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MPGGHIRLTSHSGGADAPALQWGAATAAERGPVVGTTTTRGHRNVIGTHSGAYGVYRALAVAAGALSREH RADLTNTSPTDVIGPYPQWADPETIVSLDPWGAMVADAFRGQIADGVDIRPTIAVTKAQVILPEVHDALA RGRLTPDGRVLLSTGAAQVTKAAIEPVWHLPGVARRFGCSESDLRRVLFEETGGMYPELVTRSDLEVFLP PIGGQTIYIFGDPRDLADPSVELTARVHDECNGSDVFGSDICTCRPYLTHAIEECIQGAQRGGVGLIAYS RKEGRALGEVTKFLVYNARKRQVGGDTADQYFARTECVAGVQDMRFQELMPDVLHWLGIRTIHRLVSMSN MKYDAITGSGIEVGERVSIPDELIPADAQVEIDAKTAAGYYTAGVVPDTDELKKAKGRGLQP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_3257 | - | - | 100% (412) | hypothetical protein Mflv_3257 |
| M. gilvum PYR-GCK | Mflv_3719 | - | 4e-09 | 32.00% (150) | bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1450 | ribA2 | 1e-09 | 28.57% (175) | bifunctional 3,4-dihydroxy-2-butanone 4-phosphate |
| M. tuberculosis H37Rv | Rv1415 | ribA2 | 1e-09 | 28.57% (175) | bifunctional 3,4-dihydroxy-2-butanone 4-phosphate |
| M. leprae Br4923 | MLBr_00559 | ribA | 2e-09 | 31.43% (140) | bifunctional 3,4-dihydroxy-2-butanone 4-phosphate |
| M. abscessus ATCC 19977 | MAB_2796c | - | 2e-09 | 32.14% (140) | bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP |
| M. marinum M | MMAR_2222 | ribA2 | 4e-09 | 32.14% (140) | riboflavin biosynthesis protein RibA2 |
| M. avium 104 | MAV_3365 | - | 2e-09 | 29.09% (165) | bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP |
| M. smegmatis MC2 155 | MSMEG_3471 | - | 0.0 | 84.48% (406) | hypothetical protein MSMEG_3471 |
| M. thermoresistible (build 8) | TH_1011 | - | 1e-09 | 32.00% (150) | riboflavin biosynthesis protein ribAB |
| M. ulcerans Agy99 | MUL_1809 | ribA2 | 2e-08 | 31.43% (140) | bifunctional 3,4-dihydroxy-2-butanone 4-phosphate |
| M. vanbaalenii PYR-1 | Mvan_2974 | - | 0.0 | 89.73% (409) | hypothetical protein Mvan_2974 |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1450|M.bovis_AF2122/97 ----------MTRLDSVERAVADIAAGKAVIVIDDEDRENEGDLIFAAEK
Rv1415|M.tuberculosis_H37Rv ----------MTRLDSVERAVADIAAGKAVIVIDDEDRENEGDLIFAAEK
MAV_3365|M.avium_104 ----------MTRLDSVERAVADIAAGKAVIVIDDEDRENEGDLIFAAEK
MMAR_2222|M.marinum_M ----------MTRLDSVERAVADIGAGKAVIVIDDEDRENEGDLIFAAEK
MUL_1809|M.ulcerans_Agy99 ----------MTRLDSVERAVADIGAGKAVIVIDDEDRENEGDLIFAAEK
MLBr_00559|M.leprae_Br4923 MGPFDSKVAKMTRLDSVERAVADIAAGKAVVVIDDEDRENEGDLIFAAEK
MAB_2796c|M.abscessus_ATCC_199 ----------MTRLDSIERAVADIAAGKAVVVVDDEDRENEGDLIFAAEK
TH_1011|M.thermoresistible__bu ----------MVRLDSVDRAVADIAAGKAVVVIDDEDRENEGDLIFAAEK
Mflv_3257|M.gilvum_PYR-GCK ----------------------MPGG--HIRLTSHSGGADAPALQWGAAT
Mvan_2974|M.vanbaalenii_PYR-1 -----------MSTDAVPPPAKPPGG--HIRLTSHSAGSDAPALRWGAPT
MSMEG_3471|M.smegmatis_MC2_155 ---------MVAEPNPVPPAATARSAPRHIRLTSHHGAEGALAIRWGAPT
.. : : .. . : :.* .
Mb1450|M.bovis_AF2122/97 ATPEMVAFMVRYTSGYLCVP-LDGAICDRLGLLPMYAVNQDKHGTAYTVT
Rv1415|M.tuberculosis_H37Rv ATPEMVAFMVRYTSGYLCVP-LDGAICDRLGLLPMYAVNQDKHGTAYTVT
MAV_3365|M.avium_104 ATPEMVAFMVRYTSGYLCVP-LDGAICDRLGLLPMYAVNQDKHGTAYTVT
MMAR_2222|M.marinum_M ATPELVAFMVRYTSGYLCVP-LDGAVCDRLGLLPMYAVNQDKHGTAYTVT
MUL_1809|M.ulcerans_Agy99 ATPELVAFMVRYTSGYLCVP-LDGAVCDRLGLLPMYAVNQDKHGTAYTVT
MLBr_00559|M.leprae_Br4923 ATLEMVAFMVRYTSGYLCAP-LDGAICDRLGLLPMFAVNQDKHGTAYTVT
MAB_2796c|M.abscessus_ATCC_199 ATPELVAFMVRYTSGYLCVP-LAGEDCDRLGLLPQYAVNQDKHGTAYTVT
TH_1011|M.thermoresistible__bu ATPELVAFMVRYTSGYLCVP-LEGEICDRLGLLPMYAMNQDKHGTAYTVT
Mflv_3257|M.gilvum_PYR-GCK AAERGPVVGTTTTRGHRNVIGTHSGAYGVYRALAVAAGALSREHRADLTN
Mvan_2974|M.vanbaalenii_PYR-1 AAERGPLVGTTTKRAHRNVIGTHSGAYGVYRALAVAAGKLSREHRADLTN
MSMEG_3471|M.smegmatis_MC2_155 AAERGPLIGTTTTRAHRNVIGTHSGSYSVYRALAVASGALSPEHRADLTN
*: . . . . .: . . . *. : . . * ..
Mb1450|M.bovis_AF2122/97 VDARNGIGTGISASDRATTMRLLADPTSVADDFTRPGHVVPLRAKDGGVL
Rv1415|M.tuberculosis_H37Rv VDARNGIGTGISASDRATTMRLLADPTSVADDFTRPGHVVPLRAKDGGVL
MAV_3365|M.avium_104 VDARNGVGTGISASDRATTMRLLADPTSIAEDFTRPGHVVPLRAKDGGVL
MMAR_2222|M.marinum_M VDAKNGVGTGISASDRATTMRLLADPASVAEDFTRPGHVVPLRAKDGGVL
MUL_1809|M.ulcerans_Agy99 VDAKNGVGTGISASDRATTMRLLADPASVAEDFTRPGHVVPLRAKDGGVL
MLBr_00559|M.leprae_Br4923 VDARNGVGTGISASDRATTMRLLADPASVADDFTRPGHVVPLRAKDGGVL
MAB_2796c|M.abscessus_ATCC_199 VDAKNGIGTGISASDRAATMRLLADAASTADDFTKPGHVVPLRAKDGGVL
TH_1011|M.thermoresistible__bu VDAKHGVTTGISAADRATTMRLLADPNAVADDFTRPGHVVPLRAKEGGVL
Mflv_3257|M.gilvum_PYR-GCK TSPTDVIGPYPQWADPETIVSLDPWGAMVADAFRG--------QIADGVD
Mvan_2974|M.vanbaalenii_PYR-1 TAPTDIIGPHPQWADPETIVSLDPWGAMVADVFAR--------EIADGVD
MSMEG_3471|M.smegmatis_MC2_155 TAPTDVIGPYAQWSDPSAIVSLDPWGAMVAEAFTT--------ELAAGFD
. . . : . . :* : : * . *: * *.
Mb1450|M.bovis_AF2122/97 RRPGHTEAAVDLARMAGLQPAGAICEIVSQKDEGSMAHTDELRVFADEHG
Rv1415|M.tuberculosis_H37Rv RRPGHTEAAVDLARMAGLQPAGAICEIVSQKDEGSMAHTDELRVFADEHG
MAV_3365|M.avium_104 RRPGHTEAAVDLARMAGLQPAGAICEIVSQKDEGSMAQTDELRVFADEHD
MMAR_2222|M.marinum_M RRPGHTEAAVDLARMAGLQPAGAICEIVSQKDEGSMAQTDELRVFADEHG
MUL_1809|M.ulcerans_Agy99 RRPGHTEAAVDLARMAGLQPAGAICEIVSRKDEGSMAQTDELRVFADEHG
MLBr_00559|M.leprae_Br4923 RRPGHTEAAVDLARLAGLQPAGAICEIVSQKDEGSMAQTDELRVFADEHD
MAB_2796c|M.abscessus_ATCC_199 RRPGHTEASVDLAKLAGLRPAAVICEIVSQKDEGAMAQTEELRVFADEHN
TH_1011|M.thermoresistible__bu RRPGHTEAAVDLAKLAGLQPAGAICEIVSQKDEGAMAKTDELRVFADDHG
Mflv_3257|M.gilvum_PYR-GCK IRP---TIAVTKAQVILPEVHDALARGRLTPD-GRVLLSTGAAQVTKAAI
Mvan_2974|M.vanbaalenii_PYR-1 IRP---TIAVTKAQVILPEVHDAIGKARLIPD-GRVLLGNGAAQVTKAAI
MSMEG_3471|M.smegmatis_MC2_155 IRP---TIAITKAHVILPEIADAIAKGRLQPD-GRILLPNGAALVTKAAI
** :: *:: . .: . * * : .:.
Mb1450|M.bovis_AF2122/97 LALITIADLIEWRRKHEKHIERVAEARIPTRHGEFRAIGYTSIYED--VE
Rv1415|M.tuberculosis_H37Rv LALITIADLIEWRRKHEKHIERVAEARIPTRHGEFRAIGYTSIYED--VE
MAV_3365|M.avium_104 LAMITIADLIEWRRKHEKHIERIAEARIPTRHGEFRAIGYTSIYEE--VE
MMAR_2222|M.marinum_M LALITIADLIEWRRKHEKHIERVAEARIPTRHGEFRAIGYTSIYED--VE
MUL_1809|M.ulcerans_Agy99 LALITIADLIEWRRKHEKHIERVAEARIPTRRGEFRAIGYTSIYEN--VE
MLBr_00559|M.leprae_Br4923 LALITIADLIAWRRKHEKHIERVAEARIPTRHGEFRAIGYTSIYDD--VK
MAB_2796c|M.abscessus_ATCC_199 LALVSIADLIEWRRKHEKHVQRIAEARIPTQHGEFRAVGYTSIYDD--VE
TH_1011|M.thermoresistible__bu LAMISIADLIEWRRKHEKHVERVAEARIPTRHGEFRAVGYTSIYDD--VE
Mflv_3257|M.gilvum_PYR-GCK EPVWHLPGVARRFGCSESDLRRVLFEETGGMYPELVTRSDLEVFLPPIGG
Mvan_2974|M.vanbaalenii_PYR-1 EPVWYLPGVARRFGCSETDLRRALFEETGGMYPELVTRSDLDVFLPPIGG
MSMEG_3471|M.smegmatis_MC2_155 EPVWYLPGVAARFGCSETTLRRVLFEETGGMYPELVTRSDLEVFLPPIGG
.: :..: *. :.* . *: : . .::
Mb1450|M.bovis_AF2122/97 HVALVRGEIAGPNADGDDVLVRVHSECLTGDVFGSRRCDCGPQLDAALAM
Rv1415|M.tuberculosis_H37Rv HVALVRGEIAGPNADGDDVLVRVHSECLTGDVFGSRRCDCGPQLDAALAM
MAV_3365|M.avium_104 HVALVRGEIAGPNSDGDDVLVRVHSECLTGDVFGSRRCDCGPQLDAAMAM
MMAR_2222|M.marinum_M HVALVRGEIAGPNSDGDDVLVRVHSECLTGDVFGSRRCDCGPQLDAAMAM
MUL_1809|M.ulcerans_Agy99 HVALVRGEIAGPNSDGDDVLVRVHSECLTGDVFGSRRCDCGSQLDAAMAM
MLBr_00559|M.leprae_Br4923 HVALVRGEIAGSSGDGDDILVRVHSECLTGDVFGSRRCDCGTQLDAAMAM
MAB_2796c|M.abscessus_ATCC_199 HVALVLGDISGPDGDGNDVLVRVHSECLTGDVFGSRRCDCGPQLDAAMEM
TH_1011|M.thermoresistible__bu HVALVMGDIAGPHGDGHDVLVRVHSECLTGDVFGSRRCDCGPQLDAALSM
Mflv_3257|M.gilvum_PYR-GCK QTIYIFGDPRDLADPSVELTARVHDECNGSDVFGSDICTCRPYLTHAIEE
Mvan_2974|M.vanbaalenii_PYR-1 QTIYVFGDPRALADPGVELTARVHDECNGSDVFGSDICTCRPYLTHAIEE
MSMEG_3471|M.smegmatis_MC2_155 QTLYIFGNARDLADSSVELTARVHDECNGSDVFGSDICTCRPYLTHAIEE
:. : *: . :: .***.** .***** * * . * *:
Mb1450|M.bovis_AF2122/97 VAR----EGRGVVLYMRGHEGRGIGLMHKLQAY--QLQDAGADTVDANLK
Rv1415|M.tuberculosis_H37Rv VAR----EGRGVVLYMRGHEGRGIGLMHKLQAY--QLQDAGADTVDANLK
MAV_3365|M.avium_104 VAR----EGRGIVLYMRGHEGRGIGLMHKLQAY--QLQDAGEDTVDANLK
MMAR_2222|M.marinum_M VAR----EGRGVVLYMRGHEGRGIGLLHKLQAY--QLQDAGDDTVDANLK
MUL_1809|M.ulcerans_Agy99 VAR----EGRGVVLYMRGHEGRGIGLLHKLQTY--QLQDAGDDTVDANLK
MLBr_00559|M.leprae_Br4923 VAR----EGRGVVLYMRGHEGRGIGLMHKLQAY--QLQDAGADTVDANIK
MAB_2796c|M.abscessus_ATCC_199 VAK----EGRGIVLYMRGHEGRGIGLMHKLQAY--QLQDAGEDTVDANLK
TH_1011|M.thermoresistible__bu VAR----EGRGVVLYMRGHEGRGIGLMHKLQAY--QLQDAGEDTVDANLK
Mflv_3257|M.gilvum_PYR-GCK CIQGAQRGGVGLIAYSR-KEGRALGEVTKFLVYNARKRQVGGDTADQYFA
Mvan_2974|M.vanbaalenii_PYR-1 CIQGAQRGGVGLVAYFR-KEGRALGEVTKFLVYNARKRQAGGDTADQYFA
MSMEG_3471|M.smegmatis_MC2_155 CIRGAQRGGVGLVAYSR-KEGRALGEVTKFLVYNARKRQAGGDTADQYFA
: * *:: * * :***.:* : *: .* : ::.* **.* :
Mb1450|M.bovis_AF2122/97 ----LGLPADARDYGIGAQILVDLGVRSMR-LLTNNPAKRVGLDGYGLHI
Rv1415|M.tuberculosis_H37Rv ----LGLPADARDYGIGAQILVDLGVRSMR-LLTNNPAKRVGLDGYGLHI
MAV_3365|M.avium_104 ----LGFPADARDYGIGAQILVDLGVRSMR-LLTNNPAKRVGLDGYGLHI
MMAR_2222|M.marinum_M ----LGLPADARDYGIGAQILVDLGVRSMR-LLTNNPAKRVGLDGYGLHI
MUL_1809|M.ulcerans_Agy99 ----LGLPADARDYGIGAQILVDLGVRSMR-LLTNNPAKRVGLDGYGLHI
MLBr_00559|M.leprae_Br4923 ----LGFPSDARDYGIGAQILVDLGVRSMR-LLTNNPAKRVGLDGYGLQI
MAB_2796c|M.abscessus_ATCC_199 ----LGLPADARDYGLGAQILVDLGVKSMR-LLTNNPAKRVGLDGYGLHI
TH_1011|M.thermoresistible__bu ----LGLPADARDYGIGAQILVDLGVRSMR-LLTNNPAKRAGLDGYGLHI
Mflv_3257|M.gilvum_PYR-GCK RTECVAGVQDMRFQELMPDVLHWLGIRTIHRLVSMSNMKYDAITGSGIEV
Mvan_2974|M.vanbaalenii_PYR-1 RTECVAGVQDMRFQELMPDVLHWLGIRKIHRFVSMSNMKYDAITGSGIEI
MSMEG_3471|M.smegmatis_MC2_155 RTECVAGVQDMRFQELMPDVLHWLGIRKIHRLVSMSNMKYDAIVGSGIEV
:. * * : .::* **::.:: ::: . * .: * *:.:
Mb1450|M.bovis_AF2122/97 IERVPLPVRANAENIRYLMTKRDKLGHDLAGLDDFHESVHLPG-------
Rv1415|M.tuberculosis_H37Rv IERVPLPVRANAENIRYLMTKRDKLGHDLAGLDDFHESVHLPG-------
MAV_3365|M.avium_104 IERVPLPVRANAENIRYLMTKRDKMGHDLAGLDDFHESVHLPG-------
MMAR_2222|M.marinum_M IERVPLPVRANAENIRYLMTKRDRMGHDLTGLDDFHESVHLPG-------
MUL_1809|M.ulcerans_Agy99 IERVPLPVRANAENIRYLMTKRDRMGHDLTGLDDFHESVHLPG-------
MLBr_00559|M.leprae_Br4923 IERVPLPVRANADNIRYLMTKRDKMGHDLGGLDDFHESNYFPG-------
MAB_2796c|M.abscessus_ATCC_199 IERVPLPVRANSENIRYLRTKRDRMGHDLADLDDHPEADGA---------
TH_1011|M.thermoresistible__bu IERVPLPVRATADNIRYLMTKRDRMGHDLVGLEDFDESVRMDDYDEGVYL
Mflv_3257|M.gilvum_PYR-GCK GERVSIPDELIPADAQVEIDAKTAAGYYTAGVVPDTDELKKAK-------
Mvan_2974|M.vanbaalenii_PYR-1 GERVSIPDDLIPADAQVEIDAKMAAGYYTPGQVPGADELKKPK-------
MSMEG_3471|M.smegmatis_MC2_155 GERINIPEELIPADARVEIDAKMAAGYFTPGPVPDAEELKIAK-------
**: :* . : : : *: . :
Mb1450|M.bovis_AF2122/97 ---------EFGGAL--
Rv1415|M.tuberculosis_H37Rv ---------EFGGAL--
MAV_3365|M.avium_104 ---------EFGGAL--
MMAR_2222|M.marinum_M ---------EFGGAL--
MUL_1809|M.ulcerans_Agy99 ---------EFGGAL--
MLBr_00559|M.leprae_Br4923 ---------EFGGAL--
MAB_2796c|M.abscessus_ATCC_199 -----------------
TH_1011|M.thermoresistible__bu LGDRRPTDLDLGGAL--
Mflv_3257|M.gilvum_PYR-GCK -----------GRGLQP
Mvan_2974|M.vanbaalenii_PYR-1 -----------GRGLHG
MSMEG_3471|M.smegmatis_MC2_155 -----------GRELA-