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MAEYDVIVVGFGAAGAAAAIEAADRGARVLALDRGYGGGATALSGGIIYAGAGTAEQHAGGHTDSVDNLR AYLTQEVGDAVGEDTLTRFCAESPGLIAWLKAQGVEFRGGPVSSYKTSYPTDDFYLYYSGNEKAYPYAQH AAPAPRGHRVLAPGMSSGRVLYERLRDSAKAKGVTVIPLARVHGLITDAGRVVGVRYRVLDQGHPNAHRH RVLTRATAKLGTWMPGLVNGVVARAERLWAEAAVQTEARAPSVILAAGGFIFNREWVQAHAPKFTKISPL GTAGDDGNGIALGLDAGGFTDKMGNVAAWRFLAPLSAFLEGLTVGADGRRITNEDLYGATHSNVMMREFG GTGWAIYDARTWAKIRGQVRTQTQLFQRLQLIYLFTTGHRKSSTLEGLARKNGIDPAGLRRTVDAYNSGI VSGTGDPAHKDPGLCAPMTTGPFYSIDISAASSMFYPVPGLTLGGLVVDEKTGEVMHRAGGTVAGLYAVG RTAVGICSNSYVSGLSLSDCVFSGRRAGAHAAG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. gilvum PYR-GCK | Mflv_4564 | - | - | 100% (523) | hypothetical protein Mflv_4564 |
| M. gilvum PYR-GCK | Mflv_3411 | - | 2e-57 | 31.72% (536) | hypothetical protein Mflv_3411 |
| M. gilvum PYR-GCK | Mflv_4550 | - | 1e-49 | 31.38% (529) | hypothetical protein Mflv_4550 |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1848 | - | 8e-58 | 32.51% (526) | hypothetical protein Mb1848 |
| M. tuberculosis H37Rv | Rv1817 | - | 8e-58 | 32.51% (526) | hypothetical protein Rv1817 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0623 | - | 1e-116 | 45.58% (520) | hypothetical protein MAB_0623 |
| M. marinum M | MMAR_0205 | - | 1e-120 | 45.70% (523) | flavoprotein |
| M. avium 104 | MAV_3022 | - | 3e-57 | 33.27% (535) | hypothetical protein MAV_3022 |
| M. smegmatis MC2 155 | MSMEG_2873 | - | 0.0 | 75.38% (520) | hypothetical protein MSMEG_2873 |
| M. thermoresistible (build 8) | TH_4191 | - | 0.0 | 75.48% (522) | PUTATIVE 3-ketosteroid-delta4 |
| M. ulcerans Agy99 | MUL_4900 | - | 1e-114 | 44.17% (523) | hypothetical protein MUL_4900 |
| M. vanbaalenii PYR-1 | Mvan_3165 | - | 1e-57 | 31.90% (536) | hypothetical protein Mvan_3165 |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2873|M.smegmatis_MC2_155 --------------MPTGRDYDVIIVGFGAAGASAAIEAADRGARVLVLD
TH_4191|M.thermoresistible__bu --------------MPTAQEYDVIIVGFGAAGASAAIEAADRGARVLVLD
Mflv_4564|M.gilvum_PYR-GCK -----------------MAEYDVIVVGFGAAGAAAAIEAADRGARVLALD
MMAR_0205|M.marinum_M --------MADDTPEHIVESTDVVVIGFGAAGVSAAITAREQGVQVVALD
MUL_4900|M.ulcerans_Agy99 --------MADDTPEHIVESTDVVVIGFGATGVSAAITAREQGVQVVALD
MAB_0623|M.abscessus_ATCC_1997 --------MPGRS---DMPSADVIIVGYGVAGASAALAALERGASVIILE
Mb1848|M.bovis_AF2122/97 MSTDIPATVSAETVTSWSDDVDVTVIGFGIAGGCAAVSAAAAGARVLVLE
Rv1817|M.tuberculosis_H37Rv MSTDIPATVSAETVTSWSDDVDVTVIGFGIAGGCAAVSAAAAGARVLVLE
Mvan_3165|M.vanbaalenii_PYR-1 -MQHIPETVNVGDVTSWSDEVDVVVVGFGIAGGCAAVSAAAAGARVLVLE
MAV_3022|M.avium_104 MNTDVTP-IPASSITSWDHEADVVIAGYGVAGAAAAVEAARAGADVLVLE
. ** : *:* :* .**: * *. *: *:
MSMEG_2873|M.smegmatis_MC2_155 R-GYGGGATAYSGGIVYAGAGTPEQHAGGYSDSVENMRAYLEQEVAGAVK
TH_4191|M.thermoresistible__bu R-GHGGGATAYSGGIVYAGAGTAEQQAGGHADSVENMRAYLAREVGDAVS
Mflv_4564|M.gilvum_PYR-GCK R-GYGGGATALSGGIIYAGAGTAEQHAGGHTDSVDNLRAYLTQEVGDAVG
MMAR_0205|M.marinum_M R-ANGGGATAISGGIIYAGGGTAVQQQAGVRDSFEQMLTYLRLEVADAVS
MUL_4900|M.ulcerans_Agy99 R-ANGGGATAISGDIIYAGGGTAVQQQAGVRDSFEQMLTYLRLEVADAVS
MAB_0623|M.abscessus_ATCC_1997 R-FDGGGASAISGGIYYAGGGTNIQRDAGVEDTPELMLEYLRLEVGDAVK
Mb1848|M.bovis_AF2122/97 RAAAAGGTTALAGGHFYLGGGTTVQLATGHPDSPEEMYKYL-VAVSREPD
Rv1817|M.tuberculosis_H37Rv RAAAAGGTTALAGGHFYLGGGTTVQLATGHPDSPEEMYKYL-VAVSREPD
Mvan_3165|M.vanbaalenii_PYR-1 KAAAVGGTTSMAGGHFYLGGGTAVQQATGHDDSAEEMYKYL-VSQSRDPE
MAV_3022|M.avium_104 RTGSWGGAAAMAGGFIYLGGGTPIQKACGFTDSVDNMAAFLNVAMGPGAD
: **::: :*. * *.** * * *: : : :* .
MSMEG_2873|M.smegmatis_MC2_155 PETLARFCEQSPALLEWLKAQGVPFRGGAGPSYKTSYPTDDNYLYYSGNE
TH_4191|M.thermoresistible__bu PETLTRFCEQSPAMIEWLKAQGVEFRGGPVPPYKTSYPTDEHYLYYSGNE
Mflv_4564|M.gilvum_PYR-GCK EDTLTRFCAESPGLIAWLKAQGVEFRGGPVSSYKTSYPTDDFYLYYSGNE
MMAR_0205|M.marinum_M ESTLESFVRGSPGMIDWLSHYGVPFDS-TVCPYKTSFPNNHYYLYHSGSE
MUL_4900|M.ulcerans_Agy99 ESTLESFVRGSPEMIDWLSNYGVPFDS-TVYPYKTSFPNNHYYLYHSGSE
MAB_0623|M.abscessus_ATCC_1997 PETLQKFVDGSVDTLNWLQGYGVPFEG-SLAPFKTSYPTDDYYLYFSGSE
Mb1848|M.bovis_AF2122/97 HDKIRAYCDGSVEHFNWLEGLGFQFER-SYFPGKAVIQPNTEGLMFTGNE
Rv1817|M.tuberculosis_H37Rv HDKIRAYCDGSVEHFNWLEGLGFQFER-SYFPGKAVIQPNTEGLMFTGNE
Mvan_3165|M.vanbaalenii_PYR-1 HDKIRAYCEGSVEHFNWLEALGFQFER-SYYPGKVVVPPGTEGLSYTGNE
MAV_3022|M.avium_104 ADRIADYCAGSLAHFEWLVGCGVPFKA-EFFGEPGWEPMGDQGLMYSGGE
. : : * : ** *. * . * .:*.*
MSMEG_2873|M.smegmatis_MC2_155 KAYPYVDHAQPAPRGHRVLAPGMS-----SGRVLFERLRDSALAKGVHFT
TH_4191|M.thermoresistible__bu TAFPYSEHAHPAPRGHRALAPGMR-----SGRVLFERLRDSALSKGVEFV
Mflv_4564|M.gilvum_PYR-GCK KAYPYAQHAAPAPRGHRVLAPGMS-----SGRVLYERLRDSAKAKGVTVI
MMAR_0205|M.marinum_M NSGAFRSHTPPVQRGHRVKGKGT------SGKQLYAPLAKAALSLGVQFY
MUL_4900|M.ulcerans_Agy99 NSGAFRSHTPPVQRGHRVKGKGN------SGKQLYAPLAKAALSLGVQFY
MAB_0623|M.abscessus_ATCC_1997 SSGMARAATPPRQRGHRAFGRGV------SGKALFAPLADSAERLGADVW
Mb1848|M.bovis_AF2122/97 KVWPFLELAVPAPRGHKVPVP----GDTGGAAMVIDLLLKRAASLGIQIR
Rv1817|M.tuberculosis_H37Rv KVWPFLELAVPAPRGHKVPVP----GDTGGAAMVIDLLLKRAASLGIQIR
Mvan_3165|M.vanbaalenii_PYR-1 KVWPFCEQAKPAPRGHSVPVP----GELGGAAMVIDLLLKRAADLGVQIR
MAV_3022|M.avium_104 NSYPFNTIASPAPRGHVPQMQNKKQGEASAGYMLMKPLVESATAAGARAL
. : * *** .. : * . * *
MSMEG_2873|M.smegmatis_MC2_155 PLAHVHSLIQDEDGRVTGVRYTVTDPGHRNARR-HRRIAKATGKLGTWMP
TH_4191|M.thermoresistible__bu PLAHVHSLIQADDGRVTGVRYTVLDPGHRHARR-HRLITRATGKLGTWMP
Mflv_4564|M.gilvum_PYR-GCK PLARVHGLIT-DAGRVVGVRYRVLDQGHPNAHR-HRVLTRATAKLGTWMP
MMAR_0205|M.marinum_M PHTKVTKLLQDSTGRVTGVEAMTMHDAPPRIRRTYAALAAVSTKPGIYYP
MUL_4900|M.ulcerans_Agy99 PHTKVTKLLQDSTGRVTGVEAMTMHDAPPRIRRAYAALAAVSTKPGIYYP
MAB_0623|M.abscessus_ATCC_1997 RQTRVTGLVVE-EGRVVGVRGMTLKDAPAWARRLYSRLTHYATKPGIYYP
Mb1848|M.bovis_AF2122/97 YETGATELIVDGTGKVTGVM------------------------------
Rv1817|M.tuberculosis_H37Rv YETGATELIVDGTGKVTGVM------------------------------
Mvan_3165|M.vanbaalenii_PYR-1 YETGVTGLVVDDDGAVVGVR------------------------------
MAV_3022|M.avium_104 YDVRVQRLITESDGRVVGMR------------------------------
. . *: * *.*:
MSMEG_2873|M.smegmatis_MC2_155 RAVAGAVARGERLRAEAGAEAHASAG-AVILAAGGFINDRDWVSRYAPEF
TH_4191|M.thermoresistible__bu GVVSGAVRYAERLRAEASVETETRAG-AVILAAGGFINNRGWVRQYAPQF
Mflv_4564|M.gilvum_PYR-GCK GLVNGVVARAERLWAEAAVQTEARAP-SVILAAGGFIFNREWVQAHAPKF
MMAR_0205|M.marinum_M PLRNLMERRLRALERRYARAVQIRARRGVIVCAGGFIANSEWIKRYAPRY
MUL_4900|M.ulcerans_Agy99 PLRNLMERRLRALERRYARAVQIRARRGVIVCAGGFIANSEWIKRYAPRY
MAB_0623|M.abscessus_ATCC_1997 PMRKTLEGPAYALERRFAKPFEIRADDGVILSSGGFIANRELVRRHAPAY
Mb1848|M.bovis_AF2122/97 -------------WKRFSETGAIKAKS-VIIAAGGFVMNPDMVAKYTPKL
Rv1817|M.tuberculosis_H37Rv -------------WKRFSETGAIKAKS-VIIAAGGFVMNPDMVAKYTPKL
Mvan_3165|M.vanbaalenii_PYR-1 -------------WKHFTETGEVKAKS-VVIAAGGFAMNAEMVAEYTPAL
MAV_3022|M.avium_104 -------------ARRYGTEMNIRARTGVVLATGSFAYNDSMVARYAPRI
. * *::.:*.* : : ::*
MSMEG_2873|M.smegmatis_MC2_155 LKI-----------SPLGTVGDDGTGIRLGLDAGGVTDKMGNVTAWRFLS
TH_4191|M.thermoresistible__bu LKI-----------SPLGTVGDDGTGIRLGLDAGGKTDKMGNVTAWRFLS
Mflv_4564|M.gilvum_PYR-GCK TKI-----------SPLGTAGDDGNGIALGLDAGGFTDKMGNVAAWRFLA
MMAR_0205|M.marinum_M VTG-----------LQLGTSGDDGSGIALAQSVGAVTERMDNVSAWRFIT
MUL_4900|M.ulcerans_Agy99 VTG-----------LQLGTSGDDGSGIALAQSVGAVTERMDNVSARRLIT
MAB_0623|M.abscessus_ATCC_1997 LDG-----------LELGTAGDDGTALKLAEPLGAATGHLDEISAWRFIV
Mb1848|M.bovis_AF2122/97 AEK----------PFVLGNTYDDGLGIRLGVSAGGATQHMDQMFITAPPY
Rv1817|M.tuberculosis_H37Rv AEK----------PFVLGNTYDDGLGIRLGVSAGGATQHMDQMFITAPPY
Mvan_3165|M.vanbaalenii_PYR-1 AAERKTKHHGTVAPYILGNPNDDGLGIKLGVSAGGVAANLDQLFITAAAY
MAV_3022|M.avium_104 AGR-----------PAASIEQHDGQAIRMAQALGADLAHMDATEVAIFID
. .** .: :. *. .:.
MSMEG_2873|M.smegmatis_MC2_155 PPSAFLEGLTVGADGRRIANEDLYGAAHGNVLMREFGGTGWAIYDAATWR
TH_4191|M.thermoresistible__bu PPSAFLEGLTVGADGRRIANEDLYGATHGDVLMREFGGTGWAIYDAATWR
Mflv_4564|M.gilvum_PYR-GCK PLSAFLEGLTVGADGRRITNEDLYGATHSNVMMREFGGTGWAIYDARTWA
MMAR_0205|M.marinum_M PPSAFISTVMVDQQGQRVIDESRYGAAVGKALVQDHNARAWLVADADLMN
MUL_4900|M.ulcerans_Agy99 PPSAFISTVMVDQQGQRVIDESRYGAAVGKALVHDHNARAWLVADADLMN
MAB_0623|M.abscessus_ATCC_1997 PPAAFLGSLLVDTKGQRMIDESRYGAALGKEIVRTAGGVGYLVADQPLVK
Mb1848|M.bovis_AF2122/97 PPSILLTGIIVNKLGQRFVAEDSYHSRTAGFIMEQPDSAAYLIVDEAHLE
Rv1817|M.tuberculosis_H37Rv PPSILLTGIIVNKLGQRFVAEDSYHSRTAGFIMEQPDSAAYLIVDEAHLE
Mvan_3165|M.vanbaalenii_PYR-1 PPEILLTGVIVNKDGQRFVAEDSYHSRTSAFVLEQPEQTAYLIVDEDHMQ
MAV_3022|M.avium_104 P-QQLVRGILVNGRGQRYVAEDTYPGRIGQLTLYQQDNTAYLIIDGDAQD
* :: : *. *:* *. * . . : .: : *
MSMEG_2873|M.smegmatis_MC2_155 KIKDQITEQTQVFQRLQIWYLRTIGHKKAATIEGIAAKNGIDAAALRKTV
TH_4191|M.thermoresistible__bu KIRTQITDQTQVFQRLQVWYLLTIGHKKAATIADLARKNGIDAAGLQQTV
Mflv_4564|M.gilvum_PYR-GCK KIRGQVRTQTQLFQRLQLIYLFTTGHRKSSTLEGLARKNGIDPAGLRRTV
MMAR_0205|M.marinum_M EARRQMLKQPLWFQRAQAAALMVADSVRAETLARVARKAGVDPDGLQATV
MUL_4900|M.ulcerans_Agy99 EARRQMLKQPLWFQRAQAAALMVADSVRAETLADVARKAGVEPDGLQATV
MAB_0623|M.abscessus_ATCC_1997 RARQQLGSQTLWFQRIQAEAFLNVGRKKAGSIEELAAKAGIDPEGLARTV
Mb1848|M.bovis_AF2122/97 H----------------PKMPLVPLIDGWETVVEMEAALGIPPGNLAATL
Rv1817|M.tuberculosis_H37Rv H----------------PKMPLVPLIDGWETVVEMEAALGIPPGNLAATL
Mvan_3165|M.vanbaalenii_PYR-1 M----------------PEMPLIKFVDGFETIAEIESALGIPDGNLAATL
MAV_3022|M.avium_104 EA----------MASWSPKLMLRPATWVADTVADLERDMALPPGSLQDTV
:: : .: * *:
MSMEG_2873|M.smegmatis_MC2_155 DEYNRGIAGGAGDPAHKDPSLCSPMERGPFYSIDISADSSLFYPIPGLTL
TH_4191|M.thermoresistible__bu DEYNRGISSGAGDPGHKHPSLCPPLERGPFYSINISADASLFYPIPGLTL
Mflv_4564|M.gilvum_PYR-GCK DAYNSGIVSGTGDPAHKDPGLCAPMTTGPFYSIDISAASSMFYPVPGLTL
MMAR_0205|M.marinum_M DAHNSAIDAAATDPAGKPAEFVRRVARAPFTLLNISVRPSLLNPTPMLTL
MUL_4900|M.ulcerans_Agy99 DAHNNVIDAAATDPAGKPAEFVRRVARAPFTLLNIAVRPSLLNPTPMLTL
MAB_0623|M.abscessus_ATCC_1997 SEHNRAIAGGTPDPLGKPDDIRVPIERAPFYLFNVSIKTNMLNPCPMLTL
Mb1848|M.bovis_AF2122/97 DRYNAYAARGADPDFHKQPEFLAAQDNGPWGAFDMSLGKAMYA---GFTL
Rv1817|M.tuberculosis_H37Rv DRYNAYAARGADPDFHKQPEFLAAQDNGPWGAFDMSLGKAMYA---GFTL
Mvan_3165|M.vanbaalenii_PYR-1 ECYNANAAAGVDPDFHKQPEYLAAQDKGPWAVFDLSLGRAMYS---GFTM
MAV_3022|M.avium_104 AAYNAGAARGEDPLLHKKPEWIRPIG-SPVGAVDL---RESTG---GFTL
:* . * .* .:: :*:
MSMEG_2873|M.smegmatis_MC2_155 GGLVVDEDTGAVVHRDGGVVPGLYAAGRTAVGVCSNS--YVSGLSISDCV
TH_4191|M.thermoresistible__bu GGLVVDEDSGAVVHRDGGVIPGLYAAGRNAVGVCSNS--YVSGLSISDCV
Mflv_4564|M.gilvum_PYR-GCK GGLVVDEKTGEVMHRAGGTVAGLYAVGRTAVGICSNS--YVSGLSLSDCV
MMAR_0205|M.marinum_M GGIKVDEQTGAVLDASGAAIPGLFGAGRTATGICSNS--YVSGLSIADCV
MUL_4900|M.ulcerans_Agy99 GGIKVDEQTGAVLDASGAAIPGLFGAGRTATGICSNS--YVSGLSIADCV
MAB_0623|M.abscessus_ATCC_1997 GGLVVDEETGAVQTTSGAAIPGLYAAGRAAVGICSNS--YVSGLSLADCV
Mb1848|M.bovis_AF2122/97 GGLATSVD-GQVLRDDGAVVAGLYAVGACASNIAQDGKGYASGTQLGEGS
Rv1817|M.tuberculosis_H37Rv GGLATSVD-GQVLRDDGAVVAGLYAVGACASNIAQDGKGYASGTQLGEGS
Mvan_3165|M.vanbaalenii_PYR-1 GGLTVSID-GEVLREDGSAIPGLYAAGACACNIAQDGKGYASGTQLGEGS
MAV_3022|M.avium_104 GGLATTLD-AEVLHVSGQPIPGLFAAGRCTAGLAAWG--YASGISLGDGS
**: . . . * * :.**:..* : .:. . *.** .:.:
MSMEG_2873|M.smegmatis_MC2_155 FSGRRAGADAVAKI--------------------------------
TH_4191|M.thermoresistible__bu FSGRRAGAHAAGGTR-------------------------------
Mflv_4564|M.gilvum_PYR-GCK FSGRRAGAHAAG----------------------------------
MMAR_0205|M.marinum_M FSGRRAGNHAAIE---------------------------------
MUL_4900|M.ulcerans_Agy99 FSGRRAGTHAASAALE------------------------------
MAB_0623|M.abscessus_ATCC_1997 FSGRRAGTETGRRIDA------------------------------
Mb1848|M.bovis_AF2122/97 FFGRRAGAHAAARAQGM-----------------------------
Rv1817|M.tuberculosis_H37Rv FFGRRAGAHAAARAQGM-----------------------------
Mvan_3165|M.vanbaalenii_PYR-1 FFGRRAGEAAARRAGEAAARRAGEAAARRAGEAAARRAGEAAAERA
MAV_3022|M.avium_104 FYGRRAGASAAGCRLPRV----------------------------
* ***** :