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MIDLFWPGDDLAGDLMSDGAFLSAMVAVEQAWLDGLVDAGIAPRQARADLTILLADGDAATIARRAGADG NPVSALVLMLRERSAEPTARWLHRGLTSQDVVDTALMLCTRDVLIRIGDEFAIQVRALTELAETHRDTSA LARTLTQAALPSTLGAKFARWLTGVLDAAEPIAGLIASLPVQVGGAVGSLAAATELAGSVEGAIALSDGL AATLRLAPTPPWHTTRWQVTRIGDALVSCCDAWGHIATDVTTGCRPEIGELAEGHGGGSSTLPHKNNPVR SVLIRRAALTAGPLGSILHTAAGATVDERSDGAWHTEWATLRTLARHTVVAAAHTSDLLSGLRVDPPRAA ANLAAAESLLSEQRSMTELTGRAALPGYTGAADRLIDSTLGRACRFVKDAP
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. vanbaalenii PYR-1 | Mvan_0562 | - | - | 100% (401) | fumarate lyase |
| M. vanbaalenii PYR-1 | Mvan_5145 | - | 9e-07 | 25.46% (271) | adenylosuccinate lyase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb0800 | purB | 3e-06 | 26.88% (186) | adenylosuccinate lyase |
| M. gilvum PYR-GCK | Mflv_0528 | - | 0.0 | 99.50% (401) | fumarate lyase |
| M. tuberculosis H37Rv | Rv0777 | purB | 3e-06 | 26.88% (186) | adenylosuccinate lyase |
| M. leprae Br4923 | MLBr_02230 | purB | 3e-08 | 26.57% (271) | adenylosuccinate lyase |
| M. abscessus ATCC 19977 | MAB_0290 | - | 2e-49 | 35.77% (397) | 3-carboxymuconate cycloisomerase PcaB |
| M. marinum M | MMAR_4916 | purB | 2e-05 | 27.95% (161) | adenylosuccinate lyase, PurB |
| M. avium 104 | MAV_3504 | pcaB | 1e-109 | 54.93% (406) | 3-carboxy-cis,cis-muconate cycloisomerase |
| M. smegmatis MC2 155 | MSMEG_2603 | pcaB | 1e-132 | 62.22% (397) | 3-carboxy-cis,cis-muconate cycloisomerase |
| M. thermoresistible (build 8) | TH_1267 | purB | 6e-07 | 26.83% (246) | PROBABLE ADENYLOSUCCINATE LYASE PURB (ADENYLOSUCCINASE) |
| M. ulcerans Agy99 | MUL_0490 | purB | 5e-06 | 26.40% (250) | adenylosuccinate lyase |
CLUSTAL 2.0.9 multiple sequence alignment
MMAR_4916|M.marinum_M ---MSVPNVLAARYASAEMVAIWSPQAKVVAERRLWLAVLRAQRELGAKG
MUL_0490|M.ulcerans_Agy99 ---MSVPNVLAARYASAEMVAIWSPQAKVVAERRLWLAVLRAQRELGAKG
Mb0800|M.bovis_AF2122/97 ---MSIPNVLATRYASAEMVAIWSPEAKVVSERRLWLAVLRAQAELGVA-
Rv0777|M.tuberculosis_H37Rv ---MSIPNVLATRYASAEMVAIWSPEAKVVSERRLWLAVLRAQAELGVA-
MLBr_02230|M.leprae_Br4923 ---MSIPNVLAARYASAELVAIWSPEARVIAERQLWLAVLRAQAELSVP-
TH_1267|M.thermoresistible__bu ---VTIPNVLAHRYASDEMTAIWSPKAKVVAERRLWIAVMRAQAELGVD-
Mvan_0562|M.vanbaalenii_PYR-1 -----MIDLFWPGDD--LAGDLMSDGAFLSAMVAVEQAWLDGLVDAGIAP
Mflv_0528|M.gilvum_PYR-GCK -----MIDLFWPGDD--LAGDLMSDGAFLSAMVAVEQAWLDGLVDAGIAP
MSMEG_2603|M.smegmatis_MC2_155 -----MTDLLWPGDH--RAGDLMSDRAFFDAMVAVENAWLNLLVDIGPAP
MAV_3504|M.avium_104 -----MTNLLWPGDH--RAGEHMTDAALLDAMVAVESAWLAALTGAGLAP
MAB_0290|M.abscessus_ATCC_1997 MSGYVDTGLLSPVSAGTAAEAELSDAAWLQAMLDAEAALAAAQADIGVLP
.:: : * . : * .
MMAR_4916|M.marinum_M TDVPADAIADYERVIDDVDLDSIASRERVLRHDVKARIEEFN------AL
MUL_0490|M.ulcerans_Agy99 TDVPADAIADYERVIDDVDLDSIASRERVLRHDVKARIEEFN------AL
Mb0800|M.bovis_AF2122/97 --VADSVLADYERVVDDVDLASISARERVLRHDVKARIEEFN------AL
Rv0777|M.tuberculosis_H37Rv --VADSVLADYERVVDDVDLASISARERVLRHDVKARIEEFN------AL
MLBr_02230|M.leprae_Br4923 --MPVKAIADYERVLGEVDLASIAARERVLRHDVKARIEEFN------AL
TH_1267|M.thermoresistible__bu --IPDEVIADYERVVEDVDLDAIAARERVLRHDVKARIEEFN------AR
Mvan_0562|M.vanbaalenii_PYR-1 RQARAD-LTILLADG---DAATIARRAGADGNPVSALVLMLR---ERSAE
Mflv_0528|M.gilvum_PYR-GCK RQARAD-LTILLADG---DAATIARRAGADGNPVSALVLMLR---ERSAE
MSMEG_2603|M.smegmatis_MC2_155 QKARVD-LCALSSAG---DVETVAAGAESDGNPVVGLVALLR---ERTGG
MAV_3504|M.avium_104 ADCAAAGLRNLVAGN---DFETLAVGAEDGGNPVIGLVRLLR---ERADP
MAB_0290|M.abscessus_ATCC_1997 R-AAADVIARAAAGHG-IDVRAVALSARETANPVVGLIKELSRAVDEIEP
: * ::: : * . : :
MMAR_4916|M.marinum_M AGHEHVHKGMTSRDLTENVEQLQIRQSLDLTFAHGVAVAARLAERAVAYR
MUL_0490|M.ulcerans_Agy99 AGHEHVHKGMTSRDLTENVEQLQIRQSLDLTFAHGVAVAARLAERAVAYR
Mb0800|M.bovis_AF2122/97 AGHEHVHKGMTSRDLTENVEQLQIRRSLEVIFAHGVAAVARLAERAVSYR
Rv0777|M.tuberculosis_H37Rv AGHEHVHKGMTSRDLTENVEQLQIRRSLEVIFAHGVAAVARLAERAVSYR
MLBr_02230|M.leprae_Br4923 AGHEQVHKGMTSRDLTENVEQLQIRRSLELVFCHGVAVVARLAECAVSYR
TH_1267|M.thermoresistible__bu AGHEHVHKGMTSRDLTENVEQLQIRRSLELVHAHGVAVVARLAERALSYR
Mvan_0562|M.vanbaalenii_PYR-1 PTARWLHRGLTSQDVVDTALMLCTRDVLIRIGDEFAIQVRALTELAETHR
Mflv_0528|M.gilvum_PYR-GCK PTARWLHRGLTSQDVVDTALMLCTRDVLIRIGDEFAIQVRALTELAETHR
MSMEG_2603|M.smegmatis_MC2_155 EAARWLHRGLTSQDVVDTALMMCLRDALSAVHDEMATHVRILLDLVESHR
MAV_3504|M.avium_104 AVAPWIHRGLTSQDVLDTALMLGVRALADDLIAELREQIRVLSGLTDRHR
MAB_0290|M.abscessus_ATCC_1997 SATDYVHRGSTSQDILDTGAMIVAKRVLGIVATDLGYTADALAELAGAHS
:*:* **:*: :. : : . * . :
MMAR_4916|M.marinum_M DLVMAGRSHNVAAQATTLGKRFASAAQETLIALVRLRELIDRYPLRG--I
MUL_0490|M.ulcerans_Agy99 DLVMAGRSHNVAAQATTLGKRFASAAQETLIALVRLRELIDRYPLRG--I
Mb0800|M.bovis_AF2122/97 DLIMAGRSHNVAAQATTLGKRFASAAQEMMIALRRLRELIDRYPLRG--I
Rv0777|M.tuberculosis_H37Rv DLIMAGRSHNVAAQATTLGKRFASAAQEMMIALRRLRELIDRYPLRG--I
MLBr_02230|M.leprae_Br4923 DLVMAGRSHNVAAQATTLGKRFASATQETLIALTRLRELIDRYPLRG--I
TH_1267|M.thermoresistible__bu DLVMAGRSHNVAAQATTLGKRFASAAEEMLGALTRLEEIIARYPLRG--I
Mvan_0562|M.vanbaalenii_PYR-1 DTSALARTLTQAALPSTLGAKFARWLTGVLDAAEPIAGLIASLPVQVGGA
Mflv_0528|M.gilvum_PYR-GCK DTSALARTLTQAALPSTLGAKFARWLTGVLDAAEPIAGLMASLPAQVGGA
MSMEG_2603|M.smegmatis_MC2_155 KSPMTARTLTQPALPSTAAAKFANWLSGVLDAADALA-AVPWLPVQLGGA
MAV_3504|M.avium_104 ATHMVARTLTQHAAPTTFGAKAAGWLNGVLDAFDNVIALVT--PVQIGGA
MAB_0290|M.abscessus_ATCC_1997 GTVMAARTLAMQAVPTTFGLKASGWRQLILEARARVVALADALPVSLGGA
.*: * .:* . : : : * : *
MMAR_4916|M.marinum_M KGPMGTAQDMLDLLDGDS---AKLTDLEQRVADFLGFSTVLTSVGQVYPR
MUL_0490|M.ulcerans_Agy99 KGPMGTAQDMLDLLDGDS---AKLTDLEQRVADFLGFSTVLTSVGQVYPR
Mb0800|M.bovis_AF2122/97 KGPMGTGQDMLDLLGGDR---AALADLERRVADFLGFATVFNSVGQVYPR
Rv0777|M.tuberculosis_H37Rv KGPMGTGQDMLDLLGGDR---AALADLERRVADFLGFATVFNSVGQVYPR
MLBr_02230|M.leprae_Br4923 KGPMGTGQDMLDLLGGDA---AALAELEQRIAEFLGFTKVLASVGQVYPR
TH_1267|M.thermoresistible__bu KGPMGTAQDMLDLFGGDS---ERLAELERRVAEFLGFKEVFTSVGQVYPR
Mvan_0562|M.vanbaalenii_PYR-1 VGSLAAATELAGSVEG-------AIALSDGLAATLRLAPT---PPWHTTR
Mflv_0528|M.gilvum_PYR-GCK VGSLAAATELAGSVEG-------AIALSDGLAATLRLAPT---PPWHTTR
MSMEG_2603|M.smegmatis_MC2_155 VGTHAATTELVGSPDE-------ALTLADALAGAVGLTTA---APWHTTR
MAV_3504|M.avium_104 AGTLAASTELAALRTGTVDPAAVSVELARGTAAALGLAPR---PPWHTAR
MAB_0290|M.abscessus_ATCC_1997 AGTLAGYLEYAGQHGADP--AVFVEKLNAAFAHRTGLAASG--LPWHALR
*. . : * * : *
MMAR_4916|M.marinum_M SLDHDVVSALVQLGAGPSSLAHTIRLMAGHEL--VTEGFAAGQVGSSAMP
MUL_0490|M.ulcerans_Agy99 SLDHDVVSALVQLGAGPSSLAHTIRLMAGHEL--VTEGFAPGQVGSSAMP
Mb0800|M.bovis_AF2122/97 SLDHDVVSALVQLGAGPSSLAHTIRLMAGHEL--ATEGFAPGQVGSSAMP
Rv0777|M.tuberculosis_H37Rv SLDHDVVSALVQLGAGPSSLAHTIRLMAGHEL--ATEGFAPGQVGSSAMP
MLBr_02230|M.leprae_Br4923 SLDHDVISALVQLGAGSSSLAHTIRLMAGHEL--VTEGFAPGQVGSSAMP
TH_1267|M.thermoresistible__bu SLDYEVISALVQLGAAPSSLATTIRLMAGHEL--VTEGFAPGQVGSSAMP
Mvan_0562|M.vanbaalenii_PYR-1 WQVTRIGDALVSCCDAWGHIATDVTTGCRPEIGELAE---GHGGGSSTLP
Mflv_0528|M.gilvum_PYR-GCK WQVTRIGDALVSCCDAWGHIATDVTTGCRPEIGELAE---GHGGGSSTLP
MSMEG_2603|M.smegmatis_MC2_155 AVVTRAGDALVGCCDACGHIAADVAVGSRAEIGELVE---GSGGGSSTMP
MAV_3504|M.avium_104 APITAAADALVGCTDSWGRIAADVVTLARPEIGELGEPATATRGGSSSMP
MAB_0290|M.abscessus_ATCC_1997 TPIADIGSTTAFVTGALGKFAVDVLTLSRTEIAEVAEPAPPGRGVSSAMP
.: . . . :* : . *: * **::*
MMAR_4916|M.marinum_M HKMNTRSCERVNGLQVVLRGYASMAAELAGAQWNEGDVFCSVVRRVVLPD
MUL_0490|M.ulcerans_Agy99 HKMNTRSCERVNGLQVVLRGYASMAAELAGAQWNEGDVFCSVVRRVVLPD
Mb0800|M.bovis_AF2122/97 HKMNTRSCERVNGLQVVLRGYASMVAELAGAQWNEGDVFCSVVRRVALPD
Rv0777|M.tuberculosis_H37Rv HKMNTRSCERVNGLQVVLRGYASMVAELAGAQWNEGDVFCSVVRRVALPD
MLBr_02230|M.leprae_Br4923 HKMNSRSCERVNGLQVVLRGYAAMAAELAGAQWNEGDVFCSVVRRVALPD
TH_1267|M.thermoresistible__bu HKMNARSCERVNGLQVVLRGYASMAAELAGAQWNEGDVFCSVVRRVALPD
Mvan_0562|M.vanbaalenii_PYR-1 HKNNP--------------------------------VRSVLIRRAALTA
Mflv_0528|M.gilvum_PYR-GCK HKNNP--------------------------------VRSVLIRRAALTA
MSMEG_2603|M.smegmatis_MC2_155 HKRNP--------------------------------VLSVLIRRAALAA
MAV_3504|M.avium_104 HKRNP--------------------------------VLSVLIRRAAIAG
MAB_0290|M.abscessus_ATCC_1997 HKRNP--------------------------------VLATMIRSAALQV
** *. * . ::* ..:
MMAR_4916|M.marinum_M SFFAIDGQTETFLTVLDEFGAYPAVIARELDRYLPFLATTKVLMAAVRAG
MUL_0490|M.ulcerans_Agy99 SFIAIDGQTETFLTVLDEFGAYPAVIARELDRYLPFLATTKVLMAAVRAG
Mb0800|M.bovis_AF2122/97 SFFAVDGQIETFLTVLDEFGAYPAVIGRELDRYLPFLATTKVLMAAVRAG
Rv0777|M.tuberculosis_H37Rv SFFAVDGQIETFLTVLDEFGAYPAVIGRELDRYLPFLATTKVLMAAVRAG
MLBr_02230|M.leprae_Br4923 SFFAIDGQIETFLTVLDEFGAYPAVIRRELDRYLPFLATTKVLIAAVRAG
TH_1267|M.thermoresistible__bu AFFAIDGQIETFLTVLDEFGAYPAVIQRELDRYLPFLATTRILMAAVRAG
Mvan_0562|M.vanbaalenii_PYR-1 GPLGSILHTAAGATVDERSDGAWHTEWATLRTLARHTVVAAAHTSDLLSG
Mflv_0528|M.gilvum_PYR-GCK GPLGSILHTAAGATVDERSDGAWHTEWATLRTLARHTVVAAAHTSDLLSG
MSMEG_2603|M.smegmatis_MC2_155 PALGATLHAASAASVDERSDGGWHAEWAALRTLTRRTVVAMRQTSDLLTG
MAV_3504|M.avium_104 PPLAATLHTAAALAGDERPDGAWHAEWDTLRTLGRRTAVAASQCTELLAG
MAB_0290|M.abscessus_ATCC_1997 PSLSVVL-TQSLMSEDERSAGGWHAEWLVLRECLRLAGGAAQTAVELSRG
:. : : :. . . * : : *
MMAR_4916|M.marinum_M MGRESAHHVIREHAVATALAMREHGSEPDLLDRLAADPRLPLDRAALDAA
MUL_0490|M.ulcerans_Agy99 MGRESAHHVIREHAVATALAMREHGSEPDLLDRLAADPRLPLDRAALDAA
Mb0800|M.bovis_AF2122/97 MGRESAHRLISEHAVATALAMREHGAEPDLLDRLAADPRLPLGRDALEAA
Rv0777|M.tuberculosis_H37Rv MGRESAHRLISEHAVATALAMREHGAEPDLLDRLAADPRLTLGRDALEAA
MLBr_02230|M.leprae_Br4923 MGREAAHHVIREHAVATALAMRECGAEPDLLDRLAADGRLPLDRAALDAA
TH_1267|M.thermoresistible__bu MGREAAHEVIKEHAVAVALDMREKGSEPDLLDRLAADPRLPLDRPALDAA
Mvan_0562|M.vanbaalenii_PYR-1 LRVDPPR--AAANLAAAESLLSEQRSMTELTGRAALPGYTGAADRLIDST
Mflv_0528|M.gilvum_PYR-GCK LRVDPPR--AAANLAAAESLLSEQRSMTELTGRAALPGYTGAADRLIDST
MSMEG_2603|M.smegmatis_MC2_155 LHVDVQR--ARDNLGAAGDLLAEQRVMSELVGRTTRADYLGASGHLIDAV
MAV_3504|M.avium_104 LSVHAAR--IAENLAAAD-VLGEQRAIAELAGGAPSPTYFGAVDRVIDET
MAB_0290|M.abscessus_ATCC_1997 LQVRADR--MAENLALLGGQPSAERLAAALAPRLGKGPAKAVVTNVVDQV
: : : . * :: .
MMAR_4916|M.marinum_M LADKAAFTGAAADQVDQVAAQVDALVGRYPEAAKYAPGAIL---------
MUL_0490|M.ulcerans_Agy99 LADKAAFTGAAADQVEQVAAQVDALVGRYPEAAKYAPGAIL---------
Mb0800|M.bovis_AF2122/97 LADKKAFAGAAGDQVDDVVAMVDALVSRYPDAAKYTPGAIL---------
Rv0777|M.tuberculosis_H37Rv LADKKAFAGAAGDQVDDVVAMVDALVSRYPDAAKYTPGAIL---------
MLBr_02230|M.leprae_Br4923 LADKKAFTGAAADQVDEVVAMVDKLVGRYPEAAKYTPGAIL---------
TH_1267|M.thermoresistible__bu LADRQAFTGAAASQVDTVVGAVDELVSRYPEAAKYTSGAIL---------
Mvan_0562|M.vanbaalenii_PYR-1 LGR------ACRFVKDAP--------------------------------
Mflv_0528|M.gilvum_PYR-GCK LGR------ACRFVKDAP--------------------------------
MSMEG_2603|M.smegmatis_MC2_155 AHR------ARRHLKETM--------------------------------
MAV_3504|M.avium_104 LRR------AARVRPER---------------------------------
MAB_0290|M.abscessus_ATCC_1997 IARGLSLREATRARPEIIAWLSEAEIDELLDPATYTGAAGQLVEEALTHL
* :
MMAR_4916|M.marinum_M -
MUL_0490|M.ulcerans_Agy99 -
Mb0800|M.bovis_AF2122/97 -
Rv0777|M.tuberculosis_H37Rv -
MLBr_02230|M.leprae_Br4923 -
TH_1267|M.thermoresistible__bu -
Mvan_0562|M.vanbaalenii_PYR-1 -
Mflv_0528|M.gilvum_PYR-GCK -
MSMEG_2603|M.smegmatis_MC2_155 -
MAV_3504|M.avium_104 -
MAB_0290|M.abscessus_ATCC_1997 S