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MAAHNAPTRIAMLIYPRFTTLDLIGPQQVLSVLPNTVVHLVAKTRDPVTTDSHVTIVPDRDFADCEPEYD VVFIPGGHGTSVMVQDDETLDFVRTVAGKARYLSSVCTGSLILAAAGLLEGYRAASHWAFREFLSAYGAI PDDRRVVMDRNRMTGGGVTAGLDFALQLAAVLTDETFARTLQLVLEYDPAPPFDCGTPERADQATLEAAV TRLAGGVSAMRRVAAEHAAMR
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_3366 | - | - | 100% (231) | isonitrile hydratase, putative |
| M. smegmatis MC2 155 | MSMEG_1107 | - | 4e-42 | 44.02% (209) | isonitrile hydratase, putative |
| M. smegmatis MC2 155 | MSMEG_3488 | - | 4e-16 | 32.95% (173) | transcriptional regulator, AraC family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0053 | - | 2e-25 | 40.56% (143) | hypothetical protein Mb0053 |
| M. gilvum PYR-GCK | Mflv_5266 | - | 7e-40 | 42.58% (209) | ThiJ/PfpI domain-containing protein |
| M. tuberculosis H37Rv | Rv0052 | - | 2e-25 | 40.56% (143) | hypothetical protein Rv0052 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0943 | - | 3e-44 | 44.60% (213) | hypothetical protein MAB_0943 |
| M. marinum M | MMAR_2854 | - | 9e-42 | 44.44% (207) | hypothetical protein MMAR_2854 |
| M. avium 104 | MAV_2773 | - | 2e-45 | 47.85% (209) | DJ-1/PfpI family protein |
| M. thermoresistible (build 8) | TH_3120 | - | 3e-10 | 35.94% (128) | PUTATIVE transcriptional regulator, AraC family with |
| M. ulcerans Agy99 | MUL_0070 | - | 2e-35 | 37.56% (205) | transcriptional regulatory protein |
| M. vanbaalenii PYR-1 | Mvan_0973 | - | 4e-41 | 41.63% (209) | ThiJ/PfpI domain-containing protein |
CLUSTAL 2.0.9 multiple sequence alignment
Mb0053|M.bovis_AF2122/97 --------------------------------MPSFDVVFVGHRRGEVRS
Rv0052|M.tuberculosis_H37Rv --------------------------------MPSFDVVFVGHRRGEVRS
MUL_0070|M.ulcerans_Agy99 -------MQVAIPVFPRFTALDAVGPYEVLQRIPSIDVVFIGHQRGEVRT
MMAR_2854|M.marinum_M ------MPQFAFVAYPGFTALDMIGPYEVLRNLPHAEVRFVWHDPGPITA
MAV_2773|M.avium_104 ------MTQIAFLAYPGFTALDMIGPYEVLRNLPGAEVRFVWHETGPITA
MAB_0943|M.abscessus_ATCC_1997 --MTSAATQIAIVLYPDFTALDFIGPYEVLRFIPDTEVRFVWHEPGPVTA
Mflv_5266|M.gilvum_PYR-GCK -------MQVAIMLYPGFTALDFIGPYESLRWLPDTEVRFVWHEPGPIAA
Mvan_0973|M.vanbaalenii_PYR-1 -------MQVAIMLYPGFTALDFIGPYESLRWLPDVEVRFVWHEPGPIAA
MSMEG_3366|M.smegmatis_MC2_155 MAAHNAPTRIAMLIYPRFTTLDLIGPQQVLSVLPNTVVHLVAKTRDPVTT
TH_3120|M.thermoresistible__bu ---VAALVLDGLAIFEFGVICEVFGVDRTDDGVPPVDFTVCGPRAGQPVR
:* . . .
Mb0053|M.bovis_AF2122/97 DNAMLGLLCDAAFDELTRPDVVIFPGGIGTRTLIHDQTVLDWVREAHRHT
Rv0052|M.tuberculosis_H37Rv DNAMLGLLCDAAFDELTRPDVVIFPGGIGTRTLIHDQTVLDWVREAHRHT
MUL_0070|M.ulcerans_Agy99 ENGMLGVTCDATFDEVDAPDVVAFPGGIGTRGLLEDETIRGWLQAVHPHT
MMAR_2854|M.marinum_M DSGVLVLGATHSLAETPAPDVVVVPGGPATPVHARDEKLLDWLRQAHRSA
MAV_2773|M.avium_104 DSGVLVIGATHSLAETPSPDVVLVPGGPGTAVHARDDALLDWLRTAHRTA
MAB_0943|M.abscessus_ATCC_1997 DSGVLVIGATHSFGETPAPDVVLVPGGPGTTMAARDDKLLDWLRRVHPAA
Mflv_5266|M.gilvum_PYR-GCK DSHVLLVGATHSFDETPSPDVILIPGGFATMEHARDEVVLAWVRRAHETS
Mvan_0973|M.vanbaalenii_PYR-1 DSHVLLVGATHSFDETPSPDLILIPGGFATMEHARDEKVLDWVRRAHRTS
MSMEG_3366|M.smegmatis_MC2_155 DSHVTIVPDRDFADCEPEYDVVFIPGGHGTSVMVQDDETLDFVRTVAGKA
TH_3120|M.thermoresistible__bu TSFGATLTPDSGLDGLAGADLVAIP---AIRQDDYLPEALDAVRAAADAG
. : *:: .* . :: .
Mb0053|M.bovis_AF2122/97 LLTTSVCTGGLVLAAAGLLNGLTATTHWRVQDLFNSLGARYV-PQRVVEH
Rv0052|M.tuberculosis_H37Rv LLTTSVCTGGLVLAAAGLLNGLTATTHWRVQDLFNSLGARYV-PQRVVEH
MUL_0070|M.ulcerans_Agy99 RFTTSVCTGALLLAAAGLLDGLTATTHWRAAELLNGLGARYV-PQRVVEH
MMAR_2854|M.marinum_M SWTTSVCSGSVILAAAGLLKDRRATSHWLTIPALKAFGAIPVADKRIVQQ
MAV_2773|M.avium_104 TWTTSVCTGSLILAAAGLLDGRRATSHWLTIPALKAFGVTAVPDERIVHE
MAB_0943|M.abscessus_ATCC_1997 AWTTSVCSGSLVLAAAGLLEGQRATSHWSTLPLLKPFGVTPVGDERIVRT
Mflv_5266|M.gilvum_PYR-GCK TWTTSVCSGSVILAAAGVLDGKRATSHWAALPVLKTLGAQPVGDQRIVEA
Mvan_0973|M.vanbaalenii_PYR-1 TWTTSVCSGSVILAASGVLDGKRATSHWAALPVLKTFGVQPVGDERVVVA
MSMEG_3366|M.smegmatis_MC2_155 RYLSSVCTGSLILAAAGLLEGYRAASHWAFREFLSAYGAIPD-DRRVVMD
TH_3120|M.thermoresistible__bu AIILTVCSGAFLAGAAGLLDGRPCTTHWGLTEELARRYPTARVDRNVLYV
:**:*..: .*:*:*.. .::** : ..::
Mb0053|M.bovis_AF2122/97 LPERVITAAGVSSGIDMGLRLVELLVSREAAEASQLMIEYDPQ-------
Rv0052|M.tuberculosis_H37Rv LPERVITAAGVSSGIDMGLRLVELLVSREAAEASQLMIEYDPQ-------
MUL_0070|M.ulcerans_Agy99 LPQRIITAAGVSSGIDMGLRLVELLVDREAAQVTQLLIEYDPE-------
MMAR_2854|M.marinum_M --DNIITSAGVSAGLDLGLWLAGQIGGESRAKAIQLALEYDPQ-------
MAV_2773|M.avium_104 --DGIVTSAGVSAGLDLALWLAAQIGGDGRAKAIQLALEYDPQ-------
MAB_0943|M.abscessus_ATCC_1997 GHAGLVTAAGVSAGIDLGLWLAGQIAGEERAKAIQLSIEYDPQ-------
Mflv_5266|M.gilvum_PYR-GCK D-AKTVTAAGVSAGIDLGLWLAGRIAGEEKAKAIQLSMEYDPQ-------
Mvan_0973|M.vanbaalenii_PYR-1 D-DKTVTAAGVSAGIDLGLWLAGQIAGESKAKAIQLSMEYDPQ-------
MSMEG_3366|M.smegmatis_MC2_155 R--NRMTGGGVTAGLDFALQLAAVLTDETFARTLQLVLEYDPA-------
TH_3120|M.thermoresistible__bu DDGDLITSAGTAAGIDACLHLVRRELGSEVTNTIARHMVVPPQRDGGQRQ
:*..*.::*:* * *. . :.. : *
Mb0053|M.bovis_AF2122/97 ---PPVDAGSLA------------------------KASPATHRLALEFY
Rv0052|M.tuberculosis_H37Rv ---PPVDAGSLA------------------------KASPATHRLALEFY
MUL_0070|M.ulcerans_Agy99 ---PPFDAGSLA------------------------KADEGVRARAIEFL
MMAR_2854|M.marinum_M ---PPFDSGHMS------------------------KASASTKVAATALL
MAV_2773|M.avium_104 ---PPFDSGHLS------------------------KASASTKAAATALL
MAB_0943|M.abscessus_ATCC_1997 ---PPFDSGHMS------------------------KASAATKATATAGL
Mflv_5266|M.gilvum_PYR-GCK ---PPFDSGHMS------------------------KASAGTKALATAMM
Mvan_0973|M.vanbaalenii_PYR-1 ---PPFDSGHMS------------------------KASASTKALATAMM
MSMEG_3366|M.smegmatis_MC2_155 ---PPFDCGTPE------------------------RADQATLEAAVTRL
TH_3120|M.thermoresistible__bu FIDQPIPVRHSEGFAPHLDWILSNLDKTHTVASLARRANMSPRTFARRFV
*. :*. . *
Mb0053|M.bovis_AF2122/97 QHRL----------------------------------------------
Rv0052|M.tuberculosis_H37Rv QHRL----------------------------------------------
MUL_0070|M.ulcerans_Agy99 DSRK----------------------------------------------
MMAR_2854|M.marinum_M SKDSATPVNLKAATMLAWQQALAAARARRRKRQPVDSTP-----------
MAV_2773|M.avium_104 SRDSLSPTYLKATALLAWDQALDRVRSRRRRRQPDLSPA-----------
MAB_0943|M.abscessus_ATCC_1997 AKDTFKPSVMAAGAKLLWDGALATARRRGDRRRSFGSRLDPRARP-----
Mflv_5266|M.gilvum_PYR-GCK GREMVRPAALAASTGLLWDAALKRIRRAKRRQ--GSLSAP----------
Mvan_0973|M.vanbaalenii_PYR-1 GREMAKPAALAASTGLLWDAALKRIRARRSRPEPAKLRGGS---------
MSMEG_3366|M.smegmatis_MC2_155 AGG------VSAMRRVAAEHAAMR--------------------------
TH_3120|M.thermoresistible__bu EETGRTPMQWVTDQRVLYARRLLEETDLDIHRIAARCGFGSTTLLRHHFR
Mb0053|M.bovis_AF2122/97 --------------------------------
Rv0052|M.tuberculosis_H37Rv --------------------------------
MUL_0070|M.ulcerans_Agy99 --------------------------------
MMAR_2854|M.marinum_M --------------------------------
MAV_2773|M.avium_104 --------------------------------
MAB_0943|M.abscessus_ATCC_1997 --------------------------------
Mflv_5266|M.gilvum_PYR-GCK --------------------------------
Mvan_0973|M.vanbaalenii_PYR-1 --------------------------------
MSMEG_3366|M.smegmatis_MC2_155 --------------------------------
TH_3120|M.thermoresistible__bu RVIGVTPSDYRRRFACGSTTSGSTESGAEVTD