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MPTGRDYDVIIVGFGAAGASAAIEAADRGARVLVLDRGYGGGATAYSGGIVYAGAGTPEQHAGGYSDSVE NMRAYLEQEVAGAVKPETLARFCEQSPALLEWLKAQGVPFRGGAGPSYKTSYPTDDNYLYYSGNEKAYPY VDHAQPAPRGHRVLAPGMSSGRVLFERLRDSALAKGVHFTPLAHVHSLIQDEDGRVTGVRYTVTDPGHRN ARRHRRIAKATGKLGTWMPRAVAGAVARGERLRAEAGAEAHASAGAVILAAGGFINDRDWVSRYAPEFLK ISPLGTVGDDGTGIRLGLDAGGVTDKMGNVTAWRFLSPPSAFLEGLTVGADGRRIANEDLYGAAHGNVLM REFGGTGWAIYDAATWRKIKDQITEQTQVFQRLQIWYLRTIGHKKAATIEGIAAKNGIDAAALRKTVDEY NRGIAGGAGDPAHKDPSLCSPMERGPFYSIDISADSSLFYPIPGLTLGGLVVDEDTGAVVHRDGGVVPGL YAAGRTAVGVCSNSYVSGLSISDCVFSGRRAGADAVAKI
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2873 | - | - | 100% (529) | hypothetical protein MSMEG_2873 |
| M. smegmatis MC2 155 | MSMEG_3657 | - | 2e-59 | 31.61% (541) | hypothetical protein MSMEG_3657 |
| M. smegmatis MC2 155 | MSMEG_4864 | - | 2e-22 | 25.72% (591) | 3-ketosteroid-delta-1-dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1848 | - | 2e-62 | 33.02% (530) | hypothetical protein Mb1848 |
| M. gilvum PYR-GCK | Mflv_4564 | - | 0.0 | 75.38% (520) | hypothetical protein Mflv_4564 |
| M. tuberculosis H37Rv | Rv1817 | - | 2e-62 | 33.02% (530) | hypothetical protein Rv1817 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0623 | - | 1e-122 | 47.34% (526) | hypothetical protein MAB_0623 |
| M. marinum M | MMAR_0205 | - | 1e-121 | 45.18% (529) | flavoprotein |
| M. avium 104 | MAV_2897 | - | 4e-62 | 33.52% (540) | hypothetical protein MAV_2897 |
| M. thermoresistible (build 8) | TH_4191 | - | 0.0 | 84.19% (525) | PUTATIVE 3-ketosteroid-delta4 |
| M. ulcerans Agy99 | MUL_4900 | - | 1e-117 | 43.88% (531) | hypothetical protein MUL_4900 |
| M. vanbaalenii PYR-1 | Mvan_3165 | - | 2e-60 | 31.48% (540) | hypothetical protein Mvan_3165 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2873|M.smegmatis_MC2_155 --------------MPTGRDYDVIIVGFGAAGASAAIEAADRGARVLVLD
TH_4191|M.thermoresistible__bu --------------MPTAQEYDVIIVGFGAAGASAAIEAADRGARVLVLD
Mflv_4564|M.gilvum_PYR-GCK -----------------MAEYDVIVVGFGAAGAAAAIEAADRGARVLALD
MMAR_0205|M.marinum_M --------MADDTPEHIVESTDVVVIGFGAAGVSAAITAREQGVQVVALD
MUL_4900|M.ulcerans_Agy99 --------MADDTPEHIVESTDVVVIGFGATGVSAAITAREQGVQVVALD
MAB_0623|M.abscessus_ATCC_1997 --------MPGRS---DMPSADVIIVGYGVAGASAALAALERGASVIILE
Mb1848|M.bovis_AF2122/97 MSTDIPATVSAETVTSWSDDVDVTVIGFGIAGGCAAVSAAAAGARVLVLE
Rv1817|M.tuberculosis_H37Rv MSTDIPATVSAETVTSWSDDVDVTVIGFGIAGGCAAVSAAAAGARVLVLE
MAV_2897|M.avium_104 MSTEIPATVSAHDVTSWSDDVDVVVIGFGIAGGCAAVSAAADGARVLVLE
Mvan_3165|M.vanbaalenii_PYR-1 -MQHIPETVNVGDVTSWSDEVDVVVVGFGIAGGCAAVSAAAAGARVLVLE
. ** ::*:* :* .**: * *. *: *:
MSMEG_2873|M.smegmatis_MC2_155 RGYGGG-ATAYSGGIVYAGAGTPEQHAGGYSDSVENMRAYLEQEVAGAVK
TH_4191|M.thermoresistible__bu RGHGGG-ATAYSGGIVYAGAGTAEQQAGGHADSVENMRAYLAREVGDAVS
Mflv_4564|M.gilvum_PYR-GCK RGYGGG-ATALSGGIIYAGAGTAEQHAGGHTDSVDNLRAYLTQEVGDAVG
MMAR_0205|M.marinum_M RANGGG-ATAISGGIIYAGGGTAVQQQAGVRDSFEQMLTYLRLEVADAVS
MUL_4900|M.ulcerans_Agy99 RANGGG-ATAISGDIIYAGGGTAVQQQAGVRDSFEQMLTYLRLEVADAVS
MAB_0623|M.abscessus_ATCC_1997 RFDGGG-ASAISGGIYYAGGGTNIQRDAGVEDTPELMLEYLRLEVGDAVK
Mb1848|M.bovis_AF2122/97 RAAAAGGTTALAGGHFYLGGGTTVQLATGHPDSPEEMYKYLVAVSREPD-
Rv1817|M.tuberculosis_H37Rv RAAAAGGTTALAGGHFYLGGGTTVQLATGHPDSPEEMYKYLVAVSREPD-
MAV_2897|M.avium_104 RAAAAGGTTSLAGGHFYLGGGTAVQQATGHDDSAEEMYKYLVAVSREPE-
Mvan_3165|M.vanbaalenii_PYR-1 KAAAVGGTTSMAGGHFYLGGGTAVQQATGHDDSAEEMYKYLVSQSRDPE-
: . * ::: :*. * *.** * * *: : : ** .
MSMEG_2873|M.smegmatis_MC2_155 PETLARFCEQSPALLEWLKAQGVPFRGGAGPSYKTSYPTDDNYLYYSGNE
TH_4191|M.thermoresistible__bu PETLTRFCEQSPAMIEWLKAQGVEFRGGPVPPYKTSYPTDEHYLYYSGNE
Mflv_4564|M.gilvum_PYR-GCK EDTLTRFCAESPGLIAWLKAQGVEFRGGPVSSYKTSYPTDDFYLYYSGNE
MMAR_0205|M.marinum_M ESTLESFVRGSPGMIDWLSHYGVPFDS-TVCPYKTSFPNNHYYLYHSGSE
MUL_4900|M.ulcerans_Agy99 ESTLESFVRGSPEMIDWLSNYGVPFDS-TVYPYKTSFPNNHYYLYHSGSE
MAB_0623|M.abscessus_ATCC_1997 PETLQKFVDGSVDTLNWLQGYGVPFEG-SLAPFKTSYPTDDYYLYFSGSE
Mb1848|M.bovis_AF2122/97 HDKIRAYCDGSVEHFNWLEGLGFQFER-SYFPGKAVIQPNTEGLMFTGNE
Rv1817|M.tuberculosis_H37Rv HDKIRAYCDGSVEHFNWLEGLGFQFER-SYFPGKAVIQPNTEGLMFTGNE
MAV_2897|M.avium_104 LDKIRAYCEGSVEHFNWLEDLGFQFER-SYYPGKVVVPPGTEGLSYTGNE
Mvan_3165|M.vanbaalenii_PYR-1 HDKIRAYCEGSVEHFNWLEALGFQFER-SYYPGKVVVPPGTEGLSYTGNE
..: : * : **. *. * . . *. . * .:*.*
MSMEG_2873|M.smegmatis_MC2_155 KAYPYVDHAQPAPRGHRVLAPGMS-SGRVLFERLRDSALAKGVHFTPLAH
TH_4191|M.thermoresistible__bu TAFPYSEHAHPAPRGHRALAPGMR-SGRVLFERLRDSALSKGVEFVPLAH
Mflv_4564|M.gilvum_PYR-GCK KAYPYAQHAAPAPRGHRVLAPGMS-SGRVLYERLRDSAKAKGVTVIPLAR
MMAR_0205|M.marinum_M NSGAFRSHTPPVQRGHRVKGKGT--SGKQLYAPLAKAALSLGVQFYPHTK
MUL_4900|M.ulcerans_Agy99 NSGAFRSHTPPVQRGHRVKGKGN--SGKQLYAPLAKAALSLGVQFYPHTK
MAB_0623|M.abscessus_ATCC_1997 SSGMARAATPPRQRGHRAFGRGV--SGKALFAPLADSAERLGADVWRQTR
Mb1848|M.bovis_AF2122/97 KVWPFLELAVPAPRGHKVPVPGDTGGAAMVIDLLLKRAASLGIQIRYETG
Rv1817|M.tuberculosis_H37Rv KVWPFLELAVPAPRGHKVPVPGDTGGAAMVIDLLLKRAASLGIQIRYETG
MAV_2897|M.avium_104 KVWPFCEQAKPAPRGHSVPVPGELGGAAMVIDLLVKRAEALGVQIRYETG
Mvan_3165|M.vanbaalenii_PYR-1 KVWPFCEQAKPAPRGHSVPVPGELGGAAMVIDLLLKRAADLGVQIRYETG
. : * *** . * .. : * . * * . :
MSMEG_2873|M.smegmatis_MC2_155 VHSLIQDEDGRVTGVRYTVTDPGHRNARR-HRRIAKATGKLGTWMPRAVA
TH_4191|M.thermoresistible__bu VHSLIQADDGRVTGVRYTVLDPGHRHARR-HRLITRATGKLGTWMPGVVS
Mflv_4564|M.gilvum_PYR-GCK VHGLIT-DAGRVVGVRYRVLDQGHPNAHR-HRVLTRATAKLGTWMPGLVN
MMAR_0205|M.marinum_M VTKLLQDSTGRVTGVEAMTMHDAPPRIRRTYAALAAVSTKPGIYYPPLRN
MUL_4900|M.ulcerans_Agy99 VTKLLQDSTGRVTGVEAMTMHDAPPRIRRAYAALAAVSTKPGIYYPPLRN
MAB_0623|M.abscessus_ATCC_1997 VTGLVVE-EGRVVGVRGMTLKDAPAWARRLYSRLTHYATKPGIYYPPMRK
Mb1848|M.bovis_AF2122/97 ATELIVDGTGKVTGVMWKRFSETGAIKAK---------------------
Rv1817|M.tuberculosis_H37Rv ATELIVDGTGKVTGVMWKRFSETGAIKAK---------------------
MAV_2897|M.avium_104 ATNLIVDDDGAVVGVAWKHFTETGAVKAD---------------------
Mvan_3165|M.vanbaalenii_PYR-1 VTGLVVDDDGAVVGVRWKHFTETGEVKAK---------------------
. *: * *.**
MSMEG_2873|M.smegmatis_MC2_155 GAVARGERLRAEAGAEAHASAG-AVILAAGGFINDRDWVSRYAPEFLKI-
TH_4191|M.thermoresistible__bu GAVRYAERLRAEASVETETRAG-AVILAAGGFINNRGWVRQYAPQFLKI-
Mflv_4564|M.gilvum_PYR-GCK GVVARAERLWAEAAVQTEARAP-SVILAAGGFIFNREWVQAHAPKFTKI-
MMAR_0205|M.marinum_M LMERRLRALERRYARAVQIRARRGVIVCAGGFIANSEWIKRYAPRYVTG-
MUL_4900|M.ulcerans_Agy99 LMERRLRALERRYARAVQIRARRGVIVCAGGFIANSEWIKRYAPRYVTG-
MAB_0623|M.abscessus_ATCC_1997 TLEGPAYALERRFAKPFEIRADDGVILSSGGFIANRELVRRHAPAYLDG-
Mb1848|M.bovis_AF2122/97 -----------------------SVIIAAGGFVMNPDMVAKYTPKLAEK-
Rv1817|M.tuberculosis_H37Rv -----------------------SVIIAAGGFVMNPDMVAKYTPKLAEK-
MAV_2897|M.avium_104 -----------------------AVILAAGGFAMNPQMVAEHTPALGQPR
Mvan_3165|M.vanbaalenii_PYR-1 -----------------------SVVIAAGGFAMNAEMVAEYTPALAAER
.*::.:*** : : ::*
MSMEG_2873|M.smegmatis_MC2_155 ----------SPLGTVGDDGTGIRLGLDAGGVTDKMGNVTAWRFLSPPSA
TH_4191|M.thermoresistible__bu ----------SPLGTVGDDGTGIRLGLDAGGKTDKMGNVTAWRFLSPPSA
Mflv_4564|M.gilvum_PYR-GCK ----------SPLGTAGDDGNGIALGLDAGGFTDKMGNVAAWRFLAPLSA
MMAR_0205|M.marinum_M ----------LQLGTSGDDGSGIALAQSVGAVTERMDNVSAWRFITPPSA
MUL_4900|M.ulcerans_Agy99 ----------LQLGTSGDDGSGIALAQSVGAVTERMDNVSARRLITPPSA
MAB_0623|M.abscessus_ATCC_1997 ----------LELGTAGDDGTALKLAEPLGAATGHLDEISAWRFIVPPAA
Mb1848|M.bovis_AF2122/97 ---------PFVLGNTYDDGLGIRLGVSAGGATQHMDQMFITAPPYPPSI
Rv1817|M.tuberculosis_H37Rv ---------PFVLGNTYDDGLGIRLGVSAGGATQHMDQMFITAPPYPPSI
MAV_2897|M.avium_104 RTKHHGLVAPYILGNPHDDGLAIRMGVSAGGATKHMDELFITAAAYPPEV
Mvan_3165|M.vanbaalenii_PYR-1 KTKHHGTVAPYILGNPNDDGLGIKLGVSAGGVAANLDQLFITAAAYPPEI
**. *** .: :. *. : .:.:: *
MSMEG_2873|M.smegmatis_MC2_155 FLEGLTVGADGRRIANEDLYGAAHGNVLMREFGGTGWAIYDAATWRKIKD
TH_4191|M.thermoresistible__bu FLEGLTVGADGRRIANEDLYGATHGDVLMREFGGTGWAIYDAATWRKIRT
Mflv_4564|M.gilvum_PYR-GCK FLEGLTVGADGRRITNEDLYGATHSNVMMREFGGTGWAIYDARTWAKIRG
MMAR_0205|M.marinum_M FISTVMVDQQGQRVIDESRYGAAVGKALVQDHNARAWLVADADLMNEARR
MUL_4900|M.ulcerans_Agy99 FISTVMVDQQGQRVIDESRYGAAVGKALVHDHNARAWLVADADLMNEARR
MAB_0623|M.abscessus_ATCC_1997 FLGSLLVDTKGQRMIDESRYGAALGKEIVRTAGGVGYLVADQPLVKRARQ
Mb1848|M.bovis_AF2122/97 LLTGIIVNKLGQRFVAEDSYHSRTAGFIMEQPDSAAYLIVDEAHLEHPKM
Rv1817|M.tuberculosis_H37Rv LLTGIIVNKLGQRFVAEDSYHSRTAGFIMEQPDSAAYLIVDEAHLEHPKM
MAV_2897|M.avium_104 LLTGIIVNKEGKRFVAEDSYHSRTSAFVLEQPEQTAYLIVDEAHTEMPEM
Mvan_3165|M.vanbaalenii_PYR-1 LLTGVIVNKDGQRFVAEDSYHSRTSAFVLEQPEQTAYLIVDEDHMQMPEM
:: : *. *:*. *. * : . ::. .: : * .
MSMEG_2873|M.smegmatis_MC2_155 QITEQTQVFQRLQIWYLRTIGHKKAATIEGIAAKNGIDAAALRKTVDEYN
TH_4191|M.thermoresistible__bu QITDQTQVFQRLQVWYLLTIGHKKAATIADLARKNGIDAAGLQQTVDEYN
Mflv_4564|M.gilvum_PYR-GCK QVRTQTQLFQRLQLIYLFTTGHRKSSTLEGLARKNGIDPAGLRRTVDAYN
MMAR_0205|M.marinum_M QMLKQPLWFQRAQAAALMVADSVRAETLARVARKAGVDPDGLQATVDAHN
MUL_4900|M.ulcerans_Agy99 QMLKQPLWFQRAQAAALMVADSVRAETLADVARKAGVEPDGLQATVDAHN
MAB_0623|M.abscessus_ATCC_1997 QLGSQTLWFQRIQAEAFLNVGRKKAGSIEELAAKAGIDPEGLARTVSEHN
Mb1848|M.bovis_AF2122/97 PLVPLIDGWE----------------TVVEMEAALGIPPGNLAATLDRYN
Rv1817|M.tuberculosis_H37Rv PLVPLIDGWE----------------TVVEMEAALGIPPGNLAATLDRYN
MAV_2897|M.avium_104 PLIRFLDGYE----------------TIAEMEAALGIPAGNLAATLERYN
Mvan_3165|M.vanbaalenii_PYR-1 PLIKFVDGFE----------------TIAEIESALGIPDGNLAATLECYN
: :: :: : *: * *:. :*
MSMEG_2873|M.smegmatis_MC2_155 RGIAGGAGDPAHKDPSLCSPMERGPFYSIDISADSSLFYPIPGLTLGGLV
TH_4191|M.thermoresistible__bu RGISSGAGDPGHKHPSLCPPLERGPFYSINISADASLFYPIPGLTLGGLV
Mflv_4564|M.gilvum_PYR-GCK SGIVSGTGDPAHKDPGLCAPMTTGPFYSIDISAASSMFYPVPGLTLGGLV
MMAR_0205|M.marinum_M SAIDAAATDPAGKPAEFVRRVARAPFTLLNISVRPSLLNPTPMLTLGGIK
MUL_4900|M.ulcerans_Agy99 NVIDAAATDPAGKPAEFVRRVARAPFTLLNIAVRPSLLNPTPMLTLGGIK
MAB_0623|M.abscessus_ATCC_1997 RAIAGGTPDPLGKPDDIRVPIERAPFYLFNVSIKTNMLNPCPMLTLGGLV
Mb1848|M.bovis_AF2122/97 AYAARGADPDFHKQPEFLAAQDNGPWGAFDMSLGKAMYA---GFTLGGLA
Rv1817|M.tuberculosis_H37Rv AYAARGADPDFHKQPEFLAAQDNGPWGAFDMSLGKAMYA---GFTLGGLA
MAV_2897|M.avium_104 KFAAAGEDPDFHKQPEYLAAQDNGPWAVFDLSLGRAMYS---GFTIGGLA
Mvan_3165|M.vanbaalenii_PYR-1 ANAAAGVDPDFHKQPEYLAAQDKGPWAVFDLSLGRAMYS---GFTMGGLT
. * .*: :::: : :*:**:
MSMEG_2873|M.smegmatis_MC2_155 VDEDTGAVVHRDGGVVPGLYAAGRTAVGVCSN--SYVSGLSISDCVFSGR
TH_4191|M.thermoresistible__bu VDEDSGAVVHRDGGVIPGLYAAGRNAVGVCSN--SYVSGLSISDCVFSGR
Mflv_4564|M.gilvum_PYR-GCK VDEKTGEVMHRAGGTVAGLYAVGRTAVGICSN--SYVSGLSLSDCVFSGR
MMAR_0205|M.marinum_M VDEQTGAVLDASGAAIPGLFGAGRTATGICSN--SYVSGLSIADCVFSGR
MUL_4900|M.ulcerans_Agy99 VDEQTGAVLDASGAAIPGLFGAGRTATGICSN--SYVSGLSIADCVFSGR
MAB_0623|M.abscessus_ATCC_1997 VDEETGAVQTTSGAAIPGLYAAGRAAVGICSN--SYVSGLSLADCVFSGR
Mb1848|M.bovis_AF2122/97 TSVD-GQVLRDDGAVVAGLYAVGACASNIAQDGKGYASGTQLGEGSFFGR
Rv1817|M.tuberculosis_H37Rv TSVD-GQVLRDDGAVVAGLYAVGACASNIAQDGKGYASGTQLGEGSFFGR
MAV_2897|M.avium_104 VSVD-GEVQRADGSVVPGLYAAGACASNLAQDGKGYASGTQLGEGSFFGR
Mvan_3165|M.vanbaalenii_PYR-1 VSID-GEVLREDGSAIPGLYAAGACACNIAQDGKGYASGTQLGEGSFFGR
.. . * * *..:.**:..* * .:..: .*.** .:.: * **
MSMEG_2873|M.smegmatis_MC2_155 RAGADAVAKI--------------------------------
TH_4191|M.thermoresistible__bu RAGAHAAGGTR-------------------------------
Mflv_4564|M.gilvum_PYR-GCK RAGAHAAG----------------------------------
MMAR_0205|M.marinum_M RAGNHAAIE---------------------------------
MUL_4900|M.ulcerans_Agy99 RAGTHAASAALE------------------------------
MAB_0623|M.abscessus_ATCC_1997 RAGTETGRRIDA------------------------------
Mb1848|M.bovis_AF2122/97 RAGAHAAARAQGM-----------------------------
Rv1817|M.tuberculosis_H37Rv RAGAHAAARAQGM-----------------------------
MAV_2897|M.avium_104 RAGAHAARRAAKA-----------------------------
Mvan_3165|M.vanbaalenii_PYR-1 RAGEAAARRAGEAAARRAGEAAARRAGEAAARRAGEAAAERA
*** :