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M. marinum M MMAR_3832 (erg3_2)

annotation: membrane-bound C-5 sterol desaturase Erg3_2
coordinates: 4763392 - 4764321
length: 309

MERAVPIFLTGFMVLVGLDFLSYRLGKQRNRSRPSVSARDTAANLSVYALARLTRSVGSVTAVPLVLIAS
ALTPIHLPTAQWWTWACALVLTDLAYYGRHRMTHRIRVFWAAHHVHHSSQYLNLSTGMRTPWLVPGWLFI
SAVVYVPLALIGFPVWMIFACHAIVLFYQFPIHTERINRLPRPIEYLFNTPSHHRVHHGANNPYLNKNYG
GILIVWDRLFGSYAEEDEPVRYGLQQNIATHNPIKLNYHEFVAMLSDVGRAKTWRGRVGYLLRPPGWSEV
AETPAPRSHDSDDHAVPVDGQHWAAAGNG
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. marinum MMMAR_3832erg3_2-100% (309)membrane-bound C-5 sterol desaturase Erg3_2
M. marinum MMMAR_2691erg37e-6244.19% (258) membrane-bound C-5 sterol desaturase Erg3
M. marinum MMMAR_4630erg3_13e-5844.53% (247) membrane-bound C-5 sterol desaturase Erg3_1

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb1844erg31e-6044.03% (268) membrane-bound C-5 sterol desaturase erg3
M. gilvum PYR-GCKMflv_3418-4e-6145.60% (250) sterol desaturase-related protein
M. tuberculosis H37RvRv1814erg31e-6044.03% (268) membrane-bound C-5 sterol desaturase erg3
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_0067-2e-0827.03% (222) hypothetical protein MAB_0067
M. avium 104MAV_2902-6e-6342.14% (299) C-5 sterol desaturase
M. smegmatis MC2 155MSMEG_0147-1e-10663.41% (276) C-5 sterol desaturase
M. thermoresistible (build 8)TH_2226-9e-6944.30% (298) MEMBRANE-BOUND C-5 STEROL DESATURASE ERG3
M. ulcerans Agy99MUL_3066erg38e-6244.19% (258) membrane-bound C-5 sterol desaturase Erg3
M. vanbaalenii PYR-1Mvan_3171-9e-6244.40% (268) sterol desaturase-related protein

CLUSTAL 2.0.9 multiple sequence alignment


MMAR_3832|M.marinum_M               ------------MERAVPIFLTG---FMVLVGLDFLSYRLGKQRNRS---
MSMEG_0147|M.smegmatis_MC2_155      --------MEQLAEQVKMVFVYGLPAFLLLIAVEYYSY-FRERRENT---
Mb1844|M.bovis_AF2122/97            ---------------MRDPVLFAIPCFLLLLILEWTAARKLESIETA---
Rv1814|M.tuberculosis_H37Rv         ---------------MRDPVLFAIPCFLLLLILEWTAARKLESIETA---
MAV_2902|M.avium_104                -MSALSGYLTALPPQLRDPVLVAIPFFLLLLTLEWTAARKLEHLT-----
MUL_3066|M.ulcerans_Agy99           -MSALPGFLAVLPGEMRDPVLFAIPFFLFLLTVEWAAARKLEKLEAG---
Mflv_3418|M.gilvum_PYR-GCK          -----MEFLEFLPPQMREPVLFAIPFFLLLLAIEWTAARKLEHAVEGGAD
Mvan_3171|M.vanbaalenii_PYR-1       -----MEFLDFLPPQMREPVLFAIPFFLLLLTIEWTAARKLEHTAP----
TH_2226|M.thermoresistible__bu      VDQVVVPFLDVLPAPMRDPVLFAIPFFLLLLALEWTAARRLAHVEAGEGW
MAB_0067|M.abscessus_ATCC_1997      -MAIWFVRYGYVPLMLLGINGVAIALAHRPWAPLWMVVLILVAIGLSFLA
                                                          .           :               

MMAR_3832|M.marinum_M               ---RPS-----VSARDTAANLSVYALARLTRSVGSVTAVP-LVLIASALT
MSMEG_0147|M.smegmatis_MC2_155      ---APSEPKRGVSSRDTAANISTYLIRLVVSPLEKFIELP-IIVIAAAFA
Mb1844|M.bovis_AF2122/97            ATGQPRPASGAYLTRDSVASISMGLVSIATTAGWKSLALLGYAAIYAYLA
Rv1814|M.tuberculosis_H37Rv         ATGQPRPASGAYLTRDSVASISMGLVSIATTAGWKSLALLGYAAIYAYLA
MAV_2902|M.avium_104                ----ARPAPGAHRTRDSLTSISMGLVSVATTAGWKTLALFGYAAIYAYLA
MUL_3066|M.ulcerans_Agy99           ATETPRPVSGSYHTRDSVATISMGLVSLVTIAFWKTMALLGYAAIYTYVA
Mflv_3418|M.gilvum_PYR-GCK          EDGT--PAAGAYHTRDSWASLSMGLVSTVTMSVWKFFALLGYAAIYAYLA
Mvan_3171|M.vanbaalenii_PYR-1       DGGS--PAVGAYHTRDSWASVSMGLVSTVTMSVWKFLALLGYAALYAYVA
TH_2226|M.thermoresistible__bu      EEGDRRPPPGAFHTPDARASISMGLVSIATMGAWKFLALLGYVAIYAYLA
MAB_0067|M.abscessus_ATCC_1997      ERVAPYSPEWNESMGDARRDAAHAFVN-ETALLLTVLVVPAVALLSPFHT
                                                   *:    :   :   .    .   :     : .  :

MMAR_3832|M.marinum_M               PIHLPTAQWWTWACALVLTDLAYYGRHRMTHRIRVFWAAHHVHHSSQYLN
MSMEG_0147|M.smegmatis_MC2_155      PLALPADQWWTWALALFLADATYYVKHRMGHRIRLFWAEHSVHHSSQYFN
Mb1844|M.bovis_AF2122/97            PWQLSAHRWYTWVIAIVGVDLLYYSYHRIAHRVRLIWATHQAHHSSEYFN
Rv1814|M.tuberculosis_H37Rv         PWQLSAHRWYTWVIAIVGVDLLYYSYHRIAHRVRLIWATHQAHHSSEYFN
MAV_2902|M.avium_104                PWHLPATRWYTWAIPILGVDLLYYAYHRIAHRVRLIWATHQAHHSSEYYN
MUL_3066|M.ulcerans_Agy99           PWHLSPGRWYTWVIAIVGVDLLYYTYHRIAHRVRLIWATHQAHHSSEYFN
Mflv_3418|M.gilvum_PYR-GCK          PWQLSPTQWYTWVIAIVGVDLLFYVYHRTAHRVRLVWATHQAHHSSRYFN
Mvan_3171|M.vanbaalenii_PYR-1       PWQLSATQWYTWVIALVGVDLLFYVYHRMAHRVRIVWATHQAHHSSRYFN
TH_2226|M.thermoresistible__bu      PWHLPADRWYTWVIALVGVDLLFYVYHRMAHRVQVVWATHQAHHSSEYFN
MAB_0067|M.abscessus_ATCC_1997      WWPSSIPFVLQVLIAAAVADFGITLMHYASHKVPALWRLHAVHHSIKRFY
                                        .         .   .*      *   *::  .*  * .*** .   

MMAR_3832|M.marinum_M               LSTGMRTPWLVPGWLFISAVVYVPLALIGFPVWMIFACHAIVLFYQFPIH
MSMEG_0147|M.smegmatis_MC2_155      LSTSLRLPWLVPG-SFLKSVVSIPMALIGIPVWMIFLCQAIVLVYQFPIH
Mb1844|M.bovis_AF2122/97            FATALRQKWNNSG----EILMWVPLPLMGLPPWMVFCSWSLNLIYQFWVH
Rv1814|M.tuberculosis_H37Rv         FATALRQKWNNSG----EILMWVPLPLMGLPPWMVFCSWSLNLIYQFWVH
MAV_2902|M.avium_104                FATALRQKWNNSG----EILMWIPLPLLGIPPWMVFFSFSLNLIYQFWIH
MUL_3066|M.ulcerans_Agy99           FATALRQKWNNSG----EVLMWVPLPLLGLPPWMVFFGFSVSLIYQFWVH
Mflv_3418|M.gilvum_PYR-GCK          FATALRQKWNNSG----EILMWIPLPLLGVPPWMVFVAFSISLIYQFWIH
Mvan_3171|M.vanbaalenii_PYR-1       FATALRQKWNNSG----EILMWIPLPLLGVPPWMVFFAFSVSLIYQFWIH
TH_2226|M.thermoresistible__bu      LATALRQKWNNSG----EVLLWIPLPLLGVPPWLVFFSFSISLIYQFWIH
MAB_0067|M.abscessus_ATCC_1997      GFNGLMKHPVHGG--LELMAGTAPLLIMGLP-QAVAEALTVLIAVQLLLQ
                                      ..:       *          *: ::*.*   :    :: :  *: ::

MMAR_3832|M.marinum_M               TERINRLPRPIEYLFNTPSHHRVHHGANNPYLNKNYGGILIVWDRLFGSY
MSMEG_0147|M.smegmatis_MC2_155      TERVGRLPRPIEFIFNTPSHHRVHHGSNNPYLDKNYGGILIIFDRMFGSY
Mb1844|M.bovis_AF2122/97            TERIDRLPRWFEFVFNTPSHHRVHHGMDPVYLDKNYGGILIIWDRLFGSF
Rv1814|M.tuberculosis_H37Rv         TERIDRLPRWFEFVFNTPSHHRVHHGMDPVYLDKNYGGILIIWDRLFGSF
MAV_2902|M.avium_104                TERIDKLPRPFEFVFNTPSHHRVHHGMDKVYLDKNYGGILIVWDRLFGTF
MUL_3066|M.ulcerans_Agy99           TERINKLPRWFEFIFNTPSHHRVHHGMDQMYLDKNYGGILIIWDRLFRSF
Mflv_3418|M.gilvum_PYR-GCK          TEHIGKLWRPFEFVFNTPSHHRVHHGMDPLYLDKNYGGILIIWDRLFGTF
Mvan_3171|M.vanbaalenii_PYR-1       TERIGKLWLPVEFIFNTPSHHRVHHGMDKLYLDKNYGGILIIWDRLFGTF
TH_2226|M.thermoresistible__bu      TERIGKLPAPIEFVFNTPSHHRVHHGMDPEYLDKNYGGILIIWDRLFGTF
MAB_0067|M.abscessus_ATCC_1997      HSNADYRIGRLRVVLALNEGHRFHHLKWAGIGDVNFGLFTLVWDHLLRTF
                                     .. .     .. ::   . **.**       : *:* : :::*::: ::

MMAR_3832|M.marinum_M               AEEDEPVRYGLQQNIATHNPIKLNYHEFVAMLSDVGRAKTWRGRVGYLLR
MSMEG_0147|M.smegmatis_MC2_155      AEELEPVRYGLTKNIDTNNPIKVNYHEFVLMLRDVWHAETWRGRIGYLLR
Mb1844|M.bovis_AF2122/97            QPELFRPHYGLTKRVDTFNIWKLQTREYVAIVRDWRSATRLRDRLGYVFG
Rv1814|M.tuberculosis_H37Rv         QPELFRPHYGLTKRVDTFNIWKLQTREYVAIVRDWRSATRLRDRLGYVFG
MAV_2902|M.avium_104                QAELFRPHYGLTKQVDTFNVWKLQTREYVAIARDWRSASRLRDRLGYVFG
MUL_3066|M.ulcerans_Agy99           QAETARPHYGLTKPVDTFNIWKLQTREYVAIARDWRSATRLRDRLGYAFG
Mflv_3418|M.gilvum_PYR-GCK          QPEVFRPHYGLTKPVDTFNIWKLQTHEYAAIWRDARAARGVRAKLGYIFG
Mvan_3171|M.vanbaalenii_PYR-1       QPEVFRPHYGLTKPVDTFNIWKLQTHEYVAIGRDVRAARGLRAKLGYIFG
TH_2226|M.thermoresistible__bu      CEEKFRPRYGLTKPVDTYNIWRLQTHEYLAIARDVAKARNWRERLGYIFG
MAB_0067|M.abscessus_ATCC_1997      SFDPARRFHSDDLGMAAKPNYPAGYTAQLAEPFRTSGACHFDG-LQSEVT
                                      :     :.    : :                    *      :   . 

MMAR_3832|M.marinum_M               PPGWSEVAETPAPRSHDSDDHAVPVDGQHWAAAGNG
MSMEG_0147|M.smegmatis_MC2_155      PPGWQETKTDTAQP-----------ELVHTAS----
Mb1844|M.bovis_AF2122/97            PPGWEPRTID--KSNAAASLVTSR------------
Rv1814|M.tuberculosis_H37Rv         PPGWEPRTID--KSNAAASLVTSR------------
MAV_2902|M.avium_104                PPGWAPRSAG--RTAAGAPVVTSL------------
MUL_3066|M.ulcerans_Agy99           PPGWQPSTTATPRAEDAATVTTSGWRPT--------
Mflv_3418|M.gilvum_PYR-GCK          PPGWQP---AQVQTPAPVAP----------------
Mvan_3171|M.vanbaalenii_PYR-1       PPGWEPSTAPGARAAAHATP----------------
TH_2226|M.thermoresistible__bu      PPGWQPAP-AGAPTPAPARD----------------
MAB_0067|M.abscessus_ATCC_1997      ATGRQPST----------------------------
                                    ..*