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TIYVSRLLTDRAMAHLESLGVPFRVGGGDPPSRADLEAGLAGADAAVITLTERVDTALLAAAGPQLKIIA NVAVGYDNIDVDAAVSAGVTVTNTPGVLDRATADHTFALILAATRRVLDGDRFLRSREPWVWGPRMLVGL DISASATLGILGYGRIGKAVAQRAKGFDMKVLATARSREPGTSEDGVQFVDTDTLLAESDVLSVLTPLTP QTRHLIDAAALAKMKPSAYLVNTARGGVVDEAALMSALHNGALRGAALDVFENEPHIDPRLLDTPNLVLT PHIASAGESTRDAMGILAIDNAAAVLAGKPALTPVR*
Operon Prediction Model: Genebank
Paralogs
| species | id | gene | e-value | identity (len) | annotation |
| M. smegmatis MC2 155 | MSMEG_2529 | - | - | 100% (317) | glyoxylate reductase |
| M. smegmatis MC2 155 | MSMEG_6299 | - | 2e-70 | 46.03% (315) | glyoxylate reductase |
| M. smegmatis MC2 155 | MSMEG_2378 | serA | 3e-48 | 38.03% (305) | D-3-phosphoglycerate dehydrogenase |
Closest Orthologs (e-value cutoff: 1e-4)
| species | id | gene | e-value | identity (len) | annotation |
| M. bovis AF2122 / 97 | Mb3020c | serA1 | 8e-51 | 40.00% (305) | D-3-phosphoglycerate dehydrogenase |
| M. gilvum PYR-GCK | Mflv_4234 | - | 5e-49 | 38.31% (308) | D-3-phosphoglycerate dehydrogenase |
| M. tuberculosis H37Rv | Rv2996c | serA1 | 9e-51 | 40.00% (305) | D-3-phosphoglycerate dehydrogenase |
| M. leprae Br4923 | MLBr_01692 | serA | 7e-52 | 39.34% (305) | D-3-phosphoglycerate dehydrogenase |
| M. abscessus ATCC 19977 | MAB_3304c | - | 3e-46 | 37.10% (310) | D-3-phosphoglycerate dehydrogenase |
| M. marinum M | MMAR_1715 | serA1 | 5e-50 | 39.02% (305) | D-3-phosphoglycerate dehydrogenase SerA1 |
| M. avium 104 | MAV_3847 | serA | 3e-51 | 40.00% (305) | D-3-phosphoglycerate dehydrogenase |
| M. thermoresistible (build 8) | TH_2037 | serA | 2e-52 | 40.00% (305) | PROBABLE D-3-PHOSPHOGLYCERATE DEHYDROGENASE SERA1 (PGDH) |
| M. ulcerans Agy99 | MUL_1952 | serA1 | 3e-50 | 39.02% (305) | D-3-phosphoglycerate dehydrogenase |
| M. vanbaalenii PYR-1 | Mvan_2128 | - | 2e-50 | 39.29% (308) | D-3-phosphoglycerate dehydrogenase |
CLUSTAL 2.0.9 multiple sequence alignment
Mb3020c|M.bovis_AF2122/97 MSLPVVLIADKLAPSTVAALGDQVEVRWVDGPDRDKLLAAVPEADALLVR
Rv2996c|M.tuberculosis_H37Rv MSLPVVLIADKLAPSTVAALGDQVEVRWVDGPDRDKLLAAVPEADALLVR
MLBr_01692|M.leprae_Br4923 MDLPVVLIADKLAQSTVAALGDQVEVRWVDGPDRTKLLAAVPEADALLVR
MMAR_1715|M.marinum_M MNLPVVLIADKLAQSTVAALGDQVEVRWVDGPDREKLLAAVPEADALLVR
MUL_1952|M.ulcerans_Agy99 MNLPVVLIADKLAQSTVAALGDQVEVRWVDGPDREKLLAAVPEADALLVR
MAV_3847|M.avium_104 MNLPVVLIADKLAESTVAALGDQVEVRWVDGPDREKLLAAVPEADALLVR
Mflv_4234|M.gilvum_PYR-GCK MSLPVVLIADKLAQSTVEALGDQVEVRWVDGPDREKLLAAVADADALLVR
Mvan_2128|M.vanbaalenii_PYR-1 MSLPVVLIADKLAQSTVEALGDQVEVRWVDGPDREKLLAAVADADALLVR
MAB_3304c|M.abscessus_ATCC_199 -----MLIADKLAPSTVEALGDGVEVRWVDGPDRPALLAAVPEADALLVR
TH_2037|M.thermoresistible__bu VSLPVVLIADKLAESTVAALGDQVEVRWVDGPDREKLLAAVADADALLVR
MSMEG_2529|M.smegmatis_MC2_155 MTIYVSRLLTDRAMAHLESLGVPFRVGGGDPPSRADLEAGLAGADAAVIT
: . * : : :** ..* * *.* * *.:. *** ::
Mb3020c|M.bovis_AF2122/97 SATTVDAEVLAAA-PKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNI
Rv2996c|M.tuberculosis_H37Rv SATTVDAEVLAAA-PKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNI
MLBr_01692|M.leprae_Br4923 SATTVDAEVLAAA-PKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNI
MMAR_1715|M.marinum_M SATTVDAEVLAAA-TKLKIVARAGVGLDNVDVDAATTRGVLVVNAPTSNI
MUL_1952|M.ulcerans_Agy99 SATTVDAEVLAAA-TKLKIVARAGVGLDNVDVDAATTRGVLVVNAPTSNI
MAV_3847|M.avium_104 SATTVDAEVLAAA-PKLKIVARAGVGLDNVDVDAATERGVLVVNAPTSNI
Mflv_4234|M.gilvum_PYR-GCK SATTVDAEVLAAA-PKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNI
Mvan_2128|M.vanbaalenii_PYR-1 SATTVDAEVLAAA-PKLKIVARAGVGLDNVDVDAATARGVLVVNAPTSNI
MAB_3304c|M.abscessus_ATCC_199 SATTVDAEVLAAG-TKLKIVARAGVGLDNVDVKAATARGVLVVNAPTSNI
TH_2037|M.thermoresistible__bu SATTVDAEVLAAA-PKLKIVARAGVGLDNVDVEAATARGVLVVNAPTSNI
MSMEG_2529|M.smegmatis_MC2_155 LTERVDTALLAAAGPQLKIIANVAVGYDNIDVDAAVSAGVTVTNTPGVLD
: **: :***. .:***:*...** **:**.**. ** *.*:*
Mb3020c|M.bovis_AF2122/97 HSAAEHALALLLAASRQIPAADASLREH---TWKRSSFSGTEIFG-KTVG
Rv2996c|M.tuberculosis_H37Rv HSAAEHALALLLAASRQIPAADASLREH---TWKRSSFSGTEIFG-KTVG
MLBr_01692|M.leprae_Br4923 HSAAEHALALLLAASRQIAEADASLRAH---IWKRSSFSGTEIFG-KTVG
MMAR_1715|M.marinum_M HSAAEHAMALLLAAARQIPAADASLREH---TWKRSSFSGAEIFG-KTVG
MUL_1952|M.ulcerans_Agy99 HSAAEHAMALLLAAARQIPAADASLREH---TWKRSSFSGAEIFG-KTVG
MAV_3847|M.avium_104 HSAAEHALALLLAAAREIPAADASLREH---TWKRSSFSGTEIFG-KTVG
Mflv_4234|M.gilvum_PYR-GCK HSAAEHALALLLSTARQIPAADATLREH---TWKRSAFSGTEIFG-KTVG
Mvan_2128|M.vanbaalenii_PYR-1 HSAAEHALALLLAAARQIPAADATLREH---SWKRSSFSGTEIFG-KTVG
MAB_3304c|M.abscessus_ATCC_199 HSAAEHAVTLLLATARQIPAADASLKAH---TWKRSSFNGTEIFG-KTVG
TH_2037|M.thermoresistible__bu HSAAEHAIALLLAAARQIPAADATLRQR---TWKRSEFSGVEIYD-KTVG
MSMEG_2529|M.smegmatis_MC2_155 RATADHTFALILAATRRVLDGDRFLRSREPWVWGPRMLVGLDISASATLG
:::*:*:.:*:*:::*.: .* *: : * : * :* *:*
Mb3020c|M.bovis_AF2122/97 VVGLGRIGQLVAQRIAAFGAYVVAYDPYVSPARAAQLGIELLSLDDLLAR
Rv2996c|M.tuberculosis_H37Rv VVGLGRIGQLVAQRIAAFGAYVVAYDPYVSPARAAQLGIELLSLDDLLAR
MLBr_01692|M.leprae_Br4923 VVGLGRIGQLVAARIAAFGAHVIAYDPYVAPARAAQLGIELMSFDDLLAR
MMAR_1715|M.marinum_M VVGLGRIGQLVAQRVEAFGAHVVAYDPYVSPARAAQLGIELLPLDDLLAR
MUL_1952|M.ulcerans_Agy99 VVGLGRIGQLVAQRVEAFGAHVVAYDPYVSPARAAQLGIELLPLDDLLAR
MAV_3847|M.avium_104 VVGLGRIGQLVAQRLSAFGTHLIAYDPYVSPARAAQLGIELLSLDELLAR
Mflv_4234|M.gilvum_PYR-GCK VVGLGRIGQLVAQRLAAFGAHITAYDPYVSHARAAQLGIELLTLDELLSR
Mvan_2128|M.vanbaalenii_PYR-1 VVGLGRIGQLVAQRLAAFGAHITAYDPYVSHARAAQLGIELLTLDELLGR
MAB_3304c|M.abscessus_ATCC_199 VVGLGRIGQLFAQRLAAFGTHIVAYDPYVSAARAAQLGIELLTLDELLGR
TH_2037|M.thermoresistible__bu VVGLGRIGQLVAQRLAAFGTHLIAYDPYVSPARAAQLGIELVDLDELLGR
MSMEG_2529|M.smegmatis_MC2_155 ILGYGRIGKAVAQRAKGFDMKVLATARSREPG-TSEDGVQFVDTDTLLAE
::* ****: .* * .*. : * . ::: *:::: * **..
Mb3020c|M.bovis_AF2122/97 ADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEAALADAI
Rv2996c|M.tuberculosis_H37Rv ADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEAALADAI
MLBr_01692|M.leprae_Br4923 ADFISVHLPKTPETAGLIDKEALAKTKPGVIIVNAARGGLVDEVALADAV
MMAR_1715|M.marinum_M ADFISVHLPKTPETAGLLGKEALAKTKPGVIIVNAARGGLIDESALAEAI
MUL_1952|M.ulcerans_Agy99 ADFISVHLPKTPETAGLLGKEALAKTKPGVIIVNAARGGLIDESALAEAI
MAV_3847|M.avium_104 ADFISVHLPKTPETAGLIDKDALAKTKPGVIIVNAARGGLVDEAALADAV
Mflv_4234|M.gilvum_PYR-GCK ADFISVHLPKTKETAGLIGTEALAKTKPGVIIVNAARGGLIDEQALADAI
Mvan_2128|M.vanbaalenii_PYR-1 ADFISVHLPKTKETAGLIGKEALAKTKPGVIIVNAARGGLIDEAALADAI
MAB_3304c|M.abscessus_ATCC_199 ADFISVHLPKTPETAGLIGKEALAKTKPGVIIVNAARGGLIDEAALADAI
TH_2037|M.thermoresistible__bu ADIISVHLPKTPETAGLIGADALAKVKPGVIIVNAARGGLIDEQALADAI
MSMEG_2529|M.smegmatis_MC2_155 SDVLSVLTPLTPQTRHLIDAAALAKMKPSAYLVNTARGGVVDEAALMSAL
:*.:** * * :* *:. **** **.. :**:****::** ** .*:
Mb3020c|M.bovis_AF2122/97 TGGHVRAAGLDVFATEPCTDSPLFELAQVVVTPHLGASTAEAQDRAGTDV
Rv2996c|M.tuberculosis_H37Rv TGGHVRAAGLDVFATEPCTDSPLFELAQVVVTPHLGASTAEAQDRAGTDV
MLBr_01692|M.leprae_Br4923 RSGHVRAAGLDVFATEPCTDSPLFELSQVVVTPHLGASTAEAQDRAGTDV
MMAR_1715|M.marinum_M TSGHVRGAGLDVFATEPCTDSPLFELPQVVVTPHLGASTAEAQDRAGTDV
MUL_1952|M.ulcerans_Agy99 TSGYVRGAGLDVFATEPCTDSPLFELPQVVVTPHLGASTAEAQDRAGTDV
MAV_3847|M.avium_104 RSGHVRAAGLDVFSKEPCTDSPLFELPQVVVTPHLGASTTEAQDRAGTDV
Mflv_4234|M.gilvum_PYR-GCK TSGHVRGAGLDVFSTEPCTDSPLFELPQVVVTPHLGASTVEAQDRAGTDV
Mvan_2128|M.vanbaalenii_PYR-1 NSGHVRGAGLDVFSTEPCTDSPLFELPQVVVTPHLGASTVEAQDRAGTDV
MAB_3304c|M.abscessus_ATCC_199 RSGHVRGAGLDVFSTEPCTDSPLFELDQVVVTPHLGASTSEAQDRAGTDV
TH_2037|M.thermoresistible__bu ISGRVRAAGIDVFAKEPCTDSPLFDLPQVVVTPHLGASTVEAQDRAGTDV
MSMEG_2529|M.smegmatis_MC2_155 HNGALRGAALDVFENEPHIDPRLLDTPNLVLTPHIASAGESTRDAMGILA
.* :*.*.:*** .** *. *:: ::*:***:.:: .::* * .
Mb3020c|M.bovis_AF2122/97 AESVRLALAGEFVPDAVNVGGGVVNEEVAPWLDLVRKLGVLAGVLSDELP
Rv2996c|M.tuberculosis_H37Rv AESVRLALAGEFVPDAVNVGGGVVNEEVAPWLDLVRKLGVLAGVLSDELP
MLBr_01692|M.leprae_Br4923 AESVRLALAGEFVPDAVNVDGGVVNEEVAPWLDLVCKLGVLVAALSDELP
MMAR_1715|M.marinum_M AASVKLALAGEFVPDAVNIAGGAVNEEVAPWLDLACKLGVLAAALSDEPP
MUL_1952|M.ulcerans_Agy99 AASVKLALAGEFVPDAVNIAGGAVNEEVAPWLDLACKLGVLAAALSDEPP
MAV_3847|M.avium_104 AASVKLALAGEFVPDAVNVAGGTVNEEVAPWLDLVRKLGLLAATLSDGPP
Mflv_4234|M.gilvum_PYR-GCK AASVKLALAGEFVPDAVNVGGGAVGEEVAPWLDLVRKLGLLVGALSAELP
Mvan_2128|M.vanbaalenii_PYR-1 AASVKLALAGEFVPDAVNVGGGAVGEEVAPWLDLVRKLGLLVGVLSSEPP
MAB_3304c|M.abscessus_ATCC_199 AASVQLALAGEFVPDAVNVGGGVVSEEVAPWLEVVRKLGVLIGAVSEQLP
TH_2037|M.thermoresistible__bu AASVKLALAGEFVPDAVNVGAGEVSEEVAPWVDLARKLGLLVGTLSGEPT
MSMEG_2529|M.smegmatis_MC2_155 IDNAAAVLAGKPALTPVR--------------------------------
.. .***: . .*.
Mb3020c|M.bovis_AF2122/97 VSLSVQVRGELAAEEVEVLRLSALRGLFSAVIEDAVTFVNAPALAAERGV
Rv2996c|M.tuberculosis_H37Rv VSLSVQVRGELAAEEVEVLRLSALRGLFSAVIEDAVTFVNAPALAAERGV
MLBr_01692|M.leprae_Br4923 ASLSVHVRGELASEDVEILRLSALRGLFSTVIEDAVTFVNAPALAAERGV
MMAR_1715|M.marinum_M VSLSVQARGELASEDVEVLKLSALRGLFSAVVEGPVTFVNAPALAAERGV
MUL_1952|M.ulcerans_Agy99 VSLSVQAGGELASEDVEVLKLSALRGLFSAVVEGPVTFVNAPALAAERGV
MAV_3847|M.avium_104 VSLSVQVRGELASEDVEVLKLSALRGLFSAVVEGPVTFVNAPALAEERGV
Mflv_4234|M.gilvum_PYR-GCK TNLCVQVRGELASEEVEVLRLSALRGLFSAVIEDQVTFVNAPALATERGV
Mvan_2128|M.vanbaalenii_PYR-1 VSLQVQVQGELASEEVEVLKLSALRGLFSAVIEHPVTFVNAPALASERGV
MAB_3304c|M.abscessus_ATCC_199 TSLSVDVRGELASEDVAVLKLSALRGLFSSVIEDQVTFVNAPSIAEERGV
TH_2037|M.thermoresistible__bu ATLQVRVAGELASEDVEVLRLSALRGLFSTLTDQQVTYVNAPTLAAERGM
MSMEG_2529|M.smegmatis_MC2_155 --------------------------------------------------
Mb3020c|M.bovis_AF2122/97 TAEICKASESPNHRSVVDVRAVGADGSVVTVSGTLYGPQLSQKIVQINGR
Rv2996c|M.tuberculosis_H37Rv TAEICKASESPNHRSVVDVRAVGADGSVVTVSGTLYGPQLSQKIVQINGR
MLBr_01692|M.leprae_Br4923 SAEITTGSESPNHRSVVDVRAVASDGSVVNIAGTLSGPQLVQKIVQVNGR
MMAR_1715|M.marinum_M SVEISKASESPNHRSVVDVRVVGADGSVVSVSGTLYGAQLTHKIVQINGR
MUL_1952|M.ulcerans_Agy99 SVEISKASESPNHRSVVDVRVVGADGSVVSVSGTLYGAQLTHKIVQINGR
MAV_3847|M.avium_104 TAEISTASESPNHRSVVDVRAVSHDGTVVNVAGTLSGPQLVEKIVQINGR
Mflv_4234|M.gilvum_PYR-GCK EASIDTESESPNHRSVVDVRAVAADGSTVNVSGTLTGPQLVEKIVQINGR
Mvan_2128|M.vanbaalenii_PYR-1 EASITTATESANHRSVVDVRAVAADGSTVNVAGTLTGPQLVEKIVQINGR
MAB_3304c|M.abscessus_ATCC_199 SAEITTATESPNHRSVVDVRAVYADGSVINVAGTLSGPQLVQKIVQINGR
TH_2037|M.thermoresistible__bu QAELEKVSESPNYRSVVDVRAVSTDGTVTNVAGTLSGPQQVEKIVQINGR
MSMEG_2529|M.smegmatis_MC2_155 --------------------------------------------------
Mb3020c|M.bovis_AF2122/97 HFDLRAQGINLIIHYVDRPGALGKIGTLLGTAGVNIQAAQLSEDAEGPGA
Rv2996c|M.tuberculosis_H37Rv HFDLRAQGINLIIHYVDRPGALGKIGTLLGTAGVNIQAAQLSEDAEGPGA
MLBr_01692|M.leprae_Br4923 NFDLRAQGMNLVIRYVDQPGALGKIGTLLGAAGVNIQAAQLSEDTEGPGA
MMAR_1715|M.marinum_M HFDLRAEGTNLIVNYVDQPGALGKIGTLLGAAGVNIHAAQLSEDVEGPGA
MUL_1952|M.ulcerans_Agy99 HFDLRAEGTNLIVNYVDQPGALGKIGTLLGAAGVNIHAAQLSEDVEGPGA
MAV_3847|M.avium_104 NFDLRARGINLVINYVDQPGALGKIGTLLGSAGVNIQAAQLSEDAEGPGA
Mflv_4234|M.gilvum_PYR-GCK NLDLRAEGVNVIINYHDQPGALGKIGTLLGGANVNILAAQLSQDADGEGA
Mvan_2128|M.vanbaalenii_PYR-1 NLELRAEGVNLIINYDDQPGALGKIGTLLGGAAVNILAAQLSQDADGIGA
MAB_3304c|M.abscessus_ATCC_199 NFDLRAEGVNLVINYADVPGALGKIGTVLGGAEVNIQAAQLSQDASGAAA
TH_2037|M.thermoresistible__bu NFDLRAEGVNLVMHYVDRPGALGKIGTLLGAADVNILAAQLSQDISGDGA
MSMEG_2529|M.smegmatis_MC2_155 --------------------------------------------------
Mb3020c|M.bovis_AF2122/97 TILLRLDQDVPDDVRTAIAAAVDAYKLEVVDLS
Rv2996c|M.tuberculosis_H37Rv TILLRLDQDVPDDVRTAIAAAVDAYKLEVVDLS
MLBr_01692|M.leprae_Br4923 TILLRLDQDVPGDVRSAIVAAVSANKLEVVNLS
MMAR_1715|M.marinum_M TVLLRLDQDVPEDVRSAIAAAVGANRLEVVDLS
MUL_1952|M.ulcerans_Agy99 TVLLRLDQDVPEDVRSAIAAAVGANRLEVVDLS
MAV_3847|M.avium_104 TILLRLDQDVPADVRSAIGAAVGANKLEVVDLS
Mflv_4234|M.gilvum_PYR-GCK TIMLRVDREVPADVLAGIGRDVNALTLEVVDLT
Mvan_2128|M.vanbaalenii_PYR-1 TVMLRLDREVPGEVLAAIGRDVNAVTLEVVDLT
MAB_3304c|M.abscessus_ATCC_199 TIILRIDRTAPDAVLDEIRAAVGATTLELVDLS
TH_2037|M.thermoresistible__bu TLMLRVNRDVPADVRDAIGAAVGASTLEVVDLS
MSMEG_2529|M.smegmatis_MC2_155 ---------------------------------