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VTDLLWPGDHRAGDLMSDRAFFDAMVAVENAWLNLLVDIGPAPQKARVDLCALSSAGDVETVAAGAESDG NPVVGLVALLRERTGGEAARWLHRGLTSQDVVDTALMMCLRDALSAVHDEMATHVRILLDLVESHRKSPM TARTLTQPALPSTAAAKFANWLSGVLDAADALAAVPWLPVQLGGAVGTHAATTELVGSPDEALTLADALA GAVGLTTAAPWHTTRAVVTRAGDALVGCCDACGHIAADVAVGSRAEIGELVEGSGGGSSTMPHKRNPVLS VLIRRAALAAPALGATLHAASAASVDERSDGGWHAEWAALRTLTRRTVVAMRQTSDLLTGLHVDVQRARD NLGAAGDLLAEQRVMSELVGRTTRADYLGASGHLIDAVAHRARRHLKETM
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2603 | pcaB | - | 100% (400) | 3-carboxy-cis,cis-muconate cycloisomerase |
| M. smegmatis MC2 155 | MSMEG_1677 | aspA | 3e-06 | 26.29% (232) | aspartate ammonia-lyase |
| M. smegmatis MC2 155 | MSMEG_3769 | argH | 3e-05 | 28.04% (214) | argininosuccinate lyase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | - | - | - | - | - |
| M. gilvum PYR-GCK | Mflv_0528 | - | 1e-132 | 61.96% (397) | fumarate lyase |
| M. tuberculosis H37Rv | - | - | - | - | - |
| M. leprae Br4923 | MLBr_02230 | purB | 4e-06 | 25.51% (294) | adenylosuccinate lyase |
| M. abscessus ATCC 19977 | MAB_0290 | - | 2e-52 | 36.73% (392) | 3-carboxymuconate cycloisomerase PcaB |
| M. marinum M | MMAR_2469 | argH | 3e-06 | 29.17% (240) | argininosuccinate lyase ArgH |
| M. avium 104 | MAV_3504 | pcaB | 1e-108 | 54.57% (405) | 3-carboxy-cis,cis-muconate cycloisomerase |
| M. thermoresistible (build 8) | TH_1267 | purB | 3e-07 | 26.13% (287) | PROBABLE ADENYLOSUCCINATE LYASE PURB (ADENYLOSUCCINASE) |
| M. ulcerans Agy99 | MUL_1651 | argH | 4e-06 | 29.17% (240) | argininosuccinate lyase |
| M. vanbaalenii PYR-1 | Mvan_0562 | - | 1e-132 | 62.22% (397) | fumarate lyase |
CLUSTAL 2.0.9 multiple sequence alignment
MLBr_02230|M.leprae_Br4923 -----MSIPNVLAARYASAELVAIWSPEARVIAERQLWLAVLRAQAELSV
TH_1267|M.thermoresistible__bu -----VTIPNVLAHRYASDEMTAIWSPKAKVVAERRLWIAVMRAQAELGV
Mflv_0528|M.gilvum_PYR-GCK -------MIDLFWPGDD--LAGDLMSDGAFLSAMVAVEQAWLDGLVDAGI
Mvan_0562|M.vanbaalenii_PYR-1 -------MIDLFWPGDD--LAGDLMSDGAFLSAMVAVEQAWLDGLVDAGI
MSMEG_2603|M.smegmatis_MC2_155 -------MTDLLWPGDH--RAGDLMSDRAFFDAMVAVENAWLNLLVDIGP
MAV_3504|M.avium_104 -------MTNLLWPGDH--RAGEHMTDAALLDAMVAVESAWLAALTGAGL
MAB_0290|M.abscessus_ATCC_1997 --MSGYVDTGLLSPVSAGTAAEAELSDAAWLQAMLDAEAALAAAQADIGV
MMAR_2469|M.marinum_M MSTNQGSLWGGRFAGGPSDALAALSKSTHFDWALAPYDVTASRAHAVVLF
MUL_1651|M.ulcerans_Agy99 MSTNQGSLWGGRFAGGPSDALAALSKSTHFDWALAPYDVTASRAHAVVLF
. . * : .
MLBr_02230|M.leprae_Br4923 PMPVKAIADYERVLGEV--DLASIAARERVLRHDVKARIEEFN-------
TH_1267|M.thermoresistible__bu DIPDEVIADYERVVEDV--DLDAIAARERVLRHDVKARIEEFN-------
Mflv_0528|M.gilvum_PYR-GCK APRQARAD-LTILLADG--DAATIARRAGADGNPVSALVLMLR----ERS
Mvan_0562|M.vanbaalenii_PYR-1 APRQARAD-LTILLADG--DAATIARRAGADGNPVSALVLMLR----ERS
MSMEG_2603|M.smegmatis_MC2_155 APQKARVD-LCALSSAG--DVETVAAGAESDGNPVVGLVALLR----ERT
MAV_3504|M.avium_104 APADCAAAGLRNLVAGN--DFETLAVGAEDGGNPVIGLVRLLR----ERA
MAB_0290|M.abscessus_ATCC_1997 LPR-AAADVIARAAAGHGIDVRAVALSARETANPVVGLIKELSR-AVDEI
MMAR_2469|M.marinum_M RAGLLTEEQRDGLLAGLDSLASDVADGSFGPLVSDEDVHAALERGLIERV
MUL_1651|M.ulcerans_Agy99 RAGLLTEEQRDGLLAGLDSLASDVADGSFGPLVSDEDVHAALERGLIDRV
:* :
MLBr_02230|M.leprae_Br4923 ALAGHEQVHKGMTSRDLTENVEQLQIRRSLELVFCHGVAVVARLAECAVS
TH_1267|M.thermoresistible__bu ARAGHEHVHKGMTSRDLTENVEQLQIRRSLELVHAHGVAVVARLAERALS
Mflv_0528|M.gilvum_PYR-GCK AEPTARWLHRGLTSQDVVDTALMLCTRDVLIRIGDEFAIQVRALTELAET
Mvan_0562|M.vanbaalenii_PYR-1 AEPTARWLHRGLTSQDVVDTALMLCTRDVLIRIGDEFAIQVRALTELAET
MSMEG_2603|M.smegmatis_MC2_155 GGEAARWLHRGLTSQDVVDTALMMCLRDALSAVHDEMATHVRILLDLVES
MAV_3504|M.avium_104 DPAVAPWIHRGLTSQDVLDTALMLGVRALADDLIAELREQIRVLSGLTDR
MAB_0290|M.abscessus_ATCC_1997 EPSATDYVHRGSTSQDILDTGAMIVAKRVLGIVATDLGYTADALAELAGA
MMAR_2469|M.marinum_M GPDLGGRLRAGRSRNDQVATLFRMWLRDAVRRVATGVLEVVAALGDQAAA
MUL_1651|M.ulcerans_Agy99 GPDLGGRLRAGRSRNDQVATLFRMWLRDAVRRVATGVLEVVAALGDQAAA
:: * : .* . : : : * .
MLBr_02230|M.leprae_Br4923 YRDLVMAGRSHNVAAQATTLGKRFASATQETLIALTRLRELIDRYPLRGI
TH_1267|M.thermoresistible__bu YRDLVMAGRSHNVAAQATTLGKRFASAAEEMLGALTRLEEIIARYPLRGI
Mflv_0528|M.gilvum_PYR-GCK HRDTSALARTLTQAALPSTLGAKFARWLTGVLDAAEPIAGLMASLPAQVG
Mvan_0562|M.vanbaalenii_PYR-1 HRDTSALARTLTQAALPSTLGAKFARWLTGVLDAAEPIAGLIASLPVQVG
MSMEG_2603|M.smegmatis_MC2_155 HRKSPMTARTLTQPALPSTAAAKFANWLSGVLDAADALA-AVPWLPVQLG
MAV_3504|M.avium_104 HRATHMVARTLTQHAAPTTFGAKAAGWLNGVLDAFDNVIALVT--PVQIG
MAB_0290|M.abscessus_ATCC_1997 HSGTVMAARTLAMQAVPTTFGLKASGWRQLILEARARVVALADALPVSLG
MMAR_2469|M.marinum_M HPTAIMPGKTHLQSAQPILLAHHLLAHAHPLLRDVERIVDFDKRAAVSPY
MUL_1651|M.ulcerans_Agy99 HPTAIMPGKTHLQSAQPILLAHHLLAHAHPLLRDVERIVDFDKRAAVSPY
: .:: * . . : * : .
MLBr_02230|M.leprae_Br4923 KGPMGTGQDMLDLLGGDAAA------LAELEQRIAEFLGFTKVLASVGQV
TH_1267|M.thermoresistible__bu KGPMGTAQDMLDLFGGDSER------LAELERRVAEFLGFKEVFTSVGQV
Mflv_0528|M.gilvum_PYR-GCK -GAVGSLAAATELAGSVEG-------AIALSDGLAATLRLAPT-PPWHTT
Mvan_0562|M.vanbaalenii_PYR-1 -GAVGSLAAATELAGSVEG-------AIALSDGLAATLRLAPT-PPWHTT
MSMEG_2603|M.smegmatis_MC2_155 -GAVGTHAATTELVGSPDE-------ALTLADALAGAVGLTTA-APWHTT
MAV_3504|M.avium_104 -GAAGTLAASTELAALRTGTVDPAAVSVELARGTAAALGLAPR-PPWHTA
MAB_0290|M.abscessus_ATCC_1997 -GAAGTLAGYLEYAGQHGADP--AVFVEKLNAAFAHRTGLAASGLPWHAL
MMAR_2469|M.marinum_M -GSGALAGSSLGLDP------------DAIAADLGFTTAADNS-VDATAS
MUL_1651|M.ulcerans_Agy99 -GSGALAGSSLGLDP------------DAIAADLGFTTAADNS-VDATAS
*. . : .
MLBr_02230|M.leprae_Br4923 YPRSLDHDVISALVQLGAGSSSLAHTIRLMAGHELVTEGFAPGQVGSSAM
TH_1267|M.thermoresistible__bu YPRSLDYEVISALVQLGAAPSSLATTIRLMAGHELVTEGFAPGQVGSSAM
Mflv_0528|M.gilvum_PYR-GCK RWQVTRIGDALVSCCDAWGHIATDVTTGCRPEIGELAE---GHGGGSSTL
Mvan_0562|M.vanbaalenii_PYR-1 RWQVTRIGDALVSCCDAWGHIATDVTTGCRPEIGELAE---GHGGGSSTL
MSMEG_2603|M.smegmatis_MC2_155 RAVVTRAGDALVGCCDACGHIAADVAVGSRAEIGELVE---GSGGGSSTM
MAV_3504|M.avium_104 RAPITAAADALVGCTDSWGRIAADVVTLARPEIGELGEPATATRGGSSSM
MAB_0290|M.abscessus_ATCC_1997 RTPIADIGSTTAFVTGALGKFAVDVLTLSRTEIAEVAEPAPPGRGVSSAM
MMAR_2469|M.marinum_M RDFAAEAAFIFAMIAVDLSRLAEDIIIWSSTEFGYVTLHDSWSTG-SSIM
MUL_1651|M.ulcerans_Agy99 RDFAAEAAFVFAMIAVDLSRLAEDIIIWSSTEFGYVTLHDSWSTG-SSIM
. . : . : ** :
MLBr_02230|M.leprae_Br4923 PHKMNSRSCERVNGLQVVLRG------YAAMAAELAG---AQWNEGDVFC
TH_1267|M.thermoresistible__bu PHKMNARSCERVNGLQVVLRG------YASMAAELAG---AQWNEGDVFC
Mflv_0528|M.gilvum_PYR-GCK PHKNNP-------VRSVLIRR------AALTAGPLG--------------
Mvan_0562|M.vanbaalenii_PYR-1 PHKNNP-------VRSVLIRR------AALTAGPLG--------------
MSMEG_2603|M.smegmatis_MC2_155 PHKRNP-------VLSVLIRR------AALAAPALG--------------
MAV_3504|M.avium_104 PHKRNP-------VLSVLIRR------AAIAGPPLA--------------
MAB_0290|M.abscessus_ATCC_1997 PHKRNP-------VLATMIRS------AALQVPSLS--------------
MMAR_2469|M.marinum_M PQKKNPDIAELARGKSGRLIGNLTGLLATLKAQPLAYNRDLQEDKEPVFD
MUL_1651|M.ulcerans_Agy99 PQKKNPDIAELARGKSGRLIGNLTGLLATLKSQPLAYNRDLQEDKEPVFD
*:* *. : : *.
MLBr_02230|M.leprae_Br4923 SVVRRVALPDSFFAIDGQIETFLTVLDEFGAYPAVIRRELDRYLPFLATT
TH_1267|M.thermoresistible__bu SVVRRVALPDAFFAIDGQIETFLTVLDEFGAYPAVIQRELDRYLPFLATT
Mflv_0528|M.gilvum_PYR-GCK SILHTAAGATVDERSDGAWHTEWATLRTLARHTVVAAAHTSDLLSGLRVD
Mvan_0562|M.vanbaalenii_PYR-1 SILHTAAGATVDERSDGAWHTEWATLRTLARHTVVAAAHTSDLLSGLRVD
MSMEG_2603|M.smegmatis_MC2_155 ATLHAASAASVDERSDGGWHAEWAALRTLTRRTVVAMRQTSDLLTGLHVD
MAV_3504|M.avium_104 ATLHTAAALAGDERPDGAWHAEWDTLRTLGRRTAVAASQCTELLAGLSVH
MAB_0290|M.abscessus_ATCC_1997 VVLTQSLMSE-DERSAGGWHAEWLVLRECLRLAGGAAQTAVELSRGLQVR
MMAR_2469|M.marinum_M SVVQLELLLPAMAGLVGSLTFDVERMAALAPAGYTLATDVAEWLVRQGVP
MUL_1651|M.ulcerans_Agy99 SVVQLELLLPAMAGLVGSLTFDVERMAALAPAGYTLATDVAEWLVRQGVP
: * : .
MLBr_02230|M.leprae_Br4923 KVLIAAVRAGMGREAAHHVI-REHAVATALAMRECGAEPDLLDRLAADGR
TH_1267|M.thermoresistible__bu RILMAAVRAGMGREAAHEVI-KEHAVAVALDMREKGSEPDLLDRLAADPR
Mflv_0528|M.gilvum_PYR-GCK PPRAAANLAAAESLLSEQRS-MTELTGRAALPGYTGAADRLIDSTLGR--
Mvan_0562|M.vanbaalenii_PYR-1 PPRAAANLAAAESLLSEQRS-MTELTGRAALPGYTGAADRLIDSTLGR--
MSMEG_2603|M.smegmatis_MC2_155 VQRARDNLGAAGDLLAEQRV-MSELVGRTTRADYLGASGHLIDAVAHR--
MAV_3504|M.avium_104 AARIAENLAAAD-VLGEQRA-IAELAGGAPSPTYFGAVDRVIDETLRR--
MAB_0290|M.abscessus_ATCC_1997 ADRMAENLALLGGQPSAERL-AAALAPRLGKGPAKAVVTNVVDQVIARG-
MMAR_2469|M.marinum_M FRSAHEAAGAAVRTAEERSVGLEELTDDELAAISPELTPQVRDVLTIEG-
MUL_1651|M.ulcerans_Agy99 FRSAHEAAGAAVRTAEERSVGLEELTDDELAAISPELTPQVRDVLTIEG-
. . . : *
MLBr_02230|M.leprae_Br4923 LPLDRAALDAALADKKAFTGAAADQVDEVVAMVDKLVGRYPEAAKYTPGA
TH_1267|M.thermoresistible__bu LPLDRPALDAALADRQAFTGAAASQVDTVVGAVDELVSRYPEAAKYTSGA
Mflv_0528|M.gilvum_PYR-GCK ---------ACRFVKDAP--------------------------------
Mvan_0562|M.vanbaalenii_PYR-1 ---------ACRFVKDAP--------------------------------
MSMEG_2603|M.smegmatis_MC2_155 ---------ARRHLKETM--------------------------------
MAV_3504|M.avium_104 ---------AARVRPER---------------------------------
MAB_0290|M.abscessus_ATCC_1997 ----LSLREATRARPEIIAWLSEAEIDELLDPATYTGAAGQLVEEALTHL
MMAR_2469|M.marinum_M ----------SVSARDSRGGTAPKRVAEQLQIVREITARLGHELMR----
MUL_1651|M.ulcerans_Agy99 ----------SVSARDSRGGTAPKRVAEQLQIVREITARLGHELMR----
.
MLBr_02230|M.leprae_Br4923 IL
TH_1267|M.thermoresistible__bu IL
Mflv_0528|M.gilvum_PYR-GCK --
Mvan_0562|M.vanbaalenii_PYR-1 --
MSMEG_2603|M.smegmatis_MC2_155 --
MAV_3504|M.avium_104 --
MAB_0290|M.abscessus_ATCC_1997 S-
MMAR_2469|M.marinum_M --
MUL_1651|M.ulcerans_Agy99 --