDELKKAKGRGLQP-----------------
Mvan_2974|M.vanbaalenii_PYR-1 GADELKKPKGRGLHG-----------------
MSMEG_3471|M.smegmatis_MC2_155 DAEELKIAKGRELA------------------
TH_0344|M.thermoresistible__bu VPAEPDPIRLTPSNPSTSDDKPLINTVRKVAP