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M. thermoresistible (build 8) TH_0344 (ribA2)

annotation: PROBABLE RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBA2 : GTP cyclohydrolase II + 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase)
coordinates: 762811 - 764670
length: 620

aa seq not available

Operon Prediction Model: Genebank

Paralogs

species id gene e-value identity (len) annotation
M. thermoresistible (build 8) TH_0344 ribA2 - 100% (620) PROBABLE RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBA2 : GTP cyclohydrolase II + 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase)
M. thermoresistible (build 8) TH_2774 - 2e-89 43.82% (477) PUTATIVE putative NADPH dependent 2,4-dienoyl-CoA reductase
M. thermoresistible (build 8) TH_1011 - 1e-59 58.46% (195) riboflavin biosynthesis protein ribAB

Closest Orthologs (e-value cutoff: 1e-4)

species id gene e-value identity (len) annotation
M. bovis AF2122 / 97 Mb1450 ribA2 2e-57 55.90% (195) bifunctional 3,4-dihydroxy-2-butanone 4-phosphate
M. gilvum PYR-GCK Mflv_3719 - 9e-58 56.41% (195) bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP
M. tuberculosis H37Rv Rv1415 ribA2 2e-57 55.90% (195) bifunctional 3,4-dihydroxy-2-butanone 4-phosphate
M. leprae Br4923 MLBr_00559 ribA 1e-57 55.38% (195) bifunctional 3,4-dihydroxy-2-butanone 4-phosphate
M. abscessus ATCC 19977 MAB_2796c - 3e-55 54.36% (195) bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP
M. marinum M MMAR_2222 ribA2 1e-57 56.92% (195) riboflavin biosynthesis protein RibA2
M. avium 104 MAV_3365 - 3e-57 55.90% (195) bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP
M. smegmatis MC2 155 MSMEG_3072 - 4e-57 56.41% (195) bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP
M. ulcerans Agy99 MUL_1809 ribA2 2e-56 55.90% (195) bifunctional 3,4-dihydroxy-2-butanone 4-phosphate
M. vanbaalenii PYR-1 Mvan_2694 - 1e-57 56.41% (195) bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_2222|M.marinum_M               --------------------------------------------------
MUL_1809|M.ulcerans_Agy99           --------------------------------------------------
MAV_3365|M.avium_104                --------------------------------------------------
Mb1450|M.bovis_AF2122/97            --------------------------------------------------
Rv1415|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00559|M.leprae_Br4923          -----------------------------------------------MGP
Mflv_3719|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2694|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_2796c|M.abscessus_ATCC_199      --------------------------------------------------
MSMEG_3072|M.smegmatis_MC2_155      --------------------------------------------------
TH_0344|M.thermoresistible__bu      VATAHGSGVVAGGLARPGDDDYWRRCAAGGAAMVIAGGTVVSPDSANRTG
                                                                                      

MMAR_2222|M.marinum_M               -------MTRLDSVERAVADIGAG--KAVIVIDDEDRENEGDLIFAAEKA
MUL_1809|M.ulcerans_Agy99           -------MTRLDSVERAVADIGAG--KAVIVIDDEDRENEGDLIFAAEKA
MAV_3365|M.avium_104                -------MTRLDSVERAVADIAAG--KAVIVIDDEDRENEGDLIFAAEKA
Mb1450|M.bovis_AF2122/97            -------MTRLDSVERAVADIAAG--KAVIVIDDEDRENEGDLIFAAEKA
Rv1415|M.tuberculosis_H37Rv         -------MTRLDSVERAVADIAAG--KAVIVIDDEDRENEGDLIFAAEKA
MLBr_00559|M.leprae_Br4923          FDSKVAKMTRLDSVERAVADIAAG--KAVVVIDDEDRENEGDLIFAAEKA
Mflv_3719|M.gilvum_PYR-GCK          -------MTRLDSVERAVADIAAG--KAVVVIDDEDRENEGDLIFAAEKA
Mvan_2694|M.vanbaalenii_PYR-1       -------MTRLDSVERAVADIAAG--KAVVVIDDEDRENEGDLIFAAEKA
MAB_2796c|M.abscessus_ATCC_199      -------MTRLDSIERAVADIAAG--KAVVVVDDEDRENEGDLIFAAEKA
MSMEG_3072|M.smegmatis_MC2_155      -------MTRLDSVERAIADIAAG--KAVVVIDDEDRENEGDLIFAAEKA
TH_0344|M.thermoresistible__bu      NITEAWRPEAVDGLRRRASAIAREGAVPVCQLVHLGRETLGAEIWEHPVA
                                              :*.:.*  : *.     .*  : . .**. *  *:    *

MMAR_2222|M.marinum_M               TP-------------------------ELVAFMVRYTSGYLCVPLDGAVC
MUL_1809|M.ulcerans_Agy99           TP-------------------------ELVAFMVRYTSGYLCVPLDGAVC
MAV_3365|M.avium_104                TP-------------------------EMVAFMVRYTSGYLCVPLDGAIC
Mb1450|M.bovis_AF2122/97            TP-------------------------EMVAFMVRYTSGYLCVPLDGAIC
Rv1415|M.tuberculosis_H37Rv         TP-------------------------EMVAFMVRYTSGYLCVPLDGAIC
MLBr_00559|M.leprae_Br4923          TL-------------------------EMVAFMVRYTSGYLCAPLDGAIC
Mflv_3719|M.gilvum_PYR-GCK          TP-------------------------ELVAFMVRYTSGYLCVPLAGEIC
Mvan_2694|M.vanbaalenii_PYR-1       TP-------------------------ELVAFMVRYTSGYLCVPLAGDIC
MAB_2796c|M.abscessus_ATCC_199      TP-------------------------ELVAFMVRYTSGYLCVPLAGEDC
MSMEG_3072|M.smegmatis_MC2_155      TP-------------------------ELVAFMVRYTSGYLCVPLDGEIC
TH_0344|M.thermoresistible__bu      PSPVRSPREPVRARTMSESDIDRVIDDFVVSSRHAAEAGFRAVELHAAHG
                                    .                           :*:      :*: .. * .   

MMAR_2222|M.marinum_M               DRLGLLPMYAVNQ--DKHGTAYTVTVDAKNGVGTGISASDRATTMRLLAD
MUL_1809|M.ulcerans_Agy99           DRLGLLPMYAVNQ--DKHGTAYTVTVDAKNGVGTGISASDRATTMRLLAD
MAV_3365|M.avium_104                DRLGLLPMYAVNQ--DKHGTAYTVTVDARNGVGTGISASDRATTMRLLAD
Mb1450|M.bovis_AF2122/97            DRLGLLPMYAVNQ--DKHGTAYTVTVDARNGIGTGISASDRATTMRLLAD
Rv1415|M.tuberculosis_H37Rv         DRLGLLPMYAVNQ--DKHGTAYTVTVDARNGIGTGISASDRATTMRLLAD
MLBr_00559|M.leprae_Br4923          DRLGLLPMFAVNQ--DKHGTAYTVTVDARNGVGTGISASDRATTMRLLAD
Mflv_3719|M.gilvum_PYR-GCK          DRLGLLPMYAVNQ--DKHGTAYTVTVDAKVGVGTGISASDRATTMRLLAD
Mvan_2694|M.vanbaalenii_PYR-1       DRLGLLPMYAVNQ--DKHGTAYTVTVDAKKGVGTGISAMDRATTMRLLAD
MAB_2796c|M.abscessus_ATCC_199      DRLGLLPQYAVNQ--DKHGTAYTVTVDAKNGIGTGISASDRAATMRLLAD
MSMEG_3072|M.smegmatis_MC2_155      DRLGLLPMYAVNQ--DKHGTAYTVTVDAKKDVGTGISASDRATTMRALAN
TH_0344|M.thermoresistible__bu      YLLGQFLSPAINRRPDAQNTAGRVRILHRLRSAIVEACPDLVVGVRVSVE
                                      ** :   *:*:  * :.**  * :  :   .   :. * .. :*  .:

MMAR_2222|M.marinum_M               PASVAED----------FTRPGHVVPLRAKDGGVLRRPGHTEAAVDLARM
MUL_1809|M.ulcerans_Agy99           PASVAED----------FTRPGHVVPLRAKDGGVLRRPGHTEAAVDLARM
MAV_3365|M.avium_104                PTSIAED----------FTRPGHVVPLRAKDGGVLRRPGHTEAAVDLARM
Mb1450|M.bovis_AF2122/97            PTSVADD----------FTRPGHVVPLRAKDGGVLRRPGHTEAAVDLARM
Rv1415|M.tuberculosis_H37Rv         PTSVADD----------FTRPGHVVPLRAKDGGVLRRPGHTEAAVDLARM
MLBr_00559|M.leprae_Br4923          PASVADD----------FTRPGHVVPLRAKDGGVLRRPGHTEAAVDLARL
Mflv_3719|M.gilvum_PYR-GCK          PDSVADD----------FTKPGHVVPLRAKDGGVLRRPGHTEAAVDLARL
Mvan_2694|M.vanbaalenii_PYR-1       PDAVADD----------FTKPGHVVPLRAKDGGVLRRPGHTEAAVDLARL
MAB_2796c|M.abscessus_ATCC_199      AASTADD----------FTKPGHVVPLRAKDGGVLRRPGHTEASVDLAKL
MSMEG_3072|M.smegmatis_MC2_155      PGSVADD----------FTKPGHVVPLRAKDGGVLRRPGHTEAAVDLARL
TH_0344|M.thermoresistible__bu      DADEGDLGLDRVCEILPLLEPFDYLNVTVGVRTTYVRDMATAAPPLLPHI
                                        .:           : .* . : : .    .  *   * *.  *.::

MMAR_2222|M.marinum_M               AGLQPAGAICEIVSQKDEGSMAQTDELRVFADEHGLALITIAD-------
MUL_1809|M.ulcerans_Agy99           AGLQPAGAICEIVSRKDEGSMAQTDELRVFADEHGLALITIAD-------
MAV_3365|M.avium_104                AGLQPAGAICEIVSQKDEGSMAQTDELRVFADEHDLAMITIAD-------
Mb1450|M.bovis_AF2122/97            AGLQPAGAICEIVSQKDEGSMAHTDELRVFADEHGLALITIAD-------
Rv1415|M.tuberculosis_H37Rv         AGLQPAGAICEIVSQKDEGSMAHTDELRVFADEHGLALITIAD-------
MLBr_00559|M.leprae_Br4923          AGLQPAGAICEIVSQKDEGSMAQTDELRVFADEHDLALITIAD-------
Mflv_3719|M.gilvum_PYR-GCK          AGLQAAGTICEIVSQKDEGAMAQTDELRIFADEHDLALISIAD-------
Mvan_2694|M.vanbaalenii_PYR-1       AGLQPAGAICEIVSQKDEGAMAQTDELRIFADEHDLALISIAD-------
MAB_2796c|M.abscessus_ATCC_199      AGLRPAAVICEIVSQKDEGAMAQTEELRVFADEHNLALVSIAD-------
MSMEG_3072|M.smegmatis_MC2_155      AGLQPAGAICEIVSQKDEGDMARTDELRVFADDHDLALISIAD-------
TH_0344|M.thermoresistible__bu      ERLRGATSKPLLVSQAFRSRDDIESALHRGADLIGLARPLIADPELPRKL
                                      *: *     :**:  ..     . *:  **  .**   ***       

MMAR_2222|M.marinum_M               --------------------------------------------------
MUL_1809|M.ulcerans_Agy99           --------------------------------------------------
MAV_3365|M.avium_104                --------------------------------------------------
Mb1450|M.bovis_AF2122/97            --------------------------------------------------
Rv1415|M.tuberculosis_H37Rv         --------------------------------------------------
MLBr_00559|M.leprae_Br4923          --------------------------------------------------
Mflv_3719|M.gilvum_PYR-GCK          --------------------------------------------------
Mvan_2694|M.vanbaalenii_PYR-1       --------------------------------------------------
MAB_2796c|M.abscessus_ATCC_199      --------------------------------------------------
MSMEG_3072|M.smegmatis_MC2_155      --------------------------------------------------
TH_0344|M.thermoresistible__bu      ISGADSRIRPCVSCNEDCRSFTPVLLCTVNPTLAPPGQSARPATPLRFGT
                                                                                      

MMAR_2222|M.marinum_M               ----------------LIEWR--------RKHEKHIERVAEARIPTRHGE
MUL_1809|M.ulcerans_Agy99           ----------------LIEWR--------RKHEKHIERVAEARIPTRRGE
MAV_3365|M.avium_104                ----------------LIEWR--------RKHEKHIERIAEARIPTRHGE
Mb1450|M.bovis_AF2122/97            ----------------LIEWR--------RKHEKHIERVAEARIPTRHGE
Rv1415|M.tuberculosis_H37Rv         ----------------LIEWR--------RKHEKHIERVAEARIPTRHGE
MLBr_00559|M.leprae_Br4923          ----------------LIAWR--------RKHEKHIERVAEARIPTRHGE
Mflv_3719|M.gilvum_PYR-GCK          ----------------LIEWR--------RKHEKHIARVAEARIPTRHGE
Mvan_2694|M.vanbaalenii_PYR-1       ----------------LIEWR--------RKHEKHIARVAEARIPTRHGE
MAB_2796c|M.abscessus_ATCC_199      ----------------LIEWR--------RKHEKHVQRIAEARIPTQHGE
MSMEG_3072|M.smegmatis_MC2_155      ----------------LIEWR--------RKHEKHIERIAEARIPTRHGE
TH_0344|M.thermoresistible__bu      APGTPARVAVVGAGPAGLEXXXGAPGLVGAAQPGGVRRTGIAEIPTRHGS
                                                     :             :   : * . *.***::*.

MMAR_2222|M.marinum_M               FRAIGYTSIYEDVEHVALVRGEIAGPNSDGDDVLVRVHSECLTGDVFGSR
MUL_1809|M.ulcerans_Agy99           FRAIGYTSIYENVEHVALVRGEIAGPNSDGDDVLVRVHSECLTGDVFGSR
MAV_3365|M.avium_104                FRAIGYTSIYEEVEHVALVRGEIAGPNSDGDDVLVRVHSECLTGDVFGSR
Mb1450|M.bovis_AF2122/97            FRAIGYTSIYEDVEHVALVRGEIAGPNADGDDVLVRVHSECLTGDVFGSR
Rv1415|M.tuberculosis_H37Rv         FRAIGYTSIYEDVEHVALVRGEIAGPNADGDDVLVRVHSECLTGDVFGSR
MLBr_00559|M.leprae_Br4923          FRAIGYTSIYDDVKHVALVRGEIAGSSGDGDDILVRVHSECLTGDVFGSR
Mflv_3719|M.gilvum_PYR-GCK          FRAVGYTSIYEDVEHVALVKGDIAGPHGDGHDVLVRVHSECLTGDVFGSR
Mvan_2694|M.vanbaalenii_PYR-1       FRAVGYTSIYEDVEHVALVKGEISGPHSDGHDVLVRVHSECLTGDVFGSR
MAB_2796c|M.abscessus_ATCC_199      FRAVGYTSIYDDVEHVALVLGDISGPDGDGNDVLVRVHSECLTGDVFGSR
MSMEG_3072|M.smegmatis_MC2_155      FRAVGYKSIYEDVEHVALVRGEISGPGSDGDDVLVRVHSECLTGDVFGSR
TH_0344|M.thermoresistible__bu      FQAIAYQSETGEHEHLALVRGDLEQLHDLPEGVLTRIHSECLTGDVVGSL
                                    *:*:.* *   : :*:*** *::       ..:*.*:*********.** 

MMAR_2222|M.marinum_M               RCDCGPQLDAAMAMVAREGRGVVLYMRGHEGRGIGLLHKLQAYQLQDAGD
MUL_1809|M.ulcerans_Agy99           RCDCGSQLDAAMAMVAREGRGVVLYMRGHEGRGIGLLHKLQTYQLQDAGD
MAV_3365|M.avium_104                RCDCGPQLDAAMAMVAREGRGIVLYMRGHEGRGIGLMHKLQAYQLQDAGE
Mb1450|M.bovis_AF2122/97            RCDCGPQLDAALAMVAREGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGA
Rv1415|M.tuberculosis_H37Rv         RCDCGPQLDAALAMVAREGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGA
MLBr_00559|M.leprae_Br4923          RCDCGTQLDAAMAMVAREGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGA
Mflv_3719|M.gilvum_PYR-GCK          RCDCGPQLDAALAMVAREGRGIVLYMRGHEGRGIGLMHKLQAYQLQDAGD
Mvan_2694|M.vanbaalenii_PYR-1       RCDCGPQLDAALAMVAREGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGD
MAB_2796c|M.abscessus_ATCC_199      RCDCGPQLDAAMEMVAKEGRGIVLYMRGHEGRGIGLMHKLQAYQLQDAGE
MSMEG_3072|M.smegmatis_MC2_155      RCDCGPQLDAAMAMVAREGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGE
TH_0344|M.thermoresistible__bu      RCDCGAQLDAAIAALAAEPAGVLIYLRGQEGRGIGLGPKLCAYALQEAGL
                                    *****.*****:  :* *  *:::*:**:*******  ** :* **:** 

MMAR_2222|M.marinum_M               DTVDANLKLGLPADARDYGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYG
MUL_1809|M.ulcerans_Agy99           DTVDANLKLGLPADARDYGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYG
MAV_3365|M.avium_104                DTVDANLKLGFPADARDYGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYG
Mb1450|M.bovis_AF2122/97            DTVDANLKLGLPADARDYGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYG
Rv1415|M.tuberculosis_H37Rv         DTVDANLKLGLPADARDYGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYG
MLBr_00559|M.leprae_Br4923          DTVDANIKLGFPSDARDYGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYG
Mflv_3719|M.gilvum_PYR-GCK          DTVDANLKLGLPADARDYGTGAQILVDLGVRSMRLLTNNPAKRVGLDGYG
Mvan_2694|M.vanbaalenii_PYR-1       DTVDANLKLGLPADARDYGTGAQILVDLGVRSMRLLTNNPAKRVGLDGYG
MAB_2796c|M.abscessus_ATCC_199      DTVDANLKLGLPADARDYGLGAQILVDLGVKSMRLLTNNPAKRVGLDGYG
MSMEG_3072|M.smegmatis_MC2_155      DTVDANLKLGLPADARDYGIGAQILVDLGIRSMRLLTNNPAKRVGLDGYG
TH_0344|M.thermoresistible__bu      DTVDANRALGLPVDCRDYGVAAAILHHLGIRRVRLITNNGAKSAALSRHG
                                    ******  **:* *.**** .* ** .**:: :**:*** ** ..*. :*

MMAR_2222|M.marinum_M               LHIIERVPLPVRANAENIRYLMTKRDRMGHDLTG---LDDFHESVHLPG-
MUL_1809|M.ulcerans_Agy99           LHIIERVPLPVRANAENIRYLMTKRDRMGHDLTG---LDDFHESVHLPG-
MAV_3365|M.avium_104                LHIIERVPLPVRANAENIRYLMTKRDKMGHDLAG---LDDFHESVHLPG-
Mb1450|M.bovis_AF2122/97            LHIIERVPLPVRANAENIRYLMTKRDKLGHDLAG---LDDFHESVHLPG-
Rv1415|M.tuberculosis_H37Rv         LHIIERVPLPVRANAENIRYLMTKRDKLGHDLAG---LDDFHESVHLPG-
MLBr_00559|M.leprae_Br4923          LQIIERVPLPVRANADNIRYLMTKRDKMGHDLGG---LDDFHESNYFPG-
Mflv_3719|M.gilvum_PYR-GCK          LHIIERVPLPVRANAENIRYLMTKRDRMGHDLVG---LDDFDEAVPG---
Mvan_2694|M.vanbaalenii_PYR-1       LHIIERVPLPVRANAENIRYLMTKRDRMGHDLVG---LEDFDEAVPG---
MAB_2796c|M.abscessus_ATCC_199      LHIIERVPLPVRANSENIRYLRTKRDRMGHDLAD---LDDHPEADGA---
MSMEG_3072|M.smegmatis_MC2_155      LHIIERVPLPVRANKENIRYLMTKRDRMGHDLVG---LDDYDEAVSMDDY
TH_0344|M.thermoresistible__bu      VEVSSTVHHPPHVTADNVSYLQTKRDRMGHLLPATLPVPAEPDPIRLTPS
                                    :.: . *  * :.. :*: ** ****::** *     :    :.      

MMAR_2222|M.marinum_M               -------------EFGGAL
MUL_1809|M.ulcerans_Agy99           -------------EFGGAL
MAV_3365|M.avium_104                -------------EFGGAL
Mb1450|M.bovis_AF2122/97            -------------EFGGAL
Rv1415|M.tuberculosis_H37Rv         -------------EFGGAL
MLBr_00559|M.leprae_Br4923          -------------EFGGAL
Mflv_3719|M.gilvum_PYR-GCK          -------------EFGGAV
Mvan_2694|M.vanbaalenii_PYR-1       -------------ELGGAV
MAB_2796c|M.abscessus_ATCC_199      -------------------
MSMEG_3072|M.smegmatis_MC2_155      DEAVYLLGDRRPTESGGAQ
TH_0344|M.thermoresistible__bu      NPSTSDDKPLINTVRKVAP

species	id	gene	e-value	identity (len)	annotation
M. thermoresistible (build 8)	TH_0344	ribA2	-	100% (620)	PROBABLE RIBOFLAVIN BIOSYNTHESIS PROTEIN RIBA2 : GTP cyclohydrolase II + 3,4-dihydroxy-2-butanone 4-phosphate synthase (DHBP synthase)
M. thermoresistible (build 8)	TH_2774	-	2e-89	43.82% (477)	PUTATIVE putative NADPH dependent 2,4-dienoyl-CoA reductase
M. thermoresistible (build 8)	TH_1011	-	1e-59	58.46% (195)	riboflavin biosynthesis protein ribAB