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TPVQSFRTEHDLLGDLEVPADVYYGVHTARALLNFPISGMPISRHPDLVVALASVKQAAAEANRQLGQLD STIAGAIITACTEIRDGALREQFVVDQIQGGAGTSTNMNANEVIANRACELLGHQRGSYDVVHPLEHVNL GQSTNDVYPTALKIALGTATRTLEQALRRLADHCSTKSLEFADMLKLGRTQLQDAVPMTLGQEFGAFAVT ILEDADRLGEVSALIAEINLGGTAIGTGLNTHPEYAALVCDHLRAVTGLPLTTAGNLVEATSDVGAFVQL SGVAKRSAVKLSKICNDLRLLSSGPRAGFGEINLPPVQAGSSIMPGKVNPVIPEVVNQVAFEVIGNDLTV TMAAEAGQLQLNAFEPIIARALLSSINHLAAAVNVLGERCIEGITANTDHMRDAVLRSASLATALNPVLG YEAATALVAEAIATGESIPEMVLRCALVDEAVLARVLSPENLCGLSGSERAR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_1677 | aspA | - | 100% (473) | aspartate ammonia-lyase |
| M. smegmatis MC2 155 | MSMEG_5240 | fumC | 3e-89 | 41.83% (459) | fumarate hydratase |
| M. smegmatis MC2 155 | MSMEG_3769 | argH | 7e-12 | 28.69% (237) | argininosuccinate lyase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb1128c | fumC | 9e-90 | 42.17% (460) | fumarate hydratase |
| M. gilvum PYR-GCK | Mflv_2065 | fumC | 6e-89 | 41.61% (459) | fumarate hydratase |
| M. tuberculosis H37Rv | Rv1098c | fumC | 9e-90 | 42.17% (460) | fumarate hydratase |
| M. leprae Br4923 | MLBr_01947 | fumC | 2e-92 | 43.36% (459) | fumarate hydratase |
| M. abscessus ATCC 19977 | MAB_1250c | fumC | 4e-94 | 43.38% (461) | fumarate hydratase |
| M. marinum M | MMAR_4368 | fumC | 2e-91 | 43.26% (460) | fumarase Fum |
| M. avium 104 | MAV_1221 | fumC | 1e-90 | 42.92% (459) | fumarate hydratase |
| M. thermoresistible (build 8) | TH_0559 | fum | 9e-90 | 42.28% (447) | PROBABLE FUMARASE FUM (Fumarate hydratase) |
| M. ulcerans Agy99 | MUL_0181 | fumC | 3e-91 | 43.26% (460) | fumarate hydratase |
| M. vanbaalenii PYR-1 | Mvan_4649 | fumC | 1e-90 | 42.70% (459) | fumarate hydratase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb1128c|M.bovis_AF2122/97 MAVDA-DSAN----YRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRG
Rv1098c|M.tuberculosis_H37Rv MAVDA-DSAN----YRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRG
MMAR_4368|M.marinum_M MAHSAHDDADNDTEYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRG
MUL_0181|M.ulcerans_Agy99 MAHSAHDDADNDTEYRIEHDTMGEVRVPAKALWRAQTQRAVENFPISGRG
MLBr_01947|M.leprae_Br4923 MKRTQFMADS--AEYRIEHDTMGEVRVPAIALWRAQTQRAVENFPISGRG
MAV_1221|M.avium_104 ---MATDDGD--TDYRIERDTMGEVRVPAKALWRAQTQRAVENFPISGRG
Mflv_2065|M.gilvum_PYR-GCK --MAD-----KDVEYRIEHDTMGEVRVPKDALWRAQTQRAVENFPISFRP
Mvan_4649|M.vanbaalenii_PYR-1 --MTDSA--VDNTEYRIEHDTMGEVRVPKNALWRAQTQRAVENFPISFRP
TH_0559|M.thermoresistible__bu -MSTDSAGQNGATEYRIEHDTMGEVRVPVNALWRAQTQRAVENFPISGRG
MAB_1250c|M.abscessus_ATCC_199 --MSE-------QQYRIEHDTMGEVRVPAEALWRAQTQRAVENFPISGRG
MSMEG_1677|M.smegmatis_MC2_155 --MTP------VQSFRTEHDLLGDLEVPADVYYGVHTARALLNFPISGMP
:* *:* :*::.** . : .:* **: *****
Mb1128c|M.bovis_AF2122/97 LERT--QIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDD
Rv1098c|M.tuberculosis_H37Rv LERT--QIRALGLLKGACAQVNSDLGLLAPEKADAIIAAAAEIADGQHDD
MMAR_4368|M.marinum_M LERA--QIRALGLLKGACAQVNMDLGLLAPEKAEAIIAAAAEIADGQHDD
MUL_0181|M.ulcerans_Agy99 LERA--QMRALGLLKGACAQVNMDLGLLAPEKAQAIIAAAAEIADGQHDD
MLBr_01947|M.leprae_Br4923 LERT--QIRALGLLKGACAQVNKDLGLLASEKANAIIAAAATIADGYHDD
MAV_1221|M.avium_104 LERT--QIRALGLLKGACAQVNKDLGLLAPEKADAIIAAAAEIADGRHDD
Mflv_2065|M.gilvum_PYR-GCK LERT--QIRAMGLLKGACAQVNKDLGLLAPEKADAIIAAAAEIADGRHDD
Mvan_4649|M.vanbaalenii_PYR-1 LERT--QIRALGLLKGACAQVNKDLGLLAPEKADAIIAAAAEIADGRHDD
TH_0559|M.thermoresistible__bu LERA--QIRALGLLKGACAQVNKDLGLLDPAKADAIIAAANEIAEGRHDD
MAB_1250c|M.abscessus_ATCC_199 LERT--QIRALGLLKGACAQVNKDLGLLAAEKADAIIAAAQEIADGKHDD
MSMEG_1677|M.smegmatis_MC2_155 ISRHPDLVVALASVKQAAAEANRQLGQLDSTIAGAIITACTEIRDGALRE
:.* : *:. :* *.*:.* :** * . * ***:*. * :* :
Mb1128c|M.bovis_AF2122/97 QFPIDVFQTGSGTSSNMNTNEVIAS-----IAAKGG--VTLHPNDDVNMS
Rv1098c|M.tuberculosis_H37Rv QFPIDVFQTGSGTSSNMNTNEVIAS-----IAAKGG--VTLHPNDDVNMS
MMAR_4368|M.marinum_M QFPIDVFQTGSGTSSNMNTNEVIAS-----IAGANG--VAVHPNDDVNMS
MUL_0181|M.ulcerans_Agy99 QFPIDVFQTGSGTSSNMNTNEVIAS-----IAGANG--VAVHPNDDVNMS
MLBr_01947|M.leprae_Br4923 QFPIDVFQTGSGTSSNMNTNEVIGS-----IAAANG--VPVHPNDDVNMS
MAV_1221|M.avium_104 QFPIDVFQTGSGTSSNMNTNEVIAS-----IAAANG--VTVHPNDDVNMS
Mflv_2065|M.gilvum_PYR-GCK QFPIDVFQTGSGTSSNMNTNEVIAS-----IAAANG--VTIHPNDDVNMS
Mvan_4649|M.vanbaalenii_PYR-1 QFPIDVFQTGSGTSSNMNTNEVIAS-----IAAANG--VTVHPNDDVNMS
TH_0559|M.thermoresistible__bu QFPIDVFQTGSGTSSNMNTNEVIAS-----IAARNG--VTVHPNDDVNMS
MAB_1250c|M.abscessus_ATCC_199 QFPIDVFQTGSGTSSNMNANEVIAS-----IAAQATPPVVVHPNDDVNMS
MSMEG_1677|M.smegmatis_MC2_155 QFVVDQIQGGAGTSTNMNANEVIANRACELLGHQRGSYDVVHPLEHVNLG
** :* :* *:***:***:****.. :. :** :.**:.
Mb1128c|M.bovis_AF2122/97 QSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRT
Rv1098c|M.tuberculosis_H37Rv QSSNDTFPTATHIAATEAAVAHLIPALQQLHDALAAKALDWHTVVKSGRT
MMAR_4368|M.marinum_M QSSNDTFPTATHIAATEAAVSHLIPALEILQDALATKALEWQSVVKSGRT
MUL_0181|M.ulcerans_Agy99 QSSNDTFPTATHIAATEAAVSHLIPALEILQDALATKALEWQSVVKSGRT
MLBr_01947|M.leprae_Br4923 QSSNDTFPTATHIAATEAAVRHLIPALQELHAALATKSSEWHTVVKSGRT
MAV_1221|M.avium_104 QSSNDTFPTATHIAATEAAVRHLIPALQVLHDALASKAREWHTVVKSGRT
Mflv_2065|M.gilvum_PYR-GCK QSSNDTFPTATHIAATEAAVRHLIPALEVLHESLDAKARQWRTTVKSGRT
Mvan_4649|M.vanbaalenii_PYR-1 QSSNDTFPTATHIAATEAAVRHLIPALEVLHESLDAKARQWRTTVKSGRT
TH_0559|M.thermoresistible__bu QSSNDTFPTATHVAATEAAVRDLIPALEVLHASLAAKARQWRTVVKSGRT
MAB_1250c|M.abscessus_ATCC_199 QSSNDTFPTATHLAATEAAVRDLIPALEYLQQALATKAKAWKTVVKSGRT
MSMEG_1677|M.smegmatis_MC2_155 QSTNDVYPTALKIALG-TATRTLEQALRRLADHCSTKSLEFADMLKLGRT
**:**.:*** ::* :*. * **. * :*: : :* ***
Mb1128c|M.bovis_AF2122/97 HLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLN
Rv1098c|M.tuberculosis_H37Rv HLMDAVPVTLGQEFSGYARQIEAGIERVRACLPRLGELAIGGTAVGTGLN
MMAR_4368|M.marinum_M HLMDAVPVTLGQEFSGYARQIEAGIERVRATLPRLGELAIGGTAVGTGLN
MUL_0181|M.ulcerans_Agy99 HLMDAVPVTLGQEFSGYARQIEAGIERVRATLPRLGELAIGGTAVGTGLN
MLBr_01947|M.leprae_Br4923 HLMDAVPVTLGQEFGGYARQIEAGIERVRATLPRLGELAIGGTAVGTGLN
MAV_1221|M.avium_104 HLMDAVPVTLGQEFSGYARQIEAGIERVRATLPRLGELAIGGTAVGTGLN
Mflv_2065|M.gilvum_PYR-GCK HLMDAVPVTLGQEFGGYARQIEAGIERVKATLPRLGELAIGGTAVGTGLN
Mvan_4649|M.vanbaalenii_PYR-1 HLMDAVPVTLGQEFGGYARQIQAGIERVKASLPRLGELAIGGTAVGTGLN
TH_0559|M.thermoresistible__bu HLMDAVPVTLGQEFGGYARQIEAGIERVRATLPRLGELPIGGTAVGTGLN
MAB_1250c|M.abscessus_ATCC_199 HLMDAVPVTLGQEFGGYARQIEAGIERVKATLPRLGELPIGGTAVGTGLN
MSMEG_1677|M.smegmatis_MC2_155 QLQDAVPMTLGQEFGAFAVTILEDADRLGEVSALIAEINLGGTAIGTGLN
:* ****:******..:* * . :*: . :.*: :****:*****
Mb1128c|M.bovis_AF2122/97 APDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAV
Rv1098c|M.tuberculosis_H37Rv APDDFGVRVVAVLVAQTGLSELRTAANSFEAQAARDGLVEASGALRTIAV
MMAR_4368|M.marinum_M APEGFGVKVVSVLVSQTGLPQLRTAANSFEAQAARDGLVEASGALRTIAV
MUL_0181|M.ulcerans_Agy99 APEGFGVKVVSVLVSQTGLPQLRTAANSFEAQAARDGLVEASGALRIIAV
MLBr_01947|M.leprae_Br4923 APDGFGAKVVEALIATTGLTELRPAANSFEAQAARDGLVEASGALRTIAV
MAV_1221|M.avium_104 APDGFGAKVVETLIASTGLSELRTATNSFEAQAARDGLVEASGALRTIAV
Mflv_2065|M.gilvum_PYR-GCK APDGFGAKVVEVLVDQTGIAELRTAKDSFEAQAARDGLVEASGALKTIAA
Mvan_4649|M.vanbaalenii_PYR-1 APDGFGAKVVDVLVDQTGIAELRTAVDSFEAQAARDGLVEASGALKTIAV
TH_0559|M.thermoresistible__bu APEGFGPKVVEVLVAQTGLAELRPAVDSFEAQAARDGLVEASGALRTIAV
MAB_1250c|M.abscessus_ATCC_199 APDGFGAKVVEVLKQSTGLSELKTASDSFEAQAARDGLVEGSGALKTIAA
MSMEG_1677|M.smegmatis_MC2_155 THPEYAALVCDHLRAVTGLP-LTTAGNLVEATSDVGAFVQLSGVAKRSAV
: :. * * **:. * .* : .** : ..:*: **. : *.
Mb1128c|M.bovis_AF2122/97 SLTKIANDIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQV
Rv1098c|M.tuberculosis_H37Rv SLTKIANDIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQV
MMAR_4368|M.marinum_M SLTKIANDIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQV
MUL_0181|M.ulcerans_Agy99 SLTKIANDIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQV
MLBr_01947|M.leprae_Br4923 SLTKIANDIRLMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVLPEAVTQV
MAV_1221|M.avium_104 SLTKIANDIRWMGSGPLTGLAEIALPDLQPGSSIMPGKVNPVIPEAVTQV
Mflv_2065|M.gilvum_PYR-GCK SLTKIANDIRWMGSGPLTGLGELQLPDLQPGSSIMPGKVNPVIPEAVTQV
Mvan_4649|M.vanbaalenii_PYR-1 SLTKIANDIRWMGSGPLTGLGELQLPDLQPGSSIMPGKVNPVIPEAVTQV
TH_0559|M.thermoresistible__bu SLTKIANDIRWMGSGPLTGLAEIQLPDLQPGSSIMPGKVNPVIPEAVTQV
MAB_1250c|M.abscessus_ATCC_199 SLTKIANDIRWMGSGPLTGLGEIQLPDLQPGSSIMPGKVNPVLPEAVTQV
MSMEG_1677|M.smegmatis_MC2_155 KLSKICNDLRLLSSGPRAGFGEINLPPVQAGSSIMPGKVNPVIPEVVNQV
.*:**.**:* :.*** :*:.*: ** :*.************:**.*.**
Mb1128c|M.bovis_AF2122/97 AAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQR
Rv1098c|M.tuberculosis_H37Rv AAQVIGNDAAIAWGGANGAFELNVYIPMMARNILESFKLLTNVSRLFAQR
MMAR_4368|M.marinum_M AAQVIGNDAAVAWGGANGAFELNVYIPMMARNILESFTLLTNVSKLFAQR
MUL_0181|M.ulcerans_Agy99 AAQVIGNDAAVAWGGANGAFELNVYIPMMARNILESFTLLTNVSKLFAQR
MLBr_01947|M.leprae_Br4923 AAQVIGNDAAVAWGGANGAFELNVYIPMMARNILESYQLLTNVSRLFAER
MAV_1221|M.avium_104 AAQVIGNDAAVAVGGLSGAFELNVYIPMMARNILESFKLLTNVSRLFAER
Mflv_2065|M.gilvum_PYR-GCK AAQVIGNDAAVTVGGLSGAFELNVYIPMMARNVLESFTLLANVSKLFAAK
Mvan_4649|M.vanbaalenii_PYR-1 AAQVIGNDAAVTVGGLSGAFELNVYIPMMARNLLESFTLLANVSKLFAAK
TH_0559|M.thermoresistible__bu ACQVVGNDAAIAFGGASGAFELNVYIPMMARNLLESFRLLANSSRLFAEK
MAB_1250c|M.abscessus_ATCC_199 AAQVIGNDAAITVGGLSGAFELNVYIPVMARNLLESFTLLANVSRLFVDK
MSMEG_1677|M.smegmatis_MC2_155 AFEVIGNDLTVTMAAEAGQLQLNAFEPIIARALLSSINHLAAAVNVLGER
* :*:*** ::: .. * ::**.: *::** :*.* *: .:: :
Mb1128c|M.bovis_AF2122/97 CIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIR
Rv1098c|M.tuberculosis_H37Rv CIAGLTANVEHLRRLAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIR
MMAR_4368|M.marinum_M CIAGLTANAEHLRELAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIR
MUL_0181|M.ulcerans_Agy99 CIAGLTANAEHLRELAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIR
MLBr_01947|M.leprae_Br4923 CIKGLSANIEHLRELAESSQSIVTPLNSAIGYEEAAAVVKQALKERKTLR
MAV_1221|M.avium_104 CISGLSANVEHLRELAESSPSIVTPLNSAIGYEEAAAVAKQALKERKTIR
Mflv_2065|M.gilvum_PYR-GCK CIDGLIANDQHIREQAESSPSIVTPLNSAIGYEEAAKVAKQALKEKKTIR
Mvan_4649|M.vanbaalenii_PYR-1 CIDGLVANDDHLRELAESSPSIVTPLNSAIGYEEAAKVAKQALKEKKTIR
TH_0559|M.thermoresistible__bu CIDGLVANEERLRKLAESSPSIVTPLNRAIGYEEAAKVAKQALAEGKTIR
MAB_1250c|M.abscessus_ATCC_199 CVDGLVANEDHLRTLAESSPSIVTPLNSAIGYEEAAAVAKEALKERKTIR
MSMEG_1677|M.smegmatis_MC2_155 CIEGITANTDHMRDAVLRSASLATALNPVLGYEAATALVAEAIATGESIP
*: *: ** :::* . * *:.*.** .:*** *: :. :*: :::
Mb1128c|M.bovis_AF2122/97 QTVIDRGLIGDRLSIEDLDRRLDVLAMAKAEQLDSDRL
Rv1098c|M.tuberculosis_H37Rv QTVIDRGLIGDRLSIEDLDRRLDVLAMAKAEQLDSDRL
MMAR_4368|M.marinum_M QTVIDRGLIGDKLSLEELDRRLDVLAMAKVEATDD---
MUL_0181|M.ulcerans_Agy99 QTVIDRGLIGNKLSLEELDRRLDVLAMAKVEATDD---
MLBr_01947|M.leprae_Br4923 QTVIDRGLIGDKLSLEELDRRLDVLAMAKVKPADS---
MAV_1221|M.avium_104 QTVIDRGLIGDKLSLEELDRRLDVLAMAKVKPQD----
Mflv_2065|M.gilvum_PYR-GCK QTVIDRGLIGDKLSEEELDKRLDVLAMAKVKPGDQ---
Mvan_4649|M.vanbaalenii_PYR-1 QTVIDRGLIGDKLSEEELDRRLDVLAMAKVRDGS----
TH_0559|M.thermoresistible__bu QTVIDRGLVGEKLTLEELDELLDVLAMARVKDND----
MAB_1250c|M.abscessus_ATCC_199 QTVIDRGLIGDKLSIEELDKRLDVLAMAKVKD------
MSMEG_1677|M.smegmatis_MC2_155 EMVLRCALVDEAVLARVLSP-ENLCGLSGSERAR----
: *: .*:.: : . *. :: .:: .