For questions or suggestions e-mail us at: ioerger@cs.tamu.edu

M. smegmatis MC2 155 MSMEG_2631 (-)

annotation: MATE efflux family protein
coordinates: 2712067 - 2713434
length: 455

LADAAGDLPGGPDDDAQGAALTQATGRRIAKLAFPALGVLAAEPIYLLFDLAIVGRLGAVSLAGLAIGGL
VLGLVNSQGTFLSYGTTARSARFYGAGDRTSAVAEGVQATWLALGLGLLIIAVVEAVAVPMLSALAAGGE
IAHAALPWLRVAILAAPAILVSMAGNGWMRGVQDTVRPLRYVVLGFAVSAVLCPLLVYGWLGFPRLELAG
SAVANVVGQWLAAGLFMRALLVEKVPLRLRPDVLRVQLVMGRDLLLRSLAFQACFVSAGAVAARFGAAAV
AAHQVVLQLWSFLALVLDSLAIAAQSLVGAALGAGQLAHAKSVAWRVTLFSTLAGVVLAVVFAVGASVFP
PVFTDDESVLATIGVPWWFLVAQLPVAGIVFALDGVLLGAGDAKFMRNATLASAMLGFLPLIWLSLAFGW
GLFGIWSGLSTFMVLRLVFVGWRAFSGRWLVPGTS
Operon Prediction Model: Genebank

Paralogs
speciesidgenee-valueidentity (len)annotation
M. smegmatis MC2 155MSMEG_2631--100% (455)MATE efflux family protein

Closest Orthologs (e-value cutoff: 1e-4)
speciesidgenee-valueidentity (len)annotation
M. bovis AF2122 / 97Mb2861cdinF0.074.60% (433) DNA-damage-inducible protein F
M. gilvum PYR-GCKMflv_4036-0.081.44% (431) MATE efflux family protein
M. tuberculosis H37RvRv2836cdinF0.074.83% (433) DNA-damage-inducible protein F
M. leprae Br4923-----
M. abscessus ATCC 19977MAB_3128c-1e-17570.45% (440) DNA-damage-inducible protein F
M. marinum MMMAR_1897dinF0.073.50% (449) DNA-damage-inducible protein F DinF
M. avium 104-----
M. thermoresistible (build 8)-----
M. ulcerans Agy99MUL_2125dinF0.073.27% (449) DNA-damage-inducible protein F DinF
M. vanbaalenii PYR-1Mvan_2317-0.080.88% (434) MATE efflux family protein

CLUSTAL 2.0.9 multiple sequence alignment


Mflv_4036|M.gilvum_PYR-GCK          MADP----------------VAPATGRRIAGLAFPALGVLAAEPVYLLFD
Mvan_2317|M.vanbaalenii_PYR-1       MAEP----------------VAPASSRRIAALAFPALGVLAAEPIYLLFD
MSMEG_2631|M.smegmatis_MC2_155      MADAAGDLPGGPDDDAQGAALTQATGRRIAKLAFPALGVLAAEPIYLLFD
MMAR_1897|M.marinum_M               MGPDAGRP--------------DAGGRKIAALALPALGVLAAEPLYLLFD
MUL_2125|M.ulcerans_Agy99           MGPDAGRP--------------DAGGRKIAALALPALGVLAAEPLYLLFD
Mb2861c|M.bovis_AF2122/97           MSQVGHR----------------AGGRQIAQLALPALGVLAAEPLYLLFD
Rv2836c|M.tuberculosis_H37Rv        MSQVGHR----------------AGGRQIAQLALPALGVLAAEPLYLLFD
MAB_3128c|M.abscessus_ATCC_199      MTDATGIAG------------MPGLARRIISLALPALGVLAAEPLYLLFD
                                    *                      . .*:*  **:**********:*****

Mflv_4036|M.gilvum_PYR-GCK          LAIVGRLGALSLAGLAIGALIMGVLSSQLTFLSYGTTARAARFYGAGDRN
Mvan_2317|M.vanbaalenii_PYR-1       LAVIGRLGALNLAGLAIGALIMGVLSSQLTFLSYGTTARAARFYGAGNRT
MSMEG_2631|M.smegmatis_MC2_155      LAIVGRLGAVSLAGLAIGGLVLGLVNSQGTFLSYGTTARSARFYGAGDRT
MMAR_1897|M.marinum_M               TAVIGRLGALALAGLAIGSLVLGLVGSQATFLSYGTTARSARHYGAGDRV
MUL_2125|M.ulcerans_Agy99           TAVIGRLGALALAGLAIGSLVLGLVGSQATFLSYGTTARSARHYGAGDRV
Mb2861c|M.bovis_AF2122/97           IAVVGRLGAISLAGLAIGSLVLGLVGSQATFLSYGTTARAARRYGAGNRV
Rv2836c|M.tuberculosis_H37Rv        IAVVGRLGAISLAGLAIGSLVLGLVGSQATFLSYGTTARAARRYGAGNRV
MAB_3128c|M.abscessus_ATCC_199      IAMVGRLGAVPLAGLAVGGLVLSLVGTQLTFLSYGTTARAARRFGSGDRP
                                     *::*****: *****:*.*::.::.:* **********:** :*:*:* 

Mflv_4036|M.gilvum_PYR-GCK          AAVEEGVQATWLAVGIGTVIVAAVQVTAVPLVSALAAG----GEIAETAL
Mvan_2317|M.vanbaalenii_PYR-1       AAVEEGVQATWLALGIGTTIVVAVQLTAVPLVSVLAGGAD-HGRIAETAL
MSMEG_2631|M.smegmatis_MC2_155      SAVAEGVQATWLALGLGLLIIAVVEAVAVPMLSALAAG----GEIAHAAL
MMAR_1897|M.marinum_M               AAVAEGVQATWLAVALGLLTILVVQIAAVPLVSVIAGARAGSGDIAGAAL
MUL_2125|M.ulcerans_Agy99           AAVAEGVQATWLAVALGLLTILVVQIAAVPLVSVIAGARAGSGDIAGAAL
Mb2861c|M.bovis_AF2122/97           AAVTEGVQATWLALGLGALVVVVVEATATPLVSAIA---SGDG-ITAAAL
Rv2836c|M.tuberculosis_H37Rv        AAVTEGVQATWLALGLGALVVVVVEATATPLVSAIA---SGDG-ITAAAL
MAB_3128c|M.abscessus_ATCC_199      GAVHEGVQATWLALLIGAVVVLVVHAVAGPVVRAIAAA----PDVAAQGL
                                    .** *********: :*   : .*. .* *:: .:*        ::  .*

Mflv_4036|M.gilvum_PYR-GCK          PWVRIASLAVPAILIAAAGNGWMRGVQDTMRPLRYVVVGFGLSAVLCPLL
Mvan_2317|M.vanbaalenii_PYR-1       PWVRIASLAVPAILIAAAGNGWMRGVQDTMRPLRYVIFGFAVSAVLCPLL
MSMEG_2631|M.smegmatis_MC2_155      PWLRVAILAAPAILVSMAGNGWMRGVQDTVRPLRYVVLGFAVSAVLCPLL
MMAR_1897|M.marinum_M               PWLRIAILGTPAILISLAGNGWMRGVQDTVRPLRYVVAGFGLSALLCPLL
MUL_2125|M.ulcerans_Agy99           PWLWIAILGTPAILISLAGNGWMRGVQDTVRPLRYVVAGFGLSALLCPLL
Mb2861c|M.bovis_AF2122/97           PWLRIAILGTPAILVSLAGNGWLRGVQDTVRPLRYVVAGFGSSALLCPLL
Rv2836c|M.tuberculosis_H37Rv        PWLRIAILGTPAILVSLAGNGWLRGVQDTVRPLRYVVAGFGSSALLCPLL
MAB_3128c|M.abscessus_ATCC_199      GWLRIAIFAAPAILVSLAGNGWMRGVQNTVRPLRYVIAGFAVSAVLCPVL
                                     *: :* :..****:: *****:****:*:******: **. **:***:*

Mflv_4036|M.gilvum_PYR-GCK          VFGWLGCPELGLPGSAVANVAGQYLAAALFCRALFVEKVPLRVRPAVLRA
Mvan_2317|M.vanbaalenii_PYR-1       VYGWLGAPELGLPGSAVANVVGQYLAAALFCRALVVEKVPLRLRPPVLRA
MSMEG_2631|M.smegmatis_MC2_155      VYGWLGFPRLELAGSAVANVVGQWLAAGLFMRALLVEKVPLRLRPDVLRV
MMAR_1897|M.marinum_M               VYGWLGLPRMELAGSAVANLVGQWLAALLFGGALLAERVSLRPDRHILRE
MUL_2125|M.ulcerans_Agy99           VYGWLGLPRMELAGSAVANLVGQWLAALLFGGALLAERVSLRPDRHILRE
Mb2861c|M.bovis_AF2122/97           VYGWLGLPRWGLTGSAVANLVGQWLAALLFAGALLAERVSLRPDRAVLGA
Rv2836c|M.tuberculosis_H37Rv        VYGWLGLPRWGLTGSAVANLVGQWLAALLFAGALLAERVSLRPDRAVLGA
MAB_3128c|M.abscessus_ATCC_199      IYGLAGVPRMGLAGSAVANLVGQWLAAILFLRALHAEHAPLRTDRAVLRA
                                    ::*  * *.  *.******:.**:*** **  ** .*:..**    :*  

Mflv_4036|M.gilvum_PYR-GCK          QVVMGRDLILRTMAFQACFISAGAVAARFGAASVAAHQVVLQLWSFLALV
Mvan_2317|M.vanbaalenii_PYR-1       QVVMGRDLVLRTMAFQACFISAGAVAARFGAAAVAAHQVVLQLWNFLALV
MSMEG_2631|M.smegmatis_MC2_155      QLVMGRDLLLRSLAFQACFVSAGAVAARFGAAAVAAHQVVLQLWSFLALV
MMAR_1897|M.marinum_M               QLVLARDLIVRTMAFQACFISAAAVAARFGAAALAAHQVVLQLWGFFALV
MUL_2125|M.ulcerans_Agy99           QLVLARDLIVRTMAFQACFISAAAVAARFGAAALAAHQVVLQLWGFFALV
Mb2861c|M.bovis_AF2122/97           QLMMARDLIVRTLAFQVCYVSAAAVAARFGAAALAAHQVVLQLWGLLALV
Rv2836c|M.tuberculosis_H37Rv        QLMMARDLIVRTLAFQVCYVSAAAVAARFGAAALAAHQVVLQLWGLLALV
MAB_3128c|M.abscessus_ATCC_199      QLVLARDLLVRSLAFQACFISAAAVAARFGAAALAAHQVVLQMWSFLALV
                                    *:::.***::*::***.*::**.*********::********:*.::***

Mflv_4036|M.gilvum_PYR-GCK          LDSLAIAAQSLVGAALGAGQLTHAKAVAWRVTIFSAVAGVVLAVVFALGS
Mvan_2317|M.vanbaalenii_PYR-1       LDSLAIAAQSLVGAALGAGQLTHAKAVAWRVTIFSTVAGVVLATVFALGS
MSMEG_2631|M.smegmatis_MC2_155      LDSLAIAAQSLVGAALGAGQLAHAKSVAWRVTLFSTLAGVVLAVVFAVGA
MMAR_1897|M.marinum_M               LDSLAIAAQSLVGAALGAGDAAHAKWVAWRVTVFSLLAAGMLAAALALGA
MUL_2125|M.ulcerans_Agy99           LDSLAIAAQSLVGAALGAGDAAHAKWVAWRVTVFSLLAAGMLAAALALGA
Mb2861c|M.bovis_AF2122/97           LDSLAIAAQSLVGAALGAGDAGHAKAVAWRVTAFSLLAAGILAAALGLGS
Rv2836c|M.tuberculosis_H37Rv        LDSLAIAAQSLVGAALGAGDAGHAKAVAWRVTAFSLLAAGILAAALGLGS
MAB_3128c|M.abscessus_ATCC_199      LDSLAIAAQTLVGAALGAGRVPEAKSVAWRVSIFSLGFAVLLAGILALGA
                                    *********:*********   .** *****: **   . :**  :.:*:

Mflv_4036|M.gilvum_PYR-GCK          QLIPSAFTDDQSVLDRIGVPWWFLVAQLPVAGIVFAIDGVLLGAGDATFM
Mvan_2317|M.vanbaalenii_PYR-1       SVFPAVFTDDRSVLDQIGVPWWFLVAQLPVAGIVFAIDGVLLGAGDATFM
MSMEG_2631|M.smegmatis_MC2_155      SVFPPVFTDDESVLATIGVPWWFLVAQLPVAGIVFALDGVLLGAGDAKFM
MMAR_1897|M.marinum_M               PVLPALFTDDAAVLAAVTVPWWFLVAQLPFAGIVFALDGVLLGAGDAAFM
MUL_2125|M.ulcerans_Agy99           PVLPALFTDDAAVLAAITVPWWFLVAQLPFAGVVFALDGVLLGAGDAAFM
Mb2861c|M.bovis_AF2122/97           SVLPGLFTDDRSVLAAIGVLWWFMVVQLPFAGIVFAVDGVLLGAGDAAFM
Rv2836c|M.tuberculosis_H37Rv        SVLPGLFTDDRSVLAAIGVPWWFMVVQLPFAGIVFAVDGVLLGAGDAAFM
MAB_3128c|M.abscessus_ATCC_199      PVLPRLFTSDAAVLHEMRVPWWFLVCQLPISGLVFALDGVLLGAADARFM
                                     ::*  **.* :**  : * ***:* ***.:*:***:*******.** **

Mflv_4036|M.gilvum_PYR-GCK          RNATLASALAGFLPLVWLSLAFGWGLLGIWAGLSTFMVLRLVFVGWRALS
Mvan_2317|M.vanbaalenii_PYR-1       RNATLISALVGFLPLIWLSLAFGWGLLGIWAGLSAFMVLRLVFVGWRALS
MSMEG_2631|M.smegmatis_MC2_155      RNATLASAMLGFLPLIWLSLAFGWGLFGIWSGLSTFMVLRLVFVGWRAFS
MMAR_1897|M.marinum_M               RTATVVSALAGFLPLTWLSLVYGWGLAGIWSGLATFIVLRLIFVGWRAMS
MUL_2125|M.ulcerans_Agy99           RTATVVSALAGFLPLTWLSLVYGWGLAGIWSGLATFIVLRLIFVGWRAMS
Mb2861c|M.bovis_AF2122/97           RTATVASALVGFLPLVWLSLAYGWGLAGIWSGLGTFIVLRLIFVGWRAYS
Rv2836c|M.tuberculosis_H37Rv        RTATVASALVGFLPLVWLSLAYGWGLAGIWSGLGTFIVLRLIFVGWRAYS
MAB_3128c|M.abscessus_ATCC_199      RNATMISALCGFLPSVWLALVFGWGLAGIWCGLTLFLVLRLVLVGWRALS
                                    *.**: **: ****  **:*.:**** ***.**  *:****::***** *

Mflv_4036|M.gilvum_PYR-GCK          GRWLVPGTR-
Mvan_2317|M.vanbaalenii_PYR-1       GRWLVPGTR-
MSMEG_2631|M.smegmatis_MC2_155      GRWLVPGTS-
MMAR_1897|M.marinum_M               GRWALTGTA-
MUL_2125|M.ulcerans_Agy99           GRWALTGTA-
Mb2861c|M.bovis_AF2122/97           GRWAVTGAA-
Rv2836c|M.tuberculosis_H37Rv        GRWAVTGAA-
MAB_3128c|M.abscessus_ATCC_199      GGWAVPGTGS
                                    * * :.*: