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TNLLWPGDHRAGEHMTDAALLDAMVAVESAWLAALTGAGLAPADCAAAGLRNLVAGNDFETLAVGAEDGG NPVIGLVRLLRERADPAVAPWIHRGLTSQDVLDTALMLGVRALADDLIAELREQIRVLSGLTDRHRATHM VARTLTQHAAPTTFGAKAAGWLNGVLDAFDNVIALVTPVQIGGAAGTLAASTELAALRTGTVDPAAVSVE LARGTAAALGLAPRPPWHTARAPITAAADALVGCTDSWGRIAADVVTLARPEIGELGEPATATRGGSSSM PHKRNPVLSVLIRRAAIAGPPLAATLHTAAALAGDERPDGAWHAEWDTLRTLGRRTAVAASQCTELLAGL SVHAARIAENLAAADVLGEQRAIAELAGGAPSPTYFGAVDRVIDETLRRAARVRPER*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. avium 104 | MAV_3504 | pcaB | - | 100% (408) | 3-carboxy-cis,cis-muconate cycloisomerase |
| M. avium 104 | MAV_3111 | argH | 3e-05 | 25.29% (257) | argininosuccinate lyase |
| M. avium 104 | MAV_0722 | purB | 7e-05 | 25.48% (263) | adenylosuccinate lyase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0800 | purB | 2e-05 | 23.32% (283) | adenylosuccinate lyase |
| M. gilvum PYR-GCK | Mflv_0528 | - | 1e-109 | 54.68% (406) | fumarate lyase |
| M. tuberculosis H37Rv | Rv0777 | purB | 2e-05 | 23.32% (283) | adenylosuccinate lyase |
| M. leprae Br4923 | MLBr_01413 | argH | 9e-05 | 23.72% (312) | argininosuccinate lyase |
| M. abscessus ATCC 19977 | MAB_0290 | - | 2e-66 | 40.58% (414) | 3-carboxymuconate cycloisomerase PcaB |
| M. marinum M | MMAR_0612 | - | 3e-07 | 25.91% (274) | transcriptional regulatory protein |
| M. smegmatis MC2 155 | MSMEG_2603 | pcaB | 1e-108 | 54.57% (405) | 3-carboxy-cis,cis-muconate cycloisomerase |
| M. thermoresistible (build 8) | TH_1599 | argH | 7e-05 | 24.11% (224) | Probable Argininosuccinate lyase argH |
| M. ulcerans Agy99 | - | - | - | - | - |
| M. vanbaalenii PYR-1 | Mvan_0562 | - | 1e-109 | 54.93% (406) | fumarate lyase |
CLUSTAL 2.0.9 multiple sequence alignment
Mflv_0528|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0562|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2603|M.smegmatis_MC2_155 --------------------------------------------------
MAV_3504|M.avium_104 --------------------------------------------------
MAB_0290|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0800|M.bovis_AF2122/97 --------------------------------------------------
Rv0777|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01413|M.leprae_Br4923 --------------------------------------------------
TH_1599|M.thermoresistible__bu --------------------------------------------------
MMAR_0612|M.marinum_M MSEGHASRDDTSAPPDSAAVPAPARGLIDELASGGATSVKALIGGGIGTG
Mflv_0528|M.gilvum_PYR-GCK -------------------------------------------MIDLFWP
Mvan_0562|M.vanbaalenii_PYR-1 -------------------------------------------MIDLFWP
MSMEG_2603|M.smegmatis_MC2_155 -------------------------------------------MTDLLWP
MAV_3504|M.avium_104 -------------------------------------------MTNLLWP
MAB_0290|M.abscessus_ATCC_1997 --------------------------------------MSGYVDTGLLSP
Mb0800|M.bovis_AF2122/97 ------------------------------------------MSIPNVLA
Rv0777|M.tuberculosis_H37Rv ------------------------------------------MSIPNVLA
MLBr_01413|M.leprae_Br4923 ----------------------------------------MSTNQGSLWG
TH_1599|M.thermoresistible__bu ----------------------------------------VSTNKGSLWG
MMAR_0612|M.marinum_M KTTVLGTVRDALRRAGVTVRAHPTKDCDPSEVALVVDDAHLLAEDELLRL
.
Mflv_0528|M.gilvum_PYR-GCK GDD--LAGDLMSDG--------AFLSAMVAVEQ-----------------
Mvan_0562|M.vanbaalenii_PYR-1 GDD--LAGDLMSDG--------AFLSAMVAVEQ-----------------
MSMEG_2603|M.smegmatis_MC2_155 GDH--RAGDLMSDR--------AFFDAMVAVEN-----------------
MAV_3504|M.avium_104 GDH--RAGEHMTDA--------ALLDAMVAVES-----------------
MAB_0290|M.abscessus_ATCC_1997 VSAGTAAEAELSDA--------AWLQAMLDAEA-----------------
Mb0800|M.bovis_AF2122/97 TRYAS---AEMVAI-------WSPEAKVVSERR-----------------
Rv0777|M.tuberculosis_H37Rv TRYAS---AEMVAI-------WSPEAKVVSERR-----------------
MLBr_01413|M.leprae_Br4923 GRFAAGPSEALVALSKSTHFDWVLAPYDITASR-----------------
TH_1599|M.thermoresistible__bu GRFAGGPSDALAALSKSTHFDWALAPYDITASK-----------------
MMAR_0612|M.marinum_M AEWVADPRATVVVGAQLHQQHHALRALATAIERERPQISLGPLPVADQLR
:
Mflv_0528|M.gilvum_PYR-GCK --------AWLDGLVDAGIAPRQARAD-LTILLADG--DAATIARRAGAD
Mvan_0562|M.vanbaalenii_PYR-1 --------AWLDGLVDAGIAPRQARAD-LTILLADG--DAATIARRAGAD
MSMEG_2603|M.smegmatis_MC2_155 --------AWLNLLVDIGPAPQKARVD-LCALSSAG--DVETVAAGAESD
MAV_3504|M.avium_104 --------AWLAALTGAGLAPADCAAAGLRNLVAGN--DFETLAVGAEDG
MAB_0290|M.abscessus_ATCC_1997 --------ALAAAQADIGVLPR-AAADVIARAAAGHGIDVRAVALSARET
Mb0800|M.bovis_AF2122/97 --------LWLAVLRAQAELGVAVADSVLADYERVVD-DVDLASIS--AR
Rv0777|M.tuberculosis_H37Rv --------LWLAVLRAQAELGVAVADSVLADYERVVD-DVDLASIS--AR
MLBr_01413|M.leprae_Br4923 --------AHTKMLFRAGLLNEEQRDGLLAGLDNLAE-DVADGSFLPLVT
TH_1599|M.thermoresistible__bu --------AHVRVLHRAGLLTDEQRDGLLDGLDRLAD-DVAAGRFVPDDT
MMAR_0612|M.marinum_M DSTAGVPFLVEAVSRGTGSPVPAARFALIERLRRLDEPTLDALLIMSLTQ
. :
Mflv_0528|M.gilvum_PYR-GCK GNPVSALVLMLR---ERSAEPTARWLHRGLTSQDVVDTALMLCTRDVLIR
Mvan_0562|M.vanbaalenii_PYR-1 GNPVSALVLMLR---ERSAEPTARWLHRGLTSQDVVDTALMLCTRDVLIR
MSMEG_2603|M.smegmatis_MC2_155 GNPVVGLVALLR---ERTGGEAARWLHRGLTSQDVVDTALMMCLRDALSA
MAV_3504|M.avium_104 GNPVIGLVRLLR---ERADPAVAPWIHRGLTSQDVLDTALMLGVRALADD
MAB_0290|M.abscessus_ATCC_1997 ANPVVGLIKELSRAVDEIEPSATDYVHRGSTSQDILDTGAMIVAKRVLGI
Mb0800|M.bovis_AF2122/97 ERVLRHDVKARI--EEFNALAGHEHVHKGMTSRDLTENVEQLQIRRSLEV
Rv0777|M.tuberculosis_H37Rv ERVLRHDVKARI--EEFNALAGHEHVHKGMTSRDLTENVEQLQIRRSLEV
MLBr_01413|M.leprae_Br4923 DEDVHAALERGL--IDRVGPDLGGRLRAGRSRNDQVATLFRMWLRDAVRR
TH_1599|M.thermoresistible__bu DEDVHGALERGL--IERVGPELGGRLRAGRSRNDQVATLFRLWLRDAVRS
MMAR_0612|M.marinum_M ESGTTDVAAALGVSTSDARQLVDRVHASGLVEPSHPPAFVQLVHEAVVHI
. * . : .
Mflv_0528|M.gilvum_PYR-GCK IGDEFAIQVRA---------------------------------------
Mvan_0562|M.vanbaalenii_PYR-1 IGDEFAIQVRA---------------------------------------
MSMEG_2603|M.smegmatis_MC2_155 VHDEMATHVRI---------------------------------------
MAV_3504|M.avium_104 LIAELREQIRV---------------------------------------
MAB_0290|M.abscessus_ATCC_1997 VATDLGYTADA---------------------------------------
Mb0800|M.bovis_AF2122/97 IFAHGVAAVAR---------------------------------------
Rv0777|M.tuberculosis_H37Rv IFAHGVAAVAR---------------------------------------
MLBr_01413|M.leprae_Br4923 VAAGALEVVDA---------------------------------------
TH_1599|M.thermoresistible__bu VGAGVLDVVDA---------------------------------------
MMAR_0612|M.marinum_M VGNTHHHEVETSLLRSQLDISPMSQDLALRLAEHGLHGERLATALAGYAS
:
Mflv_0528|M.gilvum_PYR-GCK -----LTELAETHRDTSALARTLTQAALPSTLG--------AKFARWLTG
Mvan_0562|M.vanbaalenii_PYR-1 -----LTELAETHRDTSALARTLTQAALPSTLG--------AKFARWLTG
MSMEG_2603|M.smegmatis_MC2_155 -----LLDLVESHRKSPMTARTLTQPALPSTAA--------AKFANWLSG
MAV_3504|M.avium_104 -----LSGLTDRHRATHMVARTLTQHAAPTTFG--------AKAAGWLNG
MAB_0290|M.abscessus_ATCC_1997 -----LAELAGAHSGTVMAARTLAMQAVPTTFG--------LKASGWRQL
Mb0800|M.bovis_AF2122/97 -----LAERAVSYRDLIMAGRSHNVAAQATTLG--------KRFASAAQE
Rv0777|M.tuberculosis_H37Rv -----LAERAVSYRDLIMAGRSHNVAAQATTLG--------KRFASAAQE
MLBr_01413|M.leprae_Br4923 -----LANQAAEHSSTIMPGKTHLQSAQPILLA--------HHLLAHAHP
TH_1599|M.thermoresistible__bu -----LADQAAAHPTAIMPGKTHLQSAQPVLLA--------HHLLAHAHP
MMAR_0612|M.marinum_M AARGEPAQTARLYRAAVAAGATGLKSQLADALARTGDCAGAAELADELLG
. : . : . . .
Mflv_0528|M.gilvum_PYR-GCK VLDAAEPIAGLMASLPAQVG-GAVGSLAAATELAGSVEG----------A
Mvan_0562|M.vanbaalenii_PYR-1 VLDAAEPIAGLIASLPVQVG-GAVGSLAAATELAGSVEG----------A
MSMEG_2603|M.smegmatis_MC2_155 VLDAADALA-AVPWLPVQLG-GAVGTHAATTELVGSPDE----------A
MAV_3504|M.avium_104 VLDAFDNVIALVT--PVQIG-GAAGTLAASTELAALRTGTVD---PAAVS
MAB_0290|M.abscessus_ATCC_1997 ILEARARVVALADALPVSLG-GAAGTLAGYLEYAGQHGADP-----AVFV
Mb0800|M.bovis_AF2122/97 MMIALRRLRELIDRYPLRGIKGPMGTGQDMLDLLGGDRA---------AL
Rv0777|M.tuberculosis_H37Rv MMIALRRLRELIDRYPLRGIKGPMGTGQDMLDLLGGDRA---------AL
MLBr_01413|M.leprae_Br4923 LLRDVGRIVDFDKRAAVS----PYGSGALAGSSLGLDPD---------AM
TH_1599|M.thermoresistible__bu LLRDVDRLLDFDRRAAVS----PYGSGALAGSSLGLDPD---------AI
MMAR_0612|M.marinum_M SADSAQRAAAVRIAASVAAHEGNAGQAAELFGWLGPYPDAVVGSSAAIVL
. * .
Mflv_0528|M.gilvum_PYR-GCK IALSDGLAATLRLAPT---PPWHTTRWQVTRIGDALVSCCDAW-------
Mvan_0562|M.vanbaalenii_PYR-1 IALSDGLAATLRLAPT---PPWHTTRWQVTRIGDALVSCCDAW-------
MSMEG_2603|M.smegmatis_MC2_155 LTLADALAGAVGLTTA---APWHTTRAVVTRAGDALVGCCDAC-------
MAV_3504|M.avium_104 VELARGTAAALGLAPR---PPWHTARAPITAAADALVGCTDSW-------
MAB_0290|M.abscessus_ATCC_1997 EKLNAAFAHRTGLAASG--LPWHALRTPIADIGSTTAFVTGAL-------
Mb0800|M.bovis_AF2122/97 ADLERRVADFLGFATVFNSVGQVYPRSLDHDVVSALVQLGAGP-------
Rv0777|M.tuberculosis_H37Rv ADLERRVADFLGFATVFNSVGQVYPRSLDHDVVSALVQLGAGP-------
MLBr_01413|M.leprae_Br4923 AQDLG----FP--AAADNSVDATAARDFAAEAAFVFAMIAVDL-------
TH_1599|M.thermoresistible__bu AEELG----FS--AAADNSIDATAARDFAAEAAFVFAMTGVDL-------
MMAR_0612|M.marinum_M AAVGDLQTARAALDVKDTGPPTMAARAARGLADGLLLTMGQPYPVAMAKL
*
Mflv_0528|M.gilvum_PYR-GCK ------------------GHIATDVTTGCRPEIGELAE---GHGGGSSTL
Mvan_0562|M.vanbaalenii_PYR-1 ------------------GHIATDVTTGCRPEIGELAE---GHGGGSSTL
MSMEG_2603|M.smegmatis_MC2_155 ------------------GHIAADVAVGSRAEIGELVE---GSGGGSSTM
MAV_3504|M.avium_104 ------------------GRIAADVVTLARPEIGELGEPATATRGGSSSM
MAB_0290|M.abscessus_ATCC_1997 ------------------GKFAVDVLTLSRTEIAEVAEPAPPGRGVSSAM
Mb0800|M.bovis_AF2122/97 ------------------SSLAHTIRLMAGHELATEGFAP-GQVG-SSAM
Rv0777|M.tuberculosis_H37Rv ------------------SSLAHTIRLMAGHELATEGFAP-GQVG-SSAM
MLBr_01413|M.leprae_Br4923 ------------------SRLAEDIILWSSTEFGYARLHDSWSTG-SSIM
TH_1599|M.thermoresistible__bu ------------------SRLAEDIILWSTTEFGYVTLHDSWSTG-SSIM
MMAR_0612|M.marinum_M GQAIAAEQPITEATPDSPAALVTLAAIHGGDPVRARSVIGRAVRSGTDQV
. :. . . :. :
Mflv_0528|M.gilvum_PYR-GCK PHKNNPVRSVLIRRAALTAGPLGSILHTAAGATVDERSD-----------
Mvan_0562|M.vanbaalenii_PYR-1 PHKNNPVRSVLIRRAALTAGPLGSILHTAAGATVDERSD-----------
MSMEG_2603|M.smegmatis_MC2_155 PHKRNPVLSVLIRRAALAAPALGATLHAASAASVDERSD-----------
MAV_3504|M.avium_104 PHKRNPVLSVLIRRAAIAGPPLAATLHTAAALAGDERPD-----------
MAB_0290|M.abscessus_ATCC_1997 PHKRNPVLATMIRSAALQVPSLSVVLTQSLMSE-DERSA-----------
Mb0800|M.bovis_AF2122/97 PHKMNTRSCERVNGLQVVLRG-YASMVAELAGAQWNEGDVFCSVVRR---
Rv0777|M.tuberculosis_H37Rv PHKMNTRSCERVNGLQVVLRG-YASMVAELAGAQWNEGDVFCSVVRR---
MLBr_01413|M.leprae_Br4923 PQKKNPDIAELARGKSGRLIGNLAGLLATLKAQPLAYN------------
TH_1599|M.thermoresistible__bu PQKKNPDIAELARGKSGRLIGNLAGLLATLKAQPLAYN------------
MMAR_0612|M.marinum_M FHQRHLLLSGWIKMQEGQLPSASADVAAACSGAPMHRRDALWAAALETAI
:: : . . :
Mflv_0528|M.gilvum_PYR-GCK -------GAWHTEWATLRTLARHTVVAAAHTSDL-----LSGLRVDPPRA
Mvan_0562|M.vanbaalenii_PYR-1 -------GAWHTEWATLRTLARHTVVAAAHTSDL-----LSGLRVDPPRA
MSMEG_2603|M.smegmatis_MC2_155 -------GGWHAEWAALRTLTRRTVVAMRQTSDL-----LTGLHVDVQRA
MAV_3504|M.avium_104 -------GAWHAEWDTLRTLGRRTAVAASQCTEL-----LAGLSVHAARI
MAB_0290|M.abscessus_ATCC_1997 -------GGWHAEWLVLRECLRLAGGAAQTAVEL-----SRGLQVRADRM
Mb0800|M.bovis_AF2122/97 -------VALPDSFFAVDGQIETFLTVLDEFGAY-----PAVIGRELDRY
Rv0777|M.tuberculosis_H37Rv -------VALPDSFFAVDGQIETFLTVLDEFGAY-----PAVIGRELDRY
MLBr_01413|M.leprae_Br4923 -------RDLQEDKEPVFDSVAQLELLLPAMAGL-----VASLTFNVERM
TH_1599|M.thermoresistible__bu -------RDLQEDKEPVFDSVAQLRLLLPAMTGL-----VATLTFDTARM
MMAR_0612|M.marinum_M ARRSGDAGALQKHWNAAMEVLGEYSLDLFALLPLGELWVAAARNRQVDQL
:
Mflv_0528|M.gilvum_PYR-GCK AANLAAAESLLSEQ-------------------------------RSMTE
Mvan_0562|M.vanbaalenii_PYR-1 AANLAAAESLLSEQ-------------------------------RSMTE
MSMEG_2603|M.smegmatis_MC2_155 RDNLGAAGDLLAEQ-------------------------------RVMSE
MAV_3504|M.avium_104 AENLAAAD-VLGEQ-------------------------------RAIAE
MAB_0290|M.abscessus_ATCC_1997 AENLALLGGQPSAE-------------------------------RLAAA
Mb0800|M.bovis_AF2122/97 LPFLATTKVLMAAV-------------------------------RAGMG
Rv0777|M.tuberculosis_H37Rv LPFLATTKVLMAAV-------------------------------RAGMG
MLBr_01413|M.leprae_Br4923 AALAPAGYTLATDI-------------------------------AEWLV
TH_1599|M.thermoresistible__bu AELAPLGYTLATDM-------------------------------AEWLV
MMAR_0612|M.marinum_M QHTLDQAFSLLNSLGNPVLWSNSLHWAGVHAGILANSPGAVAPHGQALGA
Mflv_0528|M.gilvum_PYR-GCK LTGRAALPGYTGAADRLIDSTLGR------ACRFVKDAP-----------
Mvan_0562|M.vanbaalenii_PYR-1 LTGRAALPGYTGAADRLIDSTLGR------ACRFVKDAP-----------
MSMEG_2603|M.smegmatis_MC2_155 LVGRTTRADYLGASGHLIDAVAHR------ARRHLKETM-----------
MAV_3504|M.avium_104 LAGGAPSPTYFGAVDRVIDETLRR------AARVRPER------------
MAB_0290|M.abscessus_ATCC_1997 LAPRLGKGPAKAVVTNVVDQVIARGLSLREATRARPEIIAWLSEAEIDEL
Mb0800|M.bovis_AF2122/97 RESAHRLISEHAVATALAMREHG--AEPDLLDRLAADPRLPLGRDALEAA
Rv0777|M.tuberculosis_H37Rv RESAHRLISEHAVATALAMREHG--AEPDLLDRLAADPRLTLGRDALEAA
MLBr_01413|M.leprae_Br4923 RQGVPFRSAHEAAGTAVRVAEGRGVGLEELTDDELAAISANLTPQVREVL
TH_1599|M.thermoresistible__bu RRGVPFRVAHEAAGAAVRAAEARGIGLEELSDAELAEIHPELTPQVREVL
MMAR_0612|M.marinum_M AAAGNALAHALSVAGRTWLRVLADQVDVDEVTVAARSLSGVGLTSDATRL
..
Mflv_0528|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0562|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2603|M.smegmatis_MC2_155 --------------------------------------------------
MAV_3504|M.avium_104 --------------------------------------------------
MAB_0290|M.abscessus_ATCC_1997 LDPATYTGAAGQLVEEALTHLS----------------------------
Mb0800|M.bovis_AF2122/97 LADKKAFAGAAGDQVDDVVAMVDALVSRYPDAAKYTPGAIL---------
Rv0777|M.tuberculosis_H37Rv LADKKAFAGAAGDQVDDVVAMVDALVSRYPDAAKYTPGAIL---------
MLBr_01413|M.leprae_Br4923 TVEGSVSSRAARGGTAPSQAAKQLTVVR-ANANQLRQLLMR---------
TH_1599|M.thermoresistible__bu TVEGSVNARDARGGTAPVQVARQLDLVR-DTASRLRLRLEG---------
MMAR_0612|M.marinum_M AGQAALQTADARVSGAMLQLARDLKLASGFDEPTDAEPVAGAAPAPRQPP
Mflv_0528|M.gilvum_PYR-GCK --------------------------------------------------
Mvan_0562|M.vanbaalenii_PYR-1 --------------------------------------------------
MSMEG_2603|M.smegmatis_MC2_155 --------------------------------------------------
MAV_3504|M.avium_104 --------------------------------------------------
MAB_0290|M.abscessus_ATCC_1997 --------------------------------------------------
Mb0800|M.bovis_AF2122/97 --------------------------------------------------
Rv0777|M.tuberculosis_H37Rv --------------------------------------------------
MLBr_01413|M.leprae_Br4923 --------------------------------------------------
TH_1599|M.thermoresistible__bu --------------------------------------------------
MMAR_0612|M.marinum_M AGSPLSDREREVAELLLLGMPYRDIGAQLFISAKTVEHHVARIRRRLGAG
Mflv_0528|M.gilvum_PYR-GCK -----------------
Mvan_0562|M.vanbaalenii_PYR-1 -----------------
MSMEG_2603|M.smegmatis_MC2_155 -----------------
MAV_3504|M.avium_104 -----------------
MAB_0290|M.abscessus_ATCC_1997 -----------------
Mb0800|M.bovis_AF2122/97 -----------------
Rv0777|M.tuberculosis_H37Rv -----------------
MLBr_01413|M.leprae_Br4923 -----------------
TH_1599|M.thermoresistible__bu -----------------
MMAR_0612|M.marinum_M SRSEMLSMLRAMLTAPG