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TRLDSIERAVADIAAGKAVVVVDDEDRENEGDLIFAAEKATPELVAFMVRYTSGYLCVPLAGEDCDRLGL LPQYAVNQDKHGTAYTVTVDAKNGIGTGISASDRAATMRLLADAASTADDFTKPGHVVPLRAKDGGVLRR PGHTEASVDLAKLAGLRPAAVICEIVSQKDEGAMAQTEELRVFADEHNLALVSIADLIEWRRKHEKHVQR IAEARIPTQHGEFRAVGYTSIYDDVEHVALVLGDISGPDGDGNDVLVRVHSECLTGDVFGSRRCDCGPQL DAAMEMVAKEGRGIVLYMRGHEGRGIGLMHKLQAYQLQDAGEDTVDANLKLGLPADARDYGLGAQILVDL GVKSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRANSENIRYLRTKRDRMGHDLADLDDHPEADGA*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. abscessus ATCC 19977 | MAB_2796c | - | - | 100% (417) | bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1450 | ribA2 | 0.0 | 87.20% (414) | bifunctional 3,4-dihydroxy-2-butanone 4-phosphate |
| M. gilvum PYR-GCK | Mflv_3719 | - | 0.0 | 90.10% (414) | bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP |
| M. tuberculosis H37Rv | Rv1415 | ribA2 | 0.0 | 87.20% (414) | bifunctional 3,4-dihydroxy-2-butanone 4-phosphate |
| M. leprae Br4923 | MLBr_00559 | ribA | 0.0 | 85.30% (415) | bifunctional 3,4-dihydroxy-2-butanone 4-phosphate |
| M. marinum M | MMAR_2222 | ribA2 | 0.0 | 87.68% (414) | riboflavin biosynthesis protein RibA2 |
| M. avium 104 | MAV_3365 | - | 0.0 | 87.44% (414) | bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP |
| M. smegmatis MC2 155 | MSMEG_3072 | - | 0.0 | 88.41% (414) | bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP |
| M. thermoresistible (build 8) | TH_1011 | - | 0.0 | 87.20% (414) | riboflavin biosynthesis protein ribAB |
| M. ulcerans Agy99 | MUL_1809 | ribA2 | 0.0 | 86.47% (414) | bifunctional 3,4-dihydroxy-2-butanone 4-phosphate |
| M. vanbaalenii PYR-1 | Mvan_2694 | - | 0.0 | 88.89% (414) | bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1450|M.bovis_AF2122/97 ----------MTRLDSVERAVADIAAGKAVIVIDDEDRENEGDLIFAAEK
Rv1415|M.tuberculosis_H37Rv ----------MTRLDSVERAVADIAAGKAVIVIDDEDRENEGDLIFAAEK
MAV_3365|M.avium_104 ----------MTRLDSVERAVADIAAGKAVIVIDDEDRENEGDLIFAAEK
MLBr_00559|M.leprae_Br4923 MGPFDSKVAKMTRLDSVERAVADIAAGKAVVVIDDEDRENEGDLIFAAEK
MMAR_2222|M.marinum_M ----------MTRLDSVERAVADIGAGKAVIVIDDEDRENEGDLIFAAEK
MUL_1809|M.ulcerans_Agy99 ----------MTRLDSVERAVADIGAGKAVIVIDDEDRENEGDLIFAAEK
Mflv_3719|M.gilvum_PYR-GCK ----------MTRLDSVERAVADIAAGKAVVVIDDEDRENEGDLIFAAEK
Mvan_2694|M.vanbaalenii_PYR-1 ----------MTRLDSVERAVADIAAGKAVVVIDDEDRENEGDLIFAAEK
MSMEG_3072|M.smegmatis_MC2_155 ----------MTRLDSVERAIADIAAGKAVVVIDDEDRENEGDLIFAAEK
TH_1011|M.thermoresistible__bu ----------MVRLDSVDRAVADIAAGKAVVVIDDEDRENEGDLIFAAEK
MAB_2796c|M.abscessus_ATCC_199 ----------MTRLDSIERAVADIAAGKAVVVVDDEDRENEGDLIFAAEK
*.****::**:***.*****:*:*****************
Mb1450|M.bovis_AF2122/97 ATPEMVAFMVRYTSGYLCVPLDGAICDRLGLLPMYAVNQDKHGTAYTVTV
Rv1415|M.tuberculosis_H37Rv ATPEMVAFMVRYTSGYLCVPLDGAICDRLGLLPMYAVNQDKHGTAYTVTV
MAV_3365|M.avium_104 ATPEMVAFMVRYTSGYLCVPLDGAICDRLGLLPMYAVNQDKHGTAYTVTV
MLBr_00559|M.leprae_Br4923 ATLEMVAFMVRYTSGYLCAPLDGAICDRLGLLPMFAVNQDKHGTAYTVTV
MMAR_2222|M.marinum_M ATPELVAFMVRYTSGYLCVPLDGAVCDRLGLLPMYAVNQDKHGTAYTVTV
MUL_1809|M.ulcerans_Agy99 ATPELVAFMVRYTSGYLCVPLDGAVCDRLGLLPMYAVNQDKHGTAYTVTV
Mflv_3719|M.gilvum_PYR-GCK ATPELVAFMVRYTSGYLCVPLAGEICDRLGLLPMYAVNQDKHGTAYTVTV
Mvan_2694|M.vanbaalenii_PYR-1 ATPELVAFMVRYTSGYLCVPLAGDICDRLGLLPMYAVNQDKHGTAYTVTV
MSMEG_3072|M.smegmatis_MC2_155 ATPELVAFMVRYTSGYLCVPLDGEICDRLGLLPMYAVNQDKHGTAYTVTV
TH_1011|M.thermoresistible__bu ATPELVAFMVRYTSGYLCVPLEGEICDRLGLLPMYAMNQDKHGTAYTVTV
MAB_2796c|M.abscessus_ATCC_199 ATPELVAFMVRYTSGYLCVPLAGEDCDRLGLLPQYAVNQDKHGTAYTVTV
** *:*************.** * ******** :*:*************
Mb1450|M.bovis_AF2122/97 DARNGIGTGISASDRATTMRLLADPTSVADDFTRPGHVVPLRAKDGGVLR
Rv1415|M.tuberculosis_H37Rv DARNGIGTGISASDRATTMRLLADPTSVADDFTRPGHVVPLRAKDGGVLR
MAV_3365|M.avium_104 DARNGVGTGISASDRATTMRLLADPTSIAEDFTRPGHVVPLRAKDGGVLR
MLBr_00559|M.leprae_Br4923 DARNGVGTGISASDRATTMRLLADPASVADDFTRPGHVVPLRAKDGGVLR
MMAR_2222|M.marinum_M DAKNGVGTGISASDRATTMRLLADPASVAEDFTRPGHVVPLRAKDGGVLR
MUL_1809|M.ulcerans_Agy99 DAKNGVGTGISASDRATTMRLLADPASVAEDFTRPGHVVPLRAKDGGVLR
Mflv_3719|M.gilvum_PYR-GCK DAKVGVGTGISASDRATTMRLLADPDSVADDFTKPGHVVPLRAKDGGVLR
Mvan_2694|M.vanbaalenii_PYR-1 DAKKGVGTGISAMDRATTMRLLADPDAVADDFTKPGHVVPLRAKDGGVLR
MSMEG_3072|M.smegmatis_MC2_155 DAKKDVGTGISASDRATTMRALANPGSVADDFTKPGHVVPLRAKDGGVLR
TH_1011|M.thermoresistible__bu DAKHGVTTGISAADRATTMRLLADPNAVADDFTRPGHVVPLRAKEGGVLR
MAB_2796c|M.abscessus_ATCC_199 DAKNGIGTGISASDRAATMRLLADAASTADDFTKPGHVVPLRAKDGGVLR
**: .: ***** ***:*** **:. : *:***:**********:*****
Mb1450|M.bovis_AF2122/97 RPGHTEAAVDLARMAGLQPAGAICEIVSQKDEGSMAHTDELRVFADEHGL
Rv1415|M.tuberculosis_H37Rv RPGHTEAAVDLARMAGLQPAGAICEIVSQKDEGSMAHTDELRVFADEHGL
MAV_3365|M.avium_104 RPGHTEAAVDLARMAGLQPAGAICEIVSQKDEGSMAQTDELRVFADEHDL
MLBr_00559|M.leprae_Br4923 RPGHTEAAVDLARLAGLQPAGAICEIVSQKDEGSMAQTDELRVFADEHDL
MMAR_2222|M.marinum_M RPGHTEAAVDLARMAGLQPAGAICEIVSQKDEGSMAQTDELRVFADEHGL
MUL_1809|M.ulcerans_Agy99 RPGHTEAAVDLARMAGLQPAGAICEIVSRKDEGSMAQTDELRVFADEHGL
Mflv_3719|M.gilvum_PYR-GCK RPGHTEAAVDLARLAGLQAAGTICEIVSQKDEGAMAQTDELRIFADEHDL
Mvan_2694|M.vanbaalenii_PYR-1 RPGHTEAAVDLARLAGLQPAGAICEIVSQKDEGAMAQTDELRIFADEHDL
MSMEG_3072|M.smegmatis_MC2_155 RPGHTEAAVDLARLAGLQPAGAICEIVSQKDEGDMARTDELRVFADDHDL
TH_1011|M.thermoresistible__bu RPGHTEAAVDLAKLAGLQPAGAICEIVSQKDEGAMAKTDELRVFADDHGL
MAB_2796c|M.abscessus_ATCC_199 RPGHTEASVDLAKLAGLRPAAVICEIVSQKDEGAMAQTEELRVFADEHNL
*******:****::***:.*..******:**** **:*:***:***:*.*
Mb1450|M.bovis_AF2122/97 ALITIADLIEWRRKHEKHIERVAEARIPTRHGEFRAIGYTSIYEDVEHVA
Rv1415|M.tuberculosis_H37Rv ALITIADLIEWRRKHEKHIERVAEARIPTRHGEFRAIGYTSIYEDVEHVA
MAV_3365|M.avium_104 AMITIADLIEWRRKHEKHIERIAEARIPTRHGEFRAIGYTSIYEEVEHVA
MLBr_00559|M.leprae_Br4923 ALITIADLIAWRRKHEKHIERVAEARIPTRHGEFRAIGYTSIYDDVKHVA
MMAR_2222|M.marinum_M ALITIADLIEWRRKHEKHIERVAEARIPTRHGEFRAIGYTSIYEDVEHVA
MUL_1809|M.ulcerans_Agy99 ALITIADLIEWRRKHEKHIERVAEARIPTRRGEFRAIGYTSIYENVEHVA
Mflv_3719|M.gilvum_PYR-GCK ALISIADLIEWRRKHEKHIARVAEARIPTRHGEFRAVGYTSIYEDVEHVA
Mvan_2694|M.vanbaalenii_PYR-1 ALISIADLIEWRRKHEKHIARVAEARIPTRHGEFRAVGYTSIYEDVEHVA
MSMEG_3072|M.smegmatis_MC2_155 ALISIADLIEWRRKHEKHIERIAEARIPTRHGEFRAVGYKSIYEDVEHVA
TH_1011|M.thermoresistible__bu AMISIADLIEWRRKHEKHVERVAEARIPTRHGEFRAVGYTSIYDDVEHVA
MAB_2796c|M.abscessus_ATCC_199 ALVSIADLIEWRRKHEKHVQRIAEARIPTQHGEFRAVGYTSIYDDVEHVA
*:::***** ********: *:*******::*****:**.***::*:***
Mb1450|M.bovis_AF2122/97 LVRGEIAGPNADGDDVLVRVHSECLTGDVFGSRRCDCGPQLDAALAMVAR
Rv1415|M.tuberculosis_H37Rv LVRGEIAGPNADGDDVLVRVHSECLTGDVFGSRRCDCGPQLDAALAMVAR
MAV_3365|M.avium_104 LVRGEIAGPNSDGDDVLVRVHSECLTGDVFGSRRCDCGPQLDAAMAMVAR
MLBr_00559|M.leprae_Br4923 LVRGEIAGSSGDGDDILVRVHSECLTGDVFGSRRCDCGTQLDAAMAMVAR
MMAR_2222|M.marinum_M LVRGEIAGPNSDGDDVLVRVHSECLTGDVFGSRRCDCGPQLDAAMAMVAR
MUL_1809|M.ulcerans_Agy99 LVRGEIAGPNSDGDDVLVRVHSECLTGDVFGSRRCDCGSQLDAAMAMVAR
Mflv_3719|M.gilvum_PYR-GCK LVKGDIAGPHGDGHDVLVRVHSECLTGDVFGSRRCDCGPQLDAALAMVAR
Mvan_2694|M.vanbaalenii_PYR-1 LVKGEISGPHSDGHDVLVRVHSECLTGDVFGSRRCDCGPQLDAALAMVAR
MSMEG_3072|M.smegmatis_MC2_155 LVRGEISGPGSDGDDVLVRVHSECLTGDVFGSRRCDCGPQLDAAMAMVAR
TH_1011|M.thermoresistible__bu LVMGDIAGPHGDGHDVLVRVHSECLTGDVFGSRRCDCGPQLDAALSMVAR
MAB_2796c|M.abscessus_ATCC_199 LVLGDISGPDGDGNDVLVRVHSECLTGDVFGSRRCDCGPQLDAAMEMVAK
** *:*:*. .**.*:**********************.*****: ***:
Mb1450|M.bovis_AF2122/97 EGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGADTVDANLKLGLPADARD
Rv1415|M.tuberculosis_H37Rv EGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGADTVDANLKLGLPADARD
MAV_3365|M.avium_104 EGRGIVLYMRGHEGRGIGLMHKLQAYQLQDAGEDTVDANLKLGFPADARD
MLBr_00559|M.leprae_Br4923 EGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGADTVDANIKLGFPSDARD
MMAR_2222|M.marinum_M EGRGVVLYMRGHEGRGIGLLHKLQAYQLQDAGDDTVDANLKLGLPADARD
MUL_1809|M.ulcerans_Agy99 EGRGVVLYMRGHEGRGIGLLHKLQTYQLQDAGDDTVDANLKLGLPADARD
Mflv_3719|M.gilvum_PYR-GCK EGRGIVLYMRGHEGRGIGLMHKLQAYQLQDAGDDTVDANLKLGLPADARD
Mvan_2694|M.vanbaalenii_PYR-1 EGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGDDTVDANLKLGLPADARD
MSMEG_3072|M.smegmatis_MC2_155 EGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGEDTVDANLKLGLPADARD
TH_1011|M.thermoresistible__bu EGRGVVLYMRGHEGRGIGLMHKLQAYQLQDAGEDTVDANLKLGLPADARD
MAB_2796c|M.abscessus_ATCC_199 EGRGIVLYMRGHEGRGIGLMHKLQAYQLQDAGEDTVDANLKLGLPADARD
****:**************:****:******* ******:***:*:****
Mb1450|M.bovis_AF2122/97 YGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRANAEN
Rv1415|M.tuberculosis_H37Rv YGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRANAEN
MAV_3365|M.avium_104 YGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRANAEN
MLBr_00559|M.leprae_Br4923 YGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLQIIERVPLPVRANADN
MMAR_2222|M.marinum_M YGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRANAEN
MUL_1809|M.ulcerans_Agy99 YGIGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRANAEN
Mflv_3719|M.gilvum_PYR-GCK YGTGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRANAEN
Mvan_2694|M.vanbaalenii_PYR-1 YGTGAQILVDLGVRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRANAEN
MSMEG_3072|M.smegmatis_MC2_155 YGIGAQILVDLGIRSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRANKEN
TH_1011|M.thermoresistible__bu YGIGAQILVDLGVRSMRLLTNNPAKRAGLDGYGLHIIERVPLPVRATADN
MAB_2796c|M.abscessus_ATCC_199 YGLGAQILVDLGVKSMRLLTNNPAKRVGLDGYGLHIIERVPLPVRANSEN
** *********::************.*******:***********. :*
Mb1450|M.bovis_AF2122/97 IRYLMTKRDKLGHDLAGLDDFHESVHL--------------PGEF--GGA
Rv1415|M.tuberculosis_H37Rv IRYLMTKRDKLGHDLAGLDDFHESVHL--------------PGEF--GGA
MAV_3365|M.avium_104 IRYLMTKRDKMGHDLAGLDDFHESVHL--------------PGEF--GGA
MLBr_00559|M.leprae_Br4923 IRYLMTKRDKMGHDLGGLDDFHESNYF--------------PGEF--GGA
MMAR_2222|M.marinum_M IRYLMTKRDRMGHDLTGLDDFHESVHL--------------PGEF--GGA
MUL_1809|M.ulcerans_Agy99 IRYLMTKRDRMGHDLTGLDDFHESVHL--------------PGEF--GGA
Mflv_3719|M.gilvum_PYR-GCK IRYLMTKRDRMGHDLVGLDDFDEAV----------------PGEF--GGA
Mvan_2694|M.vanbaalenii_PYR-1 IRYLMTKRDRMGHDLVGLEDFDEAV----------------PGEL--GGA
MSMEG_3072|M.smegmatis_MC2_155 IRYLMTKRDRMGHDLVGLDDYDEAVSMDDYDEAVYLLGDRRPTES--GGA
TH_1011|M.thermoresistible__bu IRYLMTKRDRMGHDLVGLEDFDESVRMDDYDEGVYLLGDRRPTDLDLGGA
MAB_2796c|M.abscessus_ATCC_199 IRYLRTKRDRMGHDLADLDDHPEAD-----------------------GA
**** ****::**** .*:*. *: **
Mb1450|M.bovis_AF2122/97 L
Rv1415|M.tuberculosis_H37Rv L
MAV_3365|M.avium_104 L
MLBr_00559|M.leprae_Br4923 L
MMAR_2222|M.marinum_M L
MUL_1809|M.ulcerans_Agy99 L
Mflv_3719|M.gilvum_PYR-GCK V
Mvan_2694|M.vanbaalenii_PYR-1 V
MSMEG_3072|M.smegmatis_MC2_155 Q
TH_1011|M.thermoresistible__bu L
MAB_2796c|M.abscessus_ATCC_199 -