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RVVIAGGHGKIALILERLLADRGDSVVGLIRNPEHAADVKAAGAEPIVLDLEKAAVDEVAGAVRGADAVV FAAGAGPGSGAARKQTVDRDAAILLADAAEAAGVDRYVMVSALAADDRSLDESYDEVFRVYMQAKSEADA NVRARSGLRTTIVRPGGLTNDAGTGLVRIAESTGRGTVPREDVARVLVAVLDAPQTAGRTFELISGATPI DDALV*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2941 | - | - | 100% (216) | NAD dependent epimerase/dehydratase family protein |
| M. smegmatis MC2 155 | MSMEG_3470 | - | 6e-05 | 28.17% (213) | NAD-dependent epimerase/dehydratase |
| M. smegmatis MC2 155 | MSMEG_5228 | - | 8e-05 | 28.49% (179) | 3-beta hydroxysteroid dehydrogenase/isomerase family protein |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1136c | - | 1e-05 | 26.63% (199) | cholesterol dehydrogenase |
| M. gilvum PYR-GCK | Mflv_1761 | - | 7e-76 | 66.98% (215) | NAD-dependent epimerase/dehydratase |
| M. tuberculosis H37Rv | Rv1106c | - | 1e-05 | 26.63% (199) | cholesterol dehydrogenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_3427 | - | 4e-54 | 54.88% (215) | hypothetical protein MAB_3427 |
| M. marinum M | MMAR_4327 | - | 8e-45 | 48.37% (215) | hypothetical protein MMAR_4327 |
| M. avium 104 | MAV_1263 | - | 9e-44 | 49.77% (213) | NAD dependent epimerase/dehydratase family protein |
| M. thermoresistible (build 8) | TH_3475 | - | 1e-41 | 45.12% (215) | PUTATIVE NAD dependent epimerase/dehydratase family protein |
| M. ulcerans Agy99 | MUL_0137 | - | 1e-43 | 47.20% (214) | hypothetical protein MUL_0137 |
| M. vanbaalenii PYR-1 | Mvan_4986 | - | 3e-76 | 67.91% (215) | NAD-dependent epimerase/dehydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_1761|M.gilvum_PYR-GCK --------------MRVVIAGGHGKIALITSRLLSARGDSVAGLIRNP--
Mvan_4986|M.vanbaalenii_PYR-1 --------------MRVVIAGGHGKIALITARLLSVRGDSVAGLIRNP--
MSMEG_2941|M.smegmatis_MC2_155 --------------MRVVIAGGHGKIALILERLLADRGDSVVGLIRNP--
MAB_3427|M.abscessus_ATCC_1997 ------------MPQKVVIAGGHGQIAAHLIRLLAARGDTAVALIRNP--
MMAR_4327|M.marinum_M -------------MTRVVVFGGHGKVALLLGHILADRGDQVSSVFRNP--
MUL_0137|M.ulcerans_Agy99 -------------MTPVVVFGGHGKVALLLGHILADRGDQVSSVFRNP--
MAV_1263|M.avium_104 -----------------MIVGGHGKVALQLSAILTQRGDAVTSLFRNP--
TH_3475|M.thermoresistible__bu -------------MARIVIIGGHGQVAMHLSRILSERGDQVTSVFRNP--
Mb1136c|M.bovis_AF2122/97 MLRRMGDASLTTELGRVLVTGGAGFVGANLVTTLLDRGHWVRSFDRAPSL
Rv1106c|M.tuberculosis_H37Rv MLRRMGDASLTTELGRVLVTGGAGFVGANLVTTLLDRGHWVRSFDRAPSL
:: ** * :. * **. . .. * *
Mflv_1761|M.gilvum_PYR-GCK -AHEDDLRVTGAEPVVLDLEDTTNGVVSSHLRGADAVIFAAGAGP-GSGA
Mvan_4986|M.vanbaalenii_PYR-1 -DHADDLRVAGAEPVVVDLENTTNGVVSTHLRGADAVIFAAGAGP-GSGA
MSMEG_2941|M.smegmatis_MC2_155 -EHAADVKAAGAEPIVLDLEKAAVDEVAGAVRGADAVVFAAGAGP-GSGA
MAB_3427|M.abscessus_ATCC_1997 -DHAADVEAWGGLPLVLDLESTDADDVAGALAGADAAVFAAGAGP-GSGP
MMAR_4327|M.marinum_M -DHRDDIAATGATPVQADIEGLDTAALAGLLTGHDAVVFSAGAG--GGNP
MUL_0137|M.ulcerans_Agy99 -DHRDDIAATGATPVQADIEGLDTAALAGLLTGHDAVVFSAGAG--GGNP
MAV_1263|M.avium_104 -DHADDVAATGAKPVVADIERLDTDALAGLLAGHDAVVFSAGAG--GGNP
TH_3475|M.thermoresistible__bu -NHAEEVMVTGAQPLRADLEQLDTDTLTEVLSGHDAVVFSAGAG--GGNP
Mb1136c|M.bovis_AF2122/97 LPAHPQLEVLQGDITDADVCAAAVDGIDTIFHTAAIIELMGGASVTDEYR
Rv1106c|M.tuberculosis_H37Rv LPAHPQLEVLQGDITDADVCAAAVDGIDTIFHTAAIIELMGGASVTDEYR
:: . . *: : . : .**. .
Mflv_1761|M.gilvum_PYR-GCK ARKETVDRDAAVLLADAAEAAGVQRYLMISAMGADANTPNDAADDVFVAY
Mvan_4986|M.vanbaalenii_PYR-1 ARKETVDRDAAILLADAAEAAGVPRYVMVSSMGADAAAPDDAGDDVFVAY
MSMEG_2941|M.smegmatis_MC2_155 ARKQTVDRDAAILLADAAEAAGVDRYVMVSALAADDRSLDESYDEVFRVY
MAB_3427|M.abscessus_ATCC_1997 ARKDTVDRAAAVLLATAAEQAQVHRFIQISAFGAGEPAPTEG-DESWIAY
MMAR_4327|M.marinum_M ARTYAVDRDAAIRVIDAATRAGVQRFVMVSYFGAG-PNHGVSVDDSFFPY
MUL_0137|M.ulcerans_Agy99 ARTYAVDRDAATRVIDAATRAGVQRFVMISYFGAG-PNHGVSVDDSFFPY
MAV_1263|M.avium_104 ARTYAVDRDAAIRVVDAAARSGVKRFVMVSYFGAG-PDHGVPQDDPFFPY
TH_3475|M.thermoresistible__bu TRTYAVDRDAAIRVIDAAGKAGVSRFIMVSYFGAG-PDHGVPEDSSFFPY
Mb1136c|M.bovis_AF2122/97 QRSFAVNVGGTENLLHAGQRAGVQRFVYTSSNSVVMGGQNIAGGDETLPY
Rv1106c|M.tuberculosis_H37Rv QRSFAVNVGGTENLLHAGQRAGVQRFVYTSSNSVVMGGQNIAGGDETLPY
*. :*: .: : *. : * *:: * .. .. *
Mflv_1761|M.gilvum_PYR-GCK --------LRAKGAADDLIRSRTELYATIVRPGQLTDDPGTG--------
Mvan_4986|M.vanbaalenii_PYR-1 --------LRAKGAADDVIRARTSLLATIVRPGLLTDDEPTG--------
MSMEG_2941|M.smegmatis_MC2_155 --------MQAKSEADANVRARSGLRTTIVRPGGLTNDAGTG--------
MAB_3427|M.abscessus_ATCC_1997 --------VIAKTAAEEDLRTRDRLDWTILRPGLLTDTAPTG--------
MMAR_4327|M.marinum_M --------AQAKAAADAHLRA-SNLDWTVLGPSRLTMEPATG--------
MUL_0137|M.ulcerans_Agy99 --------AQAKAAADAHLRA-SNLDWTVLGPSRLTMEPATG--------
MAV_1263|M.avium_104 --------AESKAAADAHLRA-SDLDWTILGPGRLTLDPPTG--------
TH_3475|M.thermoresistible__bu --------AESKAAADAHLRA-SELDWTILGPGRLTEEPATG--------
Mb1136c|M.bovis_AF2122/97 TDRFNDLYTETKVVAERFVLAQNGVDGMLTCAIRPSGIWGNGDQTMFRKL
Rv1106c|M.tuberculosis_H37Rv TDRFNDLYTETKVVAERFVLAQNGVDGMLTCAIRPSGIWGNGDQTMFRKL
:* *: : : : : . : .*
Mflv_1761|M.gilvum_PYR-GCK ---------KVAIAEHTG-RGKIPRADVAA---VLVAVLDAPQTAGQTFE
Mvan_4986|M.vanbaalenii_PYR-1 ---------RVRIAEHTG-RGSIPRADVAA---VLVAVLDTPDTAGRTFE
MSMEG_2941|M.smegmatis_MC2_155 ---------LVRIAESTG-RGTVPREDVAR---VLVAVLDAPQTAGRTFE
MAB_3427|M.abscessus_ATCC_1997 ---------SVTLSASKIERGSVPRADVAA---VVAELLGAPNTVHEILF
MMAR_4327|M.marinum_M ---------RISIGTGKSGKATVSRADVAR---VIAATLNDDSTIGRTID
MUL_0137|M.ulcerans_Agy99 ---------RISIGTGKSGKATVSRVDVAR---VIAATLNDDSTIGRTID
MAV_1263|M.avium_104 ---------RIAVGRGK---GEVSRADVAS---VAAAALADDSTIRRTID
TH_3475|M.thermoresistible__bu ---------KITVGPEAAD-SEVPREDVAL---VAAACLADDSTVRRTIE
Mb1136c|M.bovis_AF2122/97 FESVLKGHVKVLVGRKSARLDNSYVHNLIHGFILAAAHLVPDGTAPGQAY
Rv1106c|M.tuberculosis_H37Rv FESVLKGHVKVLVGRKSARLDNSYVHNLIHGFILAAAHLVPDGTAPGQAY
: :. :: : . * *
Mflv_1761|M.gilvum_PYR-GCK LISGDTDIEVAVASLAVG--------------------------------
Mvan_4986|M.vanbaalenii_PYR-1 VISGDAAVADAVAALT----------------------------------
MSMEG_2941|M.smegmatis_MC2_155 LISGATPIDDALV-------------------------------------
MAB_3427|M.abscessus_ATCC_1997 LTEGTAPIASAVAGL-----------------------------------
MMAR_4327|M.marinum_M FNNGDVPIATALAD------------------------------------
MUL_0137|M.ulcerans_Agy99 FNNGDVPIATALAD------------------------------------
MAV_1263|M.avium_104 FNNGDVPIAVALAG------------------------------------
TH_3475|M.thermoresistible__bu FNKGDTSIAEAVRAR-----------------------------------
Mb1136c|M.bovis_AF2122/97 FINDAEPINMFEFARPVLEACGQRWPKMRISGPAVRWVMTGWQRLHFRFG
Rv1106c|M.tuberculosis_H37Rv FINDAEPINMFEFARPVLEACGQRWPKMRISGPAVRWVMTGWQRLHFRFG
. .. :
Mflv_1761|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_4986|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2941|M.smegmatis_MC2_155 --------------------------------------------------
MAB_3427|M.abscessus_ATCC_1997 --------------------------------------------------
MMAR_4327|M.marinum_M --------------------------------------------------
MUL_0137|M.ulcerans_Agy99 --------------------------------------------------
MAV_1263|M.avium_104 --------------------------------------------------
TH_3475|M.thermoresistible__bu --------------------------------------------------
Mb1136c|M.bovis_AF2122/97 FPAPLLEPLAVERLYLDNYFSIAKARRDLGYEPLFTTQQALTECLPYYVS
Rv1106c|M.tuberculosis_H37Rv FPAPLLEPLAVERLYLDNYFSIAKARRDLGYEPLFTTQQALTECLPYYVS
Mflv_1761|M.gilvum_PYR-GCK --------------------
Mvan_4986|M.vanbaalenii_PYR-1 --------------------
MSMEG_2941|M.smegmatis_MC2_155 --------------------
MAB_3427|M.abscessus_ATCC_1997 --------------------
MMAR_4327|M.marinum_M --------------------
MUL_0137|M.ulcerans_Agy99 --------------------
MAV_1263|M.avium_104 --------------------
TH_3475|M.thermoresistible__bu --------------------
Mb1136c|M.bovis_AF2122/97 LFEQMKNEARAEKTAATVKP
Rv1106c|M.tuberculosis_H37Rv LFEQMKNEARAEKTAATVKP