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MSDDYVVGLTADGADATGATIFGDIGLHRLEEAGISWRLLPPIPAHGPVDPAALAGVDAVVSFGHIPFSA ELVRQVPRLRHIARFGAGYDGIDPVALAREGVVLTNTPGAVRRPLALSGLTLLLACAHRLLENHRVTVSG KWALERGAHRGIGVDGRTVGILGFGSVGSELAGMLAPLGVEVIATTRSGRSERAAQLGVELVDRETLAAR SDFVVVTAALTEENRGMLDESFFAEMRSSAYFINIARGGLVDQPALIRALRDGGIAGAALDVYDPEPPAA DDPLFAMDNVICTPHALCWTADFTRDVSRSVIDALIAVSRNEIPETALGRDALDERTWRGRATAEACGQL AAEG
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2550 | - | - | 100% (354) | glyoxylate reductase |
| M. smegmatis MC2 155 | MSMEG_2529 | - | 4e-39 | 37.15% (288) | glyoxylate reductase |
| M. smegmatis MC2 155 | MSMEG_2378 | serA | 2e-37 | 35.06% (251) | D-3-phosphoglycerate dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3020c | serA1 | 5e-36 | 32.73% (275) | D-3-phosphoglycerate dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4234 | - | 4e-36 | 34.84% (244) | D-3-phosphoglycerate dehydrogenase |
| M. tuberculosis H37Rv | Rv2996c | serA1 | 5e-36 | 32.73% (275) | D-3-phosphoglycerate dehydrogenase |
| M. leprae Br4923 | MLBr_01692 | serA | 2e-38 | 33.82% (275) | D-3-phosphoglycerate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3304c | - | 8e-38 | 35.71% (252) | D-3-phosphoglycerate dehydrogenase |
| M. marinum M | MMAR_1715 | serA1 | 1e-34 | 33.86% (251) | D-3-phosphoglycerate dehydrogenase SerA1 |
| M. avium 104 | MAV_0349 | - | 9e-37 | 38.89% (234) | D-isomer specific 2-hydroxyacid dehydrogenase family protein |
| M. thermoresistible (build 8) | TH_3809 | - | 5e-39 | 34.74% (308) | PUTATIVE putative D-3-phosphoglycerate dehydrogenase |
| M. ulcerans Agy99 | MUL_4355 | serA4 | 3e-35 | 34.93% (272) | D-3-phosphoglycerate dehydrogenase SerA4 |
| M. vanbaalenii PYR-1 | Mvan_2128 | - | 2e-36 | 34.84% (244) | D-3-phosphoglycerate dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3020c|M.bovis_AF2122/97 ----------------MSLPVVLIADKLAPSTVAALGDQVEVRWVDGPDR
Rv2996c|M.tuberculosis_H37Rv ----------------MSLPVVLIADKLAPSTVAALGDQVEVRWVDGPDR
MLBr_01692|M.leprae_Br4923 ----------------MDLPVVLIADKLAQSTVAALGDQVEVRWVDGPDR
MMAR_1715|M.marinum_M ----------------MNLPVVLIADKLAQSTVAALGDQVEVRWVDGPDR
Mflv_4234|M.gilvum_PYR-GCK ----------------MSLPVVLIADKLAQSTVEALGDQVEVRWVDGPDR
Mvan_2128|M.vanbaalenii_PYR-1 ----------------MSLPVVLIADKLAQSTVEALGDQVEVRWVDGPDR
MAB_3304c|M.abscessus_ATCC_199 ---------------------MLIADKLAPSTVEALGDGVEVRWVDGPDR
MAV_0349|M.avium_104 ------------------MPRLAILDDYARVALQVADWSRVQKRCDITVF
MUL_4355|M.ulcerans_Agy99 -----MSQPASHGFGQDHVPRVAILDDYARVATDLADWSPVRGRATLTVF
TH_3809|M.thermoresistible__bu VSGISRPRLVFERWTDPAAGELLGAADIELVRLDLTADPADGWAALESAH
MSMEG_2550|M.smegmatis_MC2_155 ---MSDDYVVGLTADGADATGATIFGDIGLHRLEEAGISWRLLPPIPAHG
. .
Mb3020c|M.bovis_AF2122/97 DKLLAAVPEADALL-------VRSATTVDAEVLAAAPKLKIVARAGVGLD
Rv2996c|M.tuberculosis_H37Rv DKLLAAVPEADALL-------VRSATTVDAEVLAAAPKLKIVARAGVGLD
MLBr_01692|M.leprae_Br4923 TKLLAAVPEADALL-------VRSATTVDAEVLAAAPKLKIVARAGVGLD
MMAR_1715|M.marinum_M EKLLAAVPEADALL-------VRSATTVDAEVLAAATKLKIVARAGVGLD
Mflv_4234|M.gilvum_PYR-GCK EKLLAAVADADALL-------VRSATTVDAEVLAAAPKLKIVARAGVGLD
Mvan_2128|M.vanbaalenii_PYR-1 EKLLAAVADADALL-------VRSATTVDAEVLAAAPKLKIVARAGVGLD
MAB_3304c|M.abscessus_ATCC_199 PALLAAVPEADALL-------VRSATTVDAEVLAAGTKLKIVARAGVGLD
MAV_0349|M.avium_104 DEHLSEQQAVDALRPFDVVCTMRERMAFPRSLIERLPHLRLLTIVGRQLP
MUL_4355|M.ulcerans_Agy99 DRHLGQAEAAEALADFDAVCTMRERMAFPRSLLERLPRLKLITIVGMNLP
TH_3809|M.thermoresistible__bu GYQVATRTDVASMAD-------GGQWLADRNLVRRCGLLLAVCSAGAGYD
MSMEG_2550|M.smegmatis_MC2_155 PVDPAALAGVDAVVS-------FGHIPFSAELVRQVPRLRHIARFGAGYD
. . :: .:: * : *
Mb3020c|M.bovis_AF2122/97 NVDVDAATARGVLVVNAPTSN------IHSAAEHALALLLAASRQIPAAD
Rv2996c|M.tuberculosis_H37Rv NVDVDAATARGVLVVNAPTSN------IHSAAEHALALLLAASRQIPAAD
MLBr_01692|M.leprae_Br4923 NVDVDAATARGVLVVNAPTSN------IHSAAEHALALLLAASRQIAEAD
MMAR_1715|M.marinum_M NVDVDAATTRGVLVVNAPTSN------IHSAAEHAMALLLAAARQIPAAD
Mflv_4234|M.gilvum_PYR-GCK NVDVDAATARGVLVVNAPTSN------IHSAAEHALALLLSTARQIPAAD
Mvan_2128|M.vanbaalenii_PYR-1 NVDVDAATARGVLVVNAPTSN------IHSAAEHALALLLAAARQIPAAD
MAB_3304c|M.abscessus_ATCC_199 NVDVKAATARGVLVVNAPTSN------IHSAAEHAVTLLLATARQIPAAD
MAV_0349|M.avium_104 NLDMAAATEHGIAVARSEFAHPRFAALRDATPELAWGLMIATVRHLADEH
MUL_4355|M.ulcerans_Agy99 NLDLAAATERGVLVAHSNFAHPRFRAARDATAEFAWGLLIATVHNLAEEH
TH_3809|M.thermoresistible__bu VIDVDACTEAGIAVCNNSGPG------AEAVAEHALGLMLDLAKRITVAD
MSMEG_2550|M.smegmatis_MC2_155 GIDPVALAREGVVLTNTPGAVR------RPLALSGLTLLLACAHRLLENH
:* * : *: : . . . . . *:: :.: .
Mb3020c|M.bovis_AF2122/97 ASLR--EHTWKRSSFSGTEIFGKTVGVVGLGRIGQLVAQRIAAFGAYVVA
Rv2996c|M.tuberculosis_H37Rv ASLR--EHTWKRSSFSGTEIFGKTVGVVGLGRIGQLVAQRIAAFGAYVVA
MLBr_01692|M.leprae_Br4923 ASLR--AHIWKRSSFSGTEIFGKTVGVVGLGRIGQLVAARIAAFGAHVIA
MMAR_1715|M.marinum_M ASLR--EHTWKRSSFSGAEIFGKTVGVVGLGRIGQLVAQRVEAFGAHVVA
Mflv_4234|M.gilvum_PYR-GCK ATLR--EHTWKRSAFSGTEIFGKTVGVVGLGRIGQLVAQRLAAFGAHITA
Mvan_2128|M.vanbaalenii_PYR-1 ATLR--EHSWKRSSFSGTEIFGKTVGVVGLGRIGQLVAQRLAAFGAHITA
MAB_3304c|M.abscessus_ATCC_199 ASLK--AHTWKRSSFNGTEIFGKTVGVVGLGRIGQLFAQRLAAFGTHIVA
MAV_0349|M.avium_104 RQMR--AGGWQRT--AGMTLSGKTLGLLGLGRVGSRMAGFAAAFGMEVIA
MUL_4355|M.ulcerans_Agy99 RQVR--AGGWQTT--TGMTLSGKTLGLLGLGRVGKRMTEYAKAFGMDVIA
TH_3809|M.thermoresistible__bu RMLRR-GDLGDRLVLRGSQLQHKTMGIVGLGAIGRRLVQLVAPFGMKVLA
MSMEG_2550|M.smegmatis_MC2_155 RVTVSGKWALERGAHRGIGVDGRTVGILGFGSVGSELAGMLAPLGVEVIA
. * : :*:*::*:* :* .. .:* : *
Mb3020c|M.bovis_AF2122/97 YDPYVSPARAAQLGIELLSLDDLLARADFISVHLPKTPETAGLIDKEALA
Rv2996c|M.tuberculosis_H37Rv YDPYVSPARAAQLGIELLSLDDLLARADFISVHLPKTPETAGLIDKEALA
MLBr_01692|M.leprae_Br4923 YDPYVAPARAAQLGIELMSFDDLLARADFISVHLPKTPETAGLIDKEALA
MMAR_1715|M.marinum_M YDPYVSPARAAQLGIELLPLDDLLARADFISVHLPKTPETAGLLGKEALA
Mflv_4234|M.gilvum_PYR-GCK YDPYVSHARAAQLGIELLTLDELLSRADFISVHLPKTKETAGLIGTEALA
Mvan_2128|M.vanbaalenii_PYR-1 YDPYVSHARAAQLGIELLTLDELLGRADFISVHLPKTKETAGLIGKEALA
MAB_3304c|M.abscessus_ATCC_199 YDPYVSAARAAQLGIELLTLDELLGRADFISVHLPKTPETAGLIGKEALA
MAV_0349|M.avium_104 WSQNLTDDAAAAVGARRVSKAALFESADVVSVHLVLSERTRGLVGEPELA
MUL_4355|M.ulcerans_Agy99 WSQNLTEEAAAAHGVRRVDKPVLFAQSDMVSIHVVLSERTRALVGAGELA
TH_3809|M.thermoresistible__bu FDPYVDEKTAEALGARSVSLEELLGCSDFVQLTCPLTAETEGLIGRAQFA
MSMEG_2550|M.smegmatis_MC2_155 TTRSGRSERAAQLGVELVDRETLAARSDFVVVTAALTEENRGMLDESFFA
* * . : * :*.: : : .. .::. :*
Mb3020c|M.bovis_AF2122/97 KTKPGVIIVNAARGGLVDEAALADAITGGHVRAAGLDVFATEPCT-DSPL
Rv2996c|M.tuberculosis_H37Rv KTKPGVIIVNAARGGLVDEAALADAITGGHVRAAGLDVFATEPCT-DSPL
MLBr_01692|M.leprae_Br4923 KTKPGVIIVNAARGGLVDEVALADAVRSGHVRAAGLDVFATEPCT-DSPL
MMAR_1715|M.marinum_M KTKPGVIIVNAARGGLIDESALAEAITSGHVRGAGLDVFATEPCT-DSPL
Mflv_4234|M.gilvum_PYR-GCK KTKPGVIIVNAARGGLIDEQALADAITSGHVRGAGLDVFSTEPCT-DSPL
Mvan_2128|M.vanbaalenii_PYR-1 KTKPGVIIVNAARGGLIDEAALADAINSGHVRGAGLDVFSTEPCT-DSPL
MAB_3304c|M.abscessus_ATCC_199 KTKPGVIIVNAARGGLIDEAALADAIRSGHVRGAGLDVFSTEPCT-DSPL
MAV_0349|M.avium_104 LMKPSAYLINTARGPIVDEPALIAALTAGRIAGAGLDVYDVEPLPGDHPL
MUL_4355|M.ulcerans_Agy99 AMKPGAYLINTSRGPIVDEGALIGALEAGRIAGAGLDVYDVEPLPVDHRL
TH_3809|M.thermoresistible__bu AMKPTAFFVTTARGRVHDEAALYEALTCGEIAGAGLDVFHDEPPRADHPL
MSMEG_2550|M.smegmatis_MC2_155 EMRSSAYFINIARGGLVDQPALIRALRDGGIAGAALDVYDPEPPAADDPL
:. . ::. :** : *: ** *: * : .*.***: ** * *
Mb3020c|M.bovis_AF2122/97 FELAQVVVTPHLGASTAEAQDRAGTDVAESVRLALAGEFVPDAVNVGGGV
Rv2996c|M.tuberculosis_H37Rv FELAQVVVTPHLGASTAEAQDRAGTDVAESVRLALAGEFVPDAVNVGGGV
MLBr_01692|M.leprae_Br4923 FELSQVVVTPHLGASTAEAQDRAGTDVAESVRLALAGEFVPDAVNVDGGV
MMAR_1715|M.marinum_M FELPQVVVTPHLGASTAEAQDRAGTDVAASVKLALAGEFVPDAVNIAGGA
Mflv_4234|M.gilvum_PYR-GCK FELPQVVVTPHLGASTVEAQDRAGTDVAASVKLALAGEFVPDAVNVGGGA
Mvan_2128|M.vanbaalenii_PYR-1 FELPQVVVTPHLGASTVEAQDRAGTDVAASVKLALAGEFVPDAVNVGGGA
MAB_3304c|M.abscessus_ATCC_199 FELDQVVVTPHLGASTSEAQDRAGTDVAASVQLALAGEFVPDAVNVGGGV
MAV_0349|M.avium_104 RSLPNVTLSPHLGYVTREMLGAFYADTVESVLAWLDGTPIRIAN------
MUL_4355|M.ulcerans_Agy99 RSLPNVTLSPHLGYVTREMLSVCYADTVEAVVAWLDGAPIRIAN------
TH_3809|M.thermoresistible__bu LTLDNVVATPHIAGITAEAARDIAVATADQWQTIFAGGVPPRLLN-----
MSMEG_2550|M.smegmatis_MC2_155 FAMDNVICTPHALCWTADFTRDVSRSVIDALIAVSRNEIPETALG-----
: :* :** * : . .
Mb3020c|M.bovis_AF2122/97 VNEEVAPWLDLVRKLGVLAGVLSDELPVSLSVQVRGELAAEEVEVLRLSA
Rv2996c|M.tuberculosis_H37Rv VNEEVAPWLDLVRKLGVLAGVLSDELPVSLSVQVRGELAAEEVEVLRLSA
MLBr_01692|M.leprae_Br4923 VNEEVAPWLDLVCKLGVLVAALSDELPASLSVHVRGELASEDVEILRLSA
MMAR_1715|M.marinum_M VNEEVAPWLDLACKLGVLAAALSDEPPVSLSVQARGELASEDVEVLKLSA
Mflv_4234|M.gilvum_PYR-GCK VGEEVAPWLDLVRKLGLLVGALSAELPTNLCVQVRGELASEEVEVLRLSA
Mvan_2128|M.vanbaalenii_PYR-1 VGEEVAPWLDLVRKLGLLVGVLSSEPPVSLQVQVQGELASEEVEVLKLSA
MAB_3304c|M.abscessus_ATCC_199 VSEEVAPWLEVVRKLGVLIGAVSEQLPTSLSVDVRGELASEDVAVLKLSA
MAV_0349|M.avium_104 --------------------------PEVLQRD-----------------
MUL_4355|M.ulcerans_Agy99 --------------------------PQAVRRPPS---------------
TH_3809|M.thermoresistible__bu --------PEVWPRYSARFAEIFGFAPEPVSRTREREAVGR---------
MSMEG_2550|M.smegmatis_MC2_155 -----------------RDALDERTWRGRATAEACGQLAAEG--------
Mb3020c|M.bovis_AF2122/97 LRGLFSAVIEDAVTFVNAPALAAERGVTAEICKASESPNHRSVVDVRAVG
Rv2996c|M.tuberculosis_H37Rv LRGLFSAVIEDAVTFVNAPALAAERGVTAEICKASESPNHRSVVDVRAVG
MLBr_01692|M.leprae_Br4923 LRGLFSTVIEDAVTFVNAPALAAERGVSAEITTGSESPNHRSVVDVRAVA
MMAR_1715|M.marinum_M LRGLFSAVVEGPVTFVNAPALAAERGVSVEISKASESPNHRSVVDVRVVG
Mflv_4234|M.gilvum_PYR-GCK LRGLFSAVIEDQVTFVNAPALATERGVEASIDTESESPNHRSVVDVRAVA
Mvan_2128|M.vanbaalenii_PYR-1 LRGLFSAVIEHPVTFVNAPALASERGVEASITTATESANHRSVVDVRAVA
MAB_3304c|M.abscessus_ATCC_199 LRGLFSSVIEDQVTFVNAPSIAEERGVSAEITTATESPNHRSVVDVRAVY
MAV_0349|M.avium_104 --------------------------------------------------
MUL_4355|M.ulcerans_Agy99 --------------------------------------------------
TH_3809|M.thermoresistible__bu --------------------------------------------------
MSMEG_2550|M.smegmatis_MC2_155 --------------------------------------------------
Mb3020c|M.bovis_AF2122/97 ADGSVVTVSGTLYGPQLSQKIVQINGRHFDLRAQGINLIIHYVDRPGALG
Rv2996c|M.tuberculosis_H37Rv ADGSVVTVSGTLYGPQLSQKIVQINGRHFDLRAQGINLIIHYVDRPGALG
MLBr_01692|M.leprae_Br4923 SDGSVVNIAGTLSGPQLVQKIVQVNGRNFDLRAQGMNLVIRYVDQPGALG
MMAR_1715|M.marinum_M ADGSVVSVSGTLYGAQLTHKIVQINGRHFDLRAEGTNLIVNYVDQPGALG
Mflv_4234|M.gilvum_PYR-GCK ADGSTVNVSGTLTGPQLVEKIVQINGRNLDLRAEGVNVIINYHDQPGALG
Mvan_2128|M.vanbaalenii_PYR-1 ADGSTVNVAGTLTGPQLVEKIVQINGRNLELRAEGVNLIINYDDQPGALG
MAB_3304c|M.abscessus_ATCC_199 ADGSVINVAGTLSGPQLVQKIVQINGRNFDLRAEGVNLVINYADVPGALG
MAV_0349|M.avium_104 --------------------------------------------------
MUL_4355|M.ulcerans_Agy99 --------------------------------------------------
TH_3809|M.thermoresistible__bu --------------------------------------------------
MSMEG_2550|M.smegmatis_MC2_155 --------------------------------------------------
Mb3020c|M.bovis_AF2122/97 KIGTLLGTAGVNIQAAQLSEDAEGPGATILLRLDQDVPDDVRTAIAAAVD
Rv2996c|M.tuberculosis_H37Rv KIGTLLGTAGVNIQAAQLSEDAEGPGATILLRLDQDVPDDVRTAIAAAVD
MLBr_01692|M.leprae_Br4923 KIGTLLGAAGVNIQAAQLSEDTEGPGATILLRLDQDVPGDVRSAIVAAVS
MMAR_1715|M.marinum_M KIGTLLGAAGVNIHAAQLSEDVEGPGATVLLRLDQDVPEDVRSAIAAAVG
Mflv_4234|M.gilvum_PYR-GCK KIGTLLGGANVNILAAQLSQDADGEGATIMLRVDREVPADVLAGIGRDVN
Mvan_2128|M.vanbaalenii_PYR-1 KIGTLLGGAAVNILAAQLSQDADGIGATVMLRLDREVPGEVLAAIGRDVN
MAB_3304c|M.abscessus_ATCC_199 KIGTVLGGAEVNIQAAQLSQDASGAAATIILRIDRTAPDAVLDEIRAAVG
MAV_0349|M.avium_104 --------------------------------------------------
MUL_4355|M.ulcerans_Agy99 --------------------------------------------------
TH_3809|M.thermoresistible__bu --------------------------------------------------
MSMEG_2550|M.smegmatis_MC2_155 --------------------------------------------------
Mb3020c|M.bovis_AF2122/97 AYKLEVVDLS
Rv2996c|M.tuberculosis_H37Rv AYKLEVVDLS
MLBr_01692|M.leprae_Br4923 ANKLEVVNLS
MMAR_1715|M.marinum_M ANRLEVVDLS
Mflv_4234|M.gilvum_PYR-GCK ALTLEVVDLT
Mvan_2128|M.vanbaalenii_PYR-1 AVTLEVVDLT
MAB_3304c|M.abscessus_ATCC_199 ATTLELVDLS
MAV_0349|M.avium_104 ----------
MUL_4355|M.ulcerans_Agy99 ----------
TH_3809|M.thermoresistible__bu ----------
MSMEG_2550|M.smegmatis_MC2_155 ----------