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ADDTPEHIVESTDVVVIGFGATGVSAAITAREQGVQVVALDRANGGGATAISGDIIYAGGGTAVQQQAGV RDSFEQMLTYLRLEVADAVSESTLESFVRGSPEMIDWLSNYGVPFDSTVYPYKTSFPNNHYYLYHSGSEN SGAFRSHTPPVQRGHRVKGKGNSGKQLYAPLAKAALSLGVQFYPHTKVTKLLQDSTGRVTGVEAMTMHDA PPRIRRAYAALAAVSTKPGIYYPPLRNLMERRLRALERRYARAVQIRARRGVIVCAGGFIANSEWIKRYA PRYVTGLQLGTSGDDGSGIALAQSVGAVTERMDNVSARRLITPPSAFISTVMVDQQGQRVIDESRYGAAV GKALVHDHNARAWLVADADLMNEARRQMLKQPLWFQRAQAAALMVADSVRAETLADVARKAGVEPDGLQA TVDAHNNVIDAAATDPAGKPAEFVRRVARAPFTLLNIAVRPSLLNPTPMLTLGGIKVDEQTGAVLDASGA AIPGLFGAGRTATGICSNSYVSGLSIADCVFSGRRAGTHAASAALE*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. ulcerans Agy99 | MUL_4900 | - | - | 100% (537) | hypothetical protein MUL_4900 |
| M. ulcerans Agy99 | MUL_3063 | - | 1e-51 | 28.86% (544) | flavoprotein |
| M. ulcerans Agy99 | MUL_4098 | - | 4e-24 | 25.13% (585) | 3-ketosteroid-delta-1-dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1848 | - | 8e-55 | 29.76% (531) | hypothetical protein Mb1848 |
| M. gilvum PYR-GCK | Mflv_4564 | - | 1e-114 | 44.17% (523) | hypothetical protein Mflv_4564 |
| M. tuberculosis H37Rv | Rv1817 | - | 8e-55 | 29.76% (531) | hypothetical protein Rv1817 |
| M. leprae Br4923 | MLBr_01226 | nadB | 1e-05 | 29.93% (137) | L-aspartate oxidase |
| M. abscessus ATCC 19977 | MAB_0623 | - | 1e-164 | 54.63% (518) | hypothetical protein MAB_0623 |
| M. marinum M | MMAR_0205 | - | 0.0 | 96.99% (532) | flavoprotein |
| M. avium 104 | MAV_3022 | - | 3e-59 | 29.53% (535) | hypothetical protein MAV_3022 |
| M. smegmatis MC2 155 | MSMEG_2873 | - | 1e-116 | 43.88% (531) | hypothetical protein MSMEG_2873 |
| M. thermoresistible (build 8) | TH_4191 | - | 1e-122 | 46.27% (523) | PUTATIVE 3-ketosteroid-delta4 |
| M. vanbaalenii PYR-1 | Mvan_2890 | - | 2e-57 | 29.05% (537) | hypothetical protein Mvan_2890 |
CLUSTAL 2.0.9 multiple sequence alignment
MUL_4900|M.ulcerans_Agy99 --------MADDTPEHIVESTDVVVIGFGATGVSAAITAREQGVQVVALD
MMAR_0205|M.marinum_M --------MADDTPEHIVESTDVVVIGFGAAGVSAAITAREQGVQVVALD
MAB_0623|M.abscessus_ATCC_1997 --------MPGRS---DMPSADVIIVGYGVAGASAALAALERGASVIILE
MSMEG_2873|M.smegmatis_MC2_155 --------------MPTGRDYDVIIVGFGAAGASAAIEAADRGARVLVLD
TH_4191|M.thermoresistible__bu --------------MPTAQEYDVIIVGFGAAGASAAIEAADRGARVLVLD
Mflv_4564|M.gilvum_PYR-GCK -----------------MAEYDVIVVGFGAAGAAAAIEAADRGARVLALD
MAV_3022|M.avium_104 MNTDVTP-IPASSITSWDHEADVVIAGYGVAGAAAAVEAARAGADVLVLE
Mvan_2890|M.vanbaalenii_PYR-1 MSTDIVP-VPAAEITHWDHEADVVIAGYGVAGAAAAVEAARAGADVLVLE
Mb1848|M.bovis_AF2122/97 MSTDIPATVSAETVTSWSDDVDVTVIGFGIAGGCAAVSAAAAGARVLVLE
Rv1817|M.tuberculosis_H37Rv MSTDIPATVSAETVTSWSDDVDVTVIGFGIAGGCAAVSAAAAGARVLVLE
MLBr_01226|M.leprae_Br4923 ----------MMAVPDWKHAADVVVIGTGVAGLAAALAAHRAGRNVVVLT
** : * * :* .**: * * *: *
MUL_4900|M.ulcerans_Agy99 R-ANGGGATAISGDIIYAGGGTAVQQQAGVRDSFEQMLTYLRLEVADAVS
MMAR_0205|M.marinum_M R-ANGGGATAISGGIIYAGGGTAVQQQAGVRDSFEQMLTYLRLEVADAVS
MAB_0623|M.abscessus_ATCC_1997 R-FDGGGASAISGGIYYAGGGTNIQRDAGVEDTPELMLEYLRLEVGDAVK
MSMEG_2873|M.smegmatis_MC2_155 R-GYGGGATAYSGGIVYAGAGTPEQHAGGYSDSVENMRAYLEQEVAGAVK
TH_4191|M.thermoresistible__bu R-GHGGGATAYSGGIVYAGAGTAEQQAGGHADSVENMRAYLAREVGDAVS
Mflv_4564|M.gilvum_PYR-GCK R-GYGGGATALSGGIIYAGAGTAEQHAGGHTDSVDNLRAYLTQEVGDAVG
MAV_3022|M.avium_104 RTGSWGGAAAMAGGFIYLGGGTPIQKACGFTDSVDNMAAFLNVAMGPGAD
Mvan_2890|M.vanbaalenii_PYR-1 RTGSWGGAAAMAGGFIYLGGGTALQKACGFDDSVDNMAAFLNVAMGPGAD
Mb1848|M.bovis_AF2122/97 RAAAAGGTTALAGGHFYLGGGTTVQLATGHPDSPEEMYKYL-VAVSREPD
Rv1817|M.tuberculosis_H37Rv RAAAAGGTTALAGGHFYLGGGTTVQLATGHPDSPEEMYKYL-VAVSREPD
MLBr_01226|M.leprae_Br4923 KADQRRGETATH----YAQGGIAVVLP-GSDDSVDAHASDTLAAGAGMCN
: * :* * .* * *: : .
MUL_4900|M.ulcerans_Agy99 ESTLESFVRGSPEMIDWLSNYGVPFDS-TVYPYKTSFPNNH--YYLYHSG
MMAR_0205|M.marinum_M ESTLESFVRGSPGMIDWLSHYGVPFDS-TVCPYKTSFPNNH--YYLYHSG
MAB_0623|M.abscessus_ATCC_1997 PETLQKFVDGSVDTLNWLQGYGVPFEG-SLAPFKTSYPTDD--YYLYFSG
MSMEG_2873|M.smegmatis_MC2_155 PETLARFCEQSPALLEWLKAQGVPFRGGAGPSYKTSYPTDD--NYLYYSG
TH_4191|M.thermoresistible__bu PETLTRFCEQSPAMIEWLKAQGVEFRGGPVPPYKTSYPTDE--HYLYYSG
Mflv_4564|M.gilvum_PYR-GCK EDTLTRFCAESPGLIAWLKAQGVEFRGGPVSSYKTSYPTDD--FYLYYSG
MAV_3022|M.avium_104 ADRIADYCAGSLAHFEWLVGCGVPFKA-EFFGEPGWEPMGD--QGLMYSG
Mvan_2890|M.vanbaalenii_PYR-1 ENRIADYCAGSVSHFDWLVGCGVPFKA-EFFGEPGWEPMGD--QGLMFSG
Mb1848|M.bovis_AF2122/97 HDKIRAYCDGSVEHFNWLEGLGFQFER-SYFPGKAVIQPNT--EGLMFTG
Rv1817|M.tuberculosis_H37Rv HDKIRAYCDGSVEHFNWLEGLGFQFER-SYFPGKAVIQPNT--EGLMFTG
MLBr_01226|M.leprae_Br4923 LDTVYSIVAEGYHAVTELVGYGARFDESIPGRWAVTCEGGHSRRRIVHAG
. : . . * * * . : .:*
MUL_4900|M.ulcerans_Agy99 SENSGAFRSHTPPVQRGHRVKGKGN------SGKQLYAPLAKAALSLGVQ
MMAR_0205|M.marinum_M SENSGAFRSHTPPVQRGHRVKGKGT------SGKQLYAPLAKAALSLGVQ
MAB_0623|M.abscessus_ATCC_1997 SESSGMARAATPPRQRGHRAFGRGV------SGKALFAPLADSAERLGAD
MSMEG_2873|M.smegmatis_MC2_155 NEKAYPYVDHAQPAPRGHRVLAPGMS-----SGRVLFERLRDSALAKGVH
TH_4191|M.thermoresistible__bu NETAFPYSEHAHPAPRGHRALAPGMR-----SGRVLFERLRDSALSKGVE
Mflv_4564|M.gilvum_PYR-GCK NEKAYPYAQHAAPAPRGHRVLAPGMS-----SGRVLYERLRDSAKAKGVT
MAV_3022|M.avium_104 GENSYPFNTIASPAPRGHVPQMQNKKQGEASAGYMLMKPLVESATAAGAR
Mvan_2890|M.vanbaalenii_PYR-1 GENSFPFNTIAISAPRGHVPQMSNKKQGEASAGFMLMKPLVETATAAGAR
Mb1848|M.bovis_AF2122/97 NEKVWPFLELAVPAPRGHKVPVP----GDTGGAAMVIDLLLKRAASLGIQ
Rv1817|M.tuberculosis_H37Rv NEKVWPFLELAVPAPRGHKVPVP----GDTGGAAMVIDLLLKRAASLGIQ
MLBr_01226|M.leprae_Br4923 GDATG----AEVQRALDHAADVLDIR-----TSHLALRVLHDGTVVNGVS
.: .* . * . : *
MUL_4900|M.ulcerans_Agy99 FYPHTKVTKLLQDSTGRVTGVEAMTMHDAPPRIRRAYAALAAVSTKPGIY
MMAR_0205|M.marinum_M FYPHTKVTKLLQDSTGRVTGVEAMTMHDAPPRIRRTYAALAAVSTKPGIY
MAB_0623|M.abscessus_ATCC_1997 VWRQTRVTGLVVE-EGRVVGVRGMTLKDAPAWARRLYSRLTHYATKPGIY
MSMEG_2873|M.smegmatis_MC2_155 FTPLAHVHSLIQDEDGRVTGVRYTVTDPGHRNARR-HRRIAKATGKLGTW
TH_4191|M.thermoresistible__bu FVPLAHVHSLIQADDGRVTGVRYTVLDPGHRHARR-HRLITRATGKLGTW
Mflv_4564|M.gilvum_PYR-GCK VIPLARVHGLIT-DAGRVVGVRYRVLDQGHPNAHR-HRVLTRATAKLGTW
MAV_3022|M.avium_104 ALYDVRVQRLITESDGRVVG------------------------------
Mvan_2890|M.vanbaalenii_PYR-1 AVYDIRAQRLVVASDGRVVG------------------------------
Mb1848|M.bovis_AF2122/97 IRYETGATELIVDGTGKVTG------------------------------
Rv1817|M.tuberculosis_H37Rv IRYETGATELIVDGTGKVTG------------------------------
MLBr_01226|M.leprae_Br4923 VLNPNGWGIVSAPSVILASGGLGHLYGATTNPEGS---------------
: . *
MUL_4900|M.ulcerans_Agy99 YPPLRNLMERRLRALERRYARAVQIRARRGVIVCAGGFIANSEWIKRYAP
MMAR_0205|M.marinum_M YPPLRNLMERRLRALERRYARAVQIRARRGVIVCAGGFIANSEWIKRYAP
MAB_0623|M.abscessus_ATCC_1997 YPPMRKTLEGPAYALERRFAKPFEIRADDGVILSSGGFIANRELVRRHAP
MSMEG_2873|M.smegmatis_MC2_155 MPRAVAGAVARGERLRAEAGAEAHASAG-AVILAAGGFINDRDWVSRYAP
TH_4191|M.thermoresistible__bu MPGVVSGAVRYAERLRAEASVETETRAG-AVILAAGGFINNRGWVRQYAP
Mflv_4564|M.gilvum_PYR-GCK MPGLVNGVVARAERLWAEAAVQTEARAP-SVILAAGGFIFNREWVQAHAP
MAV_3022|M.avium_104 -------------MRARRYGTEMNIRARTGVVLATGSFAYNDSMVARYAP
Mvan_2890|M.vanbaalenii_PYR-1 -------------LVARKFGDEITIRARRGVVLAMGSFAYNEAMVAQYAP
Mb1848|M.bovis_AF2122/97 -------------VMWKRFSETGAIKAKS-VIIAAGGFVMNPDMVAKYTP
Rv1817|M.tuberculosis_H37Rv -------------VMWKRFSETGAIKAKS-VIIAAGGFVMNPDMVAKYTP
MLBr_01226|M.leprae_Br4923 ----TGDGIALALWAGVAVSDLEFIQFHPTMLFAAGTGTGGRRPLVTEAI
. ::.. * . : :
MUL_4900|M.ulcerans_Agy99 RYVTGLQLG-TSGDDGSGIA-LAQSVGAVTERMDNVSARRLITPPSAFIS
MMAR_0205|M.marinum_M RYVTGLQLG-TSGDDGSGIA-LAQSVGAVTERMDNVSAWRFITPPSAFIS
MAB_0623|M.abscessus_ATCC_1997 AYLDGLELG-TAGDDGTALK-LAEPLGAATGHLDEISAWRFIVPPAAFLG
MSMEG_2873|M.smegmatis_MC2_155 EFLKISPLG-TVGDDGTGIR-LGLDAGGVTDKMGNVTAWRFLSPPSAFLE
TH_4191|M.thermoresistible__bu QFLKISPLG-TVGDDGTGIR-LGLDAGGKTDKMGNVTAWRFLSPPSAFLE
Mflv_4564|M.gilvum_PYR-GCK KFTKISPLG-TAGDDGNGIA-LGLDAGGFTDKMGNVAAWRFLAPLSAFLE
MAV_3022|M.avium_104 RIAGRPAAS-IEQHDGQAIR-MAQALGADLAHMDATEVAIFIDP-QQLVR
Mvan_2890|M.vanbaalenii_PYR-1 RIAGRPAAS-IEQHDGRAIQ-MAQALGADLAHMDATEVAIFADP-QQLVR
Mb1848|M.bovis_AF2122/97 KLAEKPFVLGNTYDDGLGIR-LGVSAGGATQHMDQMFITAPPYPPSILLT
Rv1817|M.tuberculosis_H37Rv KLAEKPFVLGNTYDDGLGIR-LGVSAGGATQHMDQMFITAPPYPPSILLT
MLBr_01226|M.leprae_Br4923 RGEGAILLDSKGNSVTSGVHPLGDLAPRDVVAAAIDARLKATGDSCVYLD
.: :. :
MUL_4900|M.ulcerans_Agy99 TVMVDQQGQRVIDESRYGAAVGKALVHDHNARAWLVADADLMNEARRQML
MMAR_0205|M.marinum_M TVMVDQQGQRVIDESRYGAAVGKALVQDHNARAWLVADADLMNEARRQML
MAB_0623|M.abscessus_ATCC_1997 SLLVDTKGQRMIDESRYGAALGKEIVRTAGGVGYLVADQPLVKRARQQLG
MSMEG_2873|M.smegmatis_MC2_155 GLTVGADGRRIANEDLYGAAHGNVLMREFGGTGWAIYDAATWRKIKDQIT
TH_4191|M.thermoresistible__bu GLTVGADGRRIANEDLYGATHGDVLMREFGGTGWAIYDAATWRKIRTQIT
Mflv_4564|M.gilvum_PYR-GCK GLTVGADGRRITNEDLYGATHSNVMMREFGGTGWAIYDARTWAKIRGQVR
MAV_3022|M.avium_104 GILVNGRGQRYVAEDTYPGRIGQLTLYQQDNTAYLIIDGDAQDEAMASWS
Mvan_2890|M.vanbaalenii_PYR-1 GILVNGRGQRYVPEDTYPGRIGQLTLYHQDNTAYLILDGHAQDEAMASLT
Mb1848|M.bovis_AF2122/97 GIIVNKLGQRFVAEDSYHSRTAGFIMEQPDSAAYLIVD-----EAHLEH-
Rv1817|M.tuberculosis_H37Rv GIIVNKLGQRFVAEDSYHSRTAGFIMEQPDSAAYLIVD-----EAHLEH-
MLBr_01226|M.leprae_Br4923 ARGIDGFASRFPTVTAACRTVGIDPAREP--IPVVPGAHYSCGGIVTDAY
:. . * . .
MUL_4900|M.ulcerans_Agy99 KQPLWFQRAQAAALMVADSVRAETLADVARKAGVEPDGLQATVDAHNNVI
MMAR_0205|M.marinum_M KQPLWFQRAQAAALMVADSVRAETLARVARKAGVDPDGLQATVDAHNSAI
MAB_0623|M.abscessus_ATCC_1997 SQTLWFQRIQAEAFLNVGRKKAGSIEELAAKAGIDPEGLARTVSEHNRAI
MSMEG_2873|M.smegmatis_MC2_155 EQTQVFQRLQIWYLRTIGHKKAATIEGIAAKNGIDAAALRKTVDEYNRGI
TH_4191|M.thermoresistible__bu DQTQVFQRLQVWYLLTIGHKKAATIADLARKNGIDAAGLQQTVDEYNRGI
Mflv_4564|M.gilvum_PYR-GCK TQTQLFQRLQLIYLFTTGHRKSSTLEGLARKNGIDPAGLRRTVDAYNSGI
MAV_3022|M.avium_104 PKLMLRP----------ATWVADTVADLERDMALPPGSLQDTVAAYNAGA
Mvan_2890|M.vanbaalenii_PYR-1 PQLMLRP----------PTWVADTVAELEAEIGLAPGSLQATVAAYNEGA
Mb1848|M.bovis_AF2122/97 PKMPLVP----------LIDGWETVVEMEAALGIPPGNLAATLDRYNAYA
Rv1817|M.tuberculosis_H37Rv PKMPLVP----------LIDGWETVVEMEAALGIPPGNLAATLDRYNAYA
MLBr_01226|M.leprae_Br4923 GQTELAGLFAAGEVARTGMHGANRLASNSLLEGLVVGGRAGRAAAAHAAA
: : .: :
MUL_4900|M.ulcerans_Agy99 DA--------AATDPAGKPAEFVRRVARAPFTLLNIAVRPSLLNPTPMLT
MMAR_0205|M.marinum_M DA--------AATDPAGKPAEFVRRVARAPFTLLNISVRPSLLNPTPMLT
MAB_0623|M.abscessus_ATCC_1997 AG--------GTPDPLGKPDDIRVPIERAPFYLFNVSIKTNMLNPCPMLT
MSMEG_2873|M.smegmatis_MC2_155 AG--------GAGDPAHKDPSLCSPMERGPFYSIDISADSSLFYPIPGLT
TH_4191|M.thermoresistible__bu SS--------GAGDPGHKHPSLCPPLERGPFYSINISADASLFYPIPGLT
Mflv_4564|M.gilvum_PYR-GCK VS--------GTGDPAHKDPGLCAPMTTGPFYSIDISAASSMFYPVPGLT
MAV_3022|M.avium_104 AR--------GEDPLLHKKPEWIRPIG-SPVGAVDL---RESTG---GFT
Mvan_2890|M.vanbaalenii_PYR-1 AR--------GEDPLLHKKAQWLRPIG-SPVGAIDL---RESTG---GFT
Mb1848|M.bovis_AF2122/97 AR--------GADPDFHKQPEFLAAQDNGPWGAFDMSLGKAMYA---GFT
Rv1817|M.tuberculosis_H37Rv AR--------GADPDFHKQPEFLAAQDNGPWGAFDMSLGKAMYA---GFT
MLBr_01226|M.leprae_Br4923 AGRAYVSKLEPVTHHALKRRELQRVMSRDAAVMRNAAGLQRLSDTLAEAP
* . : .
MUL_4900|M.ulcerans_Agy99 LGGIKVDEQTGAVLDASGAAIPGLFGAGRTATGICSNS--YVSGLSIADC
MMAR_0205|M.marinum_M LGGIKVDEQTGAVLDASGAAIPGLFGAGRTATGICSNS--YVSGLSIADC
MAB_0623|M.abscessus_ATCC_1997 LGGLVVDEETGAVQTTSGAAIPGLYAAGRAAVGICSNS--YVSGLSLADC
MSMEG_2873|M.smegmatis_MC2_155 LGGLVVDEDTGAVVHRDGGVVPGLYAAGRTAVGVCSNS--YVSGLSISDC
TH_4191|M.thermoresistible__bu LGGLVVDEDSGAVVHRDGGVIPGLYAAGRNAVGVCSNS--YVSGLSISDC
Mflv_4564|M.gilvum_PYR-GCK LGGLVVDEKTGEVMHRAGGTVAGLYAVGRTAVGICSNS--YVSGLSLSDC
MAV_3022|M.avium_104 LGGLATTLD-AEVLHVSGQPIPGLFAAGRCTAGLAAWG--YASGISLGDG
Mvan_2890|M.vanbaalenii_PYR-1 LGGLATTLD-AEVLHVSGEPIPGLFAAGRCTAGLAAWG--YASGVSLGDG
Mb1848|M.bovis_AF2122/97 LGGLATSVD-GQVLRDDGAVVAGLYAVGACASNIAQDGKGYASGTQLGEG
Rv1817|M.tuberculosis_H37Rv LGGLATSVD-GQVLRDDGAVVAGLYAVGACASNIAQDGKGYASGTQLGEG
MLBr_01226|M.leprae_Br4923 IRHVTGRRDFEDVALTLTARAVAAAALARNESRGCHHCTEYPDTAPEHAR
: : . * . . . . * .
MUL_4900|M.ulcerans_Agy99 VFSGRRAGTHAASAALE-----
MMAR_0205|M.marinum_M VFSGRRAGNHAAIE--------
MAB_0623|M.abscessus_ATCC_1997 VFSGRRAGTETGRRIDA-----
MSMEG_2873|M.smegmatis_MC2_155 VFSGRRAGADAVAKI-------
TH_4191|M.thermoresistible__bu VFSGRRAGAHAAGGTR------
Mflv_4564|M.gilvum_PYR-GCK VFSGRRAGAHAAG---------
MAV_3022|M.avium_104 SFYGRRAGASAAGCRLPRV---
Mvan_2890|M.vanbaalenii_PYR-1 SFYGRRAGRRAARD--------
Mb1848|M.bovis_AF2122/97 SFFGRRAGAHAAARAQGM----
Rv1817|M.tuberculosis_H37Rv SFFGRRAGAHAAARAQGM----
MLBr_01226|M.leprae_Br4923 STVIRLADDQNLVRAEALATVG
* *.