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DITMTMLLWTAPAFVVLSIVEWLDERQDPQYAQKFSARDYAGNWATYALNAVFKFAGQYLLPFSTIVIAS SLTPLRLSPRHWWVWVACLIATDFCYYWAHRADHRVRLLWTAHSVHHSSRFFNLSTNLRLPWFHPVSYTL RSLAWVPVALLGFPVWMIFVLNTAGLLFQIPCHTERIGTLWPAWEFMFNTPSHHRVHHGSNMSYIDKNYG GVFIVWDRLFGTYAAEVEPVRYGLIHDVGSQNPVKFNYLETVAMLRDVAHAKTWRARFGYVFGPPGWSEK AVPAPSLTT*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2812 | - | - | 100% (290) | C-5 sterol desaturase |
| M. smegmatis MC2 155 | MSMEG_0147 | - | 3e-79 | 50.35% (282) | C-5 sterol desaturase |
| M. smegmatis MC2 155 | MSMEG_3666 | - | 5e-61 | 42.55% (282) | C-5 sterol desaturase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1844 | erg3 | 1e-57 | 41.14% (299) | membrane-bound C-5 sterol desaturase erg3 |
| M. gilvum PYR-GCK | Mflv_3418 | - | 2e-62 | 40.88% (296) | sterol desaturase-related protein |
| M. tuberculosis H37Rv | Rv1814 | erg3 | 1e-57 | 41.14% (299) | membrane-bound C-5 sterol desaturase erg3 |
| M. leprae Br4923 | - | - | - | - | - |
| M. abscessus ATCC 19977 | MAB_0067 | - | 7e-11 | 28.34% (247) | hypothetical protein MAB_0067 |
| M. marinum M | MMAR_3832 | erg3_2 | 3e-80 | 51.09% (276) | membrane-bound C-5 sterol desaturase Erg3_2 |
| M. avium 104 | MAV_2902 | - | 8e-57 | 40.74% (297) | C-5 sterol desaturase |
| M. thermoresistible (build 8) | TH_2226 | - | 1e-59 | 38.85% (296) | MEMBRANE-BOUND C-5 STEROL DESATURASE ERG3 |
| M. ulcerans Agy99 | MUL_3066 | erg3 | 1e-56 | 39.93% (293) | membrane-bound C-5 sterol desaturase Erg3 |
| M. vanbaalenii PYR-1 | Mvan_3171 | - | 3e-61 | 40.62% (288) | sterol desaturase-related protein |
CLUSTAL 2.0.9 multiple sequence alignment
MSMEG_2812|M.smegmatis_MC2_155 ------------MDITMTMLLWTAPAFVVLSIVEWLDERQDPQYAQ----
MMAR_3832|M.marinum_M ------------MERAVPIFLTGFMVLVGLDFLSYRLGKQRNRSRP----
Mb1844|M.bovis_AF2122/97 ---------------MRDPVLFAIPCFLLLLILEWTAARKLESIETA---
Rv1814|M.tuberculosis_H37Rv ---------------MRDPVLFAIPCFLLLLILEWTAARKLESIETA---
MAV_2902|M.avium_104 -MSALSGYLTALPPQLRDPVLVAIPFFLLLLTLEWTAARKLEHLT-----
MUL_3066|M.ulcerans_Agy99 -MSALPGFLAVLPGEMRDPVLFAIPFFLFLLTVEWAAARKLEKLEAG---
Mflv_3418|M.gilvum_PYR-GCK -----MEFLEFLPPQMREPVLFAIPFFLLLLAIEWTAARKLEHAVEGGAD
Mvan_3171|M.vanbaalenii_PYR-1 -----MEFLDFLPPQMREPVLFAIPFFLLLLTIEWTAARKLEHTAP----
TH_2226|M.thermoresistible__bu VDQVVVPFLDVLPAPMRDPVLFAIPFFLLLLALEWTAARRLAHVEAGEGW
MAB_0067|M.abscessus_ATCC_1997 -----MAIWFVRYGYVPLMLLGINGVAIALAHRPWAPLWMVVLILVAIGL
.* : * :
MSMEG_2812|M.smegmatis_MC2_155 ----------KFSARDYAGNWA---TYALNAVFKFAGQYLLPFSTIVIAS
MMAR_3832|M.marinum_M ----------SVSARDTAANLS---VYALARLTRSVGS-VTAVPLVLIAS
Mb1844|M.bovis_AF2122/97 ATGQPRPASGAYLTRDSVASIS---MGLVSIATTAGWKSLALLGYAAIYA
Rv1814|M.tuberculosis_H37Rv ATGQPRPASGAYLTRDSVASIS---MGLVSIATTAGWKSLALLGYAAIYA
MAV_2902|M.avium_104 ----ARPAPGAHRTRDSLTSIS---MGLVSVATTAGWKTLALFGYAAIYA
MUL_3066|M.ulcerans_Agy99 ATETPRPVSGSYHTRDSVATIS---MGLVSLVTIAFWKTMALLGYAAIYT
Mflv_3418|M.gilvum_PYR-GCK EDGT--PAAGAYHTRDSWASLS---MGLVSTVTMSVWKFFALLGYAAIYA
Mvan_3171|M.vanbaalenii_PYR-1 DGGS--PAVGAYHTRDSWASVS---MGLVSTVTMSVWKFLALLGYAALYA
TH_2226|M.thermoresistible__bu EEGDRRPPPGAFHTPDARASIS---MGLVSIATMGAWKFLALLGYVAIYA
MAB_0067|M.abscessus_ATCC_1997 SFLAERVAPYSPEWNESMGDARRDAAHAFVNETALLLTVLVVPAVALLSP
: . . : .
MSMEG_2812|M.smegmatis_MC2_155 SLTPLRLSPRHWWVWVACLIATDFCYYWAHRADHRVRLLWTAHSVHHSSR
MMAR_3832|M.marinum_M ALTPIHLPTAQWWTWACALVLTDLAYYGRHRMTHRIRVFWAAHHVHHSSQ
Mb1844|M.bovis_AF2122/97 YLAPWQLSAHRWYTWVIAIVGVDLLYYSYHRIAHRVRLIWATHQAHHSSE
Rv1814|M.tuberculosis_H37Rv YLAPWQLSAHRWYTWVIAIVGVDLLYYSYHRIAHRVRLIWATHQAHHSSE
MAV_2902|M.avium_104 YLAPWHLPATRWYTWAIPILGVDLLYYAYHRIAHRVRLIWATHQAHHSSE
MUL_3066|M.ulcerans_Agy99 YVAPWHLSPGRWYTWVIAIVGVDLLYYTYHRIAHRVRLIWATHQAHHSSE
Mflv_3418|M.gilvum_PYR-GCK YLAPWQLSPTQWYTWVIAIVGVDLLFYVYHRTAHRVRLVWATHQAHHSSR
Mvan_3171|M.vanbaalenii_PYR-1 YVAPWQLSATQWYTWVIALVGVDLLFYVYHRMAHRVRIVWATHQAHHSSR
TH_2226|M.thermoresistible__bu YLAPWHLPADRWYTWVIALVGVDLLFYVYHRMAHRVQVVWATHQAHHSSE
MAB_0067|M.abscessus_ATCC_1997 FHTWWPSSIPFVLQVLIAAAVADFGITLMHYASHKVPALWRLHAVHHSIK
: . .*: * *:: .* * .*** .
MSMEG_2812|M.smegmatis_MC2_155 FFNLSTNLRLPWFHPVSYTLRSLAWVPVALLGFPVWMIFVLNTAGLLFQI
MMAR_3832|M.marinum_M YLNLSTGMRTPWLVPGWLFISAVVYVPLALIGFPVWMIFACHAIVLFYQF
Mb1844|M.bovis_AF2122/97 YFNFATALRQKWNNSG----EILMWVPLPLMGLPPWMVFCSWSLNLIYQF
Rv1814|M.tuberculosis_H37Rv YFNFATALRQKWNNSG----EILMWVPLPLMGLPPWMVFCSWSLNLIYQF
MAV_2902|M.avium_104 YYNFATALRQKWNNSG----EILMWIPLPLLGIPPWMVFFSFSLNLIYQF
MUL_3066|M.ulcerans_Agy99 YFNFATALRQKWNNSG----EVLMWVPLPLLGLPPWMVFFGFSVSLIYQF
Mflv_3418|M.gilvum_PYR-GCK YFNFATALRQKWNNSG----EILMWIPLPLLGVPPWMVFVAFSISLIYQF
Mvan_3171|M.vanbaalenii_PYR-1 YFNFATALRQKWNNSG----EILMWIPLPLLGVPPWMVFFAFSVSLIYQF
TH_2226|M.thermoresistible__bu YFNLATALRQKWNNSG----EVLLWIPLPLLGVPPWLVFFSFSISLIYQF
MAB_0067|M.abscessus_ATCC_1997 RFYGFNGLMKHPVHGG--LELMAGTAPLLIMGLP-QAVAEALTVLIAVQL
. : *: ::*.* : : : *:
MSMEG_2812|M.smegmatis_MC2_155 PCHTERIGTLWPAWEFMFNTPSHHRVHHGSNMSYIDKNYGGVFIVWDRLF
MMAR_3832|M.marinum_M PIHTERINRLPRPIEYLFNTPSHHRVHHGANNPYLNKNYGGILIVWDRLF
Mb1844|M.bovis_AF2122/97 WVHTERIDRLPRWFEFVFNTPSHHRVHHGMDPVYLDKNYGGILIIWDRLF
Rv1814|M.tuberculosis_H37Rv WVHTERIDRLPRWFEFVFNTPSHHRVHHGMDPVYLDKNYGGILIIWDRLF
MAV_2902|M.avium_104 WIHTERIDKLPRPFEFVFNTPSHHRVHHGMDKVYLDKNYGGILIVWDRLF
MUL_3066|M.ulcerans_Agy99 WVHTERINKLPRWFEFIFNTPSHHRVHHGMDQMYLDKNYGGILIIWDRLF
Mflv_3418|M.gilvum_PYR-GCK WIHTEHIGKLWRPFEFVFNTPSHHRVHHGMDPLYLDKNYGGILIIWDRLF
Mvan_3171|M.vanbaalenii_PYR-1 WIHTERIGKLWLPVEFIFNTPSHHRVHHGMDKLYLDKNYGGILIIWDRLF
TH_2226|M.thermoresistible__bu WIHTERIGKLPAPIEFVFNTPSHHRVHHGMDPEYLDKNYGGILIIWDRLF
MAB_0067|M.abscessus_ATCC_1997 LLQHSNADYRIGRLRVVLALNEGHRFHHLKWAGIGDVNFGLFTLVWDHLL
: .. . . :: . **.** : *:* . ::**:*:
MSMEG_2812|M.smegmatis_MC2_155 GTYAAEVEPVRYGLIHDVGSQNPVKFNYLETVAMLRDVAHAKTWRARFGY
MMAR_3832|M.marinum_M GSYAEEDEPVRYGLQQNIATHNPIKLNYHEFVAMLSDVGRAKTWRGRVGY
Mb1844|M.bovis_AF2122/97 GSFQPELFRPHYGLTKRVDTFNIWKLQTREYVAIVRDWRSATRLRDRLGY
Rv1814|M.tuberculosis_H37Rv GSFQPELFRPHYGLTKRVDTFNIWKLQTREYVAIVRDWRSATRLRDRLGY
MAV_2902|M.avium_104 GTFQAELFRPHYGLTKQVDTFNVWKLQTREYVAIARDWRSASRLRDRLGY
MUL_3066|M.ulcerans_Agy99 RSFQAETARPHYGLTKPVDTFNIWKLQTREYVAIARDWRSATRLRDRLGY
Mflv_3418|M.gilvum_PYR-GCK GTFQPEVFRPHYGLTKPVDTFNIWKLQTHEYAAIWRDARAARGVRAKLGY
Mvan_3171|M.vanbaalenii_PYR-1 GTFQPEVFRPHYGLTKPVDTFNIWKLQTHEYVAIGRDVRAARGLRAKLGY
TH_2226|M.thermoresistible__bu GTFCEEKFRPRYGLTKPVDTYNIWRLQTHEYLAIARDVAKARNWRERLGY
MAB_0067|M.abscessus_ATCC_1997 RTFSFDPARRFHSDDLGMAAKPNYPAGYTAQLAEPFRTSGACHFDG-LQS
:: : :. : : * * .
MSMEG_2812|M.smegmatis_MC2_155 VFGPPGWSEKAV-PAPSLTT-------------------
MMAR_3832|M.marinum_M LLRPPGWSEVAETPAPRSHDSDDHAVPVDGQHWAAAGNG
Mb1844|M.bovis_AF2122/97 VFGPPGWEPRTID--KSNAAASLVTSR------------
Rv1814|M.tuberculosis_H37Rv VFGPPGWEPRTID--KSNAAASLVTSR------------
MAV_2902|M.avium_104 VFGPPGWAPRSAG--RTAAGAPVVTSL------------
MUL_3066|M.ulcerans_Agy99 AFGPPGWQPSTTATPRAEDAATVTTSGWRPT--------
Mflv_3418|M.gilvum_PYR-GCK IFGPPGWQP---AQVQTPAPVAP----------------
Mvan_3171|M.vanbaalenii_PYR-1 IFGPPGWEPSTAPGARAAAHATP----------------
TH_2226|M.thermoresistible__bu IFGPPGWQPAP-AGAPTPAPARD----------------
MAB_0067|M.abscessus_ATCC_1997 EVTATGRQPST----------------------------
. ..*