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IKSLGYVTVQATDMQRWRHFAFGVLGFAEGKGPDPDALYLRMDERCARIIVTPGDVDKIVTVGWEVRDHA ALQEVKRALDAAGVPHKQLSLAEADSRRVEEAIAFEDPAGTSLEVFHGPVLDHSPVVTPFGARFVTGDQG LGHVVLPALDVNGLFEFYTETLGFKSRGAFRVPVPPEFGPVRVRFLGVNERHHSLALCPASTLRDPGLVH LMVEVDSLDAVGQALDRVNADGFQLSSTLGRHTNDKMVSFYVRAPGDWDIEFGTDGMRVDEQHYTAEEIT ADSYWGHQWVSDLPRAMQP*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2891 | - | - | 100% (300) | biphenyl-2,3-diol 1,2-dioxygenase 1 |
| M. smegmatis MC2 155 | MSMEG_6036 | - | 1e-80 | 50.00% (294) | biphenyl-2,3-diol 1,2-dioxygenase |
| M. smegmatis MC2 155 | MSMEG_2006 | - | 4e-05 | 24.66% (219) | 2,3-dihydroxybiphenyl 1,2-dioxygenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3599c | bphC | 4e-79 | 48.98% (294) | putative biphenyl-2,3-diol 1,2-dioxygenase BPHC (23OHBP |
| M. gilvum PYR-GCK | Mflv_4549 | - | 1e-150 | 83.95% (299) | glyoxalase/bleomycin resistance protein/dioxygenase |
| M. tuberculosis H37Rv | Rv3568c | bphC | 4e-79 | 48.98% (294) | biphenyl-2,3-diol 1,2-dioxygenase |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0076 | - | 1e-132 | 75.42% (297) | putative 2,3-dihydroxybiphenyl 1,2-dioxygenase or |
| M. marinum M | MMAR_5063 | bphC | 2e-78 | 48.64% (294) | biphenyl-2,3-diol 1,2-dioxygenase BphC |
| M. avium 104 | MAV_3021 | - | 1e-147 | 80.87% (298) | biphenyl-2,3-diol 1,2-dioxygenase 1 |
| M. thermoresistible (build 8) | TH_4499 | - | 1e-156 | 86.29% (299) | PUTATIVE biphenyl-2,3-diol 1,2-dioxygenase 1 |
| M. ulcerans Agy99 | MUL_4139 | bphC | 1e-78 | 48.64% (294) | biphenyl-2,3-diol 1,2-dioxygenase BphC |
| M. vanbaalenii PYR-1 | Mvan_2891 | - | 1e-157 | 87.67% (300) | glyoxalase/bleomycin resistance protein/dioxygenase |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2891|M.smegmatis_MC2_155 ---------MIKSLGYVTVQATDMQRWRHFAFGVLGFAEGKGPDPDALYL
TH_4499|M.thermoresistible__bu MRHERDTMGFIKSLGYVIVQATDMDRWRHFAYEVLGFAEGTGPNPEALYL
Mflv_4549|M.gilvum_PYR-GCK -------MSDIKSLGYVKVQATDLPRWRQFAFGVLGFAQGSGPEPDALYL
Mvan_2891|M.vanbaalenii_PYR-1 -------MSLITSLGYVTVQATDMSRWRQFAFGVLGFAEGSGPDPDAMYL
MAV_3021|M.avium_104 -------MSDLKSLGYITVSTADIERWRHFAFGVLGFAEGKGPDESALYL
MAB_0076|M.abscessus_ATCC_1997 ---------MLTSLGYLTVATRDMDRWRHFALRVLGFAEGSGPDPDALYL
Mb3599c|M.bovis_AF2122/97 --------MSIRSLGYLRIEATDMAAWREYGLKVLGMVEGKGAPEGALYL
Rv3568c|M.tuberculosis_H37Rv --------MSIRSLGYLRIEATDMAAWREYGLKVLGMVEGKGAPEGALYL
MMAR_5063|M.marinum_M --------MSIRSLGYLRIEATDMAAWREYGLKVLGMVEGKGSTEGALYL
MUL_4139|M.ulcerans_Agy99 --------MSIRSLGYLRIEATDMAAWREYGLKVLGMVEGKGSTEGALYL
: ****: : : *: **.:. ***:.:*.*. *:**
MSMEG_2891|M.smegmatis_MC2_155 RMDERCARIIVTPGDVDKIVTVGWEVRDHAALQEVKRALDAAGVPHKQLS
TH_4499|M.thermoresistible__bu RMDERTARITVEPGEVDRIVTIGWEVRDHAALEDVKRALAAAGVPHRQLS
Mflv_4549|M.gilvum_PYR-GCK RMDERAARIIVVPGDVDRIVTAGWEVRDRRGLEAVMRALDAAGTPFKELS
Mvan_2891|M.vanbaalenii_PYR-1 RMDERAARVVVSPGDTDKIVTVGWEVRDRAGLDEVKRALDAAGTPYKELS
MAV_3021|M.avium_104 RMDERAARIIVVPGDVDRVVTVGWEVRDHQALQRVKATLDGAGVAFKELS
MAB_0076|M.abscessus_ATCC_1997 RMDERAARVVVVPGETDQVITVGWEVRDGAALRAVVRALEAADIGVERLS
Mb3599c|M.bovis_AF2122/97 RMDDFPARLVVVPGEHDRLLEAGWECANAEGLQEIRNRLDLEGTPYKEAT
Rv3568c|M.tuberculosis_H37Rv RMDDFPARLVVVPGEHDRLLEAGWECANAEGLQEIRNRLDLEGTPYKEAT
MMAR_5063|M.marinum_M RMDDFPARLVIVPGTQDRLAEAGWECADAQGLQEIRNRLDVEGTPYKEAT
MUL_4139|M.ulcerans_Agy99 RMDDFPARLVIVPGTQDRLAEAGWECADAQGLQEIRNRLDVEGTPYKEAT
***: **: : ** *:: *** : .* : * . .. :
MSMEG_2891|M.smegmatis_MC2_155 LAEADSRRVEEAIAFEDPAGTSLEVFHGPVLDHSPVVTPFGARFVTGDQG
TH_4499|M.thermoresistible__bu TAEADARRVEEVVAFADPAGTALEVFHGPVLDHSPVVTPFGARFVTGDQG
Mflv_4549|M.gilvum_PYR-GCK LAEADARRVEEVIAFEDPAGNSLEVFHGAVLDHSPVVTPYGARFVTGAQG
Mvan_2891|M.vanbaalenii_PYR-1 LADADSRRVEEVIAFEDPAGTSLEVFHGAVLDHSPVVTPFGAKFVTGEQG
MAV_3021|M.avium_104 LQEADARRVEEVITFEDPAGTTLEVFHGAVLDHSPVITPFGAKFVTGDQG
MAB_0076|M.abscessus_ATCC_1997 PEEADSRRAEEVVAFTDPAGTPVEVFHGPVLDHSPVVTPYGARFVTGAQG
Mb3599c|M.bovis_AF2122/97 AAELADRRVDEMIRFADPSGNCLEVFHGTALEHRRVVSPYGHRFVTGEQG
Rv3568c|M.tuberculosis_H37Rv AAELADRRVDEMIRFADPSGNCLEVFHGTALEHRRVVSPYGHRFVTGEQG
MMAR_5063|M.marinum_M AAELADRRVDEMILFSDPSGNPLAVFHGAALEHRRVVSPYGHKFVTGEQG
MUL_4139|M.ulcerans_Agy99 AAELADRRVDEMILFSDPSGNPLAVFHGAALEHRRVVSPYGHKFVTGEQG
: **.:* : * **:*. : ****..*:* *::*:* :**** **
MSMEG_2891|M.smegmatis_MC2_155 LGHVVLPALDVNGLFEFYTETLGFKSRGAFRVP-----VPPEFGPVRVRF
TH_4499|M.thermoresistible__bu LGHVVLPTVDVDGLFEFYTEVLGFRSRGAFRVP-----APEEFGPVRVRF
Mflv_4549|M.gilvum_PYR-GCK LGHVVIPALDVNGLFDFYTQVLGFKSRGAFRVP-----TPPEYGPVRVRF
Mvan_2891|M.vanbaalenii_PYR-1 LGHVVLPALDVPAMFDFYTGVLGFKSRGAFRVP-----VPPEFGPVRVRF
MAV_3021|M.avium_104 LGHVVVPATDPNGLFDFYTEVLGFRSRGAFRVP-----LPAEFGPIRVRF
MAB_0076|M.abscessus_ATCC_1997 LGHVVLPVTDPEGAFTFYTEVLGFRPRGAFRIP-----APPEFGPMRVRF
Mb3599c|M.bovis_AF2122/97 MGHVVLSTRDDAEALHFYRDVLGFRLRDSMRLPPRMVGRPADGPPAWLRF
Rv3568c|M.tuberculosis_H37Rv MGHVVLSTRDDAEALHFYRDVLGFRLRDSMRLPPQMVGRPADGPPAWLRF
MMAR_5063|M.marinum_M LGHVVLTTRDDAEALHFYRDVLGFKLRDSMRMPPQVVGRPADGAPAWLRF
MUL_4139|M.ulcerans_Agy99 LGHVVLTTRDDAEALHFYRDVLGFKLRDSMRMPPQVVGRPADGAPAWLRF
:****:.. * : ** .***: *.::*:* * : * :**
MSMEG_2891|M.smegmatis_MC2_155 LGVNERHHSLALCPASTLRDPGLVHLMVEVDSLDAVGQALDRVNADGFQL
TH_4499|M.thermoresistible__bu LGINERHHSLALCPASTLRDPGLIHLMVEVDTLDAVGQALDRVNRDGYQL
Mflv_4549|M.gilvum_PYR-GCK LGVNQRHHSLAICPAATVRDPKLVHLMVEVDTLDAVGQALDRVHKDGFQL
Mvan_2891|M.vanbaalenii_PYR-1 LGVNQRHHSLALCPAATLRDPGLVHLMVEVDTLDAVGQALDRVNKDGFQL
MAV_3021|M.avium_104 LGINARHHSLAICPAAQQRDPGLVHVMVEVDSLDAVGQALDRVNADGFTV
MAB_0076|M.abscessus_ATCC_1997 LGINERHHSLALCPAPHGGAPGLVHVMVEVDSLDAVGQALDRVLKDDYSL
Mb3599c|M.bovis_AF2122/97 FGCNPRHHSLAFLPMPT--SSGIVHLMVEVEQADDVGLCLDRALRRKVPM
Rv3568c|M.tuberculosis_H37Rv FGCNPRHHSLAFLPMPT--SSGIVHLMVEVEQADDVGLCLDRALRRKVPM
MMAR_5063|M.marinum_M FGCNPRHHSLAFLPLPT--PSGIVHLMVEVQNSDDVGLCLDRALRRKVPM
MUL_4139|M.ulcerans_Agy99 FGCNPRHHSLAFLPLPT--PSGIVHLMVEVQNSDDVGLCLDRALRRKVPM
:* * ******: * . . ::*:****: * ** .***. :
MSMEG_2891|M.smegmatis_MC2_155 SSTLGRHTNDKMVSFYVRAPGDWDIEFGTDGMRVDEQHYTAEEITADSYW
TH_4499|M.thermoresistible__bu SSTLGRHTNDKMVSFYVRAPGDWDIEFGTAGMRVDETYYTAEEITADSYW
Mflv_4549|M.gilvum_PYR-GCK SSTLGRHTNDKMVSFYVRAPGDWDIELGTEGMLVDESSYTAEEITADSYW
Mvan_2891|M.vanbaalenii_PYR-1 SSTLGRHTNDKMVSFYVRAPGDWDIEFGTDGMRVDETCYTAEEITADSYW
MAV_3021|M.avium_104 ASTLGRHTNDKMVSFYVRAPGDWDIEFGTDGMRVDETYYTAEEITADSYW
MAB_0076|M.abscessus_ATCC_1997 SSTLGRHTNDKMVSFYVRAPGGWDIEFGTDGMRVDETCYTAEEITADSYW
Mb3599c|M.bovis_AF2122/97 SATLGRHVNDLMLSFYMKTPGGFDIEFGCEGRQVDDRDWIARESTAVSLW
Rv3568c|M.tuberculosis_H37Rv SATLGRHVNDLMLSFYMKTPGGFDIEFGCEGRQVDDRDWIARESTAVSLW
MMAR_5063|M.marinum_M SATLGRHVNDLMLSFYMKTPGGFDVEFGCEGRQVDDHDWIARESTAVSLW
MUL_4139|M.ulcerans_Agy99 SATLGRHVNDLMLSFYMKTPGGFDVEFGCEGRQVDDHDWIARESTAVSLW
::*****.** *:***:::**.:*:*:* * **: : *.* ** * *
MSMEG_2891|M.smegmatis_MC2_155 GHQWVSDLPRAMQP
TH_4499|M.thermoresistible__bu GHQWVGDLPAAMRP
Mflv_4549|M.gilvum_PYR-GCK GHEWVTDLPIAMQP
Mvan_2891|M.vanbaalenii_PYR-1 GHQWVDDLPAAMRP
MAV_3021|M.avium_104 GHEWIPEPPAAMRM
MAB_0076|M.abscessus_ATCC_1997 GHDWSGSQPLAAM-
Mb3599c|M.bovis_AF2122/97 GHDFTVGARG----
Rv3568c|M.tuberculosis_H37Rv GHDFTVGARG----
MMAR_5063|M.marinum_M GHDFTVGARG----
MUL_4139|M.ulcerans_Agy99 GHDFTVGARG----
**::